Combination Inhaled Glucocorticoid/Long-Acting Beta-Agonist Safety: The Long and Winding Road

This perspective seeks to address one of the major controversies that had plagued asthma management for over a decade. This controversy involves long-acting beta-agonist (LABA) safety, as it pertains to its use when combined with an inhaled glucocorticoid (GC). Unlike many controversies in medicine, this one can finally be put to rest. LABA's when used in combination with an inhaled GC are safe 1-4. On December 20, 2017 the FDA removed the black box warning in a Drug Safety Communication stating that there was no significant increase in risk of serious asthma outcomes with LABA's used in combination with inhaled GC's 5.

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