Effects of Timing of Extra Corporeal Shock Wave Therapy on Mandibular Distraction Osteogenesis

Publication date: Available online 24 July 2018

Source: Journal of Oral and Maxillofacial Surgery

Author(s): Jiriys George Ginini, Omri Emodi, Edmond Sabo, Gila Maor, Dekel Shilo, Adi Rachmiel

Abstract

Purpose

Distraction osteogenesis (DO) is an established method for bone lengthening in the craniofacial skeleton. Its major drawback is the long consolidation period with attendant morbidity and possible complications. Several methods have been suggested to shorten the consolidation period. In this study, we evaluate the effects and timing of extracorporeal shock wave therapy (ESWT) on bone mineralization and extra cellular bone matrix proteins during mandibular distraction osteogenesis.

Methods

Twenty-seven rats underwent mandibular DO (latency period, 3 days; distraction period, 10 days, 0.5 mm/day) and were divided into three groups according to the timing of ESWT application: group I (control) received no treatment, group II and III received (0.18 mJ/mm²) ESWT before and after the active distraction period, respectively. The distracted mandibles were harvested following four weeks of consolidation and analyzed radiographically, histologically and immunohistochemically.

Results

Group III showed significantly increased mineral density, enhanced bone formation, higher collagen orientation index and greater expression of collagen type-I and osteocalcin proteins.

Conclusion

Application of ESWT following active distraction enhances bone maturation and mineralization.

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