Cutaneous pseudomyogenic (epithelioid sarcoma-like) hemangioendothelioma FOSB immunohistochemistry demonstrating the SERPINE1-FOSB fusion gene

Abstract

Pseudomyogenic hemangioendothelioma is a distinctive vascular neoplasm characterized by a multicentric presentation that mostly involves the lower extremities of young adults. Histopathologic resemblance to epithelioid sarcoma and co-expression of both keratins and endothelial markers are its hallmarks. A specific SERPINE1-FOSB fusion gene derived from t(7;19)(q22;q13) with significantly higher FOSB mRNA expression in neoplastic cells is the characteristic cytogenetic anomaly of this tumor.

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