The Efficacy of Touch Smear Cytology in the Diagnosis of Salivary Gland Cancers

Publication date: Available online 10 March 2018
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Seiji Hosokawa, Satoru Takebayashi, Yutaka Sasaki, Hiroyuki Mineta
PurposeMethods for cytological diagnosis, such as fine-needle aspiration (FNA) and touch smear (TS) cytology, have been frequently used for malignant tumor screening; however, false-negative cases often result in misdiagnosis. The purpose of this study is to investigate the causes of false-negative cases and methods to reduce the false-negative rate in salivary gland tumor TS cytology.MethodsIn this cross-sectional study, we examined pathologically confirmed salivary gland tumors in 127 cases in which both FNA and TS cytology were performed before the operation or open biopsy at Numazu City Hospital from 2002–2016. We evaluated the false-negative rates of TS and FNA cytology separately and when used in combination and other variables such as age, sex, sensitivity, accuracy, specificity, and the overall pathological diagnosis by resection.ResultsThe overall false-negative rate of postoperative pathological diagnosis was lower when TS and FNA were combined (1/127 cases, 0.8%) compared to FNA cytology alone (10/127 cases, 7.9%), (p = 0.034). Suggested causes of a false-negative FNA (or/and TS) result include cytological difficulties present in certain malignancies, e.g., mucoepidermoid carcinoma, adenoid cystic carcinoma, and others.ConclusionFalse-negative cases were reduced when a combination of preoperative FNA and intraoperative TS cytology were performed. TS cytology appears to be a useful method to avoid misdiagnosis in salivary gland diseases.



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