Evaluation Of Cd8+ And Natural Killer Cells Defense In Oral And Oropharyngeal Squamous Cell Carcinoma

Publication date: Available online 1 February 2019

Source: Journal of Cranio-Maxillofacial Surgery

Author(s): Edilmar Moura Santos, Felipe Rodrigues de Matos, Everton Freitas de Morais, Hébel Cavalcanti Galvão, Roseana de Almeida Freitas

Abstract

Purpose

The aim of this study was to evaluate the population of CD8+ and natural killer (NK) cells in samples of oral (OSCC) and oropharyngeal (OPSCC) squamous cell carcinoma.

Patients and methods

Fifty-four cases squamous cell carcinoma (42 OSCC and 12 OPSCC) were immunohistochemically treated by CD8 and CD57 monoclonal antibodies. It was evaluated the relationship of CD8+ and NK cells with tumor size, lymph node metastasis (LNM), clinical staging (CS), overall survival (OS) and disease-free survival (DFS).

Results

Only CD8 was higher expressed in both tumors T1 and T2 than T3 and T4, as well as in tumours without LNM and with CS II or III (P < 0.05). There was no association with OS and DFS of both biomarkers.

Conclusions

These findings suggest that the differential CD8+ cells infiltration in OSCC and OPSCC might reflect a distinctive tumor microenvironment with a favorable local cytotoxic immune response against neoplastic cells.

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