Parotid adenoid cystic carcinoma: Retrospective single institute analysis

Publication date: Available online 31 March 2017
Source:American Journal of Otolaryngology
Author(s): Giuditta Mannelli, Lorenzo Cecconi, Martina Fasolati, Roberto Santoro, Alessandro Franchi, Oreste Gallo
PurposeAdenoid cystic carcinoma (ACC) is a uncommon salivary malignant tumor. Our aim was to review our experience with parotid ACC, to identify clinical-pathological parameters predictive for outcome.Materials and methodsWe retrospectively reviewed 228 patients affected by parotid gland carcinomas surgically treated at our Institution. Forty-four ACC were included in this study. Multivariate analysis risk models were built to predict recurrence free probability (RFP), distant recurrence free probability (DRFP), overall survival (OS) and disease free survival (DFS).ResultsTwenty-one patients (47.7%) died from ACC and 2.3% for other causes. The 41% presented local-regional recurrence, with a regional-RFP rate of 93%, and the 34% reported distant metastases (DM). The five and ten-year OS rates were 74% and 50%, respectively.ConclusionsRecurrences were mainly influenced by the presence of perineural invasion and nerve paralysis, whilst female gender and age<50 were predictors for good prognosis.



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