Biologic Response Modifiers: Indications, Implications and Insights

Publication date: Available online 2 March 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Benjamin P. Davis, Zuhair K. Ballas
The field of biologic immune-modulators is currently mushrooming at a dizzying pace. While most of these biologics are tested and approved for one or a few indications, their un-anticipated side effects and their off-label use have contributed significantly to our understanding of basic immune mechanisms, of the involvement of cytokines in several apparently non-immunologic diseases, and of the importance of compartmentalized immune responses. In this review, we attempt to give a bird's-eye view of the major biologics and to highlight insights and implications derived from their secondary effects and adverse reactions.



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