Simple predictor of minute ventilation: Holliday-Segar revisited

Priyankar Kumar Datta, Ajisha Aravindan, Jayanandan E Sreekumar, Ajay Singh, Shambo Guha Roy

Anesthesia: Essays and Researches 2018 12(1):24-25

Background: Minute ventilation (MV) and calorific requirement (CR) are both functions of metabolic demand. The Holliday-Segar formula is a weight-based tool for predicting CR. This study was performed to derive an equation, based on the Holliday-Segar formula, for calculating resting MV from body-weight (BW), which is applicable for all age groups. Methods: MV for BW (obtained from Radford normogram) was plotted against CR for BW (as per Holliday-Segar formula), for BWs ranging from neonates to adults. From the scatter plot thus obtained, best-fit line, with the origin as intercept, was drawn. Linear regression analysis was used to obtain R2 coefficient and P value. Results: The plot of MV against CR yields a straight line passing through the origin with a slope = 46.87. R2 value is 0.98886, P < 0.001. Conclusion: MV can be easily and reliably estimated for all age groups from the equation: MV (mL/min) = 47 × CR (kcal/h).

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