Purpose of review To provide an overview of the mechanistic and clinical evidence for the use of nonspecific immunomodulators in paediatric respiratory tract infection (RTI) and wheezing/asthma prophylaxis. Recent findings Nonspecific immunomodulators have a long history of empirical use for the prevention of RTIs in vulnerable populations, such as children. The past decade has seen an increase in both the number and quality of studies providing mechanistic and clinical evidence for the prophylactic potential of nonspecific immunomodulators against both respiratory infections and wheezing/asthma in the paediatric population. Orally administered immunomodulators result in the mounting of innate and adaptive immune responses to infection in the respiratory mucosa and anti-inflammatory effects in proinflammatory environments. Clinical data reflect these mechanistic effects in reductions in the recurrence of respiratory infections and wheezing events in high-risk paediatric populations. A new generation of clinical studies is currently underway with the power to position the nonspecific bacterial lysate immunomodulator OM-85 as a potential antiasthma prophylactic. Summary An established mechanistic and clinical role for prophylaxis against paediatric respiratory infections by nonspecific immunomodulators exists. Clinical trials underway promise to provide high-quality data to establish whether a similar role exists in wheezing/asthma prevention. This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://ift.tt/OBJ4xP Correspondence to Dr Wojciech Feleszko, Department of Pediatric Respiratory Diseases and Allergy, ul. Zwirki i Wigury 63A, 02-091 Warsaw, Poland. Tel: +48 317 94 19; e-mail: wojciech.feleszko@kliniczny.pl Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (www.co-allergy.com). Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
http://ift.tt/2FQd5tJ
Αρχειοθήκη ιστολογίου
-
►
2023
(256)
- ► Φεβρουαρίου (140)
- ► Ιανουαρίου (116)
-
►
2022
(1695)
- ► Δεκεμβρίου (78)
- ► Σεπτεμβρίου (142)
- ► Φεβρουαρίου (155)
-
►
2021
(5507)
- ► Δεκεμβρίου (139)
- ► Σεπτεμβρίου (333)
- ► Φεβρουαρίου (628)
-
►
2020
(1810)
- ► Δεκεμβρίου (544)
- ► Σεπτεμβρίου (32)
- ► Φεβρουαρίου (28)
-
►
2019
(7684)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (53)
- ► Φεβρουαρίου (2841)
- ► Ιανουαρίου (2803)
-
▼
2018
(31838)
- ► Δεκεμβρίου (2810)
- ► Σεπτεμβρίου (2870)
-
▼
Μαρτίου
(2963)
-
▼
Μαρ 21
(98)
- Micro-computed tomography-based anatomical study o...
- FDA Clears Tildrakizumab (Ilumya) for Plaque Psori...
- The Use Of Buccal Fat Pad In Surgical Treatment Of...
- Supportive topical tranexamic acid application for...
- Wheat amylase/trypsin inhibitors exacerbate intest...
- Wheat amylase/trypsin inhibitors exacerbate intest...
- Evaluation of selective attention in patients with...
- Maxillary tumour-induced osteomalacia
- Facial soft tissue changes after nonsurgical rapid...
- Vascular Malformations and Health-Related Quality ...
- Favre-Racouchot Syndrome Following Long-term Expos...
- Quality of Life and the Dermatologist
- Urticaria and Episcleritis in a Woman With Chronic...
- Utility of Baseline Transaminase Monitoring During...
- Utility of Baseline Transaminase Monitoring During...
- Chronic Urticaria Associated With Methylisothiazol...
- Treatment, outcomes, and demographics in sinonasal...
- Nationwide questionnaire-based survey of oral immu...
- Individuality of masticatory performance and of ma...
- Expression and localization of phosphodiesterase 2...
- Editorial Board
- Surface free energy of enamel treated with sodium ...
- Individuality of masticatory performance and of ma...
- Expression and localization of phosphodiesterase 2...
- Editorial Board
- Surface free energy of enamel treated with sodium ...
- Can too little be as bad as too much?
- Migration of a fractured inferior vena cava filter...
- Sequential retinal necrosis secondary to varicella...
- Serpentine thrombus in the heart: a rare case of t...
- Self-harm scar revision
- Metastatic primary anorectal melanoma developing i...
- Renal injury in a patient with lumbar scoliosis
- FAST examination diagnosing bladder rupture follow...
- Severe autosomal dominant polycystic kidney disease
- Multiple Inhibitory Mechanisms of Lidocaine on Bra...
- Anatomical Study of the Innervation of Anterior Kn...
- Interfascial Plane Blocks: Back to Basics
- Transmission of hepatitis E virus with plasma exch...
- Organ Transplantation in the Czech Republic
- Hypothermic Machine Preservation Benefits Deceased...
- E-xchange: Hepatitis E and the risk of plasma prod...
- Facial soft tissue changes after nonsurgical rapid...
- Immunohistochemical evaluation of Sonic Hedgehog s...
- How to manage food allergy in nursery or school
- Nonspecific immunomodulators for recurrent respira...
- Endotypes in allergic diseases
- Food allergy trends at the crossing among socio-ec...
- Precision medicine in the area of work-related asthma
- Management of irreducible unilateral facet joint d...
- Treatment, outcomes, and demographics in sinonasal...
- Wellness interventions for anesthesiologists
- Protective ventilation during anaesthesia reduces ...
- Hypogammaglobulinemia Observed One Year after Ritu...
- Congenital Aural Atresia prevalence in the Argenti...
- How to manage food allergy in nursery or school
- Nonspecific immunomodulators for recurrent respira...
- Endotypes in allergic diseases
- Food allergy trends at the crossing among socio-ec...
- Precision medicine in the area of work-related asthma
- SJL-1, a C-type lectin, acts as a surface defense ...
- Relative antibacterial functions of complement and...
- Editorial Board
- Expression of complement receptor 3 (CR3) and regu...
- Repair of Lower Canalicular Laceration Using the M...
- Making a Narrow Path, Then a Road, Through the Snow
- A Practical Recommendation for Teaching Neck Anato...
- Resolution of Diplopia in Late Repair of Enophthal...
- Assessment of Atlanto-Axial and Mandibular Rotatio...
- Improving Postoperative Nasal Airway Patency in Le...
- Does Mixed Conventional/Piezosurgery Implant Site ...
- The Modified Socket Shield Technique
- Surgical Simulation and Custom-Made Implant for Cr...
- Prosthetic Complications Affecting Single-Tooth Mo...
- Anterior Maxillary Segmental Distraction Osteogene...
- Submental Intubation: an Underutilized Technique f...
- Isolated Post-Shunt Metopic Synostosis and Neural ...
- Porcine Bone Incorporated With 4-Hexylresorcinol I...
- An Oculist and a Musician in Leipzig
- Review of “Social Media as a Platform for Surgical...
- Lacrimal Apparatus Procurement in Face Transplanta...
- The Privileges Enjoyed by Fellows
- Creation of Experimental Human Nose Model With Lyo...
- Surgical Management of Mandibular Angle Fractures
- Hypoxia induced EMT: A review on the mechanism of ...
- Low grade parotid mucoepidermoid carcinoma with tu...
- Onkologische Chirurgie 4.0
- Therapie des rezidivierten und refraktären multipl...
- Cardiovascular Disease Outcomes Related to Early S...
- The Impact of Renal Insufficiency Following Liver ...
- Goal-Directed Management of Coagulation: The right...
- Solid Organ Transplantation in Patients with Preex...
- Preexisting Cancer in Transplant Candidates: Time ...
- The Bronchial Arterial Circulation in Lung Transpl...
- EXTRACORPOREAL PHOTOPHERESIS FOR BRONCHIOLITIS OBL...
- Syndecan-1 shedding inhibition to protect against ...
- Quality metrics in solid organ transplantation: a ...
- Autocrine activation of fibroblasts by induction o...
-
▼
Μαρ 21
(98)
- ► Φεβρουαρίου (2420)
- ► Ιανουαρίου (2395)
-
►
2017
(31987)
- ► Δεκεμβρίου (2460)
- ► Σεπτεμβρίου (2605)
- ► Φεβρουαρίου (2785)
- ► Ιανουαρίου (2830)
-
►
2016
(5308)
- ► Δεκεμβρίου (2118)
- ► Σεπτεμβρίου (877)
- ► Φεβρουαρίου (41)
- ► Ιανουαρίου (39)
Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου