Salivary IgA Deficiency in a Patient with Cystic Fibrosis (genotype M470V/V520F)

Secretory Immunoglobulin A (SIgA) plays an important role in immunity by limiting the epithelial adherence and penetration of bacteria throughout the body's mucosal surfaces, including the gastrointestinal tract, oral cavity, and respiratory system.1 Disorders that have involvement of mucosal spaces such as cystic fibrosis in theory rely on mucosal SIgA. Salivary IgA is one example of SIgA and is often utilized as a biomarker for secretory IgA given its ease of collection.2 Cystic fibrosis (CF) is an autosomal recessive disorder that is most commonly caused by a defect in the cystic fibrosis transmembrane conductance regulator (CFTR), leading to abnormally viscous secretions.

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