Submandibular Duct Re-routing for Drooling in Neurologically Impaired Children
Submandibular Duct Re-routing for Drooling in Neurologically Impaired Children: AbstractDrooling is a challenging situation to manage especially in neurologically impaired pediatric population. Numerous surgical procedures have been described in literature but none of them is standardized. We evaluate the effectiveness of bilateral submandibular duct rerouting and sublingual gland excision in drooling paediatric patients. Prospective interventional study was conducted from November 2007 to September 2009 in twenty-eight pediatric patients with drooling who had failed conservative ... περισσότερα »
Relapse Acute Myeloid Leukemia: Myeloid Sarcoma of Temporal Bone
Myeloid Sarcoma of Temporal Bone: A Rare Manifestation of Relapse Acute Myeloid Leukemia: AbstractMyeloid sarcoma is a rare malignant extramedullary neoplasm of myeloid precursor cells. This disorder may occur in concomitance with or precede development of acute or chronic myeloid leukemia. Sometimes, it is the initial manifestation of relapse in a previously treated acute myeloid leukemia. We report a case of 11 years old boy with acute myeloid leukemia in remission state, presented with short history of right otalgia associated with facial nerve palsy. Diagnosis of right acute ma...περισσότερα »
Modified Baha Punch Technique
Modified Baha Punch Technique: Least Invasive, Shortest Time and No Suturing: AbstractTo describe a new Baha surgical procedure (Modified Punch Technique) with a smaller punch hole, a minimal incision and the use of the hydroxyapatite-coated abutment (BIA400). Retrospective chart review. Patients were implanted between 2012 and 2013 at King Abdulaziz University Hospital (Kingdom of Saudi Arabia). Eligible for initial or replacement bone-anchored hearing system; includes six patients (four adults, two children). Baha surgery using the Punch Method is described. The mean surgical ti... περισσότερα »
Healthcare Assistant Training (CHAT)
Can Healthcare Assistant Training (CHAT) improve the relational care of older people? Study protocol for a pilot cluster randomised controlled trial: Background: People aged 75 years and over account for 1 in 4 of all hospital admissions. There has been increasing recognition of problems in the care of older people, particularly in hospitals. Evidence suggests that older people judge the care they receive in terms of kindness, empathy, compassion, respectful communication and being seen as a person not just a patient. These are aspects of care to which we refer when we use the term ... περισσότερα »
Children with allergic rhinitis during sublingual immunotherapy : Decreased level of osteopontin
Decreased level of osteopontin in children with allergic rhinitis during sublingual immunotherapy via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 13 December 2015 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Chunrui Wang, Kai Wang, Shaoting Liu, Xiaowei Qin, Kewa Chen, Tianhong Zhang ObjectiveSublingual immunotherapy (SLIT) is proven to be very effective in the treatment of allergic rhinitis (AR), but its regulatory mechanism and biomarkers for predicting efficacy are still unknown. Osteopontin (OPN), as a rece...περισσότερα »
Primary Ewing’s Sarcoma of the Temporal Bone
Primary Ewing’s Sarcoma of the Temporal Bone: A Rare Case Report and Literature Review: AbstractEwing’s sarcoma is a malignant, round cell tumor arising from the bones and primarily affecting children and adolescent, accounting for 3 % of all childhood malignancies. Although the long bones and the trunk are typically affected, rare cases of it involving isolated bones throughout the body have been reported. Involvement of the skull bones is rare, constituting 1–6 % of the total Ewing’s sarcoma cases but those affecting the cranial bones are rarer still, constituting only 1 %. We de... περισσότερα »
Above the Sphenoid in to Dermoid-Expanded Endoscopic Two Nostrils Four Hand Technique
Above the Sphenoid in to Dermoid-Expanded Endoscopic Two Nostrils Four Hand Technique: A Case Report: AbstractThis rare case report presents the 2 nostrils 4 hands expanded endoscopic excision of the suprasellar dermoid through planum sphenoidale approach. This minimally invasive technique through the natural passage offers panaromic view of vital structures, complete excision of the lesion with reconstruction of the skull base defect at the same procedure.
Teflon Implants Versus Titanium Implants in Stapes Surgery
Teflon Implants Versus Titanium Implants in Stapes Surgery: AbstractOtosclerosis is the most common cause of bilateral gradually progressive conductive hearing loss with normal tympanic membrane and Eustachian tube. Otosclerosis surgical treatment is one of the most gratifying operations in Otorhinolaryngology. It is not only the surgical techniques but also the prosthesis which are evolving in the attempt of providing best hearing results. Teflon piston is the most commonly employed prosthesis in stapes surgery. Titanium pistons are relatively the new development in the evolution ... περισσότερα »
Lymphoepithelial carcinoma (LEC) of salivary glands
Management of a Rare Lymphoepithelial Carcinoma of the Submandibular Gland in Elderly: AbstractLymphoepithelial carcinoma (LEC) of salivary glands is a rare malignant salivary gland tumour and demonstrates genetic and regional distribution. It commonly occurs in major salivary gland especially parotid gland. We report a case of LEC of submandibular gland occurring in a 70 year-old lady.
Ear Reconstruction—An Update
Ear Reconstruction—An Update: Facial plast Surg 2015; 31: 561-562 DOI: 10.1055/s-0035-1567889 Alexander Berghaus, MD Microtia is a malformation of the outer ear resulting in variable phenotypic alterations of the auricle. Ear reconstruction has been an important and challenging aspect of reconstructive surgery for centuries. This is true for congenital as well as acquired severe deformities of the ear. A complex three-dimensionality, along with a delicate convoluted structure, requires high surgical expertise and a meticulous approach. Only then an aesthetically satisfactory, m... περισσότερα »
Complete Cleft Care: Cleft and Velopharyngeal Insufficiency Treatment in Children
Complete Cleft Care: Cleft and Velopharyngeal Insufficiency Treatment in Children: Facial plast Surg 2015; 31: 657-658 DOI: 10.1055/s-0035-1569146 Edited by Steven L. Goudy and Travis T. Tollefson. Thieme Medical Publishers; 2015; 228 pp; $149.99. This is a well-designed and -executed text on the management of cleft lip and palate deformities in children. The authors are highly experienced and respected clinicians with strong commitments to cleft care. This text covers all pertinent topics in this field, from genetics, family counseling, and presurgical management through primary a... περισσότερα »
Aesthetic Refinements in Patients with Prominent Eyes
Aesthetic Refinements in Patients with Prominent Eyes: Facial plast Surg 2015; 31: 633-644 DOI: 10.1055/s-0035-1568136 The treatment of prominent eyes is still a challenging task. As well as the surgery, proper preoperative diagnosis differentiating between patients with and without Graves ophthalmopathy plays an important role. In functionally asymptomatic patients with Graves disease suffering from the aesthetic impairment of prominent eyes, the transpalpebral decompression by intraorbital fat removal technique has been proved to be reliable, effective, safe, and easily performed...περισσότερα »
Ear Reconstruction in Young Children
Ear Reconstruction in Young Children: Facial plast Surg 2015; 31: 600-603 DOI: 10.1055/s-0035-1568138 The use of a porous high-density polyethylene ear implant, rather than a costal cartilage framework, allows ear reconstruction in young children before they enter school. The fact that the growth of the normal ear matures early allows for good symmetry. If the implant is covered completely with a large, well-vascularized superficial parietal fascia flap and appropriately color-matched skin, an ear with excellent projection and definition can be obtained with minimal complications a... περισσότερα »
Complications after Total Porous Implant Ear Reconstruction and Their Management
Complications after Total Porous Implant Ear Reconstruction and Their Management: Facial plast Surg 2015; 31: 617-625 DOI: 10.1055/s-0035-1567890 Microtia reconstruction using porous polyethylene implants has become an established alternative to autologous costal cartilage techniques. Few surgeons are trained in porous implant ear reconstruction (PIER), leading to a relative lack of understanding of the nuances of this type of surgery. The risks of exposure, infection, and fracture of the implant have further discouraged surgeons from performing PIERs. Meticulous technique and prop...περισσότερα »
The Rib Cartilage Concept in Microtia
The Rib Cartilage Concept in Microtia: Facial plast Surg 2015; 31: 587-599 DOI: 10.1055/s-0035-1567888 There is a long history of rib cartilage use in reconstruction for microtia. This article aims to describe the modern techniques of autologous auricular reconstruction in detail, to elucidate the modifications for certain anatomical or disease-related conditions, and to contrast the different strategies used by other surgeons. The two mainstays of successful reconstruction with excellent results are the fabrication of the framework and soft tissue management. A three-dimensional f... περισσότερα »
Single-Stage Ear Reconstruction and Hearing Restoration Using Polyethylene Implant and Implantable Hearing Devices
Single-Stage Ear Reconstruction and Hearing Restoration Using Polyethylene Implant and Implantable Hearing Devices: Facial plast Surg 2015; 31: 604-610 DOI: 10.1055/s-0035-1567887 The use of porous polyethylene in reconstructive surgery of the auricle is becoming increasingly accepted. This is a single-stage procedure providing pleasing cosmetic rehabilitation. Further advantages are the possibility of early implantation and the lack of complications caused by harvesting costal cartilage. Additional hearing restoration using middle ear implants allows functional rehabilitation at a... περισσότερα »
Surgical and Technical Modalities for Hearing Restoration in Ear Malformations
Surgical and Technical Modalities for Hearing Restoration in Ear Malformations: Facial plast Surg 2015; 31: 581-586 DOI: 10.1055/s-0035-1569062 Malformations of the external and middle ear often go along with an aesthetic and functional handicap. Independent of additional aesthetic procedures, a successful functional hearing restoration leads to a tremendous gain in quality of life for affected patients. The introduction of implantable hearing systems (bone conduction and middle ear devices) offers new therapeutic options in this field. We focus on functional rehabilitation of pat... περισσότερα »
The Role of Auricular Prostheses (Epitheses) in Ear Reconstruction
The Role of Auricular Prostheses (Epitheses) in Ear Reconstruction: Facial plast Surg 2015; 31: 626-632 DOI: 10.1055/s-0035-1568137 The artwork of making the epithesis by the dedicated anaplastologist is the prerequisite of acceptance by the patient and the key for success of this approach. However, computer science is helping with virtual planning and rapid prototyping, and it is likely to revolutionize this process in the near future. One of the advantages of the auricular prostheses is that it can be manufactured as a mirrored replica of the opposite side (if normal or near norm... περισσότερα »
Congenital Auricular Malformations: Description of Anomalies and Syndromes
Congenital Auricular Malformations: Description of Anomalies and Syndromes: Facial plast Surg 2015; 31: 567-580 DOI: 10.1055/s-0035-1568139 Half of the malformations in the ear, nose, and throat region affect the ear. Malformations of the external ear (pinna or auricle with external auditory canal [EAC]) are collectively termed microtia. Microtia is a congenital anomaly that ranges in severity from mild structural abnormalities to complete absence of the external ear (anotia). Microtia occurs more frequently in males (∼2 or 3:1), is predominantly unilateral (∼70–90%), and more ofte... περισσότερα »
Minimizing the uncertainties regarding the effects of delaying radiotherapy for Glioblastoma: A systematic review and meta-analysis
[image: gr1.sml] Previous studies have provided no clear conclusions regarding the effects of delaying radiotherapy (RT) in GBM patients. We present a systematic review and meta-analysis to address the effect of delayed RT on the overall survival (OS) of GBM patients. from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1NQpF8a via IFTTT
Injury Patterns and Reconstruction in Acquired Ear Deformities
Injury Patterns and Reconstruction in Acquired Ear Deformities: Facial plast Surg 2015; 31: 645-656 DOI: 10.1055/s-0035-1568140 Reconstruction following ear trauma presents a heterogeneous group of abnormalities with significantly more variation in presentation. The aim of the study was to analyze our experience and expound some broad principles of auricular reconstruction in acquired ear deformities. A total of 117 patients with human, animal bites and revision otoplasty presented to our clinic. Demographic data were extracted from medical records and photographs. Management optio...περισσότερα »
Milestones in the History of Ear Reconstruction
Milestones in the History of Ear Reconstruction: Facial plast Surg 2015; 31: 563-566 DOI: 10.1055/s-0035-1567886 The reconstruction of ear deformities has been challenging plastic surgeons since centuries. However, it is only in the 19th century that reports on partial and total ear reconstruction start increasing. In the quest for an aesthetically pleasing and natural-looking result, surgeons worked on the perfect framework and skin coverage. Different materials and flap techniques have evolved. Some were abandoned out of frustration, while others kept evolving over the years. In ... περισσότερα »
Compound action potentials (CAPs) of the eighth nerve
Ototoxicity of acetic acid on the guinea pig cochlea: Abstract BackgroundTo evaluate the ototoxicity of acetic acid solutions. MethodsCompound action potentials (CAPs) of the eighth nerve were measured in guinea pigs before and after the application of acetic acid in the middle ear cavity. The pH values of the acetic acid solutions were pH 3.0, 4.0, and 5.0, and the application times were 30 min, 24 h, and 1 week. ResultsAcetic acid solution (pH 3.0, *N* = 3) for 30 min caused no significant elevation in CAP threshold at 4 kHz, but a significant elevation in the threshold wa... περισσότερα »
Ototoxicity of acetic acid on the cochlea : The pH values of the acetic acid solutions were pH 3.0, 4.0, and 5.0, and the application times were 30 min, 24 h, and 1 week
Ototoxicity of acetic acid on the guinea pig cochlea: Abstract BackgroundTo evaluate the ototoxicity of acetic acid solutions. MethodsCompound action potentials (CAPs) of the eighth nerve were measured in guinea pigs before and after the application of acetic acid in the middle ear cavity. The pH values of the acetic acid solutions were pH 3.0, 4.0, and 5.0, and the application times were 30 min, 24 h, and 1 week. ResultsAcetic acid solution (pH 3.0, *N* = 3) for 30 min caused no significant elevation in CAP threshold at 4 kHz, but a significant elevation in the threshold wa... περισσότερα »
Porous Polyethylene Implant and Rib Cartilage in Ear Reconstruction: A Comparison
Porous Polyethylene Implant and Rib Cartilage in Ear Reconstruction: A Comparison: Facial plast Surg 2015; 31: 611-616 DOI: 10.1055/s-0035-1569061 Auricular reconstruction, known as the “surgical art,” is one of the most difficult and complex surgeries in medicine. There are two different techniques that involve either the use of artificial material like porous polyethylene (PE) or the patient's own rib cartilage graft. The patient's indication, age, conditions requiring previous failed surgeries, and the surgeon's skill in creating the frame are the most important factors in the ... περισσότερα »
Anaplastic and Poorly Differentiated Thyroid Carcinoma
Changes of Clinicopathologic Characteristics and Survival Outcomes of Anaplastic and Poorly Differentiated Thyroid Carcinoma: Thyroid , Vol. 0, No. 0. Author information Doh Young Lee,1 Jae-Kyung Won,2 Se-Hoon Lee,3 Do Joon Park,4 Kyeong Cheon Jung,2 Myung-Whun Sung,5 Hong-Gyun Wu,6 Kwang Hyun Kim,5 Young Joo Park,4 and J. Hun Hah5 1Department of Otorhinolaryngology—Head and Neck Surgery, Korea University College of Medicine, Seoul, Korea. 2Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. 3Division of Hematology-Oncology, Department of Medicine... περισσότερα »
Risk factors for locoregional relapse after transoral robotic surgery for human papillomavirus–related oropharyngeal squamous cell carcinoma
Risk factors for locoregional relapse after transoral robotic surgery for human papillomavirus–related oropharyngeal squamous cell carcinoma: Abstract Background Factors predicting locoregional relapse after surgery for oropharyngeal squamous cell carcinoma (SCC) were identified in the pre-human papillomavirus (HPV) era. We examined whether traditional indications for adjuvant radiotherapy (RT) or adjuvant chemoradiotherapy (CRT) still correlate with locoregional relapse in HPV-positive patients after transoral robotic surgery (TORS). Methods Retrospective review of oropharyngeal SC...περισσότερα »
Cell-free Epstein–Barr virus-DNA in patients with nasopharyngeal carcinoma: Plasma versus urine
Cell-free Epstein–Barr virus-DNA in patients with nasopharyngeal carcinoma: Plasma versus urine: ABSTRACT Background The purpose of this study was to explore urinary Epstein–Barr virus (EBV)-DNA as a potential biomarker in patients with nasopharyngeal carcinoma (NPC). Methods EBV-DNA copies were estimated in plasma/urine of patients with NPC (*n* = 76) by real-time polymerase chain reaction (PCR) at baseline, during therapy, and at follow-up. Their correlation with EBV-RNA expression in tissues (*n* = 53) was used to assess sensitivity and specificity of plasma/urine EBV-DNA. Corre...περισσότερα »
Head & Neck
Base of tongue squamous cell carcinoma with infiltrative bone marrow carcinomatosis after definitive chemoradiation: A case report Background: Oropharyngeal squamous cell carcinoma (SCC) is known for its propensity for aggressive local progression and regional lymphatic spread. Distant metastases are relatively uncommon and the likelihood of hematogenous dissemination is primarily related to the extent and location of cervical lymph node metastases. Common sites of distant metastasis include the liver and lung. Methods: We report an unusual case of base of tongue SCC with infiltrativ... περισσότερα »
Management of invasive well-differentiated thyroid cancer
Management of invasive well-differentiated thyroid cancer: An American Head and Neck Society Consensus Statement Keywords: - invasive thyroid cancer; - tracheal invasion; - recurrent laryngeal nerve invasion; - locally aggressive thyroid cancer; - vascular invasion ABSTRACT Background Invasive differentiated thyroid cancer (DTC) is relatively frequent, yet there is a paucity of specific guidelines devoted to its management. The Endocrine Committee of the American Head and Neck Society (AHNS) convened a panel to provide clinical consensus statements based on review of... περισσότερα »
The Protective Role of Autophagy in Human Vocal Fold Fibroblasts
The Protective Role of Autophagy in Human Vocal Fold Fibroblasts under Cigarette Smoke Extract Exposure: A New Insight into the Study of Reinke's Edema: *Background/Aims:* Reinke's edema (RE), one of the most common benign lesions of the human vocal folds, has been associated with cigarette smoking. We have observed an abundant number of autophagosomes in the cytoplasm of fibroblasts in the lamina propria of human vocal folds under transmission electron microscopy in RE tissue. Thus, we conducted a study about autophagy induced by cigarette smoke extract (CSE) exposure in cultured h... περισσότερα »
Oral Implants
A Comparative Analysis on Two Types of Oral Implants, Bone-Level and Tissue-Level, with Different Cantilever Lengths of Fixed Prosthesis: Abstract Purpose Depending on esthetic, anatomical, and functional aspects, in implant-prosthetic restoration of a completely edentulous jaw, the selection of implant type is highly important; however, bone- and tissue-level implants and their stress distribution in bone have not yet been comparatively investigated. Hence, finite element analysis was used to study the influence of cantilever length in a fixed prosthesis on stress distribution in ... περισσότερα »
Ridge preservation procedure using SocketKAP™
Alveolar ridge dimensional changes following ridge preservation procedure using SocketKAP™: exploratory study of serial cone-beam computed tomography and histologic analysis in canine model: [image: cover.gif?v=1&s=e60d9281048a4597d45840f4] Abstract Introduction The aim of this pilot study was to examine the kinetics of alterations in alveolar ridge width and height following tooth extraction with and without ridge preservation, using anorganic bovine bone mineral (ABBM) and a novel device (SocketKAP™) designed for obturation of socket orifice. Materials and methods Maxillary lef... περισσότερα »
Biodegradable hyper-branched tissue adhesives for the repair of meniscus tears
Development of via Acta Biomaterialia Publication date: Available online 12 December 2015 *Source:*Acta Biomaterialia Author(s): A.I. Bochyńska, T.G. Van Tienen, G. Hannink, P. Buma, D.W. Grijpma Meniscus tears are one of the most commonly occurring injuries of the knee joint. Current meniscus repair techniques are challenging and do not bring fully satisfactory results. Tissue adhesives are a promising alternative, since they are easy to apply and cause minimal tissue trauma.In this study, a series of amphiphilic copolymers based on polyethylene glycol, trimethylene carbonate and ci... περισσότερα »
Antioxidant and bone repair properties of quercetin-functionalized hydroxyapatite
: an in vitro osteoblast-osteoclast-endothelial cell co-culture study via Acta Biomaterialia Publication date: Available online 12 December 2015 *Source:*Acta Biomaterialia Author(s): Lucia Forte, Paola Torricelli, Elisa Boanini, Massimo Gazzano, Katia Rubini, Milena Fini, Adriana Bigi Quercetin (3,3’,4’,5,7–pentahydroxy-flavone) is a flavonoid known for its pharmacological activities, which include antioxidant and anti-inflammatory properties, as well as possible beneficial action on diseases involving bone loss. In this work, we explored the possibility to functionalize hydroxyapatit... περισσότερα »
{gamma}-Synuclein Expression Is a Malignant Index in Oral Squamous Cell Carcinoma
{gamma}-Synuclein Expression Is a Malignant Index in Oral Squamous Cell Carcinoma: Dysregulation of -synuclein (SNCG) has been reported in many cancers; however, its role in cancer development is still controversial. Here, we examined the potential involvement of DNA methylation in regulating SNCG and its role in oral squamous cell carcinoma (OSCC). We used 8 OSCC cell lines to investigate SNCG methylation and expression. SNCG methylation was examination by methylation-specific polymerase chain reaction and bisulfate sequencing. Cells showing a high degree of SNCG methylation were ... περισσότερα »
Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials in Relation to Normal Aging.
Diabetes-Associated Changes in Cortical Auditory-Evoked Potentials in Relation to Normal Aging.: Objectives: (1) To characterize the influence of type 2 diabetes mellitus (DM) on cortical auditory-evoked potentials (CAEPs) separate from the effects of normal aging, and (2) to determine whether the disease-related effects are modified by insulin dependence. Design: A cross-sectional study was conducted in a large cohort of Veterans to investigate the relationships among type 2 DM, age, and CAEPs in randomly selected participants with (N = 108) and without (N = 114) the disease and who...περισσότερα »
Nonlinguistic Outcome Measures in Adult Cochlear Implant Users Over the First Year of Implantation.
Nonlinguistic Outcome Measures in Adult Cochlear Implant Users Over the First Year of Implantation.: Objectives: Postlingually deaf cochlear implant users' speech perception improves over several months after implantation due to a learning process which involves integration of the new acoustic information presented by the device. Basic tests of hearing acuity might evaluate sensitivity to the new acoustic information and be less sensitive to learning effects. It was hypothesized that, unlike speech perception, basic spectral and temporal discrimination abilities will not change over...περισσότερα »
Mushroom tumor: A new disease on Flammulina velutipes caused by Ochrobactrum pseudogrignonense
Mushroom tumor on *Flammulina velutipes* has become the main disease during the off-season cultivation of *F. velutipes* while the causal organism has remained unknown*.* The present study was aimed at identifying the pathogen confirming its pathogenisity following Koch's Postulates, characterizing it using morphological, physiological, biochemical and molecular features, and studying its current distribution. We determined that mushroom tumor is a new bacterial infection disease caused by *Ochrobactrum pseudogrignonense.* It produces tumor-like structures on the surface of the sub... περισσότερα »
In vitro functional characterization of the Na+/H+ antiporters in Corynebacterium glutamicum
*Corynebacterium glutamicum*, typically used as industrial workhorse for amino acid production, is a moderately salt-alkali tolerant microorganism with optimal growth at pH 7–9. However, little is known about the mechanisms of salt-alkali tolerance in *C. glutamicum*. Here, the catalytic capacity of three putative Na+/H+ antiporters from *C. glutamicum* (designated as Cg-Mrp1, Cg-Mrp2 and Cg-NhaP) were characterized in an antiporter-deficient *Escherichia coli* KNabc strain. Only Cg-Mrp1 was able to effectively complement the Na+-sensitive of *E. coli* KNabc. Cg-Mrp1 exhibited obv... περισσότερα »
Horizontal gene transfer of chromosomal Type II toxin-antitoxin systems of Escherichia coli
Type II toxin-antitoxin systems (TAs) are small autoregulated bicistronic operons which encode a toxin protein with potential to inhibit metabolic processes and an antitoxin protein to neutralize the toxin. Most of the bacterial genomes encode multiple TAs. However, the diversity and accumulation of TAs on bacterial genomes and its physiological implications are highly debated. Here we provide evidence that *Escherichia coli* chromosomal TAs (encoding RNAse toxins) are "acquired" DNA originated likely from heterologous DNA and are the smallest known autoregulated operons with pote... περισσότερα »
Supporting cells in the cochlear ducts : Hair cell regeneration or the expression of related factors
Hair cell regeneration or the expression of related factors that regulate the fate specification of supporting cells in the cochlear ducts of embryonic and posthatch chickens via Hearing Research Publication date: Available online 12 December 2015 *Source:*Hearing Research Author(s): Lingling Jiang, Ran Jin, Jincao Xu, Yubin Ji, Meiguang Zhang, Xuebo Zhang, Xinwen Zhang, Zhongming Han, Shaoju Zeng Hair cells in posthatch chickens regenerate spontaneously through mitosis or the transdifferentiation of supporting cells in response to antibiotic injury. However, how embryonic chicken coch...περισσότερα »
Neurons of the Medial geniculate body : Sodium salicylate potentiates the GABAB-GIRK pathway to suppress rebound depolarization
Sodium salicylate potentiates the GABAB-GIRK pathway to suppress rebound depolarization in neurons of the rat's medial geniculate body via Hearing Research Publication date: Available online 12 December 2015 *Source:*Hearing Research Author(s): Xin-Xing Wang, Yan Jin, Bin Luo, Jing-Wu Sun, Jinsheng Zhang, Ming Wang, Lin Chen Rebound depolarization (RD) is a voltage response to the offset from pre-hyperpolarization of neuronal membrane potential, which manifests a particular form of the postsynaptic membrane potential response to inhibitory presynaptic inputs. We previously demonstrated...περισσότερα »
Modulation of Auditory Brainstem Responses by Serotonin and Specific Serotonin Receptors
Modulation of Auditory Brainstem Responses by Serotonin and Specific Serotonin Receptors via Hearing Research Publication date: Available online 12 December 2015 *Source:*Hearing Research Author(s): Melissa A. Papesh, Laura M. Hurley The neuromodulator serotonin is found throughout the auditory system from the cochlea to the cortex. Although effects of serotonin have been reported at the level of single neurons in many brainstem nuclei, how these effects correspond to more integrated measures of auditory processing has not been well-explored. In the present study, we aimed to character... περισσότερα »
The Use of Prosodic Cues in Sentence Processing by Prelingually Deaf Users of Cochlear Implants.
The Use of Prosodic Cues in Sentence Processing by Prelingually Deaf Users of Cochlear Implants.: Objectives: The purpose of this study is to assess the use of prosodic and contextual cues to focus by prelingually deaf adolescent users of cochlear implants (CIs) when identifying target phonemes. We predict that CI users will have slower reaction times to target phonemes compared with a group of normally-hearing (NH) peers. We also predict that reaction times will be faster when both prosodic and contextual (semantic) cues are provided. Design: Eight prelingually deaf adolescent users... περισσότερα »
Matching Automatic Gain Control Across Devices in Bimodal Cochlear Implant Users.
Matching Automatic Gain Control Across Devices in Bimodal Cochlear Implant Users.: Objectives: The purpose of this study was to improve bimodal benefit in listeners using a cochlear implant (CI) and a hearing aid (HA) in contralateral ears, by matching the time constants and the number of compression channels of the automatic gain control (AGC) of the HA to the CI. Equivalent AGC was hypothesized to support a balanced loudness for dynamically changing signals like speech and improve bimodal benefit for speech understanding in quiet and with noise presented from the side(s) at 90 deg...περισσότερα »
Interleaved Processors Improve Cochlear Implant Patients' Spectral Resolution.
Interleaved Processors Improve Cochlear Implant Patients' Spectral Resolution.: Objective: Cochlear implant patients have difficulty in noisy environments, in part, because of channel interaction. Interleaving the signal by sending every other channel to the opposite ear has the potential to reduce channel interaction by increasing the space between channels in each ear. Interleaving still potentially provides the same amount of spectral information when the two ears are combined. Although this method has been successful in other populations such as hearing aid users, interleaving w... περισσότερα »
Variability and Diagnostic Accuracy of Speech Intelligibility Scores in Children
Variability and Diagnostic Accuracy of Speech Intelligibility Scores in Children: Purpose We examined variability of speech intelligibility scores and how well intelligibility scores predicted group membership among 5-year-old children with speech motor impairment (SMI) secondary to cerebral palsy and an age-matched group of typically developing (TD) children. Method Speech samples varying in length from 1–4 words were elicited from 24 children with cerebral palsy (mean age 60.50 months) and 20 TD children (mean age 60.33 months). Two hundred twenty adult listeners made orthograp... περισσότερα »
Exploring Expressive Vocabulary Variability in Two-Year-Olds: The Role of Working Memory
Exploring Expressive Vocabulary Variability in Two-Year-Olds: The Role of Working Memory: Purpose This study explored whether measures of working memory ability contribute to the wide variation in 2-year-olds' expressive vocabulary skills. Method Seventy-nine children (aged 24–30 months) were assessed by using standardized tests of vocabulary and visual cognition, a processing speed measure, and behavioral measures of verbal working memory and phonological short-term memory. Results Strong correlations were observed between phonological short-term memory, verbal working memory, ...περισσότερα »
The Mendelsohn Maneuver (MM) is a commonly prescribed technique that is taught to individuals with dysphagia to improve swallowing ability
The Relationship Between Submental Surface Electromyography and Hyo-Laryngeal Kinematic Measures of Mendelsohn Maneuver Duration: Purpose The Mendelsohn Maneuver (MM) is a commonly prescribed technique that is taught to individuals with dysphagia to improve swallowing ability. Due to cost and safety concerns associated with videofluoroscopy (VFS) use, submental surface electromyography (ssEMG) is commonly used in place of VFS to train the MM in clinical and research settings. However, it is unknown whether ssEMG accurately reflects the prolonged hyo-laryngeal movements required for... περισσότερα »
The Relationship Between Submental Surface Electromyography and Hyo-Laryngeal Kinematic Measures of Mendelsohn Maneuver Duration
The Relationship Between Submental Surface Electromyography and Hyo-Laryngeal Kinematic Measures of Mendelsohn Maneuver Duration: Purpose The Mendelsohn Maneuver (MM) is a commonly prescribed technique that is taught to individuals with dysphagia to improve swallowing ability. Due to cost and safety concerns associated with videofluoroscopy (VFS) use, submental surface electromyography (ssEMG) is commonly used in place of VFS to train the MM in clinical and research settings. However, it is unknown whether ssEMG accurately reflects the prolonged hyo-laryngeal movements required for... περισσότερα »
Responses to Intensity-Shifted Auditory Feedback During Running Speech
Responses to Intensity-Shifted Auditory Feedback During Running Speech: Purpose Responses to intensity perturbation during running speech were measured to understand whether prosodic features are controlled in an independent or integrated manner. Method Nineteen English-speaking healthy adults (age range = 21–41 years) produced 480 sentences in which emphatic stress was placed on either the 1st or 2nd word. One participant group received an upward intensity perturbation during stressed word production, and the other group received a downward intensity perturbation. Compensations f... περισσότερα »
The role of periodicity in perceiving speech in quiet and in background noise
The role of periodicity in perceiving speech in quiet and in background noise: The ability of normal-hearing listeners to perceive sentences in quiet and in background noise was investigated in a variety of conditions mixing the presence and absence of periodicity (i.e., voicing) in both target and masker. Experiment 1 showed that in quiet, aperiodic noise-vocoded speech and speech with a natural amount of periodicity were equally intelligible, while fully periodic speech was much harder to understand. In Experiments 2 and 3, speech reception thresholds for these targets were measu... περισσότερα »
GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults
Recombinant human GH (rhGH) has been in use for 30 years, and over that time its safety and efficacy in children and adults has been subject to considerable scrutiny. In 2001, a statement from the GH Research Society (GRS) concluded that 'for approved indications, GH is safe'; however, the statement highlighted a number of areas for on-going surveillance of long-term safety, including cancer risk, impact on glucose homeostasis, and use of high dose pharmacological rhGH treatment. Over the intervening years, there have been a number of publications addressing the safety of rhGH wit...περισσότερα »
Compromised cortical bone compartment in type 2 diabetes mellitus patients with microvascular disease
Objective and design Patients with type 2 diabetes mellitus (T2D) have an increased fracture risk despite a normal or elevated bone mineral density (BMD). The aim of this cross-sectional *in vivo* study was to assess parameters of peripheral bone microarchitecture, estimated bone strength and bone remodeling in T2D patients with and without diabetic microvascular disease (MVD+ and MVD– respectively) and to compare them with healthy controls. Methods Fifty-one T2D patients (MVD+ group: *n*=25) were recruited from Funen Diabetic Database and matched for age, sex and height with 51...περισσότερα »
Hereditary hypophosphatemia in Norway: a retrospective population-based study of genotypes, phenotypes, and treatment complications
Objective Hereditary hypophosphatemias (HH) are rare monogenic conditions characterized by decreased renal tubular phosphate reabsorption. The aim of this study was to explore the prevalence, genotypes, phenotypic spectrum, treatment response, and complications of treatment in the Norwegian population of children with HH. Design Retrospective national cohort study. Methods Sanger sequencing and multiplex ligand-dependent probe amplification analysis of *PHEX* and Sanger sequencing of *FGF23*, *DMP1*, *ENPP1**KL*, and *FAM20C* were performed to assess genotype in patients with ... περισσότερα »
Influence of hydroxyapatite granule size, porosity, and crystallinity on tissue reaction in vivo. Part A: synthesis, characterization of the materials, and SEM analysis
[image: cover.gif?v=1&s=e60d9281048a4597d45840f4] Abstract Objective The aim of this study was the synthesis and analysis of the tissue reaction to three different Hydroxyapatite (HA)-based bone substitute materials differing only in granule size, porosity, and crystallinity through an animal experimental model at 60 days. Materials and methods Three different HA-based biomaterials were synthesized and characterized by X-ray diffraction, SEM, and EDS analysis, the resultant product was ground in three particle sizes: Group I (2000–4000 μm), Group II (1000–2000 μm), and Group II... περισσότερα »
Immediate dental implant placement into infected vs. non-infected sockets: a meta-analysis
Abstract Objective This meta-analysis was aimed at assessing whether immediate dental implant placement into infected vs. non-infected sites produced different effects on implant failure risk and marginal bone loss. Material and methods Relevant studies were identified by searching articles in PubMed, Web of Knowledge, and the Cochrane Library through February 2015 and by reviewing the reference lists of the retrieved articles. When an intervention led to dichotomous outcomes, the outcomes were expressed as risk ratios, whereas continuous outcomes were expressed as mean differenc...περισσότερα »
New technique for closure of an oroantral fistula using platelet-rich fibrin
An oroantral fistula forms when the blood clot comes out of an extraction socket after there has been a breach of the floor and the epithelial membrane of the maxillary sinus. The blood clot would have otherwise served as a "scaffold" for the epithelial cells to grow from the margins towards the centre of the wound to heal it. from #ΓναθοΧειρουργική via xlomafota13 on Inoreader http://ift.tt/1TMru6n via IFTTT
Virtual occlusal definition for orthognathic surgery
Computer-assisted surgical simulation is being used increasingly in orthognathic surgery. However, occlusal definition is still undertaken using model surgery with subsequent digitization via surface scanning or cone beam computed tomography. A software tool has been developed and a workflow set up in order to achieve a virtual occlusal definition. The results of a validation study carried out on 60 models of normal occlusion are presented. Inter- and intra-user correlation tests were used to investigate the reproducibility of the manual setting point procedure. from #ΓναθοΧειρουρ... περισσότερα »
Validity and reliability of the Korean version of the Speech Handicap Index in patients with oral cavity cancer
The aims of this study were to evaluate the cross-cultural adaptation of the Speech Handicap Index (SHI) for Korean subjects and to determine its reliability and utility in patients with oral cavity cancer. The Korean version of the SHI was administered to 50 healthy subjects and 56 patients with speech problems resulting from treatment for oral cavity cancers. The content and construct validity, internal consistency, and test–retest reliability were examined. Healthy subject and patient group scores were compared, and the Mann–Whitney U-test was used to determine discriminatory a... περισσότερα »
‘Stylo-mandibular complex’ fracture from a maxillofacial surgeon's perspective – review of the literature and proposal of a management algorithm
The incidence of fractures of styloid process, either in isolation or association with mandibular fractures, is rare, and frequently overlooked. When present, they pose clinical dilemma in diagnosis and management. Proper management of styloid fractures is essential, not just to alleviate the patients' symptoms, but also to prevent potential complications like post-traumatic styloid syndrome and injury to adjacent vital structures. This article features a review of literature on 'styloid fracture concomitant with mandibular fracture' along with a case report. from #ΓναθοΧειρουργικ... περισσότερα »
Ryan White HIV/AIDS Program Assistance and HIV Treatment Outcomes
*Background.* The Ryan White HIV/AIDS Program (RWHAP) provides persons infected with human immunodeficiency virus (HIV) with services not covered by other healthcare payer types. Limited data exist to inform policy decisions about the most appropriate role for RWHAP under the Patient Protection and Affordable Care Act (ACA). *Methods.* We assessed associations between RWHAP assistance and antiretroviral therapy (ART) prescription and viral suppression. We used data from the Medical Monitoring Project, a surveillance system assessing characteristics of HIV-infected adults receiving...περισσότερα »
First bite syndrome after bimaxillary osteotomy: case report
We read the recently published paper by Scholey and Suida,1 in which they described a case of first bite syndrome that developed after a bimaxillary osteotomy. They described symptoms consistent with first bite syndrome and diagnosed the condition with no evidence of intraoral or extraoral disease. The syndrome has a specific symptom of facial pain that occurs only with the first bite of a meal. We reproduced this by introducing lemon glycerine swabs into the mouth to stimulate the secretion of saliva, which seems to be a reliable technique for diagnosis. from #ORL-AlexandrosSfaki... περισσότερα »
Le Fort I advancement osteotomies of 1 cm or more. How safe or stable?
We studied the results and stability of Le Fort I maxillary osteotomies with advancement of at least 1cm. We analysed prospective data from 32 consecutive patients who were operated on by a single surgeon between 1985 and 2007, and who had mean advancement of the maxilla of 14mm (range 10–22mm).Mean relapse for all cases antero-posteriorly was 1mm, 10% (range 0–4mm). Relapse was marginally greater in the 24 patients with a repaired cleft palate (11%) compared with those without a cleft (8%). The results were essentially stable at least one year after surgery and without significan...περισσότερα »
Non-invasive single-trial detection of variable population spike responses in human somatosensory evoked potentials
Non-invasive electroencephalography during peripheral nerve stimulation provides functional information about central stimulus processing. In particular, the clinically established low-frequency EEG (<100Hz) mainly reflects cortical postsynaptic potentials, i.e., the input of neuronal computation (Okada et al., 1997). In contrast, somatosensory evoked potentials (SEPs) contain an additional oscillatory high-frequency EEG burst (≈600Hz), denoted here as 'σ-burst', which is concomitant with the first cortical low-frequency component (the post-synaptically generated 'N20' for median ... περισσότερα »
New technique for closure of an oroantral fistula using platelet-rich fibrin
An oroantral fistula forms when the blood clot comes out of an extraction socket after there has been a breach of the floor and the epithelial membrane of the maxillary sinus. The blood clot would have otherwise served as a "scaffold" for the epithelial cells to grow from the margins towards the centre of the wound to heal it. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1TMru6n via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P4dtzJ via IFTTT
Evidence of small fiber neuropathy in a patient with Ehlers–Danlos syndrome, hypermobility-type
Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome hypermobility type (EDS-HT) are two clinically overlapping heritable connective tissue diseases. Their clinical identity has been recently suggested and many researchers are now considering EDS-HT and JHS as one and the same (i.e. JHS/EDS-HT) (Castori et al., 2013). As the molecular basis of JHS/EDS-HT is largely unknown, the diagnosis remains based exclusively on clinical criteria. Generalized joint hypermobility, joint complications and skin hyperextensibility are the major features of JHS/EDS-HT and chronic pain, fat...περισσότερα »
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients
Abstract Background Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. *SHMT1* C1420T may lead to the abnormal biosynthesis involved in DNA synthesis and methylation, and it may eventually increase cancer susceptibility. Many epidemiologic studies have explored the association between C1420T polymorphism and the risk of non-Hodgkin lymphoma (NHL), but the results have been contradictory. Therefore, we performed this meta-analysis to evaluate the relationship. Methods ... περισσότερα »
Virtual occlusal definition for orthognathic surgery
Computer-assisted surgical simulation is being used increasingly in orthognathic surgery. However, occlusal definition is still undertaken using model surgery with subsequent digitization via surface scanning or cone beam computed tomography. A software tool has been developed and a workflow set up in order to achieve a virtual occlusal definition. The results of a validation study carried out on 60 models of normal occlusion are presented. Inter- and intra-user correlation tests were used to investigate the reproducibility of the manual setting point procedure. from #ORL-Alexandr... περισσότερα »
Sociodemographic impact on survival in unresectable hepatocellular carcinoma: a survival epidemiology and end results study
Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1MefNj0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P4dvHP via IFTTT
Maternal obesity and malnourishment exacerbate perinatal oxidative stress resulting in diabetogenic programming in F1 offspring
Abstract The effect of in-utero environment on fetal health and survival is long-lasting, and this is known as the fetal origin hypothesis. The oxidative stress state during gestation could play a pivotal role in fetal programming and development of diseases such as diabetes. In this study, we investigated the effect of intra-uterine obesity and malnutrition on oxidative stress markers in pancreatic and peripheral tissues of F1 offspring both prenatally and postnatally. Furthermore, the effect of postnatal diet on oxidative stress profile was evaluated. The results indicated that ... περισσότερα »
Validity and reliability of the Korean version of the Speech Handicap Index in patients with oral cavity cancer
The aims of this study were to evaluate the cross-cultural adaptation of the Speech Handicap Index (SHI) for Korean subjects and to determine its reliability and utility in patients with oral cavity cancer. The Korean version of the SHI was administered to 50 healthy subjects and 56 patients with speech problems resulting from treatment for oral cavity cancers. The content and construct validity, internal consistency, and test–retest reliability were examined. Healthy subject and patient group scores were compared, and the Mann–Whitney U-test was used to determine discriminatory a... περισσότερα »
‘Stylo-mandibular complex’ fracture from a maxillofacial surgeon’s perspective – review of the literature and proposal of a management algorithm
The incidence of fractures of styloid process, either in isolation or association with mandibular fractures, is rare, and frequently overlooked. When present, they pose clinical dilemma in diagnosis and management. Proper management of styloid fractures is essential, not just to alleviate the patients' symptoms, but also to prevent potential complications like post-traumatic styloid syndrome and injury to adjacent vital structures. This article features a review of literature on 'styloid fracture concomitant with mandibular fracture' along with a case report. from #ORL-AlexandrosS... περισσότερα »
Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis?
Abstract Despite continuous improvements in treating clinical symptoms and the identification of single compounds that effectively rescue some rare mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), associated lung and liver pathologies remain largely untreatable and no real breakthrough is visible for the majority of patients suffering from cystic fibrosis (CF). Novel compounds have to be identified and tailored in combination to specific CFTR mutations, to different tissues, or even to the individual patient. Immortalized cell lines overexpressing mutan... περισσότερα »
Analytical Study of Vocal Vibrato and Mordent of Indian Popular Singers
Two very important ornamentations that singers introduce while singing are vibrato and mordent. Exploring vibrato characteristics of different styles of singing is currently a major interest in musical research. This work presents an analysis of vocal vibrato of Indian pop singers. This paper also reviews a direct relationship between tempo and vibrato, which has been established on Indian pop singers. Another ornament called mordent is also widely used by the Indian singers spontaneously. This study performs an analysis of mordent and tries to define its characteristics with the ... περισσότερα »
Continuous Combined Estrogen Plus Progestin and Endometrial Cancer: The Womens Health Initiative Randomized Trial
Background: While progestin addition to estrogen mitigates endometrial cancer risk, the magnitude of the effect on incidence, specific endometrial cancer histologies, and endometrial cancer mortality remains unsettled. These issues were assessed by analyses after extended follow-up of the Women's Health Initiative (WHI) randomized clinical trial evaluating continuous combined estrogen plus progestin use. Methods: The WHI enrolled 16 608 postmenopausal women into a randomly assigned, double-blind, placebo-controlled trial. Women age 50 to 79 years with intact uteri with normal en...περισσότερα »
Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia
[image: F1.medium.gif] White matter hyperintensities as seen on brain T2-weighted magnetic resonance imaging are associated with varying degrees of cognitive dysfunction in stroke, cerebral small vessel disease and dementia. The pathophysiological mechanisms within the white matter accounting for cognitive dysfunction remain unclear. With the hypothesis that gliovascular interactions are impaired in subjects with high burdens of white matter hyperintensities, we performed clinicopathological studies in post-stroke survivors, who had exhibited greater frontal white matter hyperinte...περισσότερα »
Continuous Joint Use of Estrogen and Progestin Decreases Risk of EC in Postmenopausal Women
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1O1eB3O via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P4dtzz via IFTTT
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients
Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. SHMT1 C1420T may lead to the abnormal biosynthe… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1NtTK9Y via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QkdTWc via IFTTT
Axial myopathy: an overlooked feature of muscle diseases
Classically, myopathies are categorized according to limb or cranial nerve muscle affection, but with the growing use of magnetic resonance imaging it has become evident that many well-known myopathies have significant involvement of the axial musculature. New disease entities with selective axial muscle involvement have also been described recently, but overall the axial myopathy is unexplored. We performed a PubMed search using the search terms 'myopathy', 'paraspinal', 'axial' and 'erector'. Axial myopathy was defined as involvement of paraspinal musculature. We found evidence o...περισσότερα »
Accurate and sensitive real-time PCR assays using intergenic spacer 1 region to differentiate Cryptococcus gattii sensu lato and Cryptococcus neoformans sensu lato
In this work, two accurate and sensitive real-time polymerase chain reaction (PCR) assays to differentiate pathogenic *Cryptococcus gattii sensu lato* (*s.l.*) and *C. neoformans sensu lato* (*s.l.*) targeting the intergenic spacer 1 (IGS1) region from rDNA locus were developed. Specific primers were designed based on their IGS1 sequence analyses and the optimal real-time PCR assays showed that the dissociation curves generated two different melting peaks, at 82.8 and 84.2ºC for *C. gattii s.l.* and *C. neoformans s.l.*, respectively. No amplifications were observed in the negativ...περισσότερα »
Letter to the Editor Regarding “Is magnetic resonance imaging in addition to a computed tomographic scan necessary to identify clinically significant cervical spine injuries in obtunded blunt trauma patients?”
We would like to thank the authors Fisher et al. for raising an important issue regarding the utility of magnetic resonance imaging (MRI) in obtunded cervical spine (CS) blunt trauma patients in their study titled "Is magnetic resonance imaging in addition to a computed tomographic scan necessary to identify clinically significant cervical spine injuries in obtunded blunt trauma patients 1." This is a timely effort to address this longstanding controversy. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QIfweE via IFTTT from #Med Blogs by Alexandr... περισσότερα »
Coronary artery bypass grafting in Takayasu’s disease – importance of the proximal anastomosis: a case report
IntroductionTreatment of coronary artery involvement in Takayasu's arteritis is challenging. Coronary artery bypass grafting may be required. The use of saphenous vein grafts is recommended because of possible inflammatory involvement of the internal thoracic arteries. However, inserting the proximal anastomosis on inflamed aortic tissue may give rise to stenosis. Only a few cases of inserting a proximal anastomosis in patients with Takayasu's arteritis have been reported in the literature. To date, no consensus has been reached on the best way to perform this procedure in patient... περισσότερα »
Management of Acute Appendicitis in a Rural Population
Our system uses a Hub and Spoke Approach (HSA) to provide surgical care for our rural population. Patients access care anywhere in the system, but are transferred centrally for surgical care. We sought to determine if surgical outcome differed depending on where initial care occurred. We chose Acute Appendicitis (AA) to investigate our care model. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UrMyQs via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Z9bSgO via IFTTT
Fatal coma in a young adult due to late-onset urea cycle deficiency presenting with a prolonged seizure: a case report
IntroductionUnexplained hyperammonemic coma in adults can be a medical dilemma in the absence of triggering factors and known comorbidities. Ornithine transcarbamylase deficiency presents most commonly with hyperammonemic coma. Although a rare disorder, ornithine transcarbamylase deficiency is the most common of the urea cycle disorders, which can occur both in children, and less commonly, in adults. The urea cycle disorder is usually acquired as an X-linked trait, and very rarely, similar to our reported case, may be acquired as a "new" mutation. Mutations that lead to later-onse...περισσότερα »
Clinical Impact of Gadoxetic Acid-Enhanced Magnetic Resonance Imaging on Hepatoma Management: A Prospective Study
Abstract Background For patients with hepatocellular carcinoma (HCC), gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) improved the diagnosis, migrated Barcelona Clinic Liver Cancer (BCLC) stage, and changed therapeutic decision in retrospective analysis. Aim This prospective study was to evaluate the clinical impact of EOB-MRI on HCC management. Methods From September 2012 to February 2014, consecutive patients with suspicion of HCC in BCLC early stage by multidetector computed tomography or dynamic MRI with non-specific gadolinium, well liver function reserve, and ... περισσότερα »
Hyperbilirubinemia and Leukocytosis in Gangrenous Cholecystitis
After reading the article "Risk factors for acute gangrenous cholecystitis in emergency general surgery patients" by Bourikian et al,1 I found it surprising that leukocytosis was not a predictor of gangrenous cholecystitis. Hyperbilirubinemia and leukocytosis continue to be important predictors of gangrenous cholecystitis. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QIfvaD via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P3RfzF via IFTTT
Maternal obesity and malnourishment exacerbate perinatal oxidative stress resulting in diabetogenic programming in F1 offspring
Abstract The effect of in-utero environment on fetal health and survival is long-lasting, and this is known as the fetal origin hypothesis. The oxidative stress state during gestation could play a pivotal role in fetal programming and development of diseases such as diabetes. In this study, we investigated the effect of intra-uterine obesity and malnutrition on oxidative stress markers in pancreatic and peripheral tissues of F1 offspring both prenatally and postnatally. Furthermore, the effect of postnatal diet on oxidative stress profile was evaluated. The results indicated that ... περισσότερα »
Inter-observer agreement of MRI-based tumor delineation for preoperative radiotherapy boost in locally advanced rectal cancer
[image: gr1.sml] While surgery remains the cornerstone of rectal cancer treatment, organ-preservation is upcoming. Therefore, neo-adjuvant treatment should be optimized. By escalating doses, response can be increased. To limit toxicity of boost, accurate gross tumor volume (GTV) definition is required. MRI, especially undeformed fast spin echo diffusion-weighted MRI (DWI), looks promising for delineation. However, inconsistencies between observers should be quantified before clinical implementation. We aim to find which MRI sequence (T2w, DWI or combination) is optimal and clinical...περισσότερα »
Swallowing sparing intensity modulated radiotherapy (SW-IMRT) in head and neck cancer: Clinical validation according to the model-based approach
[image: gr1.sml] The aim of this study was to clinically validate a multivariable normal tissue complication probability (NTCP) model for grade 2–4 swallowing dysfunction at 6months after radiotherapy or chemoradiation (SWALM6) in head and neck cancer patients treated with swallowing sparing intensity modulated radiotherapy (SW-IMRT) and to test if SW-IMRT resulted in a reduction of the prevalence of SWALM6. from Rathiotherapy via ola Kala on Inoreader http://ift.tt/1NQpGce via IFTTT
Expanding the scientific role of medical physics in radiotherapy: Time to act
The current issue of this journal includes highlighted papers that were presented (as oral presentations) at the most recent ESTRO Forum in Barcelona. This selection confirms the high level of scientific and research activity of the European medical physics community in radiotherapy (RT). This is undoubtedly due to the presence of many active groups (although heterogeneously distributed within Europe, as shown in the Supplementary material), reflecting a lively field and representing the continuation of a long and "high" tradition. from Rathiotherapy via ola Kala on Inoreader http... περισσότερα »
Re: First bite syndrome after bimaxillary osteotomy: case report
We read the recently published paper by Scholey and Suida,1 in which they described a case of first bite syndrome that developed after a bimaxillary osteotomy. They described symptoms consistent with first bite syndrome and diagnosed the condition with no evidence of intraoral or extraoral disease. The syndrome has a specific symptom of facial pain that occurs only with the first bite of a meal. We reproduced this by introducing lemon glycerine swabs into the mouth to stimulate the secretion of saliva, which seems to be a reliable technique for diagnosis. from OroFacial Medicine v... περισσότερα »
Le Fort I advancement osteotomies of 1 cm or more. How safe or stable?
We studied the results and stability of Le Fort I maxillary osteotomies with advancement of at least 1cm. We analysed prospective data from 32 consecutive patients who were operated on by a single surgeon between 1985 and 2007, and who had mean advancement of the maxilla of 14mm (range 10–22mm).Mean relapse for all cases antero-posteriorly was 1mm, 10% (range 0–4mm). Relapse was marginally greater in the 24 patients with a repaired cleft palate (11%) compared with those without a cleft (8%). The results were essentially stable at least one year after surgery and without significan...περισσότερα »
New technique for closure of an oroantral fistula using platelet-rich fibrin
An oroantral fistula forms when the blood clot comes out of an extraction socket after there has been a breach of the floor and the epithelial membrane of the maxillary sinus. The blood clot would have otherwise served as a "scaffold" for the epithelial cells to grow from the margins towards the centre of the wound to heal it. from OroFacial Medicine via ola Kala on Inoreader http://ift.tt/1TMru6n via IFTTT
Virtual occlusal definition for orthognathic surgery
Computer-assisted surgical simulation is being used increasingly in orthognathic surgery. However, occlusal definition is still undertaken using model surgery with subsequent digitization via surface scanning or cone beam computed tomography. A software tool has been developed and a workflow set up in order to achieve a virtual occlusal definition. The results of a validation study carried out on 60 models of normal occlusion are presented. Inter- and intra-user correlation tests were used to investigate the reproducibility of the manual setting point procedure. from OroFacial Med... περισσότερα »
Validity and reliability of the Korean version of the Speech Handicap Index in patients with oral cavity cancer
The aims of this study were to evaluate the cross-cultural adaptation of the Speech Handicap Index (SHI) for Korean subjects and to determine its reliability and utility in patients with oral cavity cancer. The Korean version of the SHI was administered to 50 healthy subjects and 56 patients with speech problems resulting from treatment for oral cavity cancers. The content and construct validity, internal consistency, and test–retest reliability were examined. Healthy subject and patient group scores were compared, and the Mann–Whitney U-test was used to determine discriminatory a... περισσότερα »
‘Stylo-mandibular complex’ fracture from a maxillofacial surgeon's perspective – review of the literature and proposal of a management algorithm
The incidence of fractures of styloid process, either in isolation or association with mandibular fractures, is rare, and frequently overlooked. When present, they pose clinical dilemma in diagnosis and management. Proper management of styloid fractures is essential, not just to alleviate the patients' symptoms, but also to prevent potential complications like post-traumatic styloid syndrome and injury to adjacent vital structures. This article features a review of literature on 'styloid fracture concomitant with mandibular fracture' along with a case report. from OroFacial Medici... περισσότερα »
Aspergillus oerlinghausenensis, a new mould species closely related to A. fumigatus
Two isolates belonging to *Aspergillus* section *Fumigati* were recovered from German soil on itraconazole containing agar media. Phylogenetic analysis and phenotypic characterization of both isolates show that they represent a novel species named *Aspergillus oerlinghausenensis* (holotype CBS H-22119HT, ex-type CBS 139183T = IBT 33878 = DTO 316-A3). The species is phylogenetically related to *Aspergillus fischeri* and *Aspergillus fumigatus*. *Aspergillus oerlinghausenensis* can be differentiated from *A. fischeri* by its higher growth rate at 50°C. Furthermore, *A. oerlinghausen... περισσότερα »
The Critical Role of the Staff Nurse in Antimicrobial Stewardship--Unrecognized, but Already There
An essential participant in antimicrobial stewardship who has been unrecognized and underutilized is the "staff nurse." Although the role of staff nurses has not formally been recognized in guidelines for implementing and operating antimicrobial stewardship programs (ASPs) or defined in the medical literature, they have always performed numerous functions that are integral to successful antimicrobial stewardship. Nurses are antibiotic first responders, central communicators, coordinators of care, as well as 24-hour monitors of patient status, safety, and response to antibiotic the... περισσότερα »
Ryan White HIV/AIDS Program Assistance and HIV Treatment Outcomes
*Background.* The Ryan White HIV/AIDS Program (RWHAP) provides persons infected with human immunodeficiency virus (HIV) with services not covered by other healthcare payer types. Limited data exist to inform policy decisions about the most appropriate role for RWHAP under the Patient Protection and Affordable Care Act (ACA). *Methods.* We assessed associations between RWHAP assistance and antiretroviral therapy (ART) prescription and viral suppression. We used data from the Medical Monitoring Project, a surveillance system assessing characteristics of HIV-infected adults receiving...περισσότερα »
The Future of HIV-1 Therapeutics. Resistance is Futile?
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1jZmu1Z via IFTTT
Respiratory Infections With Human Bocavirus
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1lKpyAL via IFTTT
Bad Faith--When Religious Belief Undermines Modern Medicine
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Reply to Musher
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1jZmsaa via IFTTT
Genetic Control of Antibody Responses to Pneumococcal Capsular Polysaccharides
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1lKpy3K via IFTTT
Clinical and Microbiological Characteristics of Invasive Group A Streptococcal Infections Before and After Implementation of a Universal Varicella Vaccine Program
Since the introduction of the varicella vaccine to the routine immunization schedule, we have observed a 70% reduction in the rate of varicella-associated invasive group A streptococcal infections (IGASI). In the mean time, the clinical presentation of IGASI and microbiological characteristics of GAS strains have changed significantly. from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1lKpxNe via IFTTT
Editorial Commentary: Which Patients Would Benefit From Antibiotic Prophylaxis: A "Burning" Question?
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1jZmtuS via IFTTT
Risk Factors for Invasive Methicillin-Resistant Staphylococcus aureus Infection After Recent Discharge From an Acute-Care Hospitalization, 2011-2013
*Background.* Significant progress has been made in reducing methicillin-resistant *Staphylococcus aureus* (MRSA) infections among hospitalized patients. However, the decreases in invasive MRSA infections among recently discharged patients have been less substantial. To inform prevention strategies, we assessed risk factors for invasive MRSA infection after acute-care hospitalizations. *Methods.* We conducted a prospective, matched case-control study. A case was defined as MRSA cultured from a normally sterile body site in a patient discharged from a hospital within the prior 12 w...περισσότερα »
A 59-Year-Old Man With Multiple Liver Lesions, Rash, and Uveitis
from #Infections via alexandrossfakianakis on Inoreader http://ift.tt/1lKpxga via IFTTT
Treatment for Tuberculosis Infection With 3 Months of Isoniazid and Rifapentine in New York City Health Department Clinics
*Background.* Completion of treatment for tuberculosis infection (TBI) with 9 months of self-administered daily isoniazid (9H) has historically been low (<50%) among New York City (NYC) Health Department tuberculosis clinic patients. Treatment of TBI with 3 months of once-weekly isoniazid and rifapentine (3HP) administered under directly observed therapy (DOT) might increase treatment acceptance and completion. *Methods.* The study population included patients diagnosed with TBI at 2 NYC Health Department tuberculosis clinics from January 2013 through November 2013. Treatment acce...περισσότερα »
Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow
Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1ROFU7s via IFTTT
Ionizing Radiation Impacts on Cardiac Differentiation of Mouse Embryonic Stem Cells
Stem Cells and Development , Vol. 0, No. 0. from Cell via ola Kala on Inoreader http://ift.tt/1ROFU7m via IFTTT
A “systems medicine” approach to the study of non-alcoholic fatty liver disease
The prevalence of fatty liver (steatosis) in the general population is rapidly increasing worldwide. The progress of knowledge in the physiopathology of fatty liver is based on the systems biology approach to studying the complex interactions among different physiological systems. Similarly, translational and clinical research should address the complex interplay between these systems impacting on fatty liver. The clinical needs drive the applications of systems medicine to re-define clinical phenotypes, assessing the multiple nature of disease susceptibility and progression (e.g.... περισσότερα »
The burden of anaemia in patients with inflammatory bowel diseases
Anaemia (AN) is frequently associated with inflammatory bowel diseases (IBD) and can negatively influence the quality of life of patients. from C via ola Kala on Inoreader http://ift.tt/1I5Xxh2 via IFTTT
Pediatric parenteral nutrition-associated liver disease and cholestasis: Novel advances in pathomechanisms-based prevention and treatment
Parenteral nutrition constitutes a life-saving therapeutic tool in patients unable to ingest/absorb oral or enteral delivered nutrients. Liver function tests abnormalities are a common therapy-related complication, thus configuring the so-called Parenteral Nutrition Associated Liver Disease (PNALD) or cholestasis (PNAC). Although the damage is frequently mild, and resolves after discontinuation of parenteral nutrition, in some cases it progresses into cirrhotic changes, especially in neonates and infants. from C via ola Kala on Inoreader http://ift.tt/1UrXnSF via IFTTT
Achilles Tendon Vascularization of Proximal, Medial, and Distal Portion Before and After Partial Lesion in Rats Treated with Phototherapy
Photomedicine and Laser Surgery Dec 2015, Vol. 33, No. 12: 579-584. from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/1YgIDWV via IFTTT
Psycho- und Pharmakotherapie bei schädlichem Tabakgebrauch und -abhängigkeit
Zusammenfassung Tabakkonsum gehört zu den wichtigsten vermeidbaren gesundheitlichen Risikofaktoren. Jährlich versterben etwa 110.000 Menschen vorzeitig an tabakbedingten Erkrankungen. Etwa 50 % der regelmäßigen Raucher gelten als tabakabhängig. Dennoch ist die Aufhörbereitschaft gering und die langfristigen Abstinenzquoten sind bei bestehendem Abstinenzwunsch ohne professionelle Unterstützung bei weniger als 10 % angesiedelt. Im Rahmen der S3-Leitlinien wurden nach umfassender systematischer Recherche der aktuellen Literatur 78 Behandlungsempfehlungen zur Motivation und Frühinterv... περισσότερα »
Vom Lob der „Zitronenkur“ und den Grenzen von S3-Leitlinien
from Neurology via xlomafota13 on Inoreader http://ift.tt/1YbNMEX via IFTTT
Axial myopathy: an overlooked feature of muscle diseases
Classically, myopathies are categorized according to limb or cranial nerve muscle affection, but with the growing use of magnetic resonance imaging it has become evident that many well-known myopathies have significant involvement of the axial musculature. New disease entities with selective axial muscle involvement have also been described recently, but overall the axial myopathy is unexplored. We performed a PubMed search using the search terms 'myopathy', 'paraspinal', 'axial' and 'erector'. Axial myopathy was defined as involvement of paraspinal musculature. We found evidence o...περισσότερα »
Pim Kinases Mediate Resistance to MET Inhibitors
Mesenchymal-epithelial transition (MET) blockade offers a new targeted therapy particularly in those cancers with MET amplification. However, the efficacy and the duration of the response to MET inhibitors are limited by the emergence of drug resistance. Here, we report that resistance to small-molecule inhibitors of MET can arise from increased expression of the prosurvival Pim protein kinases. This resistance mechanism was documented in non–small cell lung cancer and gastric cancer cells with MET amplification. Inhibition of Pim kinases enhanced cell death triggered by short-ter... περισσότερα »
Genomic Profiling of Merkel Cell Carcinomas
Merkel cell carcinoma (MCC) is an uncommon, but highly malignant, cutaneous tumor. Merkel cell polyoma virus (MCV) has been implicated in a majority of MCC tumors; however, viral-negative tumors have been reported to be more prevalent in some geographic regions subject to high sun exposure. While the impact of MCV and viral T-antigens on MCC development has been extensively investigated, little is known about the etiology of viral-negative tumors. We performed targeted capture and massively parallel DNA sequencing of 619 cancer genes to compare the gene mutations and copy number a...περισσότερα »
Comprehensive Phenotyping of Rare PIK3CA Variants
Large-scale sequencing efforts are uncovering the complexity of cancer genomes, which are composed of causal "driver" mutations that promote tumor progression along with many more pathologically neutral "passenger" events. The majority of mutations, both in known cancer drivers and uncharacterized genes, are generally of low occurrence, highlighting the need to functionally annotate the long tail of infrequent mutations present in heterogeneous cancers. Here we describe a mutation assessment pipeline enabled by high-throughput engineering of molecularly barcoded gene variant expre... περισσότερα »
Ryan White HIV/AIDS Program Assistance and HIV Treatment Outcomes
*Background.* The Ryan White HIV/AIDS Program (RWHAP) provides persons infected with human immunodeficiency virus (HIV) with services not covered by other healthcare payer types. Limited data exist to inform policy decisions about the most appropriate role for RWHAP under the Patient Protection and Affordable Care Act (ACA). *Methods.* We assessed associations between RWHAP assistance and antiretroviral therapy (ART) prescription and viral suppression. We used data from the Medical Monitoring Project, a surveillance system assessing characteristics of HIV-infected adults receiving...περισσότερα »
First bite syndrome after bimaxillary osteotomy: case report
We read the recently published paper by Scholey and Suida,1 in which they described a case of first bite syndrome that developed after a bimaxillary osteotomy. They described symptoms consistent with first bite syndrome and diagnosed the condition with no evidence of intraoral or extraoral disease. The syndrome has a specific symptom of facial pain that occurs only with the first bite of a meal. We reproduced this by introducing lemon glycerine swabs into the mouth to stimulate the secretion of saliva, which seems to be a reliable technique for diagnosis. from #ORL-AlexandrosSfaki... περισσότερα »
Le Fort I advancement osteotomies of 1 cm or more. How safe or stable?
We studied the results and stability of Le Fort I maxillary osteotomies with advancement of at least 1cm. We analysed prospective data from 32 consecutive patients who were operated on by a single surgeon between 1985 and 2007, and who had mean advancement of the maxilla of 14mm (range 10–22mm).Mean relapse for all cases antero-posteriorly was 1mm, 10% (range 0–4mm). Relapse was marginally greater in the 24 patients with a repaired cleft palate (11%) compared with those without a cleft (8%). The results were essentially stable at least one year after surgery and without significan...περισσότερα »
Non-invasive single-trial detection of variable population spike responses in human somatosensory evoked potentials
Non-invasive electroencephalography during peripheral nerve stimulation provides functional information about central stimulus processing. In particular, the clinically established low-frequency EEG (<100Hz) mainly reflects cortical postsynaptic potentials, i.e., the input of neuronal computation (Okada et al., 1997). In contrast, somatosensory evoked potentials (SEPs) contain an additional oscillatory high-frequency EEG burst (≈600Hz), denoted here as 'σ-burst', which is concomitant with the first cortical low-frequency component (the post-synaptically generated 'N20' for median ... περισσότερα »
New technique for closure of an oroantral fistula using platelet-rich fibrin
An oroantral fistula forms when the blood clot comes out of an extraction socket after there has been a breach of the floor and the epithelial membrane of the maxillary sinus. The blood clot would have otherwise served as a "scaffold" for the epithelial cells to grow from the margins towards the centre of the wound to heal it. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1TMru6n via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P4dtzJ via IFTTT
Evidence of small fiber neuropathy in a patient with Ehlers–Danlos syndrome, hypermobility-type
Joint hypermobility syndrome (JHS) and Ehlers-Danlos syndrome hypermobility type (EDS-HT) are two clinically overlapping heritable connective tissue diseases. Their clinical identity has been recently suggested and many researchers are now considering EDS-HT and JHS as one and the same (i.e. JHS/EDS-HT) (Castori et al., 2013). As the molecular basis of JHS/EDS-HT is largely unknown, the diagnosis remains based exclusively on clinical criteria. Generalized joint hypermobility, joint complications and skin hyperextensibility are the major features of JHS/EDS-HT and chronic pain, fat...περισσότερα »
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients
Abstract Background Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. *SHMT1* C1420T may lead to the abnormal biosynthesis involved in DNA synthesis and methylation, and it may eventually increase cancer susceptibility. Many epidemiologic studies have explored the association between C1420T polymorphism and the risk of non-Hodgkin lymphoma (NHL), but the results have been contradictory. Therefore, we performed this meta-analysis to evaluate the relationship. Methods ... περισσότερα »
Virtual occlusal definition for orthognathic surgery
Computer-assisted surgical simulation is being used increasingly in orthognathic surgery. However, occlusal definition is still undertaken using model surgery with subsequent digitization via surface scanning or cone beam computed tomography. A software tool has been developed and a workflow set up in order to achieve a virtual occlusal definition. The results of a validation study carried out on 60 models of normal occlusion are presented. Inter- and intra-user correlation tests were used to investigate the reproducibility of the manual setting point procedure. from #ORL-Alexandr... περισσότερα »
Sociodemographic impact on survival in unresectable hepatocellular carcinoma: a survival epidemiology and end results study
Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1MefNj0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P4dvHP via IFTTT
Maternal obesity and malnourishment exacerbate perinatal oxidative stress resulting in diabetogenic programming in F1 offspring
Abstract The effect of in-utero environment on fetal health and survival is long-lasting, and this is known as the fetal origin hypothesis. The oxidative stress state during gestation could play a pivotal role in fetal programming and development of diseases such as diabetes. In this study, we investigated the effect of intra-uterine obesity and malnutrition on oxidative stress markers in pancreatic and peripheral tissues of F1 offspring both prenatally and postnatally. Furthermore, the effect of postnatal diet on oxidative stress profile was evaluated. The results indicated that ... περισσότερα »
Validity and reliability of the Korean version of the Speech Handicap Index in patients with oral cavity cancer
The aims of this study were to evaluate the cross-cultural adaptation of the Speech Handicap Index (SHI) for Korean subjects and to determine its reliability and utility in patients with oral cavity cancer. The Korean version of the SHI was administered to 50 healthy subjects and 56 patients with speech problems resulting from treatment for oral cavity cancers. The content and construct validity, internal consistency, and test–retest reliability were examined. Healthy subject and patient group scores were compared, and the Mann–Whitney U-test was used to determine discriminatory a... περισσότερα »
‘Stylo-mandibular complex’ fracture from a maxillofacial surgeon’s perspective – review of the literature and proposal of a management algorithm
The incidence of fractures of styloid process, either in isolation or association with mandibular fractures, is rare, and frequently overlooked. When present, they pose clinical dilemma in diagnosis and management. Proper management of styloid fractures is essential, not just to alleviate the patients' symptoms, but also to prevent potential complications like post-traumatic styloid syndrome and injury to adjacent vital structures. This article features a review of literature on 'styloid fracture concomitant with mandibular fracture' along with a case report. from #ORL-AlexandrosS... περισσότερα »
Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis?
Abstract Despite continuous improvements in treating clinical symptoms and the identification of single compounds that effectively rescue some rare mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), associated lung and liver pathologies remain largely untreatable and no real breakthrough is visible for the majority of patients suffering from cystic fibrosis (CF). Novel compounds have to be identified and tailored in combination to specific CFTR mutations, to different tissues, or even to the individual patient. Immortalized cell lines overexpressing mutan... περισσότερα »
Analytical Study of Vocal Vibrato and Mordent of Indian Popular Singers
Two very important ornamentations that singers introduce while singing are vibrato and mordent. Exploring vibrato characteristics of different styles of singing is currently a major interest in musical research. This work presents an analysis of vocal vibrato of Indian pop singers. This paper also reviews a direct relationship between tempo and vibrato, which has been established on Indian pop singers. Another ornament called mordent is also widely used by the Indian singers spontaneously. This study performs an analysis of mordent and tries to define its characteristics with the ... περισσότερα »
Continuous Combined Estrogen Plus Progestin and Endometrial Cancer: The Womens Health Initiative Randomized Trial
Background: While progestin addition to estrogen mitigates endometrial cancer risk, the magnitude of the effect on incidence, specific endometrial cancer histologies, and endometrial cancer mortality remains unsettled. These issues were assessed by analyses after extended follow-up of the Women's Health Initiative (WHI) randomized clinical trial evaluating continuous combined estrogen plus progestin use. Methods: The WHI enrolled 16 608 postmenopausal women into a randomly assigned, double-blind, placebo-controlled trial. Women age 50 to 79 years with intact uteri with normal en...περισσότερα »
Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia
[image: F1.medium.gif] White matter hyperintensities as seen on brain T2-weighted magnetic resonance imaging are associated with varying degrees of cognitive dysfunction in stroke, cerebral small vessel disease and dementia. The pathophysiological mechanisms within the white matter accounting for cognitive dysfunction remain unclear. With the hypothesis that gliovascular interactions are impaired in subjects with high burdens of white matter hyperintensities, we performed clinicopathological studies in post-stroke survivors, who had exhibited greater frontal white matter hyperinte...περισσότερα »
Continuous Joint Use of Estrogen and Progestin Decreases Risk of EC in Postmenopausal Women
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1O1eB3O via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P4dtzz via IFTTT
SHMT1 C1420T polymorphism contributes to the risk of non-Hodgkin lymphoma: evidence from 7309 patients
Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. SHMT1 C1420T may lead to the abnormal biosynthe… from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1NtTK9Y via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QkdTWc via IFTTT
Axial myopathy: an overlooked feature of muscle diseases
Classically, myopathies are categorized according to limb or cranial nerve muscle affection, but with the growing use of magnetic resonance imaging it has become evident that many well-known myopathies have significant involvement of the axial musculature. New disease entities with selective axial muscle involvement have also been described recently, but overall the axial myopathy is unexplored. We performed a PubMed search using the search terms 'myopathy', 'paraspinal', 'axial' and 'erector'. Axial myopathy was defined as involvement of paraspinal musculature. We found evidence o...περισσότερα »
Accurate and sensitive real-time PCR assays using intergenic spacer 1 region to differentiate Cryptococcus gattii sensu lato and Cryptococcus neoformans sensu lato
In this work, two accurate and sensitive real-time polymerase chain reaction (PCR) assays to differentiate pathogenic *Cryptococcus gattii sensu lato* (*s.l.*) and *C. neoformans sensu lato* (*s.l.*) targeting the intergenic spacer 1 (IGS1) region from rDNA locus were developed. Specific primers were designed based on their IGS1 sequence analyses and the optimal real-time PCR assays showed that the dissociation curves generated two different melting peaks, at 82.8 and 84.2ºC for *C. gattii s.l.* and *C. neoformans s.l.*, respectively. No amplifications were observed in the negativ...περισσότερα »
Letter to the Editor Regarding “Is magnetic resonance imaging in addition to a computed tomographic scan necessary to identify clinically significant cervical spine injuries in obtunded blunt trauma patients?”
We would like to thank the authors Fisher et al. for raising an important issue regarding the utility of magnetic resonance imaging (MRI) in obtunded cervical spine (CS) blunt trauma patients in their study titled "Is magnetic resonance imaging in addition to a computed tomographic scan necessary to identify clinically significant cervical spine injuries in obtunded blunt trauma patients 1." This is a timely effort to address this longstanding controversy. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QIfweE via IFTTT from #Med Blogs by Alexandr... περισσότερα »
Coronary artery bypass grafting in Takayasu’s disease – importance of the proximal anastomosis: a case report
IntroductionTreatment of coronary artery involvement in Takayasu's arteritis is challenging. Coronary artery bypass grafting may be required. The use of saphenous vein grafts is recommended because of possible inflammatory involvement of the internal thoracic arteries. However, inserting the proximal anastomosis on inflamed aortic tissue may give rise to stenosis. Only a few cases of inserting a proximal anastomosis in patients with Takayasu's arteritis have been reported in the literature. To date, no consensus has been reached on the best way to perform this procedure in patient... περισσότερα »
Management of Acute Appendicitis in a Rural Population
Our system uses a Hub and Spoke Approach (HSA) to provide surgical care for our rural population. Patients access care anywhere in the system, but are transferred centrally for surgical care. We sought to determine if surgical outcome differed depending on where initial care occurred. We chose Acute Appendicitis (AA) to investigate our care model. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1UrMyQs via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Z9bSgO via IFTTT
Fatal coma in a young adult due to late-onset urea cycle deficiency presenting with a prolonged seizure: a case report
IntroductionUnexplained hyperammonemic coma in adults can be a medical dilemma in the absence of triggering factors and known comorbidities. Ornithine transcarbamylase deficiency presents most commonly with hyperammonemic coma. Although a rare disorder, ornithine transcarbamylase deficiency is the most common of the urea cycle disorders, which can occur both in children, and less commonly, in adults. The urea cycle disorder is usually acquired as an X-linked trait, and very rarely, similar to our reported case, may be acquired as a "new" mutation. Mutations that lead to later-onse...περισσότερα »
Clinical Impact of Gadoxetic Acid-Enhanced Magnetic Resonance Imaging on Hepatoma Management: A Prospective Study
Abstract Background For patients with hepatocellular carcinoma (HCC), gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) improved the diagnosis, migrated Barcelona Clinic Liver Cancer (BCLC) stage, and changed therapeutic decision in retrospective analysis. Aim This prospective study was to evaluate the clinical impact of EOB-MRI on HCC management. Methods From September 2012 to February 2014, consecutive patients with suspicion of HCC in BCLC early stage by multidetector computed tomography or dynamic MRI with non-specific gadolinium, well liver function reserve, and ... περισσότερα »
Hyperbilirubinemia and Leukocytosis in Gangrenous Cholecystitis
After reading the article "Risk factors for acute gangrenous cholecystitis in emergency general surgery patients" by Bourikian et al,1 I found it surprising that leukocytosis was not a predictor of gangrenous cholecystitis. Hyperbilirubinemia and leukocytosis continue to be important predictors of gangrenous cholecystitis. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1QIfvaD via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P3RfzF via IFTTT
A Century Later and Not Much Has Changed in Use of Anatomic Nomenclature: Should Surgeons and Anatomists Be Speaking the Same Language?
Recently, the Journal of the American Medical Association published in the "JAMA Revisited" section a centennial paper entitled "Anatomic Nomenclature"1 by anatomist Dr Albert Eycleshymer (1867-1925). Dr Eycleshymer's advocacy for uniformity in the use of anatomic terminology where its impact is most strongly felt echo's the sentiments of anatomists today who are vested in the education of future physicians. While the use of anatomical terminology is today governed by the international standard on human anatomic terminology the challenge of maintaining coherency between anatomical...περισσότερα »
Epidural Analgesia Utilization Rate for Hepatic and Pancreatic Surgery, That Low?
I read with interest the article "a nationwide analysis of the use and outcomes of perioperative epidural analgesia in patients undergoing hepatic and pancreatic surgery" .1 I congratulate the authors for this important analysis and their publication in your esteemed journal; however, I have few concerns about this study I would like the authors to address. The first concern is the low post-operative epidural analgesia (EA) utilization rate (7.4%) reported in this study for the selected surgical procedures. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://if... περισσότερα »
A Conversation with Allan Balmain
*Editor's Note: Allan Balmain is the Distinguished Professor of Cancer Genetics at the University of California, San Francisco and a Fellow of the Royal Society. He has been publishing important papers on RAS biology for almost 30 years. RAS Central editors recently interviewed Dr. Balmain about his personal history and scientific career.* *Can we ask you how you came to be at the UCSF? What was your path? Are you a Scot originally, is that correct?* from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1mkPq6i via IFTTT from #Med Blogs by Alexandros G.Sfakianak... περισσότερα »
A note of thanks
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1O5Xx2L via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lKmKn5 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QIfq6M via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1P3Rfjh via IFTTT
Coronary artery bypass grafting in Takayasu’s disease – importance of the proximal anastomosis: a case report
[image: s13256-015-0767-5-1.gif] IntroductionTreatment of coronary artery involvement in Takayasu's arteritis is challenging. Coronary artery bypass grafting may be required. The use of saphenous vein grafts is recommended because of possible inflammatory involvement of the internal thoracic arteries. However, inserting the proximal anastomosis on inflamed aortic tissue may give rise to stenosis. Only a few cases of inserting a proximal anastomosis in patients with Takayasu's arteritis have been reported in the literature. To date, no consensus has been reached on the best way to ... περισσότερα »
Chimeric transcripts resulting from complex duplications in chromosome Xq28
Abstract Gene fusions have been observed in somatic alterations in cancer and in schizophrenia. However, the underlying mechanism(s) for their formation are poorly understood. We experimentally demonstrated the expression of splicing variants of in silico predicted chimeric genes *F8/CSAG1* and *BCAP31/TEX28* in two individuals with de novo complex genomic rearrangements of Xq28; *F8/CSAG1* includes exonization of an ERVL-MaLR intronic repetitive element. We provide evidence that replicative repair may contribute to exon shuffling processes and diversify the repertoire of expresse...περισσότερα »
Coronary artery bypass grafting in Takayasu’s disease – importance of the proximal anastomosis: a case report
IntroductionTreatment of coronary artery involvement in Takayasu's arteritis is challenging. Coronary artery bypass grafting may be required. The use of saphenous vein grafts is recommended because of possible inflammatory involvement of the internal thoracic arteries. However, inserting the proximal anastomosis on inflamed aortic tissue may give rise to stenosis. Only a few cases of inserting a proximal anastomosis in patients with Takayasu's arteritis have been reported in the literature. To date, no consensus has been reached on the best way to perform this procedure in patient... περισσότερα »
Fatal coma in a young adult due to late-onset urea cycle deficiency presenting with a prolonged seizure: a case report
IntroductionUnexplained hyperammonemic coma in adults can be a medical dilemma in the absence of triggering factors and known comorbidities. Ornithine transcarbamylase deficiency presents most commonly with hyperammonemic coma. Although a rare disorder, ornithine transcarbamylase deficiency is the most common of the urea cycle disorders, which can occur both in children, and less commonly, in adults. The urea cycle disorder is usually acquired as an X-linked trait, and very rarely, similar to our reported case, may be acquired as a "new" mutation. Mutations that lead to later-onse...περισσότερα »
Clinical Impact of Gadoxetic Acid-Enhanced Magnetic Resonance Imaging on Hepatoma Management: A Prospective Study
Abstract Background For patients with hepatocellular carcinoma (HCC), gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) improved the diagnosis, migrated Barcelona Clinic Liver Cancer (BCLC) stage, and changed therapeutic decision in retrospective analysis. Aim This prospective study was to evaluate the clinical impact of EOB-MRI on HCC management. Methods From September 2012 to February 2014, consecutive patients with suspicion of HCC in BCLC early stage by multidetector computed tomography or dynamic MRI with non-specific gadolinium, well liver function reserve, and ... περισσότερα »
A Conversation with Allan Balmain
*Editor's Note: Allan Balmain is the Distinguished Professor of Cancer Genetics at the University of California, San Francisco and a Fellow of the Royal Society. He has been publishing important papers on RAS biology for almost 30 years. RAS Central editors recently interviewed Dr. Balmain about his personal history and scientific career.* *Can we ask you how you came to be at the UCSF? What was your path? Are you a Scot originally, is that correct?* from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1mkPq6i via IFTTT from #Med Blogs by Alexandros G.Sfakiana...περισσότερα »
A note of thanks
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1O5Xx2L via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1lKmKn5 via IFTTT
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