Evaluating proteins for potential allergenicity using bioinformatic approaches

Ever since the introduction of a tougher tomato1 and, more recently, the discovery of a "DNA nanosurgery" system based on CRISPR-CAS,2 we are inexorably headed to a new world where genetically modified (GM) animals will consume GM plants, both of which will be labeled GM foods. These in turn will be (futuristically) consumed by GM humans. It is natural for allergists to wonder whether this could increase the incidence of allergy as we strive to primum non nocere and apply bioinformatics approaches to assess this at the bedside.

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