Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τετάρτη 21 Μαρτίου 2018

The Bronchial Arterial Circulation in Lung Transplantation: Bedside to Bench to Bedside, and Beyond

Chronic allograft dysfunction (CLAD) remains a major complication, causing the poor survival after lung transplantation. Although strenuous efforts have been made at preventing CLAD, surgical approaches for lung transplantation have not been updated over the last 2 decades. The bronchial artery, which supplies oxygenated blood to the airways and constitutes a functional microvasculature, has occasionally been revascularized during transplants, but this technique did not gain popularity and is not standard in current lung transplantation protocols, despite the fact that a small number of studies have shown beneficial effects of bronchial artery revascularization (BAR) on limiting CLAD. Also, recent basic and clinical evidence has demonstrated the relationship between microvasculature damage and CLAD. Thus, the protection of the bronchial circulation and microvasculature in lung grafts may be a key factor to overcome CLAD. This review revisits the history of BAR, discusses the role of the bronchial circulation in lung transplantation, and advocates for novel bronchial-arterial-circulation-sparing (BACS) approaches as a future direction for overcoming CLAD. While there are some already published review articles summarizing the surgical techniques and their possible contribution to outcomes in lung transplantation, to the best of our knowledge, this review is the first to elaborate on bronchial circulation that will contribute to prevent CLAD from both scientific and clinical perspectives: from bedside to bench to bedside, and beyond. *Address for Correspondence: Norihisa Shigemura, MD, PhD. Surgical Director of Lung Transplantation and Lung Failure, Temple University Hospital, 3401 N Broad Street, Parkinson Pavilion, Suite 301, Zone C, Philadelphia, PA 19140. E-mail address: Norihisa.Shigemura@tuhs.temple.edu Authorship Shinya Tane (ST): shinyatane@gmail.com Kentaro Noda (KN): nodak@upmc.edu Participated in review design: NS, ST. Participated in data collection: NS, ST and KN. Participated in the writing of the paper: NS, ST. Funding Sources: N/A Competing interests: All the authors declare no conflict of interests. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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