Comment on “Mediator of DNA Damage Checkpoint Protein 1 (MDC1) as a prognostic marker for patients with oral squamous cell carcinoma”

Abstract

The article by Dave et al. (1) aimed to correlate the expression of Mediator of DNA Damage Checkpoint Protein 1 (MDC1) with clinicopathological parameters and to evaluate its prognostic significance in 100 patients with oral squamous cell carcinoma (OSCC). Today, the main goal of oncological research remains the translation of newly discovered biochemical and histopathological biomarkers into clinical practice. Biomarkers can be mainly included in four classes: a) diagnostic biomarkers, b) prognostic biomarkers, c) predictive biomarkers, and d) surveillance biomarkers. During the last two decades, several authors have investigated potential prognostic and predictive biomarkers for OSCC (2, 3).

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