Determination of role of ceruloplasmin in oral potentially malignant disorders and oral malignancy – A cross sectional study

Abstract

Objectives

In the process of carcinogenesis, lipid peroxidation and increased oxidative stress leads to changes in certain antioxidants. The present study was aimed to assess and co-relate serum levels of ceruloplasmin in oral premalignancies and oral cancer so as to gauge its possible association with the process of carcinogenesis and to determine its role as tumor marker.

Material and Methods

The total of 300 participants, were equally divided in six study groups i.e. Oral Submucous Fibrosis (OSMF), Oral Leukoplakia (OL), Nicotina Stomatitis (NS), Oral Malignancy (OM), Controls (C) and Healthy Controls (HC). 5 ml of blood was collected from ante cubetal vein from each participant. The serum was analyzed for ceruloplasmin levels using ERBA CHEM 5 PLUS semi automated chemistry analyzer and diagnostic kit by turbidimetric immunoassay.

Results

There were total 242 males and 58 females, who were between 18 to 82 years of age, with a mean of 45.31 ± 13.97 years. The serum ceruloplasmin levels were significantly increased in OM, OSMF, OL & NS groups as compared to C and HC groups (p<0.001). No statistically significant difference was found in intragroup analysis of the disease groups (p>0.05).

Conclusion

Serum ceruloplasmin can be used as diagnostic marker for oral premalignant and malignant lesions.

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