Combination therapy improves immune response and prognosis in patients with advanced oral mucosal melanoma: a clinical treatment success

Publication date: Available online 29 May 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Jing Zhang, Mei Yu, Xiaolong Li, Xiaofeng Huang, Hua Wang
ObjectiveThis study was undertaken to analyse the disease response and the immune response to assess treatment effectiveness and success in patients with advanced oral mucosal melanoma (OMM) treated with cytokines injection, cryosurgery and adoptive cell transfer therapy(ACT).Study designTen patients were enrolled, and the relevant characteristics and immunological differences were evaluated.ResultsAll patients achieved an objective clinical response according to the Response Evaluation Criteria in Solid Tumors, including seven cases of continuing complete remission (55, 27, 87⁺, 58⁺, 58⁺, 45⁺ and 37⁺ months) and three cases of partial remission (30, 12 and 9 months). Five responders are currently alive. After combination therapy, we observed that the proportion of CD3+ lymphocytes and the secretion of IFN-γincreased, while IL-10 decreased. In the assay of improved cytokine-induced killer cells (iCIKs), CD4+CD25+ Treg (regulatory T) cells declined and NK (nature killer) cells up-regulated. Meanwhile, the proliferation rate of in vitro cultured iCIKs improved after courses of therapy.ConclusionCombination therapy of Cytokine injection, cryosurgery and iCIKs transfer may be a promising approach for OMM patients in the future.



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