Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τρίτη 6 Φεβρουαρίου 2018

Epidermal lipid composition, barrier integrity and eczematous inflammation are associated with skin microbiome configuration

Publication date: Available online 5 February 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Hansjörg Baurecht, Malte C. Rühlemann, Elke Rodríguez, Frederieke Thielking, Inken Harder, Anna-Sophie Erkens, Dora Stölzl, Eva Ellinghaus, Melanie Hotze, Wolfgang Lieb, Sheng Wang, Femke-Anouska Heinsen, Andre Franke, Stephan Weidinger
BackgroundGenomic approaches have revealed characteristic site-specificities of skin bacterial community structures. In addition, in children with atopic dermatitis (AD), characteristic shifts were described at creases and in particular during flares, which have been postulated to mirror the disturbed skin barrier function and/or cutaneous inflammation.ObjectiveWe sought to comprehensively analyse microbial configurations in AD across body sites, and to explore the impact of distinct abnormalities of epidermal barrier function.MethodsThe skin microbiome was determined by bacterial 16S rRNA sequencing at 4 nonlesional body sites as well as acute and chronic lesions of 10 AD patients and 10 healthy controls matched for age, sex and FLG mutation status. Nonlesional sampling sites were characterized for skin physiology parameters including chromatography-based lipid profiling.ResultsEpidermal lipid composition, in particular levels of long-chain unsaturated free fatty acids, strongly correlated with bacterial composition, in particular Propionibacteria and Corynebacteria abundance. AD displayed a distinct community structure with increased abundance and altered composition of staphylococcal species across body sites with the strongest loss of diversity and increase of S. aureus seen on chronic lesions, and a progressive shift from nonlesional skin to acute and chronic lesions. FLG deficient skin showed a distinct microbiome composition partly resembling the AD-related pattern.ConclusionEpidermal barrier integrity and function impact the skin microbiome composition. AD shows an altered microbial configuration across diverse body sites, which however is most pronounced at sites of predilection and atopic dermatitis. Eczematous affection appears to be a more important determinant than body site.



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