A clinicopathologic study on central odontogenic fibroma: with special reference to amyloid variant

Publication date: Available online 6 September 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Author(s): Chuan-Xiang Zhou, Tie-Jun Li

Abstract

Objective

. To clarify the clinicopathological features of central odontogenic fibroma (OF), especially the amyloid variant, and to discuss its relationship with Langerhans cell variant of calcifying epithelial odontogenic tumor (CEOT).

Study design

. The clinicopathological features and immuophenotypes of 17 OFs, including six amyloid variants, were analyzed. The Langerhans cell variant of CEOT is reviewed and its relationship with OF is discussed.

Results

. Most OFs (13/17) were located at the anterior region of the jaws, often with root resorption. The amyloid variant exhibited typical clinicopathological features of OFs characterized by dispersed small epithelial nests embedded in fibrous stroma. Immunohistochemically, the epithelial component in all central OFs, including amyloid variants, exhibited dispersed staining for CK10/13 but was negative for CK7 and CK8/18. Langerhans cells were positive for S-100 and Langerin in the epithelium of OFs including the amyloid variants.

Conclusions

. The amyloid variant of OF is a rare benign tumor exhibiting typical clinicopathological features of conventional OFs, which should not be diagnosed as CEOT even with the amyloid deposits. Previously reported cases described as "Langerhans cell variant of CEOT" should be classified as the "amyloid variant of OF" given that it shares features more in common with OFs than with CEOTs.

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