Oral lichenoid reactions may possibly be associated with abatacept: A case report and literature update

Publication date: Available online 30 June 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Bethany Zembiec-Wheeler, Abberly Lott-Limbach, Hans Malmström, Sharon Elad
Oral Lichenoid Reactions (OLRs) are a group of conditions, with a common clinical appearance and histopathologic pattern that may be induced by several conditions or medications. This report describes an OLR possibly induced by a biologic agent. A 69-year-old woman with rheumatoid arthritis (RA) presented with a chief complaint of oral pain. The patient retroactively reported of skin lesions as well. Clinically, she had mixed red-white mucosal lesions and ulcers suggestive of an OLR. This diagnosis was supported by the histopathologic findings. Withholding the putative etiologic agent, abatacept, resulted in an immediate improvement of both oral and skin lesions.Abatacept and other biologics are thought to help treat inflammation and are becoming more commonly prescribed to treat RA. However, the clinicians should explore these medications as a causative factor for OLR.



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