Efficacy of a glycopolymer-based oral rinse upon pain associated with ulcerative and erosive lesions of the oral mucosa: A within subject pilot study

Publication date: Available online 29 May 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Joel B. Epstein, Diplomate ABOM, Dana C. Villines, Shenda Baker
ObjectivesThe purpose of this pilot study was to assess the magnitude of effect for a new topical rinse that may impact oral soreness and function in ulcerative oral mucosal lesions.Study DesignTwenty-five consecutive patients with ulcerative/erosion lesion and moderate pain visual analogue pain score (VAS>4) rated their mouth and throat soreness and oral symptoms at baseline, 24, 48 and 72 hours after open-label use of a chitosan-based, non-anesthetic oral rinse (Synvaza®) at least twice per day. No changes in prior therapy including analgesics were allowed during the trial.ResultsAll measures of oral soreness decreased in severity from baseline to 72 hours and overall oral soreness decreased 28% (p<0.01). Oral soreness associated with talking decreased 67% (p<0.01), drinking 62% (p<0.01), swallowing 56% (p=0.04), sleeping 51% (p=0.02) and eating 50% (p<0.01). The product was rated favorably for texture, flavor, soothing relief, mouth feel and burning/stinging with use.ConclusionOral rinsing with the study product reduced mucosal pain without anesthetic effect and improved oral function.



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