Patient‐derived xenografts (PDX) of a case of ameloblastic fibrodentinoma

Abstract

Ameloblastic Fibrodentinoma (AFD) is a benign odontogenic tumour of unclear pathogenesis. It is usually diagnosed before the age of 20 years and treatment is conservative surgery, with occasional segmental resection (Philipsen et al., 1997, Chrcanovic & Gomez, 2017). AFD can perforate cortical bone and recur.

AFD is composed of odontogenic ectomesenchyme resembling the dental papilla and epithelial strands and nests resembling dental lamina and enamel organ, in addition to scattered dentinoid deposits (Slootweg, 1981, Cassidy et al, 1987, Bavle et al., 2017). During development odontoma can resemble AFD (Slootweg, 1981) and ameloblastic fibroodontoma (AFO) and the WHO 2017 head and neck tumours classification considered these lesions part of the spectrum of developing odontomas (EI‐Naggar et al., 2017). However, there is sufficient evidence that at least some AFD and AFO are true neoplastic lesions (Chrcanovic & Gomez, 2017, Slootweg, 1981, EI‐Naggar et al., 2017).

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