Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Παρασκευή 2 Φεβρουαρίου 2018

Biocompatibility and efficiency of biodegradable magnesium-based plates and screws in the facial fracture model of beagles

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Publication date: Available online 2 February 2018
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Byung Jun Kim, Yinglan Piao, Maierdanjiang Wufuer, Woo-Chan Son, Tae Hyun Choi
PurposeA biodegradable magnesium alloy system has been developed as a substitute for conventional plates and screws made of titanium or absorbable polymer. However, previous studies were limited to small animal experiments using screws or wires. In the present study, we preliminarily evaluated the biocompatibility and effectiveness of human standard-sized biodegradable magnesium-based plates and screws in facial fractures of beagles.MethodsFracture lines were created bilaterally in the zygomatic arches of six beagles. They were fixed in situ with plates and screws made of magnesium alloy mixed with calcium and zinc (experimental group) or absorbable polymer (control group). Laboratory testing, radiologic imaging, histological analysis, and mechanical testing were performed 4 weeks postoperatively.ResultsInflammatory reactions were not significantly increased in any animal. Mechanical testing showed higher ultimate load and structural stiffness values in the experimental group. In the histologic analysis, the void area and bone regeneration area were increased in the experimental group, while the implant area and soft tissue area were increased in the control group. Radiologically, three-dimensional micro-computed tomography showed no difference in the bone gap area between the two groups. A temporary increase in hydrogen gas around the magnesium implants regressed spontaneously and did not affect bone healing significantly.ConclusionMagnesium-based biodegradable plates and screws showed good biocompatibility and offered considerable stability for fixating facial bone fractures in the early bone-healing process. These results show the possibilities for the future development of magnesium alloy plates and screws for craniomaxillofacial fixation in humans.



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