Abstract
Background
Bcl-2 and E-cadherin proteins are known to be involved in the control of apoptotic cell death and invasive potential, respectively, which is an important hallmark of tumor regulation that influences their biologic behavior.
Aim
The current study investigates the relationship of Bcl-2 and E-cadherin immunoexpression to histopathological and clinical prognostic factors in oral squamous cell carcinomas, and correlates E-cadherin/Bcl-2 ratio with Bryne's patterns of invasion.
Material & Methods
Immunohistochemical analyses for Bcl-2 and E-cadherin were performed on paraffin embedded tissue sections on 32 cases of oral squamous cell carcinoma and were scored using qualitative and quantitative (percentage positive) analysis.
Statistical analysis
The resulting data was analyzed using SPSS software version 19. Correlation between patterns of invasion and qualitative scores of Bcl-2 and E-cadherin was calculated using spearman rho correlation. Difference of mean percentage of positive cells of Bcl-2 and E-cadherin in different patterns of invasion was tested by ANOVA followed by tukey HSD test.
Results
Bcl-2 and E-cadherin immunoreactivity was positively correlated with Bryne's pattern of invasion (p value<0.05). An inverse relation was found between Bcl-2 and E-cadherin expression with a significant decrease in ratio of E-cadherin/ Bcl2 from well to poorly differentiated OSCC,stage 1 to stage 4 according to TNM staging and Bryne's patterns 1 to 5 of invasion.
Conclusions
The results pointed to the antagonistic role of E-cadherin and Bcl-2 and thus provide the opportunity for cell survival along with increased invasive potential. The ratio of these molecules can be hypothesized to evaluate risk assessment and prognosis.
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