Initial in vitro functional characterization of serum exosomal microRNAs from patients with metastatic basal cell carcinoma

Abstract

Basal cell carcinoma (BCC) is the most common of human malignancies, but the mechanism by which metastasis occurs is poorly understood¹. Serum exosomes, 30-100 nanometer membrane-bound vesicles containing regulatory microRNAs (miRs), are emerging as a mechanism for cancer metastasis in melanoma², breast³, prostate⁴, and lung cancers⁵, but the role of exosomes in BCC metastasis is not known. In this pilot study, we assessed for differences in exosomal composition in BCC patients with and without metastasis, and whether these differences confer functional changes in vitro.

This article is protected by copyright. All rights reserved.

http://ift.tt/2nzpiqj