The extremely broad odorant response profile of mouse olfactory sensory neurons expressing the odorant receptor MOR256-17 includes TAAR ligands
Abstract The mouse olfactory system employs ~1,100 G-protein coupled odorant receptors (ORs). Each mature olfactory sensory neuron (OSN) is thought to express just one OR gene, *and* the expressed OR determines the odorant response properties of the OSN. The broadest odorant response profile thus far demonstrated in native mouse OSNs is for OSNs that express the OR gene *SR1* (also known as *Olfr124* and *MOR256-3*). Here we show that the odorant responsiveness of native mouse OSNs expressing the OR gene *MOR256-17* (also known as *Olfr15* and *OR3*) is even broader than that of O... περισσότερα »
Declined hTERT expression of peripheral blood CD4+ T cells in oral lichen planus correlated with clinical parameter
Declined hTERT expression of peripheral blood CD4+ T cells in oral lichen planus correlated with clinical parameter: Background Oral lichen planus (OLP) is a chronic, T-cell-mediated inflammatory autoimmune disease. Human telomerase reverse transcriptase (hTERT), a catalytic subunit bearing the enzymatic activity of telomerase, may have a unique function in regulating the activation, proliferation, and function of T lymphocytes. The goal of this study was to investigate the expression of hTERT in CD4+ and CD8+ T cells from patients with OLP and its correlation with clinical paramet...περισσότερα »
ALK1 expression in oral lichen planus: a possible relation to microvessel density
ALK1 expression in oral lichen planus: a possible relation to microvessel density: Objective To assess the expression of activin receptor-like kinase 1 (ALK1) and investigate its possible relationship with microvessel density (MVD) in different forms of oral lichen planus (OLP) compared to controls' biopsies. Methods Biopsies from 20 reticular/papular OLP (R/PLP), 20 atrophic/erosive OLP (A/ELP) patients, and 20 healthy subjects were immunohistochemically analyzed and statistically compared and correlated for ALK1 expression and MVD as assessed by CD34 expression. Results All OLP sp...περισσότερα »
Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer
Genomic aberrations of MDM2, MDM4, FGFR1 and FGFR3 are associated with poor outcome in patients with salivary gland cancer: Fibroblast growth factor receptor 1 and 3 (FGFR1, FGFR3) impact on tissue homoeostasis, embryonic development and carcinogenesis. Murine double minute protein 4 (MDM4) and mouse double minute 2 homologue (MDM2) are regulators of p53-protein and may be the origin of an apoptosis overpowering cascade. A collective of 266 carcinomas of salivary glands were investigated for MDM2, MDM4, FGFR1 and FGFR3 aberrations by fluorescence *in situ* hybridization (FISH). The... περισσότερα »
Evaluation of prolidase activity and oxidative stress in patients with oral lichen planus and oral lichenoid contact reactions
Evaluation of prolidase activity and oxidative stress in patients with oral lichen planus and oral lichenoid contact reactions: Objective The aim of this study was to evaluate prolidase activity and oxidative stress in patients with oral lichen planus (OLP) and oral lichenoid contact reactions (OLCR) using serum and salivary samples and to compare these biomarkers with each other as well as with a group of healthy subjects in order to be able to opine their role in the estimation of OLP and OLCR. Patients and Methods Eighteen recently diagnosed patients with OLP, 32 patients with OLC... περισσότερα »
The role of HOX genes in head and neck squamous cell carcinoma
The role of HOX genes in head and neck squamous cell carcinoma: Recent decades have witnessed the publication of numerous studies reporting alterations in the genome and transcriptome of head and neck squamous cell carcinoma (HNSCC). Currently, the utilisation of these alterations as biomarkers and targets for therapy is limited and new, useful molecular characteristics are being sought. Many of the published HNSCC gene expression profiles demonstrate alterations in the expression of *HOX* genes. These are a family of Homeobox-containing genes which are involved in developmental pa... περισσότερα »
Ultrasound of the salivary glands is a strong predictor of labial gland biopsy histopathology in patients with sicca symptoms
Ultrasound of the salivary glands is a strong predictor of labial gland biopsy histopathology in patients with sicca symptoms: Background The international classification criteria for Sjögren's syndrome necessitate the presence of either extractable nuclear antibody or a characteristic focal inflammatory infiltrate in a minor salivary gland. Thus, patients who are extractable nuclear antibody-negative will need to have a labial salivary gland biopsy, which is an invasive procedure associated with morbidity. The aim of this study was to evaluate the viability of ultrasound imaging o... περισσότερα »
Assessment of Alar Flare and Efficacy of Alar Cinch Suture in the Management of Alar Flare Following Le Fort 1 Superior Repositioning: A Comparative Study
Assessment of Alar Flare and Efficacy of Alar Cinch Suture in the Management of Alar Flare Following Le Fort 1 Superior Repositioning: A Comparative Study: Abstract ObjectivesTo prospectively analyze the amount of alar flare, factors contributing to alar flare and efficacy of cinch suture as an adjunctive procedure for alar flare reduction. Study DesignThirty adult patients with vertical maxillary excess, who underwent Le Fort 1 impaction, were divided into 2 groups of 15 each. Alar cinch was performed as an adjunct procedure in group 2 patients and results were compared to gr... περισσότερα »
Orbital Navigation Surgery
Use of Occlusal Splint for Noninvasive Fixation of a Reference Frame in Orbital Navigation Surgery: Abstract IntroductionWhen prepping for navigation surgery, a reference frame must be fixed to the patient’s head with a Mayfield clamp, bone anchor, headset, or headband. Fixation of the clamp or bone anchor with a screw or head pins is invasive, whereas use of a headband or headset is noninvasive. However, during orbital surgery for blowout fractures or orbital tumors, surgeons or instruments can interfere between the reference frame and the optical tracking navigation system, even...περισσότερα »
‘Stylo-mandibular complex’ fracture
‘Stylo-mandibular complex’ fracture from a maxillofacial surgeon's perspective – review of the literature and proposal of a management algorithm: The incidence of fractures of styloid process, either in isolation or association with mandibular fractures, is rare, and frequently overlooked. When present, they pose clinical dilemma in diagnosis and management. Proper management of styloid fractures is essential, not just to alleviate the patients’ symptoms, but also to prevent potential complications like post-traumatic styloid syndrome and injury to adjacent vital structures. This ar... περισσότερα »
The Speech Handicap Index in patients with oral cavity cancer
Validity and reliability of the Korean version of the Speech Handicap Index in patients with oral cavity cancer: The aims of this study were to evaluate the cross-cultural adaptation of the Speech Handicap Index (SHI) for Korean subjects and to determine its reliability and utility in patients with oral cavity cancer. The Korean version of the SHI was administered to 50 healthy subjects and 56 patients with speech problems resulting from treatment for oral cavity cancers. The content and construct validity, internal consistency, and test–retest reliability were examined. Healthy sub... περισσότερα »
New technique for closure of an oroantral fistula using platelet-rich fibrin
New technique for closure of an oroantral fistula using platelet-rich fibrin: An oroantral fistula forms when the blood clot comes out of an extraction socket after there has been a breach of the floor and the epithelial membrane of the maxillary sinus. The blood clot would have otherwise served as a “scaffold” for the epithelial cells to grow from the margins towards the centre of the wound to heal it.
Virtual occlusal definition for orthognathic surgery
Virtual occlusal definition for orthognathic surgery: Computer-assisted surgical simulation is being used increasingly in orthognathic surgery. However, occlusal definition is still undertaken using model surgery with subsequent digitization via surface scanning or cone beam computed tomography. A software tool has been developed and a workflow set up in order to achieve a virtual occlusal definition. The results of a validation study carried out on 60 models of normal occlusion are presented. Inter- and intra-user correlation tests were used to investigate the reproducibility of th... περισσότερα »
Le Fort I advancement osteotomies of 1 cm or more. How safe or stable?
Le Fort I advancement osteotomies of 1 cm or more. How safe or stable?: We studied the results and stability of Le Fort I maxillary osteotomies with advancement of at least 1cm. We analysed prospective data from 32 consecutive patients who were operated on by a single surgeon between 1985 and 2007, and who had mean advancement of the maxilla of 14mm (range 10–22mm).Mean relapse for all cases antero-posteriorly was 1mm, 10% (range 0–4mm). Relapse was marginally greater in the 24 patients with a repaired cleft palate (11%) compared with those without a cleft (8%). The results were ess...περισσότερα »
Disease management the future of OSA and TMD therapy?
Disease management the future of OSA and TMD therapy?: *Obstructive sleep apnea is a a lifetime disorder that requires the clinical team to plan long term and treat the whole patient. The literature and more importantly medical insurance providers urge careful evaluation of temporomandibular joint as a part of oral appliance clinical work up. I read the following article by Dr. James Fricton, which was previously published in the CDA journal, and I really got excited about his approach. * *This comprehensive Patient focused program seems to be exactly what the sleep apnea dentistry... περισσότερα »
Continuous and Loud Snoring Only in the Supine Posture
Continuous and Loud Snoring Only in the Supine Posture: Snoring and suspected sleep apneas are the most frequent causes for referral for a sleep study. Snoring varies across night and is usually recorded in all body postures. Here we report a unique patient showing continuous and loud snoring only in the supine posture. Citation:Oksenberg A, Gadoth N. Continuous and loud snoring only in the supine posture. *J Clin Sleep Med* 2015;11(12):1463–1464.
Consumer Sleep Technologies
Consumer Sleep Technologies: A Review of the Landscape: Objective:To review sleep related consumer technologies, including mobile electronic device “apps,” wearable devices, and other technologies. Validation and methodological transparency, the effect on clinical sleep medicine, and various social, legal, and ethical issues are discussed. Methods:We reviewed publications from the digital libraries of the Association for Computing Machinery, Institute of Electrical and Electronics Engineers, and PubMed; publications from consumer technology websites; and mobile device app market...περισσότερα »
Temporal Characteristics of the Sleep EEG Power Spectrum in Critically Ill Children
Temporal Characteristics of the Sleep EEG Power Spectrum in Critically Ill Children: Study Objectives:Although empirical evidence is limited, critical illness in children is associated with disruption of the normal sleep-wake rhythm. The objective of the current study was to examine the temporal characteristics of the sleep electroencephalogram (EEG) in a sample of children with critical illness. Methods:Limited montage EEG recordings were collected for at least 24 hours from 8 critically ill children on mechanical ventilation for respiratory failure in a pediatric intensive ca... περισσότερα »
Obstructive Sleep Apnea and Premolar Extraction
Evidence Supports No Relationship between Obstructive Sleep Apnea and Premolar Extraction: An Electronic Health Records Review: Objective:A controversy exists concerning the relationship, if any, between obstructive sleep apnea (OSA) and the anatomical position of the anterior teeth. Specifically, there has been speculation that extraction orthodontics and retraction of the anterior teeth contributes to OSA by crowding the tongue and decreasing airway space. This retrospective study utilized electronic medical and dental health records to examine the association between missing p... περισσότερα »
Technology Use and Sleep Quality in Preadolescence and Adolescence
Technology Use and Sleep Quality in Preadolescence and Adolescence: Study Objectives:The purpose of this study was to analyze differences between preadolescents and adolescents on the use of technology and to test the contribution of using Internet and mobile phone, and circadian preference on sleep quality. Methods:We recruited a sample of 850 (364 males) preadolescents and adolescents. Self-report questionnaires about sleep schedule, sleep wake behavior problems, circadian preferences, and the use of technology (e.g., Internet and mobile phone) were administered. Students were... περισσότερα »
Hypopneas in an Adult Sleep Center Population
The 2012 AASM Respiratory Event Criteria Increase the Incidence of Hypopneas in an Adult Sleep Center Population: Study Objectives:To investigate the effect of the 2012 American Academy of Sleep Medicine (AASM) respiratory event criteria on severity and prevalence of obstructive sleep apnea (OSA) relative to previous respiratory event criteria. Methods:A retrospective, randomized comparison was conducted in an Australian clinical sleep laboratory in a tertiary hospital. The polysomnograms (PSG) of 112 consecutive patients undertaking polysomnography (PSG) for suspected OSA were...περισσότερα »
Nocturnal Hypoxemia Is Associated with White Matter Hyperintensities in Patients with a Minor Stroke or Transient Ischemic Attack
Nocturnal Hypoxemia Is Associated with White Matter Hyperintensities in Patients with a Minor Stroke or Transient Ischemic Attack: Study Objectives:Obstructive sleep apnea (OSA) is a risk factor for stroke, which is modulated by accompanying nocturnal hypoxemia. White matter hyperintensities (WMH) share many of the same risk factors as stroke. The purpose of this study was to investigate whether OSA and nocturnal hypoxemia are associated with white matter disease in patients with minor stroke and transient ischemic attack. Methods:Patients with minor stroke or TIA were recruited... περισσότερα »
Facilitators and Barriers to Noninvasive Ventilation Adherence in Youth with Nocturnal Hypoventilation Secondary to Obesity or Neuromuscular Disease
Facilitators and Barriers to Noninvasive Ventilation Adherence in Youth with Nocturnal Hypoventilation Secondary to Obesity or Neuromuscular Disease: Objective:Many youth struggle with adherence to bilevel noninvasive ventilation (NIV), often shortly after initiation of treatment. Anecdotal evidence suggests youths with comorbid obesity struggle with adherence while youths with comorbid neuromuscular disease demonstrate better adherence rates. The objective of this study was to explore factors relating to bilevel NIV adherence, and to compare these between youths with underlying... περισσότερα »
Obstructive Sleep Apnea and Parkinson Disease
A 5-Year Follow-up Study on the Relationship between Obstructive Sleep Apnea and Parkinson Disease: Study Objective:Sleep disturbances are among the most common nonmotor symptoms of Parkinson disease. However, no large epidemiological data regarding the association between obstructive sleep apnea (OSA) and Parkinson disease have been reported. The goal of this study was to investigate the risk for Parkinson disease during a 5-y follow-up period after a diagnosis of OSA using a population-based dataset. Methods:The data for this retrospective longitudinal cohort study were retri... περισσότερα »
Sleep Disordered Breathing in Active Duty Service Members with and without Combat-Related Posttraumatic Stress Disorder
A Comparative Analysis of Sleep Disordered Breathing in Active Duty Service Members with and without Combat-Related Posttraumatic Stress Disorder: Study Objectives:Posttraumatic stress disorder (PTSD) and obstructive sleep apnea (OSA) are frequently co-occurring illnesses. The purpose of this study was to determine whether comorbid PTSD/OSA is associated with increased PTSD symptoms or decreased OSA severity compared to PTSD or OSA alone in recently deployed Active Duty Service Members (ADSM). Methods:Cross-sectional observational study of ADSM who returned from combat within 24... περισσότερα »
Is Metabolic Syndrome Associated with Obstructive Sleep Apnea in Obese Adolescents?
Is Metabolic Syndrome Associated with Obstructive Sleep Apnea in Obese Adolescents?: Objective:To investigate whether there is an association between metabolic syndrome and obstructive sleep apnea syndrome (OSAS) in obese adolescents. Methods:In total, 240 pubertal children or prepubertal children older than 11 y recruited consecutively from the pediatric endocrinology unit, obesity clinic. Patients with tonsillar and adenoid hypertrophy (grade 3/4), systemic illnesses, or chronic drug usage were excluded. After anthropometric measurement and laboratory study, patients were divi... περισσότερα »
Polysomnographic Study of Sleep
Polysomnographic Study of Sleep in Survivors of Breast Cancer: Study Objective:Insomnia is a frequent complaint in breast cancer patients during and after treatment. Breast cancer survivors, 1–10 years posttreatment, underwent in-lab polysomnography (PSG) to objectively define the insomnia in those patients with such a complaint. Methods:Twenty-six breast cancer survivors (aged 39–80, mean 54.0 months posttreatment) spent 2 nights in the sleep laboratory. Sleep on Night 2 was scored for sleep stages, sleep onset latency, REM sleep onset latency, wake time, apneas and hypopneas, ...περισσότερα »
Validation of Capturing Sleep Diary Data via a Wrist-Worn Device
Validation of Capturing Sleep Diary Data via a Wrist-Worn Device: Paper sleep diaries are the gold standard for assessment of sleep continuity variables in clinical practice as well as research. Unfortunately, paper diaries can be filled out weekly instead of daily, lost, illegible or destroyed; and are considered out of date according to the newer technology savvy generations. In this study, we assessed the reliability and validity of using a wrist-worn electronic sleep diary. Design. A prospective design was used to compare capturing 14 days of sleep continuity data via paper to a... περισσότερα »
Multi-Modality Imaging for Head & Neck Cancer Free Flap Design Assessment
Multi-Modality Imaging for Head & Neck Cancer Free Flap Design Assessment: *Condition*: Head and Neck Neoplasms *Interventions*: Procedure: Pre-op CTA with IV contrast; Device: Computed tomography angiography (CTA) *Sponsor*: University Health Network, Toronto Surgical reconstruction of anatomical structures after head and neck cancer resection has made enormous strides in the past 20 years with advancing flap techniques and the usage of perforating vessels, but accurate and consistent identification of these perforators has remained a challenge due to the varying anatomy... περισσότερα »
Safety Study of MGD009 in B7-H3-expressing Tumors
Safety Study of MGD009 in B7-H3-expressing Tumors: *Conditions*: Mesothelioma; Bladder Cancer; Melanoma; Squamous Cell Carcinoma of the Head and Neck; Non Small Cell Lung Cancer; Clear Cell Renal Cell Carcinoma; Ovarian Cancer; Thyroid Cancer; Breast Cancer; Pancreatic Cancer; Prostate Cancer; Colon Cancer; Soft Tissue Sarcoma *Intervention*: Biological: MGD009 *Sponsor*: MacroGenics ArmsAssigned InterventionsExperimental: MGD009 Humanized B7-H3 x CD3 Dual-Affinity Re-Targeting (DART®) Protein Biological: MGD009 B7-H3 x CD3 DART protein Detailed D... περισσότερα »
Clinical Target Volume Based on Disease Extension Risk Atlas and Computer-aided Delineation in Nasopharyngeal Carcinoma
Clinical Target Volume Based on Disease Extension Risk Atlas and Computer-aided Delineation in Nasopharyngeal Carcinoma: *Condition*: Nasopharyngeal Neoplasms *Interventions*: Radiation: IMRT using individualized CTV; Radiation: IMRT using traditional CTV; Drug: Gemcitabine and cisplatin (induction chemotherapy); Drug: Docetaxel and cisplatin (induction chemotherapy); Drug: Cisplatin 100mg/m² concurrent chemotherapy; Drug: Cisplatin 80mg/m² concurrent chemotherapy *Sponsor*: Sun Yat-sen University ArmsAssigned InterventionsExperimental: Individualized CTV Patient...περισσότερα »
Assessment of the “July Effect”: outcomes after early resident transition in adult neurosurgery
Journal of Neurosurgery, Ahead of Print. OBJECT Each July, 4th-year medical students become 1st-year resident physicians and have much greater responsibility in making management decisions. In addition, incumbent residents and fellows advance to their next postgraduate year and face greater challenges. It has been suggested that among patients who have resident physicians as members of their neurosurgical team, this transition may be associated with increased rates of morbidity and mortality, a phenomenon known as the "July Effect." In this study, the authors compared morbidity and...περισσότερα »
Confocal Laser Microlaryngoscopy (CLMx)
Confocal Laser Microlaryngoscopy (CLMx): *Conditions*: Laryngeal Dysplasia; Laryngeal Neoplasm *Interventions*: Drug: Fluorescein injection, USP 10%; Device: Confocal laser microlaryngoscopy; Procedure: Biopsy (standard of care); Procedure: KTP laser photoablation (standard of care) *Sponsor*: Washington University School of Medicine The purpose of this study is to evaluate the accuracy and efficacy of using confocal laser microlaryngoscopy (CLM) as a tool to perform non-invasive, in vivo, real time pathologic assessment of laryngeal lesions. In order to achieve this ... περισσότερα »
Management of the critical airway
Moral considerations in non-EXIT airway management via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 10 December 2015 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Paul Walker The case report “Management of the critical airway when an EXIT procedure is not an option” has important moral decision-making implications. If intubation was not quickly successful, then significant hypoxic brain injury may have resulted. A full discussion of the moral implications in cases such as this, prior to delivery, is important - bo... περισσότερα »
Expression of CXCL4 and Aquaporin 3 and 10 mRNAs in Patients with Otitis Media with Effusion
Expression of CXCL4 and Aquaporin 3 and 10 mRNAs in Patients with Otitis Media with Effusion via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 11 December 2015 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Zhe Jin, Chung Ho Cha, Yong-Sung Choi, Young Il Kim, Sun A. Choi, Seung Geun Yeo PurposeBacterial infections in children with underdeveloped Eustachian tubes are a major cause of otitis media with effusion (OEM), and persistent effusion in the middle ear in these patients is a major cause of surgical interventio...περισσότερα »
Ultrasonography Guided Excision of Isolated Cysticercosis of the Temporalis Muscle Causing Intractable Headache: A Rare Case Report
Ultrasonography Guided Excision of Isolated Cysticercosis of the Temporalis Muscle Causing Intractable Headache: A Rare Case Report: AbstractCysticercosis cellulosae is a systemic parasitic infection caused by the larval stage of pork tapeworm, *Taenia solium* which involve humans as either a definitive or secondary hosts. The central nervous system is the most important primary site of involvement. Cases of cysticercosis presenting as an isolated muscle mass is an extremely rare entity and demands documentation. We report an extremely unusual case of isolated cysticercosis of the ...περισσότερα »
Tumour–node–metastasis staging of human papillomavirus negative upper aerodigestive tract cancers
Review ArticlesTumour–node–metastasis staging of human papillomavirus negative upper aerodigestive tract cancers: a critical appraisalU Aydila1 c1, U Duvvuria3a4, Y Kizila1 and A Köybaşioğlua2 a1 Department of Otorhinolaryngology, Head & Neck Surgery, Gazi University School of Medicine, Ankara, Turkey a2 Department of Otorhinolaryngology, Head & Neck Surgery, Memorial Ankara Hospital, Turkey a3 Department of Otorhinolaryngology, Head & Neck Surgery, University of Pittsburgh Medical Center, Pennsylvania, USA a4 Section of Otolaryngology, Veterans Affairs Pittsburgh Health System, Penns... περισσότερα »
Removal of the Evolution® Esophageal Stent - Fully Covered
Removal of the Evolution® Esophageal Stent - Fully Covered: *Conditions*: Esophageal Fistula; Esophageal Neoplasms; Esophageal Perforation; Esophageal Stenosis; Stents *Intervention*: Device: Evolution® Esophageal Stent - Fully Covered *Sponsor*: Cook ArmsAssigned InterventionsExperimental: Evolution® Esophageal StentDevice: Evolution® Esophageal Stent - Fully Covered Placement of the Evolution® Esophageal Stent for benign or malignant strictures, fistulas, perforations or leaks with the intention of removal
E10A for the Treatment of Squamous Cell Carcinoma of the Head and Neck
E10A for the Treatment of Squamous Cell Carcinoma of the Head and Neck: *Condition*: Head and Neck Neoplasms *Interventions*: Drug: Endostatins; Drug: Paclitaxel injection; Drug: Cisplatin injection *Sponsor*: Guangzhou Double Bioproducts Co., Ltd ArmsAssigned InterventionsExperimental: Combination therapy E10A+chemotherapy group (360 subjects): 1. E10A (Endostatins) of 1.0×1012VP on day 1 and 6 2. Paclitaxel Injection 160mg/m2 on day 3 3. Cisplatin Injection 25mg/m2 on day 3, 4, and 5. Repeat every 21 days. Drug: Endostatins Specification: 1mL/division, 1×1012 V...περισσότερα »
Interest of Narrow Band Imaging in Detection of Upper Aerodigestive Cancers
Interest of Narrow Band Imaging in Detection of Upper Aerodigestive Cancers: *Conditions*: Squamous Cell Carcinoma of Oropharynx; Squamous Cell Carcinoma of Hypopharynx; Squamous Cell Carcinoma of Larynx *Intervention*: Procedure: WL and NBI *Sponsor*: University Hospital, Toulouse ArmsAssigned InterventionsExperimental: Videoendoscopy with WL and NBI The day before the laryngoscopy under general anesthesia (LGA), two endoscopies by two different physicians were performed for each patients and recorded: the first one with white light (WL) and the second one with NBI (NBI...περισσότερα »
Parenteral Nutrition for Patients Treated for Locally Advanced Inoperable Tumors of the Head and Neck
Parenteral Nutrition for Patients Treated for Locally Advanced Inoperable Tumors of the Head and Neck: *Conditions*: Squamous Cell Carcinoma of the Hypopharynx Stage III; Squamous Cell Carcinoma of the Hypopharynx Stage IV; Laryngeal Squamous Cell Carcinoma Stage III; Laryngeal Squamous Cell Carcinoma Stage IV; Oropharyngeal Squamous Cell Carcinoma Stage III; Oropharyngeal Squamous Cell Carcinoma Stage IV; Squamous Cell Carcinoma of the Oral Cavity Stage III; Squamous Cell Carcinoma of the Oral Cavity Stage IV; Locally Advanced Malignant Neoplasm *Interventions*: ...περισσότερα »
Post-tonsillectomy Pain Control in Adults
Post-tonsillectomy Pain Control in Adults: *Conditions*: Pain, Postoperative; Postoperative Nausea and Vomiting; Postoperative Hemorrhage; Body Weight Changes *Interventions*: Drug: Norco (Hydrocodone and Acetaminophen); Drug: Percocet (Oxycodone and Acetaminophen); Drug: Dilaudid (hydromorphone); Drug: Tylenol (Acetaminophen) *Sponsor*: University of Nebraska This is a randomized prospective study to determine the optimal postoperative pain medication regimen for adults (18 years old and older) undergoing tonsillectomy with or without adenoidectomy for chronic ...περισσότερα »
Melatonin Oral Gel for Oral Mucositis in Patients With Head and Neck Cancer Undergoing Chemoradiation
Melatonin Oral Gel for Oral Mucositis in Patients With Head and Neck Cancer Undergoing Chemoradiation: *Condition*: Oral Mucositis *Interventions*: Drug: Melatonin oral gel 3%; Drug: Placebo oral gel *Sponsors*: Spherium Biomed; Institut Català d'Oncologia L'Hospitalet; Hospital Universitari de la Vall de Hebron; Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau; Institut Català d'Oncologia ICO Girona ArmsAssigned InterventionsExperimental: Melatonin Melatonin oral gel 3% Drug: Melatonin oral gel 3%Placebo Comparator: Placebo Placebo oral gel Dr... περισσότερα »
Smartphone speech-to-text applications for communication with profoundly deaf patients
Short CommunicationSmartphone speech-to-text applications for communication with profoundly deaf patientsF C Lyalla1 c1, P J Clampa2 and D Hajioffa2 a1 Peninsula Radiology Academy, Plymouth, UK a2 Department of ENT Surgery, University Hospitals Bristol, UK Abstract Objective: Visual communication aids, such as handwriting or typing, are often used to communicate with deaf patients in the clinic. This study aimed to establish the feasibility of communicating through smartphone speech recognition software compared with writing or typing. Method: Thirty doctors and medical students were ti... περισσότερα »
Local anaesthesia and conscious sedation for cochlear implantation
Main ArticleLocal anaesthesia and conscious sedation for cochlear implantation: experience with 20 patientsB Paterona1 c1, D Bakhosa1a2, A LeLouarna3, P Bordurea4, A Bozorg Grayelia5, B Godeya6and E Lescannea1a2 a1 Otorhinolaryngology and Head and Neck Surgery Department, University Hospital Center of Tours, France a2 Joint Research Unit (French National Institute of Health and Medical Research – Unit 930, and French National Center for Scientific Research – Accredited Research Team 3106), François Rabelais University Hospital Center of Tours, France a3 Medical Information, Epidemiolo... περισσότερα »
Immune imbalance of regulatory T/type 2 helper cells in the pathogenesis of allergic rhinitis in children
Main ArticleImmune imbalance of regulatory T/type 2 helper cells in the pathogenesis of allergic rhinitis in childrenR Suna1, X-Y Tanga2a3a4 c1 and Y Yanga2a3a4 a1 Department of Physical Examination, First Affiliated Hospital of Chongqing Medical University, Chongqing, China a2 Department of Otolaryngology, Children's Hospital of Chongqing Medical University, Chongqing, China a3 Pediatric Research Institute of Chongqing Medical University, Chongqing, China a4 National Key Disciplinary Areas of Pediatrics, Ministry of Education, Chongqing, China Abstract Objectives: To determine the ro...περισσότερα »
Laryngeal biopsies
Main ArticleLaryngeal biopsies: are we doing more, and why? A decade of resultsS Lima1 c1, P Saua2, L Coopera3, A McPhadena3 and K MacKenziea1 a1 Department of Otolaryngology Head and Neck Surgery, University of Glasgow, Scotland, UK a2 Department of Medical School, University of Glasgow, Scotland, UK a3 Department of Pathology, Glasgow Royal Infirmary, University of Glasgow, Scotland, UK Abstract Background: Over the last decade, we have observed an escalating trend in the number of laryngeal biopsies performed, despite the incidence of laryngeal cancer remaining constant. This study ... περισσότερα »
Modified approach to powered endoscopic dacryocystorhinostomy
Main ArticleModified approach to powered endoscopic dacryocystorhinostomyT N Janakirama1, N Suria2 c1 and S B Sharmaa1 a1 Department of Otolaryngology, Royal Pearl Hospital, Tiruchirapalli, Tamil Nadu a2 Department of ENT, Gujarat Medical Education and Research Society (‘GMERS’) Medical College, Gandhinagar, India Abstract Objective: This paper presents modifications to powered endoscopic dacryocystorhinostomy without stenting for the management of acquired nasolacrimal duct obstruction. Study design: A retrospective, non-randomised review. Method: A total of 105 patients with epiphora... περισσότερα »
Prognostic value of mean platelet volume on tinnitus
Main ArticlePrognostic value of mean platelet volume on tinnitusO Kemala1 c1, T Müderrisa2, F Başara1, G Kutlara1 and F Güla2 a1 Otolaryngology Department, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey a2 Otolaryngology Department, Ankara Atatürk Education and Research Hospital, Turkey Abstract Objective: This study aimed to determine whether there was any relationship between tinnitus and mean platelet volume. Methods: This retrospective study was conducted between January 2013 and January 2014 in Ankara Atatürk Hospital and Ondokuz Mayıs University Hospital, Turkey, ... περισσότερα »
Eosinophilic oesophagitis
Review ArticlesEosinophilic oesophagitis: a systematic review for otolaryngologistsM Bahgata1, N Dawea1 and L Flooda1 c1 a1 Department of ENT, James Cook University Hospital, Middlesbrough, UK Abstract Background: Eosinophilic oesophagitis is a chronic, immune/antigen-mediated oesophageal disease, only recently, but increasingly, recognised in the world literature. It is diagnosed and managed primarily by medical gastroenterologists and allergy specialists, and is a distinct disease entity, affecting both children and adults. Few studies have been published in otolaryngology journals,...περισσότερα »
The Journal of Laryngology & Otology
FirstView Article(s) The Journal of Laryngology Otology, FirstView Article(s) The Journal of Laryngology Otology ( JLO ) is a leading monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialities. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area, regardless of the country in which they practise. JLO contains main articles (original, review and historical), case ... περισσότερα »
Spontaneous regression of laryngeal squamous cell carcinoma
Clinical RecordsSpontaneous regression of laryngeal squamous cell carcinoma F Sipaula1 c1, B Linga2, C Masona3 and A Keasta2 a1 ENT Department, Southampton General Hospital, UK a2 Department of ENT, Christchurch Public Hospital, New Zealand a3 Department of Pathology, Christchurch Public Hospital, New Zealand Abstract Background: Spontaneous regression of solid malignancy is extremely rare. It is virtually unheard of in the last half century in the published literature. The overwhelming majority of medical professionals do not know that this phenomenon exists. Case report: This paper rep...περισσότερα »
Endoscopic transpterygoidal repair of a large cranial defect with cerebrospinal fluid leak
Clinical RecordsEndoscopic transpterygoidal repair of a large cranial defect with cerebrospinal fluid leak in a patient with extensive osteoradionecrosis of the skull base: case report and technical noteY Brand a1, E Lima1, V Warana2 and N Prepagerana1 c1 a1 Department of Otorhinolaryngology, University of Malaya, Kuala Lumpur, Malaysia a2 Department of Neurosurgery, University of Malaya, Kuala Lumpur, Malaysia Abstract Background: Endoscopic endonasal techniques have recently become the method of choice in dealing with cerebrospinal fluid leak involving the anterior cranial fossa. How...περισσότερα »
Labyrinthine sequestration secondary to auditory implantation
Clinical RecordsLabyrinthine sequestration secondary to auditory implantation: report of two cases and review of the literatureE Warnera1, N Ezea1, S Connora2 and D Jianga3 c1 a1 Department on Otolaryngology, Guy's Hospital, Guy's and St Thomas’ NHS Foundation Trust, London, UK a2 Department of Radiology, Guy's Hospital, Guy's and St Thomas’ Hospital NHS Foundation Trust, London, UK a3 St Thomas’ Hearing Implant Centre, St Thomas’ Hospital, Guy’s and St Thomas’ NHS Foundation Trust, London, UK Abstract Background: Auditory implantation into the inner ear is increasingly performed for ... περισσότερα »
Transoral endoscopic ENT surgical procedures
Short CommunicationElective dental extractions and osseointegrated implant replacement to facilitate transoral endoscopic ENT surgical proceduresC J Butterwortha1 c1, J Lancastera1 and H S Shaha1 a1 Regional Head and Neck Surgery Unit, University Hospital Aintree, Liverpool, UK Abstract Background: Transoral endoscopic ENT surgical procedures are a mainstay of treatment for a variety of conditions and are often preferable to open surgery where possible. Cases of micrognathia, prominent incisor teeth or trismus may create difficulties in gaining sufficient access to undertake such pro...περισσότερα »
The otolaryngology undergraduate medical clerkship
Main ArticlesValidation and evaluation of new assessments for the otolaryngology undergraduate medical clerkshipR Woodsa1 c1, T Subramaniama1, A Pattersona2, M Hennessya2 and C Timona1 a1 Department of Otolaryngology, Trinity College Dublin, Ireland a2 School of Medicine, Trinity College Dublin, Ireland Abstract Objectives: To validate and evaluate a short answer question paper and objective structured clinical examination. Validity and effect on overall performance were considered. Methods: Students completed a voluntary short answer question paper during their otolaryngology attachme...περισσότερα »
Knowledge of the epidemiology and distribution of oral mucosal lesions is essential to promote early diagnosis and treatment. Further epidemiological studies exploring the causal relationships and risk factors for lip lesions are necessary for a better understanding of lip diseases
Main ArticlesA 15-year retrospective study of 160 cases of benign lip lesionsS Arslana1 c1, B Çobanoğlua3, A Urala1, İ Sayğina2 and A Ü Işika1 a1 Department of Otorhinolaryngology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey a2 Department of Pathology, School of Medicine, Karadeniz Technical University, Trabzon, Turkey a3 Department of Otorhinolaryngology, Kanuni Training and Research Hospital, Trabzon, Turkey Abstract Objective: This study aimed to describe the results of a retrospective analysis of a specific cohort of patients with benign lip lesions encount...περισσότερα »
Bronchoscopy in panendoscopy
Main ArticlesBronchoscopy in panendoscopy: review and assessmentA Shahangian a1 and E J Damrosea1 c1 a1 Division of Laryngology, Department of Otolaryngology/Head and Neck Surgery, Stanford University School of Medicine, California, USA Abstract Objective: To determine the utility of bronchoscopy to identify synchronous primaries in head and neck cancer patients. Study design: Case series with chart review. Method: The charts of all patients undergoing bronchoscopy between January 2008 and December 2013 were reviewed. Only those undergoing bronchoscopy as part of panendoscopy for head a... περισσότερα »
Positron emission tomography computed tomography should be used with caution for the pre-operative staging of head and neck cancers because of its high false positive and false negative rates
Main ArticlesComparing staging by positron emission tomography with contrast-enhanced computed tomography and by pathology in head and neck squamous cell carcinomaJ R Qualliotinea1, W K Mydlarza1, J YK Chana1, X Zhou a2, H Wanga2 and N Agrawala1 c1 a1 Department of Otolaryngology – Head and Neck Surgery, Division of Biostatistics and Bioinformatics, Johns Hopkins School of Medicine, Baltimore, MD, USA a2 Department of Oncology, Division of Biostatistics and Bioinformatics, Johns Hopkins School of Medicine, Baltimore, MD, USA Abstract Objective: This study aimed to evaluate the ability ... περισσότερα »
The marked fibrosis observed in OK-432-injected turbinates may be responsible for a reduction in turbinate size
Main ArticlesThe effect of OK-432 (Picibanil) injection on the histopathology of nasal turbinateS Sengula1, İ Kaygusuza2 c1, M M Akina3, Ş Yalcina2, T Karlidaga2, E Kelesa2 and İ Arslana4 a1 Department of Otorhinolaryngology, Government Hospital, Karabük, Turkey a2 Department of Otorhinolaryngology, Medical Faculty, Firat University, Elazig, Turkey a3 Department of Pathology, Medical Faculty, Firat University, Elazig, Turkey a4 Department of Otorhinolaryngology, Government Hospital, Bingöl, Turkey Abstract Objective: This study aimed to assess the histopathological effect of OK-432 (Pi... περισσότερα »
Post-traumatic olfactory loss
Main ArticlesRisk of decline and chance of improvement in olfaction among patients with post-traumatic olfactory lossC-L Kuoa1a2a3a4a5 and C-H Shua1a3 c1 a1 Department of Otolaryngology – Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China a2 Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan, Republic of China a3 Department of Otolaryngology, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China a4 Department of Otolaryngology, Taoyuan Armed Forces General Hospital, Taiwan, Republic of China a... περισσότερα »
Arginase isoform expression in patients with different subtypes of chronic rhinosinusitis
Main ArticlesComparison of arginase isoform expression in patients with different subtypes of chronic rhinosinusitisT Taruyaa1, S Takenoa1 c1, K Kubotaa1, A Sasakia1, T Ishinoa1 and K Hirakawaa1 a1 Department of Otolaryngology, Head and Neck Surgery, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan Abstract Objective: Although human paranasal sinuses are critical organs for nitric oxide production, little information is available regarding the role of arginase in alterations of argini... περισσότερα »
The Parnes particle repositioning manoeuvre for posterior canal benign paroxysmal positional vertigo
Main ArticlesEffectiveness of the Parnes particle repositioning manoeuvre for posterior canal benign paroxysmal positional vertigoB L Kinnea1 c1 and J S Leafmana2 a1 Department of Physical Therapy, Grand Valley State University, Grand Rapids, Michigan, USA a2 College of Graduate Health Studies, A T Still University, Mesa, Arizona, USA Abstract Background: Benign paroxysmal positional vertigo is a common vestibular disorder that negatively affects an individual's health-related quality of life. This study aimed to examine the effectiveness of the Parnes particle repositioning manoeuvr...περισσότερα »
Surgery for vertigo
Main ArticlesSurgery for vertigo: 10-year audit from a contemporary vertigo clinicU Patnaika1a2, A Srivastavaa1, K Sikkaa1 and A Thakara1 c1 a1 Department of Otolaryngology – Head and Neck Surgery, All India Institute of Medical Sciences, New Delhi, India a2 Department of Otolaryngology – Head and Neck Surgery, Army Hospital Research and Referral, New Delhi, India Abstract Objective: To present the profile of patients undergoing surgical treatment for vertigo at a contemporary institutional vertigo clinic. Study design: A retrospective analysis of clinical charts. Methods: The charts of... περισσότερα »
Distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposure
Main ArticlesComparison of distortion product otoacoustic emissions and pure tone audiometry in occupational screening for auditory deficit due to noise exposureN Woolesa1a2, M Mulherana2 c1, P Braya3, M Brewstera4 and A R Banerjeea1 a1 Department of Otolaryngology, Leicester Royal Infirmary, UK a2 University of Leicester Medical School, UK a3 DGS Diagnostics, Assens, Denmark a4 Industrial Diagnostics, Leicester, UK Abstract Objective: To examine whether distortion product otoacoustic emissions can serve as a replacement for pure tone audiometry in longitudinal screening for occupation... περισσότερα »
New anticoagulant medications for ENT surgeons
Main ArticlesA guide to new anticoagulant medications for ENT surgeons M Bajalana1 c1, T C Biggsa1, S Jayarama2, J Mainwaringa3 and R Saliba1 a1 Department of ENT Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK a2 Department of ENT Surgery, Birmingham City Hospital, Southampton, UK a3 Department of Haematology, Royal Bournemouth & Poole Hospitals, Southampton, UK Abstract Objectives: This study aimed to ascertain otolaryngologists’ current knowledge of new (e.g. apixaban, rivaroxaban) and old (e.g. warfarin) anticoagulant medications, and to provide an edu... περισσότερα »
Expression of CXCL4 and Aquaporin 3 and 10 mRNAs in Patients with Otitis Media with Effusion
Expression of CXCL4 and Aquaporin 3 and 10 mRNAs in Patients with Otitis Media with Effusion: Bacterial infections in children with underdeveloped Eustachian tubes are a major cause of otitis media with effusion (OEM), and persistent effusion in the middle ear in these patients is a major cause of surgical intervention. CXCL4 is associated with bacterial infection, and aquaporins 3 and 10 are associated with water metabolism. This study assessed the expression of mRNAs encoding CXCL-4 and aquaporins 3 and 10 in the effusion of pediatric OME patients, and the association of this expr...περισσότερα »
Squamous cell carcinoma and inflammatory myofibroblastic tumor : Carcinosarcoma
Carcinosarcoma of the larynx consisting of squamous cell carcinoma and inflammatory myofibroblastic tumor components via Auris Nasus Larynx Publication date: Available online 11 December 2015 *Source:*Auris Nasus Larynx Author(s): Shinsuke Suzuki, Kyoshi Hanata, Satoshi Toyoma, Hiroshi Nanjo, Hidekazu Saito, Nobuko Iikawa, Kazuo Ishikawa ObjectiveCarcinosarcoma is a rare malignant tumor with both carcinomatous and sarcomatous components. Carcinosarcoma can appear in various organs, but its occurrence in the head and neck, particularly larynx, is extremely rare. Furthermore, its respons... περισσότερα »
Dizziness is among the most common complaints in the elderly population
The institutionalized elderly: sociodemographic and clinical-functional profiles related to dizziness via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 11 December 2015 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): Tábada Samantha Marques Rosa, Anaelena Bragança de Moraes, Valdete Alves Valentins dos Santos Filha IntroductionDizziness is among the most common complaints in the elderly population.ObjectiveTo determine the sociodemographic and clinical-functional profiles of institutionalized elderly people related to... περισσότερα »
Suppurative labyrinthitis associated with otitis media
: 26 years’ experience via ScienceDirect Publication: Brazilian Journal of Otorhinolaryngology Publication date: Available online 11 December 2015 *Source:*Brazilian Journal of Otorhinolaryngology Author(s): André Souza de Albuquerque Maranhão, Valeria Romero Godofredo, Norma de Oliveira Penido IntroductionSuppurative labyrinthitis continues to result in significant hearing impairment, despite scientific efforts to improve not only its diagnosis but also its treatment. The definitive diagnosis depends on imaging of the inner ear, but it is usually clinically presumed.ObjectiveTo analyz... περισσότερα »
Ultrasonography Guided Excision of Isolated Cysticercosis of the Temporalis Muscle Causing Intractable Headache: A Rare Case Report
Ultrasonography Guided Excision of Isolated Cysticercosis of the Temporalis Muscle Causing Intractable Headache: A Rare Case Report: AbstractCysticercosis cellulosae is a systemic parasitic infection caused by the larval stage of pork tapeworm, *Taenia solium* which involve humans as either a definitive or secondary hosts. The central nervous system is the most important primary site of involvement. Cases of cysticercosis presenting as an isolated muscle mass is an extremely rare entity and demands documentation. We report an extremely unusual case of isolated cysticercosis of the ...περισσότερα »
Adenoid Cystic Carcinoma of Buccal Mucosa
Adenoid Cystic Carcinoma of Buccal Mucosa: A Rare Case Report: AbstractAdenoid cystic carcinoma is a malignant neoplasm most commonly originating in salivary glands of head and neck region. Among intra oral adenoid cystic carcinoma, buccal mucosa is among the rarest sites. We report a case of adenoid cystic of buccal mucosa in a 40-year old female. We have discussed the clinical features, histopathology, diagnosis and treatment along with a brief review of the relevant literature. Although the buccal mucosa is an uncommon site for adenoid cystic carcinoma, the relatively indolent g... περισσότερα »
Evaluation of Association of Allergic Rhinitis with Bronchial Asthma
Evaluation of Association of Allergic Rhinitis with Bronchial Asthma: AbstractAllergic rhinitis represents a global health problem. It is a common disease worldwide affecting about 10–50 % of the population and its prevalence is increasing. Although allergic rhinitis is not a fatal disease, it alters the social life of patients, affecting learning performance and work productivity. Moreover, the costs incurred by allergic rhinitis are substantial. In recent years allergic rhinitis has been recognized to be an important risk factor for asthma. The concept of “One Airway, One Disease... περισσότερα »
Submandibular Duct Re-routing for Drooling in Neurologically Impaired Children
Submandibular Duct Re-routing for Drooling in Neurologically Impaired Children: AbstractDrooling is a challenging situation to manage especially in neurologically impaired pediatric population. Numerous surgical procedures have been described in literature but none of them is standardized. We evaluate the effectiveness of bilateral submandibular duct rerouting and sublingual gland excision in drooling paediatric patients. Prospective interventional study was conducted from November 2007 to September 2009 in twenty-eight pediatric patients with drooling who had failed conservative ... περισσότερα »
Auditory brainstem response (ABR) thresholds related to otitis media with effusion (OME) in infants with and without cleft palate and/or lip (CP±L)
ABR thresholds in infants born with CLP and OME and infants with OME via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 12 December 2015 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): H. Sundman, T. Flynn, B. Tengroth, A. Lohmander ObjectivesThe aim of this study was to investigate and compare auditory brainstem response (ABR) thresholds related to otitis media with effusion (OME) in infants with and without cleft palate and/or lip (CP±L).MethodsForty-seven infants with CP±L and 67 infants with OME participated in t... περισσότερα »
Stapeschirurgie bei Otosklerose mit einer neuen Titanprothese mit superelastischem Nitinol-Clip
Stapeschirurgie bei Otosklerose mit einer neuen Titanprothese mit superelastischem Nitinol-Clip: Zusammenfassung HintergrundDie Ankopplung am langen Ambossfortsatz ist ein entscheidender Schritt in der Steigbügelchirurgie. Die Autoren berichten über erste Erfahrungen mit der neuen NiTiFLEX®-Stapesprothese, einer Weiterentwicklung der Soft-CliP®-Stapesprothese (Fa. Kurz, Dusslingen). Der CliP® besteht nicht mehr aus reinem Titan, sondern aus „superelastischem“ Nitinol, einer Nickel-Titan-Legierung. Die Applikationskraft auf den langen Ambossfortsatz wurde dadurch weiter reduziert. ...περισσότερα »
Cranial Nerve Palsy : Traumatic Internal Carotid Artery Pseudoaneurysm
Traumatic Internal Carotid Artery Pseudoaneurysm. A Rare Cause of Cranial Nerve Palsy via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Francesca Jaume, Isam Alobid, Cristobal Langdon [image: Image for figure Figure 1] [image: Image for figure Figure 2] [image: Image for figure Figure 3]
Recently published in BMC Sports Science, Medicine and Rehabilitation
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 1 ώρα
[image: BMC Sports Science, Medicine and Rehabilitation] *Submit a Manuscript* *Editorial Board* *Author Instructions* *Article Alerts* Dear Dr Sfakianakis, I would like to let you know about some recent articles published in *BMC Sports Science, Medicine and Rehabilitation* and invite you to submit your next manuscript to the journal. *Articles* [image: Does the frequency and intensity of physical activity in adolescence have an impact on bone? The Tromsø Study] *Research article* *Does the frequency and intensity of physical activity in adolescence have an impact on bone? The Tr... περισσότερα »
Synchronous Adenocarcinoma and Meningioma of the Ethmoid
Synchronous Adenocarcinoma and Meningioma of the Ethmoid via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Andrés Coca-Pelaz, Fernando López, José Luis Llorente [image: Image for figure Figure 1] [image: Image for figure Figure 2] [image: Image for figure Figure 3]
Osteoma of the Internal Auditory Canal
Osteoma of the Internal Auditory Canal via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Daniel Soliva Martínez, Isabel Belda González, Pedro Fernández Iglesias [image: Image for figure Figure 1] [image: Image for figure Figure 2] [image: Image for figure Figure 3]
Neurosensory Deafness: Superficial Siderosis of the Central Nervous System
Neurosensory Deafness: Superficial Siderosis of the Central Nervous System via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Mercedes Tuñón Gómez, Beatriz Brea Álvarez, Ana Piazza Dobarganes [image: Image for figure Figure 1] [image: Image for figure Figure 2] [image: Image for figure Figure 3]
Submaxillary Adenopathy : Primary Nasal Tuberculosis
Primary Nasal Tuberculosis as the Origin of Submaxillary Adenopathy via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Aleix Rovira Casas, Francesc Xavier González-Compta, Jorge Luis Vega-Céliz, Enric Cisa Lluis [image: Adenopathy (20mm×31mm) at left level Ib where a FNA sample was taken.] [image: PET showing hypercaptation in LNF.]
Eikenella corrodens is a commensal of the human mouth and upper respiratory tract : A Rare Cause of Deep Neck Infection
Eikenella corrodens: A Rare Cause of Deep Neck Infection via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Fernando Javier Rivas Castillo, Justo Ramón Gómez Martinez, Fernando López Álvarez, Fabián García Velasco [image: Sagittal T1-weighted MRI slice with gadolinium contrast. A poorly defined ...] [image: Axial MRI diffusion slice. Hyper-intense lesion with diffuse edges located on ...] *Eikenella corrodens* From Wikipedia, the free encyclopedia *Eikenella*Scientific class...περισσότερα »
Perforating Pilomatricoma Presenting as an Ulcer in the Helix of the Pinna
Perforating Pilomatricoma Presenting as an Ulcer in the Helix of the Pinna via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Mainak Dutta, Soumya Ghatak, Rahul Sarkar, Shaswati Sengupta [image: The ulcerative lesion with mild erythema and oozing of necrotic slough and blood ...] [image: (a) Histopathology shows aggregate of basophilic basaloid cells (B) at the ...]
Exostosis of the Internal Auditory Canal
: 10-Year Follow-Up via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Guilherme Vianna Coelho, Guilherme Machado de Carvalho, Alexandre Caixeta Guimarães, Leopoldo Nizam Pfeilsticker [image: CT and MRI of 2002.] [image: CT and MRI of 2012.]
Thyroid Nodule as a First Sign of Progression in Uterine Cervical Carcinoma
Thyroid Nodule as a First Sign of Progression in Uterine Cervical Carcinoma via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Nelson Fuentes-Martínez, Jorge Santos Juanes, Blanca Vivanco-Allende, Sebastian Grzegorz Gagatek 1. [image: The arrow indicates an irregular nodular lesion of approx. 5cm, occupying the ...] [image: (A) Cell block from fine needle aspiration of the thyroid nodule. Pleomorphic ...]
Rhino-Orbito-Cerebral Mucormycosis
. Management Strategies to Avoid or Limit Intracraneal Affection and Improve Survival via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Olga Plowes Hernández, Héctor M. Prado Calleros, Galo Santiago Soberón Marmissolle Daguerre, Andrés Sadek González Mucormycosis is a rare opportunistic infection. The aim of the study was to review the cases presented in our department with rhino-orbital mucormycosis as well as to describe the clinical protocol, diagnosis and therapy used ...περισσότερα »
Otoneurology
Survey on the State of Otoneurology in Spain via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Oscar Alemán-López, Hermino Pérez-Garríguez, Paz Pérez-Vásquez, Ismael Arán-González, Eduardo Martin-Sanz Otoneurology is a sub-specialty of otolaryngology–neurology, which has experienced extraordinary progress in the last 50 years and is currently fully consolidated in our environment.Through this study, prepared by the Otoneurology Commission of the Spanish Society of Otorhinol... περισσότερα »
Cochlear Reimplantation
Experience in Cochlear Reimplantation. Descriptive Study of a 20-Year Period via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Andrés Gutiérrez-Salazar, Constanze Cop, Ángel Osorio-Acosta, Silvia Borkoski-Barreiro, Juan C. Falcón-González, Ángel Ramos-Macías Introduction and objectivesThe cochlear implant is a surgical procedure that has increased substantially, because the paediatric population is diagnosed and implanted early and because there are increased potential indi... περισσότερα »
Head and Neck Paragangliomas
: Experience in 126 Patients With 162 Tumours via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Ricardo José González-Orús Álvarez-Morujo, Miguel Ángel Arístegui Ruiz, Julia da Costa Belisario, Tomás Martinez Guirado, Bartolomé Scola Yurrita IntroductionHead and neck paragangliomas are rare tumours of a neuroendocrine nature. The aim of this study was to show our experience in the management of these kind of tumours.MethodsThis was a retrospective study of head and neck pa... περισσότερα »
Neonatal Hyperbilirubinemia and Sensorineural Hearing Loss
The Relationship Between via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Cándido Corujo-Santana, Juan Carlos Falcón-González, Silvia Andrea Borkoski-Barreiro, Daniel Pérez-Plasencia, Ángel Ramos-Macías Introduction and ObjectiveSevere jaundice that requires exchange transfusion has become a relatively rare situation today. About 60% of full term neonates and 80% of premature ones will suffer from jaundice within the first week of life.Hyperbilirubinemia at birth is a ris...περισσότερα »
Osirix® and Stereolithography
Improved Planning of Endoscopic Sinonasal Surgery From 3-Dimensional Images With Osirix® and Stereolithography via Acta Otorrinolaringologica English Publication date: November–December 2015 *Source:*Acta Otorrinolaringologica (English Edition), Volume 66, Issue 6 Author(s): Serafín Sánchez-Gómez, Tomás F. Herrero-Salado, Juan M. Maza-Solano, Francisco Ropero-Romero, Jaime González-García, Jesús Ambrosiani-Fernández Introduction and ObjectivesThe high variability of sinonasal anatomy requires the best knowledge of its three-dimensional (3D) conformation to perform surgery more safely a... περισσότερα »
Meniere's Disease and Migraine
An Epidemiological Study to Investigate the Relationship between Meniere's Disease and Migraine: Abstract Objectives A relationship between Meniere's disease and migraine has been postulated previously. This study investigates this relationship further and determines the most influential factors for developing Meniere's disease. Design Epidemiological study. Setting Two tertiary referral Neuro-Otological centres in Sheffield and Sydney. Participants Adult patients referred to the Neuro-Otology clinic between 2003 and 2010. Main Outcome Measures Past history and family history of Menier...περισσότερα »
Nichtinvasive Bildgebung mittels Autofluoreszenzendoskopie
Nichtinvasive Bildgebung mittels Autofluoreszenzendoskopie: Zusammenfassung HintergrundDie Autofluoreszenzendoskopie kann Malignome farblich von Normalgewebe abgrenzen. In der vorliegenden Studie soll der Stellenwert dieses nichtinvasiven bildgebenden Verfahrens bei der Früherfassung des Kehlkopfkarzinoms und dessen Vorstufen ermittelt werden. Patienten und MethodenIn einer prospektiven Studie wurden 152 Patienten mit einer Kehlkopfveränderung untersucht, die sich einer Mikrolaryngoskopie unterzogen. Die Autofluoreszenzendoskopie erfolgte im Anschluss an die konventionelle Weiß... περισσότερα »
Optische Kohärenztomographie zur Früherkennung epithelialer Dysplasien und mikroinvasiver Karzinome im oberen Luft-Speise-Weg
Optische Kohärenztomographie zur Früherkennung epithelialer Dysplasien und mikroinvasiver Karzinome im oberen Luft-Speise-Weg: Zusammenfassung HintergrundBisheriger Goldstandard in der Diagnostik von Läsionen des oberen Aerodigestivtrakts (OADT) ist die Weißlichtuntersuchung, gefolgt von der invasiven Gewebebiopsie – dieses Verfahren ist zeitaufwendig und teuer. Die optische Kohärenztomographie (OCT) ist ein nichtinvasives Verfahren, das hochauflösende Schnittbilder oberflächlicher Gewebeschichten in Echtzeit liefert. Ziel der ArbeitEs wird eine aktuelle und verständliche Übers... περισσότερα »
Aktuelle Aspekte in der Diagnostik und Therapie der obstruktiven Schlafapnoe
Aktuelle Aspekte in der Diagnostik und Therapie der obstruktiven Schlafapnoe: ZusammenfassungIn den letzten Jahren haben sich zahlreiche neue Entwicklungen im Bereich der Diagnostik und Therapie der obstruktiven Schlafapnoe (OSA) ergeben. Auf Basis einer aktuellen Literaturübersicht und den Erfahrungen der Autoren werden die wichtigsten Neuerungen praxisrelevant dargestellt. Mit der dritten Auflage der „International Classification of Sleep Disorders“ wurden die schlafbezogenen Atmungsstörungen neu klassifiziert. Dies betrifft die Einführung weiterer klinischer Kriterien für die ...περισσότερα »
Correlation between personality type and vocal pathology: A nonrandomized case control study
Correlation between personality type and vocal pathology: A nonrandomized case control study: Objectives/Hypothesis In this study we have made an attempt to find out if there is any correlation with type of personality (type A or B) and incidence of vocal pathology, subsequent to a tendency of vocal abuse. We also noted the loudness of speech and rate of speech for both personality types and compared these parameters for each personality type. Study Design A total of 100 subjects (50 with vocal pathologies and 50 with normal vocal folds) underwent voice and personality assessment, a... περισσότερα »
Familiarity modulates motor activation while observing other species’ actions: A magnetic stimulation study
Abstract Observing other people's actions facilitates the observer's motor system as compared to observing the same individuals at rest. This motor activation is thought to result from mirror-like activity in fronto-parietal areas, which enhance the excitability of M1 via cortico-cortical pathways. Although covert motor activation in response to observed actions has been widely investigated between conspecifics, the study of how humans cope with other species' actions has received less attention. For example, it remains unclear if the human motor system is activated by observing ot... περισσότερα »
Reduced serum levels of syndecan-1 in patients with tongue squamous cell carcinoma
Reduced serum levels of syndecan-1 in patients with tongue squamous cell carcinoma: Objectives/Hypothesis To investigate soluble syndecan-1 (Sdc-1) in the sera of patients with tongue squamous cell carcinoma (SCC) and its correlation with the histopathological criteria of tumors. Study Design In a case-control study using a convenient method of sampling, 18 female and 25 male patients with confirmed diagnosis of tongue SCC, and 19 healthy females and 27 males were studied. Methods Soluble Sdc-1 was measured in the sera of 43 patients with tongue SCC and was compared with that of hea... περισσότερα »
Evaluation of depression and anxiety in empty nose syndrome after surgical treatment
Evaluation of depression and anxiety in empty nose syndrome after surgical treatment: Objectives/Hypothesis Empty nose syndrome (ENS) is often associated with psychological symptoms. With the absence of psychiatric instruments utilized in the current literature, the assessment of psychological disorder is limited, and the effectiveness of surgical intervention in improving such disorders in ENS are not well understood. The aim of this study was to evaluate the change in depression and anxiety before and after surgical treatment for ENS Study Design Prospective cohort study in a tert... περισσότερα »
Tracheobronchopathia osteochondroplastica
Tracheobronchopathia osteochondroplastica: Tracheobronchopathia osteochondroplastica (TBOC) is a rare disease of the trachea and bronchi characterized by submucosal nodules of osseous and cartilaginous tissue. In this series, we present three cases highlighting the varied clinical presentations of this rare disease process, which ranged from a rough voice to a chronic cough to lobar pneumonia. The disorder may mimic other lesions. We review the clinical presentations, pathophysiology, lab tests, imaging, diagnosis, and management of TBOC patients. Level of Evidence NA *Laryngoscope...περισσότερα »
Prospective study of vocal fold function after loss of the neuromonitoring signal in thyroid surgery: The International Neural Monitoring Study Group's POLT study
Prospective study of vocal fold function after loss of the neuromonitoring signal in thyroid surgery: The International Neural Monitoring Study Group's POLT study: Objectives/Hypothesis Intraoperative neuromonitoring identifies recurrent laryngeal nerve (RLN) injury and gives prognostic information regarding postoperative glottic function. Loss of the neuromonitoring signal (LOS) signifies segmental type 1 or global type 2 RLN injury. This study aimed at identifying risk factors for RLN injury and determining vocal fold (VF) function initially and 6 months after definitive LOS. Stu... περισσότερα »
Multicompartment metabolism in papillary thyroid cancer
Multicompartment metabolism in papillary thyroid cancer: Objectives/Hypothesis In many cancers, varying regions within the tumor are often phenotypically heterogeneous, including their metabolic phenotype. Further, tumor regions can be metabolically compartmentalized, with metabolites transferred between compartments. When present, this metabolic coupling can promote aggressive behavior. Tumor metabolism in papillary thyroid cancer (PTC) is poorly characterized. Study Design Immunohistochemical staining of tissue samples. Methods Papillary thyroid cancer specimens from 46 patients wi... περισσότερα »
Benign paroxysmal positional vertigo commonly occurs following repair of superior canal dehiscence
Benign paroxysmal positional vertigo commonly occurs following repair of superior canal dehiscence: Objectives/Hypothesis Repair of superior canal dehiscence (SCD) often results in the resolution of preoperative auditory and vestibular symptoms; however, many patients experience dizziness in the postoperative period. Postoperative dizziness may be the result of new-onset benign paroxysmal positional vertigo (BPPV). This study aims to investigate the prevalence of BPPV before and following SCD repair. Study Design Retrospective chart review at a tertiary care center. Methods Electron... περισσότερα »
Atypical cartilaginous tumor/chondrosarcoma of the mastoid
Atypical cartilaginous tumor/chondrosarcoma, grade 1, of the mastoid in three family members: A new entity: We present a case series of a family with three members having cartilaginous tumors of the mastoid. All patients presented between the ages of 9 to 12 years with acute onset facial nerve paralysis. Histologic analysis of all tumors showed similar features, consistent with atypical cartilaginous tumors/chondrosarcoma, low-grade. Conventional cytogenetic analysis performed on one of the sons' tumor showed no evidence of chromosomal abnormality. High-resolution array comparative... περισσότερα »
Spindle Cell Carcinoma of the Larynx
Spindle Cell Carcinoma of the Larynx: A Confusing Diagnosis for the Pathologist and Clinician: Laryngeal spindle cell carcinoma (SpCC) is an uncommon subtype of squamous cell carcinoma which represents 0.5% of all laryngeal squamous cell carcinomas. It is a biphasic tumor consisting of the combination of a malignant mesenchymal spindle cell component and a squamous cell component that includes dysplasia, carcinoma in situ, or invasive carcinoma. Although it has aggressive biological features, the probability of making a diagnosis in the early stages is high as it often leads to obst...περισσότερα »
Brivaracetam in Unverricht-Lundborg disease (EPM1): Results from two randomized, double-blind, placebo-controlled studies
Summary Objective To evaluate efficacy, tolerability, and safety of adjunctive brivaracetam (BRV) in patients with Unverricht-Lundborg disease (EPM1). Methods Two prospective, multicenter, double-blind, phase III trials (N01187/NCT00357669; N01236/NCT00368251) in patients (≥16 years) with genetically ascertained EPM1, showing moderate–severe myoclonus (action myoclonus score ≥30/160), randomized (1:1:1) to twice-daily BRV (N01187: 50 or 150 mg/day; N01236: 5 or 150 mg/day), or placebo. Both studies comprised a baseline period (2 weeks), 2-week up-titration period, 12-week stable...περισσότερα »
Intraoral pH and temperature during sleep with and without mouth breathing
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 2 ώρες
Summary To measure and compare the intraoral pH and temperature of individuals during sleep with and without mouth breathing. Ten healthy participants [mean age = 25·8 (± 4·3)] wore a custom-made appliance fitted with a pH probe and thermocouple for two sets of 48 h. Continuous pH and temperature measurements were taken from the palatal aspect of the upper central incisors. To simulate mouth breathing during sleep, participants wore a nose clip for two nights of the four, with the first group (*n* = 5) wearing the nose clip during the first night and the rest (*n* = 5) wearing the... περισσότερα »
3 Easy Magic Tricks
ï»؟3 no bother charm Tricks Performing magic is great nearing to meet people or to simply impress your friends. There are some magic tricks that look great to other people but are actually easy to perform. 3 easy magic tricks that you incumbency perform are the Water to Ice trick, the Disappearing parent trick, and the Magically Burned String trick. The first trick is very easy to do. It’s called Water to Ice. What you will do is pour water into a cup further then dump out a couple ice cubes and no bedew. People will wonder how the water turned recreation ice. For this trick you... περισσότερα »
About Italy Import Export
ï»؟About Italy Import Export Italy is a extraordinarily lucrative hawk for starting an import export vivacity in. The IMF (International Monetary Fund) has declared in 2008, Italy is the seventh largest economy imprint the world and the fourth largest in Europe. So that should paint you exactly how much the Italian economy is flourishing befitting now. The World Bank states that the country gives you a lot of freedom to trade, open businesses and design. This is one of the main reasons why the country has seen same exponential growth. There are some of the reasons why Italy is ... περισσότερα »
Lewy bodies and the mechanisms of neuronal cell death in parkinson's disease and dementia with lewy bodies
Abstract Neuronal loss in specific brain regions and neurons with intracellular inclusions termed Lewy bodies are the pathologic hallmark in both Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Lewy bodies comprise of aggregated intracellular vesicles and proteins and α-synuclein is reported to be a major protein component. Using human brain tissue from control, PD and DLB and light and confocal immunohistochemistry with antibodies to superoxide dismutase 2 as a marker for mitochondria, α-synuclein for Lewy bodies and βIII Tubulin for microtubules we have examined th... περισσότερα »
10 Funny Personalised Plates
<p><font size="4"><br> ï»ØŸ10 Funny Personalised Plates<br> A blaze plate is a convivial access to express yourself to the world or at least, to the driver behind you. Barring any encounter language or threatening meaning, you can ring in almost item combination of letters, numbers and sometimes symbols together. The amusing part is watching people “get” the conclusion of your suggested message. Personalised plates run the gambit from the innocuous to the risque. They can also signify a thumbs evolvement or a thumbed nose – unreduced supremacy useful ...</font></p>
A B C D Of Erectile Dysfunction
The first also the remarkably prominent cause of erectile dysfunction is aging, it is fraudulent that thanks to 50% of the sex suffering from Ed are veteran above 40. This has created a myth that ED is a disorder associated with ripe but that’s wrong, age has nothing to conclude ensconce ED also it is treatable at piece age. Physical again Physiological Factors: The fast animation of which we are an public part leads to traumatic physical and screwball hindrance which can result in erectile dysfunction. unaccompanied wringer of the total cases of ED are due to these factors, hect... περισσότερα »
7 Tips On Taking Care Of Your Designer Handbags
ï»؟7 Tips on taking trouble of Your Designer Handbags With the assortment thanks to the allurement world oozing out into our lives, authentic absolutely was only a make any difference of your time when people just now cede be making use using the diversiform customized wears and accessories. customized handbags have develop to be quite well-known these days, with numerous people pdq wanting to purchase one for themselves. However, to possess customized handbags with you is not enough, as collectively secrete it you need to confront the challenge of sustaining solid. once the c...περισσότερα »
5 Great Ways To Use Spreadsheets And Stay Organized
ï»؟5 Great Ways To Use Spreadsheets And ride Organized! Does just the propose of the what’s what ‘spreadsheet’ cause your maw to go dry? Do you immediately think of sums, formulae, and figures? Well solicitude not moiety additional — I’m here to tell you that spreadsheets aren’t just for sums! I’m going to share with you my favorite top five tips on how you can use spreadsheets drag your every day hoopla to help you keep organized and on top of your work – further experienced isn’t a routine in sight! No.1 ‘To Do’ List How do you manage your day-to-day tasks? accomplish you have ... περισσότερα »
Allergic airway inflammation disrupts interleukin-17 mediated host defense against streptococcus pneumoniae infection
Publication date: February 2016 *Source:*International Immunopharmacology, Volume 31 Author(s): Sheng Guo, Liang-Xia Wu, Can-Xin Jones, Ling Chen, Chun-Li Hao, Li He, Jian-Hua Zhang Despite decreasing rates of invasive pneumococcal disease caused by vaccine serotypes, the prevalence of invasive pneumococcal pneumonia in asthmatic patients remains high. However, little is known about the mechanisms underlying the susceptibility of the asthmatic airway to bacterial infections. In this study, we used a combined model of allergic airway inflammation and Streptococcus pneumoniae lung inf... περισσότερα »
Inter-observer agreement of MRI-based tumor delineation for preoperative radiotherapy boost in locally advanced rectal cancer
Publication date: Available online 14 December 2015 *Source:*Radiotherapy and Oncology Author(s): Johannes Peter Maarten Burbach, Jean-Paul Johannes Kleijnen, Onne Reerink, Enrica Seravalli, Marielle E.P. Philippens, Tim Schakel, Bram van Asselen, Bas W. Raaymakers, Marco van Vulpen, Martijn Intven BackgroundWhile surgery remains the cornerstone of rectal cancer treatment, organ-preservation is upcoming. Therefore, neo-adjuvant treatment should be optimized. By escalating doses, response can be increased. To limit toxicity of boost, accurate gross tumor volume (GTV) definition is re... περισσότερα »
Swallowing sparing intensity modulated radiotherapy (SW-IMRT) in head and neck cancer: Clinical validation according to the model-based approach
Publication date: Available online 14 December 2015 *Source:*Radiotherapy and Oncology Author(s): Miranda E.M.C. Christianen, Arjen van der Schaaf, Hans Paul van der Laan, Irma M. Verdonck-de Leeuw, Patricia Doornaert, Olga Chouvalova, Roel J.H.M. Steenbakkers, Charles René Leemans, Sjoukje F. Oosting, Bernard F.A.M. van der Laan, Jan L.N. Roodenburg, Ben J. Slotman, Hendrik P. Bijl, Johannes A. Langendijk PurposeThe aim of this study was to clinically validate a multivariable normal tissue complication probability (NTCP) model for grade 2–4 swallowing dysfunction at 6months after r... περισσότερα »
Estimation of late rectal normal tissue complication probability parameters in carbon ion therapy for prostate cancer
Publication date: Available online 14 December 2015 *Source:*Radiotherapy and Oncology Author(s): Mai Fukahori, Naruhiro Matsufuji, Takeshi Himukai, Nobuyuki Kanematsu, Hideyuki Mizuno, Akifumi Fukumura, Hiroshi Tsuji, Tadashi Kamada PurposeThe aim of this study was to estimate normal tissue complication probability (NTCP) parameters for late rectal complications after carbon ion radiotherapy (C-ion RT) for prostate cancer.Methods and materialsA total of 163 patients were used to derive NTCP parameters. These patients were treated with relative biological effectiveness (RBE)-weighted... περισσότερα »
Expanding the scientific role of medical physics in radiotherapy: Time to act
Publication date: Available online 14 December 2015 *Source:*Radiotherapy and Oncology Author(s): Claudio Fiorino, Ludvig P. Muren, Catharine H. Clark, Wouter van Elmpt, Nuria Jornet from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1RlLFtX via IFTTT
In vitro characterization of transport and metabolism of the alkaloids: vincamine , vinpocetine and eburnamonine
Abstract Purpose Vincamine, vinpocetine and eburnamonine are alkaloids known for their neuroprotective attributes, enhancement of cerebrovascular blood flow and antitumor effect of their derivatives. However, the relative metabolic stability of these alkaloids and their extrusion by the drug efflux transporters expressed at the blood–brain barrier (BBB) are not clear. In this study, we developed rapid and sensitive methods for the detection of these alkaloids and investigated their relative metabolic stability and their interaction with drug efflux transporters. Methods UPLC meth... περισσότερα »
Phase II trial of salvage therapy with trabectedin in metastatic pancreatic adenocarcinoma
Abstract Purpose No standard salvage chemotherapy has been identified for metastatic pancreatic adenocarcinoma (mPA), and there is an urgent need for active agents against this disease. This phase II trial explored the activity of trabectedin in mPA progressing after gemcitabine-based first-line chemotherapy. Methods Patients with gemcitabine-resistant disease received trabectedin 1.3 mg/m2 as a 3-h intravenous continuous infusion every 3 weeks until disease progression or unacceptable toxicity or for a maximum of 6 months. The primary endpoint was progression-free survival rate ...περισσότερα »
Brain tumor-targeted delivery and therapy by focused ultrasound introduced doxorubicin-loaded cationic liposomes
Abstract Brain tumor lacks effective delivery system for treatment. Focused ultrasound (FUS) can reversibly open BBB without impacts on normal tissues. As a potential drug carrier, cationic liposomes (CLs) have the ability to passively accumulate in tumor tissues for their positive charge. In this study, FUS introduced doxorubicin-loaded cationic liposomes (DOX-CLs) were applied to improve the efficiency of glioma-targeted delivery. Doxorubicin-loaded CLs (DOX-CLs) and quantum dot-loaded cationic liposomes (QD-CLs) were prepared using extrusion technology, and their characterizati...περισσότερα »
Aktuelle Aspekte in der Diagnostik und Therapie der obstruktiven Schlafapnoe
Zusammenfassung In den letzten Jahren haben sich zahlreiche neue Entwicklungen im Bereich der Diagnostik und Therapie der obstruktiven Schlafapnoe (OSA) ergeben. Auf Basis einer aktuellen Literaturübersicht und den Erfahrungen der Autoren werden die wichtigsten Neuerungen praxisrelevant dargestellt. Mit der dritten Auflage der „International Classification of Sleep Disorders" wurden die schlafbezogenen Atmungsstörungen neu klassifiziert. Dies betrifft die Einführung weiterer klinischer Kriterien für die Diagnosestellung und die Berücksichtigung der ambulanten Untersuchungsverfahre...περισσότερα »
Optische Diagnoseverfahren zur Verbesserung der Tumorfrühdiagnostik im oberen Luft-Speise-Weg
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1Nutjku via IFTTT
Optische Kohärenztomographie zur Früherkennung epithelialer Dysplasien und mikroinvasiver Karzinome im oberen Luft-Speise-Weg
Zusammenfassung Hintergrund Bisheriger Goldstandard in der Diagnostik von Läsionen des oberen Aerodigestivtrakts (OADT) ist die Weißlichtuntersuchung, gefolgt von der invasiven Gewebebiopsie – dieses Verfahren ist zeitaufwendig und teuer. Die optische Kohärenztomographie (OCT) ist ein nichtinvasives Verfahren, das hochauflösende Schnittbilder oberflächlicher Gewebeschichten in Echtzeit liefert. Ziel der Arbeit Es wird eine aktuelle und verständliche Übersicht über die Rolle der OCT in der Frühdiagnostik und Differenzierung epithelialer Dysplasien und mikroinvasiver Karzinome des ...περισσότερα »
Optische Diagnoseverfahren zur Tumorfrühdiagnostik im oberen Luft-Speise-Weg
Zusammenfassung Hintergrund Optische Diagnoseverfahren können die Tumorfrühdiagnostik im oberen Luft-Speise-Weg erleichtern und verbessern, haben sich jedoch bisher in der klinischen Routine nicht durchsetzen können. Ziel der Arbeit Ziel war die Definition der Probleme, die den Routineeinsatz optischer Diagnoseverfahren bisher verhindern, sowie Aufführung und Erläuterung möglicher, zukunftsweisender Lösungsansätze zur Überwindung derselben. Material und Methoden Es erfolgte eine kombinierte Auswertung öffentlich zugänglicher Datenbanken (PubMed MEDLINE, Thompson Reuters Web of Sc... περισσότερα »
Dank an die Gutachter 2015
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1Nuthcj via IFTTT
Nichtinvasive Bildgebung mittels Autofluoreszenzendoskopie
Zusammenfassung Hintergrund Die Autofluoreszenzendoskopie kann Malignome farblich von Normalgewebe abgrenzen. In der vorliegenden Studie soll der Stellenwert dieses nichtinvasiven bildgebenden Verfahrens bei der Früherfassung des Kehlkopfkarzinoms und dessen Vorstufen ermittelt werden. Patienten und Methoden In einer prospektiven Studie wurden 152 Patienten mit einer Kehlkopfveränderung untersucht, die sich einer Mikrolaryngoskopie unterzogen. Die Autofluoreszenzendoskopie erfolgte im Anschluss an die konventionelle Weißlichtendoskopie, unmittelbar bevor eine Exzisionsbiopsie zur... περισσότερα »
Registering prostate external beam radiotherapy with a boost from high-dose-rate brachytherapy: a comparative evaluation of deformable registration algorithms
Registering CTs for patients receiving external beam radiotherapy (EBRT) with a boost dose from high-dose-rate brachytherapy (HDR) can be challenging due to considerable image discrepancies (e.g. rectal fillin... from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1NQTDZB via IFTTT
5th International ACC Symposium: An Outlook to Current and Future Research on the Biology of Adrenocortical Carcinoma: Diagnostic and Therapeutic Applications
Abstract Groundbreaking progress has been recently made in elucidating the signaling pathways that are altered in adrenocortical carcinoma (ACC), an endocrine malignancy that still has an unfavorable prognosis, and in understanding its genomic structure. These advances need now to be translated to create cellular and animal models more relevant to human disease in order to develop new and more effective diagnostic procedures and targeted therapies against this deadly malignancy. from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1NQUdqt via IFTTT
Coming up for air: exploring an intergenerational perspective on social work
From the late 1980s until now, scholars, educators and social workers have criticised the diminution of interest in the structural level of social problems. In this lament, former social work is beguiled, while critiques are targeted at the new generation of social workers. These critiques forewarn of important issues and problems, but at the same time they portray social work in a devolutionary way. It is argued that this one-sided debate conceals frictions between different generations of social workers. In reference to the work of Karl Mannheim, an intergenerational perspective... περισσότερα »
A functional approach for research on cognitive control: Analyzing cognitive control tasks and their effects in terms of operant conditioning.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1O27J64 via IFTTT
Fear expression and the return of fear following threat instruction with or without direct contingency experience.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1RlR0Bp via IFTTT
Early numerical competencies in 4- and 5-year-old children with autism spectrum disorder.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1O27Iz8 via IFTTT
Riding the waves: A functional-cognitive perspective on the relations among Behavior Therapy, Cognitive Behavior Therapy, and Acceptance and Commitment Therapy.
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1RlR0l6 via IFTTT
The meaning of the sperm donor for heterosexual couples: confirming the position of the father
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1RlR1FC via IFTTT
Altered intrinsic organisation of brain networks implicated in attentional processes in adult attention-deficit/hyperactivity disorder: a resting state study of attention, default mode and salience network connectivity
Deficits in task-related attentional engagement in attention-deficit/hyperactivity disorder (ADHD) have been hypothesized to be due to altered interrelationships between attention, default mode and salience networks. We examined the intrinsic connectivity during rest within and between these networks. Six minutes resting state scans were obtained. Using a network-based approach, connectivity within and between the dorsal and ventral attention, the default mode and the salience networks was compared between the ADHD and control group. The ADHD group displayed hyperconnectivity betw...περισσότερα »
Joint Task Switching
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1RlR04v via IFTTT
Instruction-based approach-avoidance effects: changing stimulus evaluation via the mere instruction to approach or avoid stimuli
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1RlR18C via IFTTT
CCL21-CCR7 promotes the lymph node metastasis of esophageal squamous cell carcinoma by up-regulating MUC1
CCR7 and MUC1 are correlated with lymph node metastasis in ESCC, but the role of MUC1 in the CCR7-induced lymphatic metastasis and the underlying molecular mechanism is still unclear. from Cancer via ola Kala on Inoreader http://ift.tt/1Rm48Xo via IFTTT
Intertumor heterogeneity in vascularity and invasiveness of artificial melanoma brain metastases
Patients diagnosed with melanoma brain metastases have few treatment options and poor prognosis, and improved treatment strategies for these patients require detailed understanding of the underlying pathobiolo... from Cancer via ola Kala on Inoreader http://ift.tt/1P4x6JY via IFTTT
Unique features of trabectedin mechanism of action
Abstract Trabectedin (Yondelis®, ET-743) is a marine-derived natural product that was initially isolated from the marine ascidian *Ecteinascidia turbinata* and is currently prepared synthetically. Trabectedin is used as a single agent for the treatment of patients with soft tissue sarcoma after failure of doxorubicin or ifosfamide or who are unsuited to receive these agents, and in patients with relapsed, platinum-sensitive ovarian cancer in combination with pegylated liposomal doxorubicin. Trabectedin presents a complex mechanism of action affecting key cell biology processes in t... περισσότερα »
A new animal model of intestinal mucositis induced by the combination of irinotecan and 5-fluorouracil in mice
Abstract Purpose Intestinal mucositis (IM) is a common side effect of anticancer agents. Despite polychemotherapy use in clinical practice, the pathogenesis of IM has been investigated in single drug injection animal models. However, the progression of IM could vary according to drug regimens. Thus, we aimed to develop a new experimental mucositis model induced by combining irinotecan and 5-fluorouracil (5-FU) treatments. Methods IM was induced in male C57BL/6 mice by the intraperitoneal administration of either 0.9 % saline (5 mL/kg), irinotecan (IRI, 30 or 45 mg/kg), 5-FU (25, ... περισσότερα »
International randomized phase 2 study on the addition of docetaxel to the combination of cisplatin and 5-fluorouracil in the induction treatment for nasopharyngeal carcinoma in children and adolescents
Abstract Purpose Nasopharyngeal carcinoma (NPC) is a rare but aggressive malignancy in children and adolescents. An international, randomized phase 2 trial was conducted to compare induction chemotherapy with docetaxel plus cisplatin and 5-fluorouracil (TPF) with cisplatin and 5-fluorouracil (PF) in NPC patients under the age of 21. Methods Patients with stage IIB–IV NPC were randomly assigned, in a 2:1 ratio, to receive TPF or PF 3-weekly for three cycles, followed by chemoradiotherapy. The primary endpoint was the complete response rate achieved with TPF or PF. Docetaxel pharma...περισσότερα »
In vitro characterization of transport and metabolism of the alkaloids: vincamine , vinpocetine and eburnamonine
Abstract Purpose Vincamine, vinpocetine and eburnamonine are alkaloids known for their neuroprotective attributes, enhancement of cerebrovascular blood flow and antitumor effect of their derivatives. However, the relative metabolic stability of these alkaloids and their extrusion by the drug efflux transporters expressed at the blood–brain barrier (BBB) are not clear. In this study, we developed rapid and sensitive methods for the detection of these alkaloids and investigated their relative metabolic stability and their interaction with drug efflux transporters. Methods UPLC meth... περισσότερα »
Phase II trial of salvage therapy with trabectedin in metastatic pancreatic adenocarcinoma
Abstract Purpose No standard salvage chemotherapy has been identified for metastatic pancreatic adenocarcinoma (mPA), and there is an urgent need for active agents against this disease. This phase II trial explored the activity of trabectedin in mPA progressing after gemcitabine-based first-line chemotherapy. Methods Patients with gemcitabine-resistant disease received trabectedin 1.3 mg/m2 as a 3-h intravenous continuous infusion every 3 weeks until disease progression or unacceptable toxicity or for a maximum of 6 months. The primary endpoint was progression-free survival rate ...περισσότερα »
Brain tumor-targeted delivery and therapy by focused ultrasound introduced doxorubicin-loaded cationic liposomes
Abstract Brain tumor lacks effective delivery system for treatment. Focused ultrasound (FUS) can reversibly open BBB without impacts on normal tissues. As a potential drug carrier, cationic liposomes (CLs) have the ability to passively accumulate in tumor tissues for their positive charge. In this study, FUS introduced doxorubicin-loaded cationic liposomes (DOX-CLs) were applied to improve the efficiency of glioma-targeted delivery. Doxorubicin-loaded CLs (DOX-CLs) and quantum dot-loaded cationic liposomes (QD-CLs) were prepared using extrusion technology, and their characterizati...περισσότερα »
Reconstructing the foundations of joined-up working: from organisational reform towards a joint engagement of child and family services
In a diversity of European countries, an ambitious pursuit of organisational reform is stressed in the field of social work policy and practice, which is rhetorically rooted in 'joined-up thinking'. Emerging criticism about joined-up working has been identified in the body of available research, particularly in terms of the construction and pursuit of joint goals. In this article, we discuss the empirical findings that were acquired during a recent qualitative research project in Belgium. The underlying assumptions of joined-up working in child and family services were examined in... περισσότερα »
Intraspecific variation in flowering phenology affects seed germinability in the forest herb Primula elatior
Background and aims - Phenological responses to environmental cues are known to be phylogenetically conserved across species, but the adaptive nature of phenological responses to the local environment within the populations of individual species needs further exploration. In temperate forests, the canopy green up timing is expected to act selectively upon the growth and flowering phenology of understorey plants. Methods - Here we quantified the variation in the flowering phenology of a forest herb growing in the understorey of early versus late leafing tree species and explored th... περισσότερα »
Electroencephalographic activity before and after cognitive effort in children with attention-deficit/hyperactivity disorder
Numerous studies have detected elevated electroencephalographic (EEG) theta/beta ratio (TBR) or theta power in children with attention deficit/hyperactivity disorder (ADHD) and therefore TBR has been suggested to be a promising biomarker of ADHD. At the same time, recent theoretical models have emphasized the heterogeneity of ADHD and the notion that cognitive deficits in ADHD are not fixed but fluctuate according to contextual and state factors. Surprisingly, so far the context- or state-dependency of EEG abnormalities in ADHD has hardly been addressed. Therefore, in the current ...περισσότερα »
Management of a Rare Lymphoepithelial Carcinoma of the Submandibular Gland in Elderly
Abstract Lymphoepithelial carcinoma (LEC) of salivary glands is a rare malignant salivary gland tumour and demonstrates genetic and regional distribution. It commonly occurs in major salivary gland especially parotid gland. We report a case of LEC of submandibular gland occurring in a 70 year-old lady. from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1O5s5lh via IFTTT
Teflon Implants Versus Titanium Implants in Stapes Surgery
Abstract Otosclerosis is the most common cause of bilateral gradually progressive conductive hearing loss with normal tympanic membrane and Eustachian tube. Otosclerosis surgical treatment is one of the most gratifying operations in Otorhinolaryngology. It is not only the surgical techniques but also the prosthesis which are evolving in the attempt of providing best hearing results. Teflon piston is the most commonly employed prosthesis in stapes surgery. Titanium pistons are relatively the new development in the evolution of stapes prosthesis. The aim of this review article is to ... περισσότερα »
Above the Sphenoid in to Dermoid-Expanded Endoscopic Two Nostrils Four Hand Technique: A Case Report
Abstract This rare case report presents the 2 nostrils 4 hands expanded endoscopic excision of the suprasellar dermoid through planum sphenoidale approach. This minimally invasive technique through the natural passage offers panaromic view of vital structures, complete excision of the lesion with reconstruction of the skull base defect at the same procedure. from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1RN1Rnb via IFTTT
Primary Ewing’s Sarcoma of the Temporal Bone: A Rare Case Report and Literature Review
Abstract Ewing's sarcoma is a malignant, round cell tumor arising from the bones and primarily affecting children and adolescent, accounting for 3 % of all childhood malignancies. Although the long bones and the trunk are typically affected, rare cases of it involving isolated bones throughout the body have been reported. Involvement of the skull bones is rare, constituting 1–6 % of the total Ewing's sarcoma cases but those affecting the cranial bones are rarer still, constituting only 1 %. We describe an 8 months old infant having Ewing sarcoma, of the petrous and mastoid parts of... περισσότερα »
Intraforaminal ozone therapy
from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1I6cuQ4 via IFTTT
Valved or valveless ventriculoperitoneal shunting in the treatment of post-haemorrhagic hydrocephalus: a population-based consecutive cohort study
Abstract Background Implant infection and obstruction are major complications for ventriculoperitoneal shunts in patients with post-haemorrhagic hydrocephalus. In an effort to (1) reduce the incidence of these complications, (2) reduce the rate of shunt failure and (3) shorten the duration of neurosurgical hospitalisation, we have implemented valveless ventriculoperitoneal shunts at our department for adult patients with post-haemorrhagic hydrocephalus and haemorrhagic cerebrospinal fluid at the time of shunt insertion. Methods All adult patients (>18 years old) treated for post-... περισσότερα »
Editorial board
Publication date: 1 January 2016 *Source:*Bioorganic & Medicinal Chemistry, Volume 24, Issue 1 from #MedicinebyAlexandrosSfakianakis via xlomafota13 on Inoreader http://ift.tt/1NQPzZq via IFTTT
Organoids and the genetically encoded self-assembly of embryonic stem cells
Understanding the mechanisms of early embryonic patterning and the timely allocation of specific cells to embryonic regions and fates as well as their development into tissues and organs, is a fundamental problem in Developmental Biology. The classical explanation for this process had been built around the notion of positional information. Accordingly the programmed appearance of sources of Morphogens at localized positions within a field of cells directs their differentiation. Recently, the development of organs and tissues from unpatterned and initially identical stem cells (ad... περισσότερα »
With or without rafts? Alternative views on cell membranes
The fundamental mechanisms of protein and lipid organization at the plasma membrane have continued to engage researchers for decades. Among proposed models, one idea has been particularly successful which assumes that sterol-dependent nanoscopic phases of different lipid chain order compartmentalize proteins, thereby modulating protein functionality. This model of membrane rafts has sustainably sparked the fields of membrane biophysics and biology, and shifted membrane lipids into the spotlight of research; by now, rafts have become an integral part of our terminology to describe... περισσότερα »
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου