Higher fractional exhaled nitric oxide and Der p 1 exposure in children with asthma living in tropical environments

The interaction between environmental exposure and airway inflammation in pediatric asthma is multifactorial, but a specific clinical association exists.1,2 We attempted to study allergens common to our patient population who live in 2 distinctly different indoor environments and their effect on markers of airway inflammation. Our primary objective was to evaluate specific allergen sensitivities and exposures that would affect clinical airway inflammatory markers.3,4 Skin test results and levels of indoor allergens of dust mites, cat, dog, and cockroach were examined and compared with respiratory markers, fractional exhaled nitric oxide (FeNO) and spirometry, and systemic atopic markers, serum eosinophils, and total IgE.

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