HIF-1α, NOTCH1, ADAM12 and HB-EGF are overexpressed in mucoepidermoid carcinoma

Publication date: Available online 5 October 2018

Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

Author(s): Dimitra Castelo Branco, Natacha Malu Miranda da Costa, Caio Tadashi Saab Abe, Maria Sueli da Silva Kataoka, João de Jesus Viana Pinheiro, Júnior Sérgio de Melo Alves

Abstract

Objective

Intratumoral hypoxia (IH) occurs during cellular proliferation of malignant tumors. This phenomenon is characterized by a decrease in oxygen levels in the neoplastic microenvironment. Throughout this condition, HIF-1α, NOTCH1, ADAM12, and HB-EGF proteins can be activated, triggering signaling pathways associated with tumor invasiveness through invadopodia formation. This study aimed to evaluate the immunostaining of HIF-1α, NOTCH1, ADAM12, and HBEGF in 19 cases of mucoepidermoid carcinoma (MEC) and 10 samples of salivary glands (control group).

Study Design

The immunoperoxidase technique was employed to detect the proteins of interest. A Student´s t-test was used to compare immunoexpression between MEC samples and the control group

Results

Protein immunostaining was statistically significantly higher in MEC samples than in the control group (p < 0.01), and the proteins were especially overexpressed in epidermoid cells of MEC

Conclusion

We suggest an association between the NOTCH1 signaling pathway activated by IH and the biologic behavior of MEC.

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