A single amino acid in MRGPRX2 necessary for binding and activation by pruritogens

Publication date: Available online 6 July 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Vemuri B. Reddy, Thomas A. Graham, Ehsan Azimi, Ethan A. Lerner

Teaser

Substance P, a neuropeptide associated with itch, atopic dermatitis and inflammation, activates MRGPRX2, a member of the mas-related GPCR family. A specific amino acid in the receptor has been found to be critical for activity.


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