Anterior Foramen Magnum Meningioma or Cranio-cervical Junction Tumors
Vertebral Artery Transposition via an Extreme-Lateral Approach for Anterior Foramen Magnum Meningioma or Cranio-cervical Junction Tumors via World Neurosurgery [image: alertIcon.gif] Publication date: Available online 31 December 2015 *Source:*World Neurosurgery Author(s): Hun Ho Park, Kyu-Sung Lee, Chang-Ki Hong Highlights The extreme-lateral transcondylar approach provides a wide surgical field with ease of access to the anterior foramen magnum. Several modifications of the approach can be tailored accordingly through the transcondylar, supracondylar, and paracondylar route. VA trans... περισσότερα »
Craniotomy vs craniectomy for acute traumatic subdural hematoma
in the United States: a national retrospective cohort analysis via World Neurosurgery [image: alertIcon.gif] Publication date: Available online 31 December 2015 *Source:*World Neurosurgery Author(s): Barret Rush, Justin Rousseau, Mypinder Sekhon, Donald Griesdale Highlights • Management of acute traumatic subdural hematoma controversial • Craniectomy and Craniotomy are both preformed for ATSH • Craniotomy preformed 10:1 ratio over craniectomy for ATSH in the USA • The case-mortality rate for craniectomy significantly increased from 25.6% in 2006 to 47.5% in 2011 • Patients who underwent ... περισσότερα »
Delayed Migration of Fractured K-wire Causing Vertebral Artery Invagination Following Anterior Atlantoaxial Fixation
: A Case Report via World Neurosurgery [image: alertIcon.gif] Publication date: Available online 31 December 2015 *Source:*World Neurosurgery Author(s): Ahmad Hafez, Tarik Ibrahim, Rahul Raj, Jussi Antinheimo, Jari Siironen, Juha Hernesniemi Most of attention during spinal surgery, when using wires and screws, is going to avoid injuries of the critical structures (nerves and vessels). When these wires are broken during surgery, the most important point is to take them out safely or, if it is impossible, to leaf them in secure place and follow the patient closely. Migrations broken k-wi... περισσότερα »
Upper and lower esophageal sphincter kinetics
Upper and lower esophageal sphincter kinetics are modified during maturation: effect of pharyngeal stimulus in premature infants.: [image: http:--www.nature.com-images-lo_pr.gif] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Related Articles*Upper and lower esophageal sphincter kinetics are modified during maturation: effect of pharyngeal stimulus in premature infants.* Pediatr Res. 2015 Jan;77(1-1):99-106 Authors: Jadcherla SR, Shubert TR, Gulati IK, Jensen PS, Wei L, Shaker R Abstract BACKGROUND: We hypothesized that changes in proximal and distal esophageal sphincter kinet... περισσότερα »
Effect of submental sensitive transcutaneous electrical stimulation on virtual lesions of the oropharyngeal cortex.
Effect of submental sensitive transcutaneous electrical stimulation on virtual lesions of the oropharyngeal cortex.: *Effect of submental sensitive transcutaneous electrical stimulation on virtual lesions of the oropharyngeal cortex.* Ann Phys Rehabil Med. 2015 Dec 21; Authors: Cugy E, Leroi AM, Kerouac-Laplante J, Dehail P, Joseph PA, Gerardin E, Marie JP, Verin É Abstract OBJECTIVE: The aim of this study was to assess the effect of submental sensitive transcutaneous electrical stimulation (SSTES) on pharyngeal cortical representation after the creation of an oropharyngeal corti... περισσότερα »
Maternal junk food diet
Sex and age-dependent effects of a maternal junk food diet on the mu-opioid receptor in rat offspring via Behavioural Brain Research [image: S01664328.gif] Publication date: 15 March 2016 *Source:*Behavioural Brain Research, Volume 301 Author(s): Jessica R. Gugusheff, Sung Eun Bae, Alexandra Rao, Iain J. Clarke, Lucilla Poston, Paul D. Taylor, Clive W. Coen, Beverly S. Muhlhausler Perinatal junk food exposure increases the preference for palatable diets in juvenile and adult rat offspring. Previous studies have implicated reduced sensitivity of the opioid pathway in the programming o... περισσότερα »
Effects of Leg-Press Training with Moderate Vibration on Muscle Strength, Pain, and Function after Total Knee Arthroplasty: A Randomized Controlled Trial
Publication date: Available online 4 January 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Walter Bily, Carlo Franz, Lukas Trimmel, Stefan Loefler, Jan Cvecka, Sandra Zampieri, Waltraud Kasche, Nejc Sarabon, P. Zenz, H. Kern ObjectivesTo examine the effects of a time saving leg-press training program with moderate vibration on strength parameters, pain, and functional outcomes of patients following total knee arthroplasty in comparison with functional physiotherapy.DesignRandomized controlled trial.SettingOutpatient Rehabilitation Department at a Universit...περισσότερα »
Shoulder Strength Changes One Year after Axillary Lymph Node Dissection or Sentinel Lymph Node Biopsy in Breast Cancer Patients
Publication date: Available online 4 January 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Sandra Monleon, Montse Ferrer, Marta Tejero, Roser Belmonte ObjectiveTo assess the changes in shoulder strength of breast cancer patients during the first year after surgery; and to compare the effect of sentinel lymph node biopsy (SLNB) and axillary lymph node dissection (ALND) on shoulder strength.DesignProspective longitudinal observational study from pre-surgery to one year after.SettingTertiary hospital.ParticipantsOf 129 consecutive patients examined for eligib...περισσότερα »
The PCome of Ascaris suum as a model system for intestinal nematodes: identification of phosphorylcholine-substituted proteins and first characterization of the PC-epitope structures
Abstract In multicellular parasites (e.g., nematodes and protozoa), proteins and glycolipids have been found to be decorated with phosphorylcholine (PC). PC can provoke various effects on immune cells leading to an immunomodulation of the host's immune system. This immunomodulation allows long-term persistence but also prevents severe pathology due to downregulation of cellular immune responses. PC-containing antigens have been found to interfere with key proliferative signaling pathways in B and T cells, development of dendritic cells and macrophages, and mast cell degranulation....περισσότερα »
Phytochemical screening and in vivo antimalarial activity of extracts from three medicinal plants used in malaria treatment in Nigeria
Abstract The use of plant to meet health-care needs has greatly increased worldwide in the recent times. The search for new plant-derived bioactive agents that can be explored for the treatment of drug-resistant malaria infection is urgently needed. Thus, we evaluated the antimalarial activity of three medicinal plants used in Nigerian folklore for the treatment of malaria infection. A modified Peter's 4-day suppressive test was used to evaluate the antimalarial activity of the plant extracts in a mouse model of chloroquine-resistant *Plasmodium berghei* ANKA strain. Animals were ... περισσότερα »
RETRACTED ARTICLE: Molecular diagnosis of leishmaniasis at the subgenus and species level
from #Medicine via ola Kala on Inoreader http://ift.tt/1TzBIai Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Isolation and identification of pathogenic free-living amoeba from surface and tap water of Shiraz City using morphological and molecular methods
Abstract Free-living amoebae (FLA) are the most abundant and widely distributed protozoa in the environment. An investigation was conducted to determine the presence of free-living amoebae (FLA), *Acanthamoeba* and *Vermamoeba* in waterfronts of parks and squares and tap water of Shiraz City, Iran. FLA are considered pathogenic for human. These ubiquitous organisms have been isolated from different environments such as water, soil, and air. Eighty-two water samples were collected from different places of Shiraz City during the summer of 2013. All samples were processed in Dept. of ...περισσότερα »
Erratum to: Sarcocystis oreamni , n. sp. (Apicomplexa: Sarcocystidae) from the mountain goat ( Oreamnos americanus )
from #Medicine via ola Kala on Inoreader http://ift.tt/1TzBKPr Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Morphological and molecular identification of free living amoeba isolated from hospital water in Tunisia
Abstract Free-living amoebae (FLA) are opportunistic and ubiquitous protozoa that are widely found in various environmental sources. They are known to cause serious human infections. The aim of our study was to detect FLA and *Acanthamoeba* spp. in hospital water circuits. Eighty-four water samples were collected over a period of 4 months (September–December 2011) from different wards of the Sfax University Hospital (surgical services, intensive care unit, operating theater, and water storage tanks). FLA were detected in 53.5 % of samples as follows: surgical services (80 %), oper... περισσότερα »
Isolated unilateral trismus as a presentation of Chiari malformation
Isolated unilateral trismus as a presentation of Chiari malformation: case report: Journal of Neurosurgery: Pediatrics, Ahead of Print. The authors present a case of Chiari malformation manifesting as isolated trismus, describe the typical symptoms associated with Chiari malformation, and discuss the potential anatomical causes for this unique presentation. A 3-year-old boy presented with inability to open his jaw for 6 weeks with associated significant weight loss. The results of medical and radiological evaluation were negative except for Type I Chiari malformation with cerebella... περισσότερα »
Higher prevalence and levels of Nosema ceranae than Nosema apis infections in Canadian honey bee colonies
Abstract This study was conducted to determine the prevalence and infection levels of the microsporidia fungi *Nosema apis* and/or *Nosema ceranae* in honey bee colonies of two Canadian provinces. Three surveys were conducted in the springs of 2008, 2010 and 2012 and PCR identification of *Nosema* species were performed in samples from 169 and 181 Ontario colonies and from 76 Alberta colonies that tested positive to *Nosema* spp. Infection levels of positive colonies were determined by microscopy and analyzed by *Nosema* spp. Results showed that *N. ceranae* was the dominant specie...περισσότερα »
Effects of the cestode parasite, Cyathocephalus truncatus , on the fecundity and feeding rate of Gammarus pulex (Crustacea: Amphipoda)
Abstract The amphipod *Gammarus pulex* is an intermediate host to the Cestode fish parasite *Cyathocephalus truncatus*. In this study, we investigate effect of parasitism on female fecundity and feeding rate and compare ours results to those obtained previously with acanthocephalan parasite. Similar reduction of the female fecundity was measured, whereas ours results on feeding rate were inconsistent, with a decrease of feeding rate induced by *C. truncatus*. The impacts of *C. truncatus* on *G. pulex* and similarities on the host infection effect between parasites from different p... περισσότερα »
Detection of Dirofilaria repens microfilariae in a dog from Portugal
Abstract *Dirofilaria repens* causes subcutaneous infection in dogs and cats, and is the main agent of human dirofilariosis in Europe. Detection of *D. repens* is described in a dog from Portugal, a finding that simultaneously represents the first presumable case of autochthonous infection with the parasite in any animal host species in the country. A mixed *D. repens*/*Dirofilaria immitis* infection (20:1 ratio) was found, with an overall density of 1267 microfilariae per millilitre of blood. Morphological features, including morphometry, and acid phosphatase histochemical stainin... περισσότερα »
Progression of Jackhammer Esophagus to Type II Achalasia.
Progression of Jackhammer Esophagus to Type II Achalasia.: *Progression of Jackhammer Esophagus to Type II Achalasia.* J Neurogastroenterol Motil. 2016 Jan 31;22(1):153-6 Authors: Abdallah J, Fass R Abstract It has been suggested that patients with certain motility disorders may progress overtime to develop achalasia. We describe a 66 year-old woman who presented with dysphagia for solids and liquids for a period of 18 months. Her initial workup showed normal endoscopy and non-specific esophageal motility disorder on conventional manometry. Six months later, due to persistence of... περισσότερα »
What to do when people with Parkinson's disease cannot take their usual oral medications.
What to do when people with Parkinson's disease cannot take their usual oral medications.: *What to do when people with Parkinson's disease cannot take their usual oral medications.* Pract Neurol. 2015 Dec 30; Authors: Alty J, Robson J, Duggan-Carter P, Jamieson S Abstract People with Parkinson's disease have limited brain reserves of endogenous dopamine; thus, their medications must not be omitted or delayed as this may lead to a significant drop in brain dopamine levels. This has two main clinical consequences: first, a deterioration in disease control, with distressing sympto...περισσότερα »
Severe edematous dermatomyositis
[Severe edematous dermatomyositis].: *[Severe edematous dermatomyositis].* Ann Dermatol Venereol. 2015 Dec 21; Authors: Goussot R, Wettlé C, Le Coz C, Cribier B, Lipsker D Abstract INTRODUCTION: Edematous dermatomyositis is a rare entity with localized or generalized subcutaneous edema and only 21cases have been reported in the literature. It is considered to be a severe form of dermatomyositis which needs quick therapeutic decision. We report 2cases with difficult therapeutic decisions. OBSERVATIONS: Two patients aged 23 and 80years were admitted in hospital for DM with typical...περισσότερα »
Myotonic Dystrophy and Dysphagia
Hard to Swallow: A Phenomenological Exploration of the Experience of Caring for Individuals With Myotonic Dystrophy and Dysphagia.: *Hard to Swallow: A Phenomenological Exploration of the Experience of Caring for Individuals With Myotonic Dystrophy and Dysphagia.* J Neurosci Nurs. 2016 Feb;48(1):42-51 Authors: LaDonna KA, Koopman WJ, Ray SL, Venance SL Abstract PURPOSE: Myotonic dystrophy (DM1), a genetic, multisystemic disorder, is the most prevalent adult form of muscular dystrophy. Dysphagia is a common symptom that may be difficult to diagnose and treat and can be associated ...περισσότερα »
Computer Speech & Language
Ensemble of deep neural networks using acoustic environment classification for statistical model-based voice activity detection Publication date: July 2016 *Source:*Computer Speech & Language, Volume 38 Author(s): Inyoung Hwang, Hyung-Min Park, Joon-Hyuk Chang In this paper, we investigate the ensemble of deep neural networks (DNNs) by using an acoustic environment classification (AEC) technique for the statistical model-based voice activity detection (VAD). From an investigation of the statistical model-based VAD, it is known that the traditional decision rule is based on the ge...περισσότερα »
Gaze-independent hybrid Brain computer interfaces (BCIs) combining visual and natural auditory stimuli
Toward a reliable via Journal of Neuroscience Methods [image: S01650270.gif] Publication date: 1 March 2016 *Source:*Journal of Neuroscience Methods, Volume 261 Author(s): Sara Barbosa, Gabriel Pires, Urbano Nunes BackgroundBrain computer interfaces (BCIs) are one of the last communication options for patients in the locked-in state (LIS). For complete LIS patients, interfaces must be gaze-independent due to their eye impairment. However, unimodal gaze-independent approaches typically present levels of performance substantially lower than gaze-dependent approaches. The combination o... περισσότερα »
Pediatric patients following elective uncomplicated craniotomy for brain tumors
Questioning the need for ICU level of care in pediatric patients following elective uncomplicated craniotomy for brain tumors: Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECTIVE The object of this study is to address what factors may necessitate the need for intensive care monitoring after elective uncomplicated craniotomy in pediatric patients who are initially managed in a non–intensive care unit setting postoperatively. METHODS A retrospective chart review was undertaken for all patients who underwent elective craniotomy for brain tumor between April of 2007 and Apri... περισσότερα »
Neurotrophins and B-cell malignancies
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Abstract Neurotrophins and their receptors act as important proliferative and pro-survival factors in a variety of cell types. Neurotrophins are produced by multiple cell types in both pro- and mature forms, and can act in an autocrine or paracrine fashion. The p75NTR and Trk receptors can elicit signalling in response to the presence or absence of their corresponding neurotrophin ligands. This signalling, along with neurotrophin and receptor expression, varies between different cell types. Neurotrophins and their receptors have been shown to be expressed by and elicit signalling i... περισσότερα »
The endoplasmic reticulum: structure, function and response to cellular signaling
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Abstract The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions of the ER are performed by distinct domains; consisting of tubules, sheets and the nuclear envelope. Several proteins that contribute to the overall architecture and dynamics of the ER have been identified, but many questions remain as to how the ER changes shape in response to cellular cues, cell type, cell cycle state and during development of the organism. Here we discuss what is known ab...περισσότερα »
The helicase-like transcription factor (HLTF) in cancer: loss of function or oncomorphic conversion of a tumor suppressor?
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Abstract The Helicase-like Transcription Factor (HLTF) belongs to the SWI/SNF family of proteins involved in chromatin remodeling. In addition to its role in gene transcription, HLTF has been implicated in DNA repair, which suggests that this protein acts as a tumor suppressor. Accumulating evidence indicates that HLTF expression is altered in various cancers via two mechanisms: gene silencing through promoter hypermethylation or alternative mRNA splicing, which leads to the expression of truncated proteins that lack DNA repair domains. In either case, the alteration of *HLTF* exp... περισσότερα »
A novel family of katanin-like 2 protein isoforms (KATNAL2), interacting with nucleotide-binding proteins Nubp1 and Nubp2, are key regulators of different MT-based processes in mammalian cells
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Abstract Katanins are microtubule (MT)-severing AAA proteins with high phylogenetic conservation throughout the eukaryotes. They have been functionally implicated in processes requiring MT remodeling, such as spindle assembly in mitosis and meiosis, assembly/disassembly of flagella and cilia and neuronal morphogenesis. Here, we uncover a novel family of katanin-like 2 proteins (KATNAL2) in mouse, consisting of five alternatively spliced isoforms encoded by the *Katnal2* genomic locus. We further demonstrate that in vivo these isoforms are able to interact with themselves, with each... περισσότερα »
The emerging role of aryl hydrocarbon receptor in the activation and differentiation of Th17 cells
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Abstract The aryl hydrocarbon receptor (AHR) is a cytoplasmic transcription factor, which plays an essential role in the xenobiotic metabolism in a wide variety of cells. The AHR gene is evolutionarily conserved and it has a central role not only in the differentiation and maturation of many tissues, but also in the toxicological metabolism of the cell by the activation of metabolizing enzymes. Several lines of evidence support that both AHR agonists and antagonists have profound immunological effects; and recently, the AHR has been implicated in antibacterial host defense. Accord... περισσότερα »
Factors controlling permeability of the blood–brain barrier
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Abstract As the primary protective barrier for neurons in the brain, the blood–brain barrier (BBB) exists between the blood microcirculation system and the brain parenchyma. The normal BBB integrity is essential in protecting the brain from systemic toxins and maintaining the necessary level of nutrients and ions for neuronal function. This integrity is mediated by structural BBB components, such as tight junction proteins, integrins, annexins, and agrin, of a multicellular system including endothelial cells, astrocytes, pericytes, etc. BBB dysfunction is a significant contributor ... περισσότερα »
Molecular basis of claudin-17 anion selectivity
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Abstract Claudin-17 is a paracellular channel-forming tight junction protein. Unlike the cation channels claudin-2 and -15, claudin-17 forms a distinct anion-selective channel. Aim of this study was to determine the molecular basis of channel formation and charge selectivity of this protein. To achieve this, residues located in the extracellular loops (ECL) 1 and 2 of claudin-17 were substituted, preferably those whose charges differed in claudin-17 and in claudin-2 or -15. The respective mutants were stably expressed in MDCK C7 cells and their ability to form charge-selective cha... περισσότερα »
lnflammation-induced epigenetic switches in cancer
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Abstract The link between inflammation and cancer is well established. Chronic inflammation promotes cancer initiation and progression. Various studies showed that the underlying mechanisms involve epigenetic alterations. These epigenetic alterations might culminate into an epigenetic switch that transforms premalignant cells into tumor cells or non-invasive into invasive tumor cells, thereby promoting metastasis. Epigenetic switches require an initiating event, which can be inflammation, whereas the resulting phenotype is inherited without the initiating signal. Epigenetic switch... περισσότερα »
Gut microbiota and obesity
Alexandros G. SfakianakisστοCell and Tissue Research by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Abstract The human intestine harbors a complex bacterial community called the gut microbiota. This microbiota is specific to each individual despite the existence of several bacterial species shared by the majority of adults. The influence of the gut microbiota in human health and disease has been revealed in the recent years. Particularly, the use of germ-free animals and microbiota transplant showed that the gut microbiota may play a causal role in the development of obesity and associated metabolic disorders, and lead to identification of several mechanisms. In humans, differenc... περισσότερα »
Isolated unilateral trismus as a presentation of Chiari malformation
Isolated unilateral trismus as a presentation of Chiari malformation: case report: Journal of Neurosurgery: Pediatrics, Ahead of Print. The authors present a case of Chiari malformation manifesting as isolated trismus, describe the typical symptoms associated with Chiari malformation, and discuss the potential anatomical causes for this unique presentation. A 3-year-old boy presented with inability to open his jaw for 6 weeks with associated significant weight loss. The results of medical and radiological evaluation were negative except for Type I Chiari malformation with cerebella... περισσότερα »
Phosphaturic mesenchymal tumor (mixed connective tissue variant) (PMT-MCT)
Phosphaturic mesenchymal tumor of the brain without tumor-induced osteomalacia in an 8-year-old girl: case report: Journal of Neurosurgery: Pediatrics, Ahead of Print. Phosphaturic mesenchymal tumor (mixed connective tissue variant) (PMT-MCT) are tumors that may cause tumor-induced osteomalacia and rarely appear intracranially. The authors describe the case of an 8-year-old girl who was found to have PMT-MCT with involvement of the cerebellar hemisphere and a small tumor pedicle breaching the dura mater and involving the skull. This was removed surgically in gross-total fashion wit... περισσότερα »
Phosphaturic mesenchymal tumor of the brain
Phosphaturic mesenchymal tumor of the brain without tumor-induced osteomalacia in an 8-year-old girl: case report: Journal of Neurosurgery: Pediatrics, Ahead of Print. Phosphaturic mesenchymal tumor (mixed connective tissue variant) (PMT-MCT) are tumors that may cause tumor-induced osteomalacia and rarely appear intracranially. The authors describe the case of an 8-year-old girl who was found to have PMT-MCT with involvement of the cerebellar hemisphere and a small tumor pedicle breaching the dura mater and involving the skull. This was removed surgically in gross-total fashion wit... περισσότερα »
Irreducible pediatric subaxial cervical unilateral facet dislocation
Surgical treatment for irreducible pediatric subaxial cervical unilateral facet dislocation: case report: Journal of Neurosurgery: Pediatrics, Ahead of Print. Unilateral facet dislocation at the subaxial cervical spine (C3–7) in children younger than 8 years of age is rare. The authors describe a surgical approach for irreducible subaxial cervical unilateral facet dislocation (SCUFD) at C3–4 in a 5-year-old boy and present a literature review. A dorsal unilateral approach was applied, and a biodegradable plate was used for postreduction fixation without fusion after failed conserv... περισσότερα »
Hyperglycemia in the immediate postoperative period after elective pediatric neurosurgery
Association of increased morbidity with the occurrence of hyperglycemia in the immediate postoperative period after elective pediatric neurosurgery: Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECTIVE The acute elevation of blood glucose in perioperative pediatric patients subjected to cardiac surgery and in victims of head trauma is associated with higher rates of postoperative complications. Data on the occurrence of hyperglycemia and its association with unfavorable outcomes among patients who have undergone elective neurosurgery are scarce in the literature. This stu... περισσότερα »
Language, learning, and memory in children with and without single-suture craniosynostosis
Language, learning, and memory in children with and without single-suture craniosynostosis: Journal of Neurosurgery: Pediatrics, Ahead of Print. OBJECTIVE The language and memory functions of children with and without single-suture craniosynostosis (SSC) were compared at school age (mean 7.45 years, standard deviation [SD] 0.54 years). The children in this cohort were originally recruited in infancy and prior to cranial surgery for those with SSC. METHODS Individual evaluations of 179 school-aged children with SSC and 183 controls were conducted (70% of the original cohort) using s...περισσότερα »
Chin-tuck Maneuver to Facilitate Swallowing in Neurologic Dysphagia.
Effectiveness of Chin-tuck Maneuver to Facilitate Swallowing in Neurologic Dysphagia.: *Effectiveness of Chin-tuck Maneuver to Facilitate Swallowing in Neurologic Dysphagia.* Int Arch Otorhinolaryngol. 2016 Jan;20(1):13-7 Authors: Saconato M, Chiari BM, Lederman HM, Gonçalves MI Abstract Introduction The chin-tuck maneuver is the most frequently employed postural maneuver in the treatment of neurogenic oropharyngeal dysphagia caused by encephalic vascular strokes and degenerative diseases. Objective The purpose of this study was to investigate the effectiveness of this maneuver ... περισσότερα »
Course of induced infection by Eimeria krijgsmannni in immunocompetent and immunodeficient mice
Abstract Recently, we have demonstrated the utility of *Eimeria krijgsmanni* as a novel mouse eimerian parasite for elucidating the biological diversity. The parasite showed notable infectivity to mice with various levels of immune status and susceptibility to antimicrobial agents including coccidiostat. However, the detailed lifecycle of *E. krijgsmanni* had not yet been determined and this information was lacking in discussion of previous findings. In the present study, we clarified the morphological characteristics of *E. krijgsmanni* and its lifecycle in normal mice, and exami... περισσότερα »
Bacteria-induced hatching of Trichuris muris eggs occurs without direct contact between eggs and bacteria
Abstract Using three isolates of the murine parasitic nematode *Trichuris muris*, E, E/J (the E isolate maintained in Japan), and S, I have previously demonstrated that when the embryonated eggs of the E/J and E isolates are incubated with the intestinal bacteria *Escherichia coli* and *Staphylococcus aureus*, they are induced to hatch in vitro. However, the eggs of the S isolate are unresponsive to these bacteria. In the present study, I investigated whether direct contact between the embryonated eggs of the E/J and E isolates and bacteria is required to induce their hatching. To ... περισσότερα »
Study of the gastrointestinal parasitic fauna of captive non-human primates ( Macaca fascicularis )
Abstract The aim of this study was to examine helminths and protozoans in cynomolgus macaques (*Macaca fascicularis*) imported from registered breeding facilities in China and their relation to health risks for non-human primate handlers in biomedical research centers and in breeding facilities. Fresh fecal samples were collected from a total of 443 *M. fascicularis* and analyzed by copromicroscopical analysis, immunoenzymatic, or molecular assays. As to helminths, whose eggs were shed in 2.03% of the samples, *Trichuris* and *Oesophagostomum* were the only two taxa found, with low... περισσότερα »
Some observations on overwintering sites of adult Culex quinquefasciatus (Diptera: Culicidae) and strategies followed under natural and seminatural conditions
Abstract Field population of adult *Culex quinquefasciatus* Say, landed in December, congregated and overwintered in indoor artificial sites in Delhi. Repeated sampling strategy by individually collecting the adults was adopted to study their overwintering strategies for 4 years (December to April). They remained vagile and readily repopulated the resting sites after the removal of samples. A large percentage of females was fertile, unfed and nulliparous indicating that reproduction ceased in them. Adult survival was significantly prolonged to a maximum of 3 months under natural co... περισσότερα »
Molecular cloning and functional characterization of a glucose transporter (CsGLUT) in Clonorchis sinensis
Abstract A complementary DNA (cDNA) encoding a glucose transporter of *Clonorchis sinensis* (CsGLUT) was isolated from the adult *C. sinensis* cDNA library. The open reading frame of CsGLUT cDNA consists of 1653 base pairs that encode a 550-amino acid residue protein. Hydropathy analysis suggested that CsGLUT possess 12 putative membrane-spanning domains. The Northern blot analysis result using poly(A)+RNA showed a strong band at ~2.1 kb for CsGLUT. When expressed in *Xenopus* oocytes, CsGLUT mediated the transport of radiolabeled deoxy-d-glucose in a time-dependent but sodium-inde... περισσότερα »
Impact of sex differences in brain response to infection with Plasmodium berghei
Abstract Malaria is considered to be one of the most prevalent diseases in the world. Severity of the disease between males and females is very important in clinical research areas. In this study, we investigated the impact of sex differences in brain response to infection with *Plasmodium berghei*. Male and female C57Bl/6 mice were infected with *P. berghei-*infected erythrocytes. The infection induced a significant change in weight loss in males (−7.2 % ± 0.5) than females (−4.9 % ± 0.6). The maximum parasitemia reached about 15 % at day 9 postinfection. Also, *P. berghei* infect... περισσότερα »
Toxoplasma gondii , Dirofilaria immitis , feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections in stray and pet cats ( Felis catus ) in northwest China: co-infections and risk factors
Abstract This study was conducted to estimate the prevalence of *Toxoplasma gondii*, *Dirofilaria immitis*, feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections among stray and pet cats in Lanzhou, northwest China, and to identify the influence of age, gender, and regions on seropositivity. *T. gondii* antibodies were examined in cat sera by the modified agglutination test (MAT). The circulating antigens of *D. immitis* and FeLV and specific antibodies to FIV were examined using kits commercially available. The overall prevalence of *T. gondii*, FIV, FeL... περισσότερα »
Investigation on oxidative stress of nitric oxide synthase interacting protein from Clonorchis sinensis
Abstract Numerous evidences indicate that excretory–secretory products (ESPs) from liver flukes trigger the generation of free radicals that are associated with the initial pathophysiological responses in host cells. In this study, we first constructed a *Clonorchis sinensis* (*C. sinensis*, *Cs*)-infected BALB/c mouse model and examined relative results respectively at 3, 5, 7, and 9 weeks postinfection (p.i.). Quantitative reverse transcription (RT)-PCR indicated that the transcriptional level of both endothelial nitric oxide synthase (eNOS) and superoxide dismutase (SOD) gradual...περισσότερα »
Muscle attachment site (MAS) patterns for species determination in five species of Sarcophaga (Diptera: Sarcophagidae)
Abstract To further establish species determination using the muscle attachment site (MAS) pattern method, third instar larvae of five forensically important species of *Sarcophaga* Meigen were investigated: *Sarcophaga argyrostoma* (Robineau-Desvoidy), *Sarcophaga caerulescens* Zetterstedt, *Sarcophaga melanura* Meigen, *Sarcophaga albiceps* Meigen and *Sarcophaga similis* Meade. As in the previously investigated Calliphoridae, patterns were found to be species specific. The main feature of the *Sarcophaga* patterns is the divided central horizontal row of segment four. A genus pa...περισσότερα »
Sustainability, Vol. 8, Pages 41: General Spatiotemporal Patterns of Urbanization: An Examination of 16 World Cities
Urbanization is the most dramatic form of land use change that has profoundly influenced environmental and socioeconomic conditions around the world. To assess these impacts and promote urban sustainability, a better understanding of urbanization patterns is needed. Recent studies have suggested several spatiotemporal patterns of urbanization, but their generality is yet to be adequately tested with long-term data. Thus, the main goal of our study was two-fold: (1) to examine the spatiotemporal patterns of urbanization of 16 world cities over a period of 200 years (1800–2000); and... περισσότερα »
Constructive engagement is the key to climate action
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
This year, scientists should resolve to follow the lead of Pope Francis and seek an inclusive approach to climate change, says Daniel Sarewitz. Nature 529 6 doi: 10.1038/529006a from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1kF00Ub via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Constructive engagement is the key to climate action
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
This year, scientists should resolve to follow the lead of Pope Francis and seek an inclusive approach to climate change, says Daniel Sarewitz. Nature 529 6 doi: 10.1038/529006a from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1kF00Ub via IFTTT
The efficacy and safety of the Shaoyao Shujin tablet for knee osteoarthritis: study protocol for a randomized controlled trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Abstract Background Knee osteoarthritis (KOA) is a major public health issue causing chronic disability as well as a burden on healthcare resources. In China, a herbal drug tablet has been used as an effective and conventional therapy to alleviate clinical symptoms caused by KOA. However, evidence gathered from systematic reviews or randomized controlled trials that […]
Systemic therapy for vulval Erosive Lichen Planus (the ‘hELP’ trial): study protocol for a randomised controlled trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Abstract Background Erosive lichen planus affecting the vulva (ELPV) is a relatively rare, chronic condition causing painful raw areas in the vulvovaginal region. Symptoms are pain and burning, which impact upon daily living. There is paucity of evidence regarding therapy. A 2012 Cochrane systematic review found no randomised controlled trials (RCTs) in this field. Topically […]
Guided, internet-based, rumination-focused cognitive behavioural therapy (i-RFCBT) versus a no-intervention control to prevent depression in high-ruminating young adults, along with an adjunct assessment of the feasibility of unguided i-RFCBT, in the REducing Stress and Preventing Depression trial (RESPOND): study protocol for a phase III randomised controlled trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 14 δευτερόλεπτα
Abstract Background Depression is a global health challenge. Prevention is highlighted as a priority to reduce its prevalence. Although effective preventive interventions exist, the efficacy and coverage can be improved. One proposed means to increase efficacy is by using interventions to target specific risk factors, such as rumination. Rumination-focused CBT (RFCBT) was developed to specifically […]
Aglossia
Aglossia: Case Report.: *Aglossia: Case Report.* Int Arch Otorhinolaryngol. 2016 Jan;20(1):87-92 Authors: Bommarito S, Zanato LE, Vieira MM, Angelieri F Abstract Introduction Aglossia is a rare condition caused by failure of the tongue embryogenesis process (in the fourth to eighth weeks of gestation). The tongue is an organ used in different activities such as sucking, swallowing, chewing, and talking. It is also responsible for shaping palate dental arches (in its absence, they become atrophic). There are few similar cases reported in the literature. Objective To describe a rar... περισσότερα »
Major salivary gland carcinoma following postoperative radiotherapy.
Outcomes and prognostic factors for major salivary gland carcinoma following postoperative radiotherapy.: *Outcomes and prognostic factors for major salivary gland carcinoma following postoperative radiotherapy.* Oral Oncol. 2015 Dec 23; Authors: Hosni A, Huang SH, Goldstein D, Xu W, Chan B, Hansen A, Weinreb I, Bratman SV, Cho J, Giuliani M, Hope A, Kim J, O'Sullivan B, Waldron J, Ringash J Abstract PURPOSE: To report outcomes of postoperative radiotherapy (PORT) for major salivary gland carcinoma (SGC) and identify patients at high risk of distant metastases (DM). METHODS AND...περισσότερα »
Posterior Atlantoaxial Fusion for Traumatic Odontoid Fractures.
Early Morbidity and Mortality in 50 Very Elderly after Posterior Atlantoaxial Fusion for Traumatic Odontoid Fractures.: *Early Morbidity and Mortality in 50 Very Elderly after Posterior Atlantoaxial Fusion for Traumatic Odontoid Fractures.* World Neurosurg. 2015 Dec 24; Authors: Ryang YM, Török E, Janssen I, Reinke A, Buchmann N, Gempt J, Ringel F, Meyer B Abstract BACKGROUND: Traumatic odontoid fractures (tOF) in the very elderly are associated with a high morbidity and mortality. The best treatment strategy (conservative vs. surgery) is still unclear. METHODS: Between April 20...περισσότερα »
Journal of Voice
Vocal Performance of Group Fitness Instructors Vocal Performance of Group Fitness Instructors Before and After Instruction: Changes in Acoustic Measures and Self-Ratings via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Katherine Dallaston, Anna F. Rumbach Objectives(1) To quantify acute changes in acoustic parameters of the voices of group fitness instructors (GFIs) before and after exercise instruction. (2) To determine whether these changes are discernible perceptually by the instructor.Study DesignThis is a pilot prospective cohort st...περισσότερα »
Study of the gastrointestinal parasitic fauna of captive non-human primates ( Macaca fascicularis )
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Abstract The aim of this study was to examine helminths and protozoans in cynomolgus macaques (*Macaca fascicularis*) imported from registered breeding facilities in China and their relation to health risks for non-human primate handlers in biomedical research centers and in breeding facilities. Fresh fecal samples were collected from a total of 443 *M. fascicularis* and analyzed by copromicroscopical analysis, immunoenzymatic, or molecular assays. As to helminths, whose eggs were shed in 2.03% of the samples, *Trichuris* and *Oesophagostomum* were the only two taxa found, with low... περισσότερα »
Some observations on overwintering sites of adult Culex quinquefasciatus (Diptera: Culicidae) and strategies followed under natural and seminatural conditions
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Abstract Field population of adult *Culex quinquefasciatus* Say, landed in December, congregated and overwintered in indoor artificial sites in Delhi. Repeated sampling strategy by individually collecting the adults was adopted to study their overwintering strategies for 4 years (December to April). They remained vagile and readily repopulated the resting sites after the removal of samples. A large percentage of females was fertile, unfed and nulliparous indicating that reproduction ceased in them. Adult survival was significantly prolonged to a maximum of 3 months under natural co... περισσότερα »
Molecular cloning and functional characterization of a glucose transporter (CsGLUT) in Clonorchis sinensis
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Abstract A complementary DNA (cDNA) encoding a glucose transporter of *Clonorchis sinensis* (CsGLUT) was isolated from the adult *C. sinensis* cDNA library. The open reading frame of CsGLUT cDNA consists of 1653 base pairs that encode a 550-amino acid residue protein. Hydropathy analysis suggested that CsGLUT possess 12 putative membrane-spanning domains. The Northern blot analysis result using poly(A)+RNA showed a strong band at ~2.1 kb for CsGLUT. When expressed in *Xenopus* oocytes, CsGLUT mediated the transport of radiolabeled deoxy-d-glucose in a time-dependent but sodium-inde... περισσότερα »
Impact of sex differences in brain response to infection with Plasmodium berghei
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Abstract Malaria is considered to be one of the most prevalent diseases in the world. Severity of the disease between males and females is very important in clinical research areas. In this study, we investigated the impact of sex differences in brain response to infection with *Plasmodium berghei*. Male and female C57Bl/6 mice were infected with *P. berghei-*infected erythrocytes. The infection induced a significant change in weight loss in males (−7.2 % ± 0.5) than females (−4.9 % ± 0.6). The maximum parasitemia reached about 15 % at day 9 postinfection. Also, *P. berghei* infect... περισσότερα »
Toxoplasma gondii , Dirofilaria immitis , feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections in stray and pet cats ( Felis catus ) in northwest China: co-infections and risk factors
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Abstract This study was conducted to estimate the prevalence of *Toxoplasma gondii*, *Dirofilaria immitis*, feline immunodeficiency virus (FIV), and feline leukemia virus (FeLV) infections among stray and pet cats in Lanzhou, northwest China, and to identify the influence of age, gender, and regions on seropositivity. *T. gondii* antibodies were examined in cat sera by the modified agglutination test (MAT). The circulating antigens of *D. immitis* and FeLV and specific antibodies to FIV were examined using kits commercially available. The overall prevalence of *T. gondii*, FIV, FeL... περισσότερα »
Investigation on oxidative stress of nitric oxide synthase interacting protein from Clonorchis sinensis
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Abstract Numerous evidences indicate that excretory–secretory products (ESPs) from liver flukes trigger the generation of free radicals that are associated with the initial pathophysiological responses in host cells. In this study, we first constructed a *Clonorchis sinensis* (*C. sinensis*, *Cs*)-infected BALB/c mouse model and examined relative results respectively at 3, 5, 7, and 9 weeks postinfection (p.i.). Quantitative reverse transcription (RT)-PCR indicated that the transcriptional level of both endothelial nitric oxide synthase (eNOS) and superoxide dismutase (SOD) gradual...περισσότερα »
Muscle attachment site (MAS) patterns for species determination in five species of Sarcophaga (Diptera: Sarcophagidae)
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Abstract To further establish species determination using the muscle attachment site (MAS) pattern method, third instar larvae of five forensically important species of *Sarcophaga* Meigen were investigated: *Sarcophaga argyrostoma* (Robineau-Desvoidy), *Sarcophaga caerulescens* Zetterstedt, *Sarcophaga melanura* Meigen, *Sarcophaga albiceps* Meigen and *Sarcophaga similis* Meade. As in the previously investigated Calliphoridae, patterns were found to be species specific. The main feature of the *Sarcophaga* patterns is the divided central horizontal row of segment four. A genus pa...περισσότερα »
Sustainability, Vol. 8, Pages 41: General Spatiotemporal Patterns of Urbanization: An Examination of 16 World Cities
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Urbanization is the most dramatic form of land use change that has profoundly influenced environmental and socioeconomic conditions around the world. To assess these impacts and promote urban sustainability, a better understanding of urbanization patterns is needed. Recent studies have suggested several spatiotemporal patterns of urbanization, but their generality is yet to be adequately tested with long-term data. Thus, the main goal of our study was two-fold: (1) to examine the spatiotemporal patterns of urbanization of 16 world cities over a period of 200 years (1800–2000); and... περισσότερα »
Sustainability, Vol. 8, Pages 40: Research on Steady States of Fuzzy Cognitive Map and its Application in Three-Rivers Ecosystem
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Fuzzy Cognitive Map (FCM) offers many advantages such intuitive knowledge representation and fast numerical reasoning ability, etc. It suits modeling and decision-making of dynamic systems. With the aims to effectively help to analyze and control system sustainable evolution, the paper defines the steady states of fixed point and limited cycle of a FCM modeling system. Accordingly, the rules of steady states of the FCM model and the factors influencing the steady states are presented and proved. The Three-Rivers represents a system including population, ecological environment, soci...περισσότερα »
IJMS, Vol. 17, Pages 32: In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Recent studies have revealed the high cytotoxicity of p-menthane derivatives against human tumor cells. In this study, the substance perillaldehyde 8,9-epoxide, a p-menthane class derivative obtained from (S)-(−)-perillyl alcohol, was selected in order to assess antitumor activity against experimental sarcoma 180 tumors. Toxicological effects related to the liver, spleen, kidneys and hematology were evaluated in mice submitted to treatment. The tumor growth inhibition rate was 38.4%, 58.7%, 35.3%, 45.4% and 68.1% at doses of 100 and 200 mg/kg/day for perillaldehyde 8,9-epoxide, pe...περισσότερα »
Sustainability, Vol. 8, Pages 42: The Impact of Restaurants’ Green Supply Chain Practices on Firm Performance
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
This study investigated crucial green supply chain management (GSCM) practice dimensions and firm performance based on restaurants firms in Taiwan. On the basis of a factor analysis, four green supply chain management dimensions were identified: corporate environment policy, green packing, green product, and economic transport. This study investigated crucial GSCM practice dimensions (including corporate environment policy, packaging waste, economic transport, and product recycling), green capability and organizational performance. The results shown: first, green practices in rest...περισσότερα »
Energies, Vol. 9, Pages 25: A Fuzzy-Logic Power Management Strategy Based on Markov Random Prediction for Hybrid Energy Storage Systems
Alexandros G. SfakianakisστοNews in OtoRhinoLaryngology - Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Over the last few years; issues regarding the use of hybrid energy storage systems (HESSs) in hybrid electric vehicles have been highlighted by the industry and in academic fields. This paper proposes a fuzzy-logic power management strategy based on Markov random prediction for an active parallel battery-UC HESS. The proposed power management strategy; the inputs for which are the vehicle speed; the current electric power demand and the predicted electric power demand; is used to distribute the electrical power between the battery bank and the UC bank. In this way; the battery ban... περισσότερα »
Effects of Leg-Press Training with Moderate Vibration on Muscle Strength, Pain, and Function after Total Knee Arthroplasty: A Randomized Controlled Trial
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Publication date: Available online 4 January 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Walter Bily, Carlo Franz, Lukas Trimmel, Stefan Loefler, Jan Cvecka, Sandra Zampieri, Waltraud Kasche, Nejc Sarabon, P. Zenz, H. Kern ObjectivesTo examine the effects of a time saving leg-press training program with moderate vibration on strength parameters, pain, and functional outcomes of patients following total knee arthroplasty in comparison with functional physiotherapy.DesignRandomized controlled trial.SettingOutpatient Rehabilitation Department at a Universit...περισσότερα »
Shoulder Strength Changes One Year after Axillary Lymph Node Dissection or Sentinel Lymph Node Biopsy in Breast Cancer Patients
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
Publication date: Available online 4 January 2016 *Source:*Archives of Physical Medicine and Rehabilitation Author(s): Sandra Monleon, Montse Ferrer, Marta Tejero, Roser Belmonte ObjectiveTo assess the changes in shoulder strength of breast cancer patients during the first year after surgery; and to compare the effect of sentinel lymph node biopsy (SLNB) and axillary lymph node dissection (ALND) on shoulder strength.DesignProspective longitudinal observational study from pre-surgery to one year after.SettingTertiary hospital.ParticipantsOf 129 consecutive patients examined for eligib...περισσότερα »
PulmCrit- Ultrasound-assisted thrombolysis of PE works. The question is, why?
Alexandros G. SfakianakisστοRehabilitation,Sports and Exercise Medicine by Alexandros G. SfakianakisΠριν από 17 δευτερόλεπτα
[image: inception.gif?resize=750%2C204] Ultrasound-assisted catheter-directed thrombolysis is increasingly popular for submassive PE. Unfortunately, the actual mechanism of action of this therapy remains unclear. EMCrit by Josh Farkas. from #Rehabilitation via ola Kala on Inoreader http://ift.tt/1RZmvll via IFTTT
Vocal Performance of Group Fitness Instructors
Vocal Performance of Group Fitness Instructors Before and After Instruction: Changes in Acoustic Measures and Self-Ratings via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Katherine Dallaston, Anna F. Rumbach Objectives(1) To quantify acute changes in acoustic parameters of the voices of group fitness instructors (GFIs) before and after exercise instruction. (2) To determine whether these changes are discernible perceptually by the instructor.Study DesignThis is a pilot prospective cohort study.MethodsParticipants were six female GFIs, b...περισσότερα »
Hyperfunctional Voice Disorder in Children
Hyperfunctional Voice Disorder in Children With Attention Deficit Hyperactivity Disorder (ADHD). A Phenotypic Characteristic? via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Luz Barona-Lleo, Secundino Fernandez ObjectiveThe purpose of this study was to detect specific vocal aerodynamic patterns in attention deficit hyperactivity disorder (ADHD) patients and to define a possible new phenotypic feature of this disorder that must be diagnosed and treated.Study DesignThis is a prospective study.MethodsSeventy-nine children aged 5–13 years w... περισσότερα »
Indoor Air Problems and Hoarseness
in Children via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Emma Kallvik, Tuula Putus, Susanna Simberg ObjectivesA well-functioning voice is becoming increasingly important because voice-demanding professions are increasing. The largest proportion of voice disorders is caused by factors in the environment. Moisture damage is common and can initiate microbial growth and/or diffusion of chemicals from building materials. Indoor air problems due to moisture damage are associated with a number of health symptoms, for example, rhinitis, cou... περισσότερα »
Cricothyroid Muscle Botulinum Toxin Injection to Improve Airway for Bilateral Recurrent Laryngeal Nerve Paralysis
, A Case Series via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Michael S. Benninger, Andrea Hanick, Douglas M. Hicks Bilateral vocal fold paralysis most commonly results from iatrogenic trauma to the recurrent laryngeal nerve during surgical procedures in the anterior neck. Patients may require tracheostomy because of acute or gradual onset of dyspnea and airway compromise. The intralaryngeal injection of Botox has been considered as a possible therapy for these airway symptoms of bilateral vocal fold paralysis. Chronic unopposed activ... περισσότερα »
In-Office Excision En Masse of a Vocal Process Granuloma Using the Potassium-Titanyl-Phosphate Laser
In-Office Excision En Masse of a Vocal Process Granuloma Using the Potassium-Titanyl-Phosphate Laser via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Marco A. Mascarella, Jonathan Young BackgroundIn-office laryngeal surgery is taking on a more commonplace role in the treatment of laryngeal disorders. The potassium-titanyl-phosphate (KTP) laser has been a resourceful adjunct to the management of patients with mucosal lesions of the vocal cords. However, a paucity of data exists for its use in postintubation granulomas treated in-office.Cl...περισσότερα »
Menstrual Dysphonia
Is Menstrual Dysphonia Associated With Greater Disability and Lower Quality of Life? via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Maria Rosaria Barillari, Umberto Volpe, Nadia Innaro, Umberto Barillari ObjectivesThe aim of the present study had been to examine the relationships between menstrual dysphonia and measures of psychosocial distress, in a sample of female professional voice users.Design and MethodsThis is a prospective study of 52 consecutive professional voice users, aged 18–40 years, affected by transient dysphonia relat...περισσότερα »
Voice Disorders in Rheumatoid Arthritis
Descriptive Epidemiology of Voice Disorders in Rheumatoid Arthritis: Prevalence, Risk Factors, and Quality of Life Burden via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Nelson Roy, Kristine Tanner, Ray M. Merrill, Charisse Wright, Karla L. Miller, Katherine A. Kendall ObjectivesRheumatoid arthritis (RA) is an autoimmune inflammatory disease which may adversely affect phonatory function. This study aimed to establish the prevalence, risks, and quality of life effects of voice disorders in RA.Study DesignThis is a cross-sectional, descri...περισσότερα »
Voice in Pregnancy
Objective and Subjective Aspects of via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Ziya Saltürk, Tolgar Lütfi Kumral, Güler Bekiten, Yavuz Atar, Enes Ataç, İmran Aydoğdu, Güven Yıldırım, Aydın Kılıç, Yavuz Uyar ObjectiveThis study aimed to evaluate vocal changes in pregnancy according to trimesters both objectively and subjectively.MethodsFifty pregnant women and 15 nonpregnant women were included in the study. Eighteen of the 50 pregnant women were in the first trimester, 17 in the second trimester, and 15 in the third trimester of t... περισσότερα »
Vocal Health in Primary School Teachers
Working Conditions and Workplace Barriers to via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Caitriona Munier, Rory Farrell ObjectivesThe purpose of this study was to identify the working conditions and workplace barriers to vocal health in primary school teachers. The relationship between working conditions and voice is analyzed.Study designThis is a survey study in 42 randomized schools from a restricted geographical area.MethodsAn 85-item questionnaire was administered to 550 primary school teachers in 42 schools in Dublin. It was d...περισσότερα »
Vocal Effects in Intense Recruit Training
Vocal Effects in Military Students Submitted to an Intense Recruit Training: A Pilot Study via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Camila Lima Nascimento, Ana Carolina Constantini, Lúcia Figueiredo Mourão ObjectivesThis study aims at evaluating the vocal parameters of military officers before and after an Intense Recruit Training (IRT), consisting of a 48-hour exercise protocol involving high vocal demand combined with physical effort, lower body hydration levels, and fewer hours of sleep.Study DesignEighty-three young male mil... περισσότερα »
Perceptual and auditory vocals and acoustic aspects that suggest instability, noise, and vocal tremor
Vocal Characteristics of Elderly Women Engaged in Aerobics in Private Institutions of Salvador, Bahia via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Famiely Colman Machado de Machado, Carla Aparecida Cielo, Marcus Miranda Lessa, Luiz Henrique Fonseca Barbosa PurposeTo characterize the voice of elderly people engaged in aerobics.MethodsCollection of phonation /a:/ from 58 elderly people engaged in aerobics for perceptual voice analysis (RASATI scale) and computed acoustics (Multi Dimensional Voice Program Advanced, software of Kay Pent... περισσότερα »
Speech Usage in Daily Activities
Describing Speech Usage in Daily Activities in Typical Adults via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Laine Anderson, Carolyn R. Baylor, Tanya L. Eadie, Kathryn M. Yorkston Objectives“Speech usage” refers to what people want or need to do with their speech to meet communication demands in life roles. The purpose of this study was to contribute to validation of the Levels of Speech Usage scale by providing descriptive data from a sample of adults without communication disorders, comparing this scale to a published Occupational V... περισσότερα »
Tubes Commonly Used for Semi-occluded Vocal Tract Exercises
The Flow and Pressure Relationships in Different via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Pedro Amarante Andrade, Greta Wistbacka, Hans Larsson, Maria Södersten, Britta Hammarberg, Susanna Simberg, Jan G. Švec, Svante Granqvist This experimental study investigated the back pressure (Pback) versus flow (U) relationship for 10 different tubes commonly used for semi-occluded vocal tract exercises, that is, eight straws of different lengths and diameters, a resonance tube, and a silicone tube similar to a Lax Vox tube. All tubes wer... περισσότερα »
OSA : Formant Frequencies and Bandwidths
Formant Frequencies and Bandwidths in Relation to Clinical Variables in an Obstructive Sleep Apnea Population via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Ana Montero Benavides, José Luis Blanco Murillo, Rubén Fernández Pozo, Fernando Espinoza Cuadros, Doroteo Torre Toledano, José D. Alcázar-Ramírez, Luis A. Hernández Gómez ObjectivesWe investigated whether differences in formants and their bandwidths, previously reported comparing small sample population of healthy individuals and patients with obstructive sleep apnea (OSA), are de...περισσότερα »
Subglottal Pressure and Sound Pressure Level
Relationship Between Subglottal Pressure and Sound Pressure Level in Untrained Voices via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Staffan Björklund, Johan Sundberg ObjectivesSubglottal pressure (Ps) is strongly correlated with sound pressure level (SPL) and is easy to measure by means of commonly available equipment. The SPL/Ps ratio is strongly dependent on the efficiency of the phonatory apparatus and should be of great relevance to clinical practice. However, published normative data are still missing.MethodThe subjects produced... περισσότερα »
Vocal Qualities in Music Theater Voice
: Perceptions of Expert Pedagogues via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Tracy Bourne, Dianna Kenny Objectives/HypothesisTo gather qualitative descriptions of music theater vocal qualities including belt, legit, and mix from expert pedagogues to better define this voice type.Study DesignThis is a prospective, semistructured interview.MethodsTwelve expert teachers from United States, United Kingdom, Asia, and Australia were interviewed by Skype and asked to identify characteristics of music theater vocal qualities including voc...περισσότερα »
Voice Onset Type on Vocal Attack Time
Effect of via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Ben C. Watson, R.J. Baken, Rick M. Roark Vocal attack time (VAT) is the time lag between the growth of sound pressure (SP) and electroglottographic (EGG) signals at vocal initiation. The characteristics of voice initiation are associated with issues of vocal hygiene, efficiency, and quality. Vocal onsets have commonly been qualitatively characterized into three types: hard, simultaneous, and breathy. This study examines the effect of voice onset type on VAT values in normal spe... περισσότερα »
Moving Window on Acoustic Analysis
The Effect of via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Min Shu, Jack J. Jiang, Malachi Willey ObjectiveTo investigate the effects of the moving window method on acoustic measures and discrimination ability between normal and disordered voices.MethodsFifty-three normal voices and 50 disordered voices were recruited. Three selection methods, the moving window method, the mid-vowel method, and the whole vowel method, were applied to each raw audio signal to determine the most stable segment of each signal. Acoustic parameters such...περισσότερα »
Toxins, Vol. 8, Pages 13: Rapid Microfluidic Assay for the Detection of Botulinum Neurotoxin in Animal Sera
Potent Botulinum neurotoxins (BoNTs) represent a threat to public health and safety. Botulism is a disease caused by BoNT intoxication that results in muscle paralysis that can be fatal. Sensitive assays capable of detecting BoNTs from different substrates and settings are essential to limit foodborne contamination and morbidity. In this report, we describe a rapid… Continue reading Toxins, Vol. 8, Pages 13: Rapid Microfluidic Assay for the Detection of Botulinum Neurotoxin in Animal Sera
Nurses’ leader warns government not to pick fight with profession over seven day working
If ministers target nurses’ payments for unsocial hours they are more likely to face a flight from the NHS than strike action, according to the new leader of the Royal College of Nursing.Four months… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1mzN8jB via IFTTT
John Anthony Chappel
bmj;352/jan04_3/h6858/FIG1F1fig1John Anthony Chappel was born in Yorkshire, the grandson of a miner. His father worked in banks and moved the family to London just after the war. John gained his… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Rlq7fH via IFTTT
Case-control study evaluating competing risk factors for angioedema in a high-risk population
Objectives/Hypothesis Black race is a risk factor for angioedema. The primary aim was to examine the relationship between race–ethnicity and risk factors for angioedema. Study Design Using a retrospective case-control study design, data was extracted with the Clinical Looking Glass utility, a data collection and management tool that captures data from electronic medical record systems… Continue reading Case-control study evaluating competing risk factors for angioedema in a high-risk population
Antioxidant and anti-aging activities of the polysaccharide TLH-3 from Tricholoma lobayense
Publication date: April 2016 Source:International Journal of Biological Macromolecules, Volume 85 Author(s): Qiuying Ding, Dan Yang, Wenna Zhang, Yongming Lu, Mingzhu Zhang, Liming Wang, Xuehui Li, Liyuan Zhou, Qingxi Wu, Wenjuan Pan, Yan Chen Polysaccharides from edible fungi usually exhibit many bioactivities. Our previous studies found that polysaccharide TLH-3 extracted from Tricholoma lobayense possessed noticeable… Continue reading Antioxidant and anti-aging activities of the polysaccharide TLH-3 from Tricholoma lobayense
A Simple Catalytic Route for Alkynylgermanes
Abstract We report a new one-pot, iridium(I)-catalyzed direct method for the synthesis of alkynyl-substituted germanium compounds with various functional groups from commercially available reagents. More than 25 compounds were obtained and spectroscopically characterized. Moreover, detailed DFT calculations were performed to study the mechanism of the catalytic cycle of the germylative coupling. The results confirm our… Continue reading A Simple Catalytic Route for Alkynylgermanes
A systematic review on the surgical outcome of preauricular sinus excision techniques
Objectives/Hypothesis Preauricular sinuses are benign congenital malformations of preauricular soft tissues. Complete excision using either sinectomy or supra-auricular approach is advised to prevent recurrence. Reported recurrence varies between 0 and 42%. We evaluated which surgical technique resulted in lowest complication and recurrence rates. Study Design PubMed, Embase, Scopus, Web of Science. Methods Two authors appraised… Continue reading A systematic review on the surgical outcome of preauricular sinus excision techniques
The efficacy and safety of the Shaoyao Shujin tablet for knee osteoarthritis: study protocol for a randomized controlled trial
Abstract Background Knee osteoarthritis (KOA) is a major public health issue causing chronic disability as well as a burden on healthcare resources. In China, a herbal drug tablet has been used as an effective and conventional therapy to alleviate clinical symptoms caused by KOA. However, evidence gathered from systematic reviews or randomized controlled trials that… Continue reading The efficacy and safety of the Shaoyao Shujin tablet for knee osteoarthritis: study protocol for a randomized controlled trial
Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss
Objectives/Hypothesis To investigate the clinical significance of arterial stiffness in the development and prognosis of idiopathic sudden sensorineural hearing loss (SSNHL). Study Design A prospective case-control study. Methods Fifty-four adult patients with idiopathic SSNHL and 54 age- and sex-matched controls were evaluated between January 2014 and May 2015. Arterial stiffness was assessed from brachial-ankle pulse… Continue reading Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss
tRNA conjugation with chitosan nanoparticles: An AFM imaging study
Publication date: April 2016 Source:International Journal of Biological Macromolecules, Volume 85 Author(s): D. Agudelo, L. Kreplak, H.A. Tajmir-Riahi The conjugation of tRNA with chitosan nanoparticles of different sizes 15,100 and 200kDa was investigated in aqueous solution using multiple spectroscopic methods and atomic force microscopy (AFM). Structural analysis showed that chitosan binds tRNA via G-C and… Continue reading tRNA conjugation with chitosan nanoparticles: An AFM imaging study
Visual Pattern Recognition
Evaluation of Singer's Voice Quality by Means of via Voice Publication date: January 2016 *Source:*Journal of Voice, Volume 30, Issue 1 Author(s): Paweł Forczmański The article presents a description of the algorithm of singing voice quality assessment that uses selected methods from the field of digital image processing and recognition. It adopts the assumption that an audio signal with recorded vocal exercise can be converted into a visual representation, and processed further, as an image. Presented approach is based on generating a sound spectrogram of a sample in the form of a r... περισσότερα »
Implant micromobility after healing (secondary implant stability)
Validation of value of actual micromotion as a direct measure of implant micromobility after healing (secondary implant stability). An in vivo histologic and biomechanical study: Abstract Objectives The osseointegration process replaces the surgically damaged bone with newly formed bone in contact to the implant surface. This involves some loss of primary stability, which will continue until new bone is formed providing a new stability, known as “secondary stability.” A direct measurement of secondary implant stability appears fundamental to determine the period and modalities for ... περισσότερα »
Functional outcome and quality of life after a maxillectomy
Functional outcome and quality of life after a maxillectomy: a comparison between an implant supported obturator and implant supported fixed prostheses in a free vascularized flap: Abstract Objective Defects of the maxilla caused by tumor resection create high levels of psychological and physical trauma for patients. The application of osseointegrated dental implants using either an obturator prosthesis or a free vascularized flap has tremendously changed the retention and stability of the superstructure. However, no study has been performed to compare the function of the aforement...περισσότερα »
Healing of BoneCeramic™ at buccal dehiscence defects at implants installed immediately into extraction sockets. An experimental study in dogs
Healing of BoneCeramic™ at buccal dehiscence defects at implants installed immediately into extraction sockets. An experimental study in dogs: Abstract Objective To assess the healing outcomes at buccal dehiscence defects after 4 months following implant placement immediately into extraction sockets (IPIES) and filled with a mixture of synthetic hydroxyl apatite (HA) 60% and β-tri-calcium phosphate (β-TCP) 40% in comparison with leaving a blood clot. Material and methods Eight Labrador dogs were used, and an implant was placed immediately following tooth extraction into the distal al... περισσότερα »
Healing of the tympanic membrane after surgical intervention for atelectasis of the middle ear in sixty-two adults
Healing of the tympanic membrane after surgical intervention for atelectasis of the middle ear in sixty-two adults: Abstract In treating atelectasis of the middle ear multiple techniques have been described, including grafting of the eardrum defect e.g. with perichondrium or cartilage.1 Several studies suggested that excision of the retraction pocket in pediatric ears does not require grafting. The spontaneous healing capacity of the pediatric tympanic membrane (TM) ranged from 87.2% to 96.8%. 2-5 These results are comparable to spontaneous healing after traumatic perforations of th... περισσότερα »
Brain Health as a Key Concept in the Development of Strategies for Delaying Age- Related Cognitive Decline and Alzheimer’s Disease
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
The post Brain Health as a Key Concept in the Development of Strategies for Delaying Age- Related Cognitive Decline and Alzheimer’s Disease appeared first on Welcome to Avens. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1TzvxD5 via IFTTT
Design and Implementation of Automatic Wheat Mower Based on Smart Sensor Fed by a Photovoltaic
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
The biggest problems of our time are environmental pollution and the reduction of fossil fuel resources. In recent years, photovoltaic (PV) has started to be used efficiently in order to produce electrical energy from solar energy throughout the world. In this study, a wheat mover machine taking its energy with PV technology transformation from the […]
Adjusting of Wind Input Source Term in WAVEWATCH III Model for the Middle-Sized Water Body on the Basis of the Field Experiment
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Adjusting of wind input source term in numerical model WAVEWATCH III for the middle-sized water body is reported. For this purpose, the field experiment on Gorky Reservoir is carried out. Surface waves are measured along with the parameters of the airflow. The measurement of wind speed in close proximity to the water surface is performed. […]
An Optimal Routing Algorithm in Service Customized 5G Networks
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
With the widespread use of Internet, the scale of mobile data traffic grows explosively, which makes 5G networks in cellular networks become a growing concern. Recently, the ideas related to future network, for example, Software Defined Networking (SDN), Content-Centric Networking (CCN), and Big Data, have drawn more and more attention. In this paper, we propose […]
Comparing Erlang Distribution and Schwinger Mechanism on Transverse Momentum Spectra in High Energy Collisions
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
We study the transverse momentum spectra of and mesons by using two methods: the two-component Erlang distribution and the two-component Schwinger mechanism. The results obtained by the two methods are compared and found to be in agreement with the experimental data of proton-proton (), proton-lead (-Pb), and lead-lead (Pb-Pb) collisions measured by the LHCb and […]
JCM, Vol. 5, Pages 5: An Overview of Insulin Pumps and Glucose Sensors for the Generalist
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Continuous subcutaneous insulin, or the insulin pump, has gained popularity and sophistication as a near-physiologic programmable method of insulin delivery that is flexible and lifestyle-friendly. The introduction of continuous monitoring with glucose sensors provides unprecedented access to, and prediction of, a patient’s blood glucose levels. Efforts are underway to integrate the two technologies, from “sensor-augmented” […]
Erratum to: Efficacy of Transcatheter Arterial Chemoembolization Followed by Sorafenib for Intermediate/Advanced Hepatocellular Carcinoma in Patients in Japan: A Retrospective Analysis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OGc1qv via IFTTT
Extra-nodal natural killer/T cell lymphoma in elderly patients: the impact of aging on clinical outcomes and treatment tolerability
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
Abstract Extra-nodal natural killer/T cell lymphoma (ENKTL) is rare in elderly patients, and its clinical course is unclear. The efficacy and tolerability of non-anthracycline-based treatments as a standard regimen in elderly patients have not been fully investigated. This study assessed the impact of aging on clinical outcomes and treatment tolerability. We retrospectively analyzed 51 patients […]
A case of MYH9 disorders caused by a novel mutation (p.K74E)
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 28 δευτερόλεπτα
from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1O02J5e via IFTTT
Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss
Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss: Objectives/Hypothesis To investigate the clinical significance of arterial stiffness in the development and prognosis of idiopathic sudden sensorineural hearing loss (SSNHL). Study Design A prospective case-control study. Methods Fifty-four adult patients with idiopathic SSNHL and 54 age- and sex-matched controls were evaluated between January 2014 and May 2015. Arterial stiffness was assessed from brachial-ankle pulse wave velocity (baPWV), and other cardiovascular markers including blood p...περισσότερα »
A systematic review on the surgical outcome of preauricular sinus excision techniques
A systematic review on the surgical outcome of preauricular sinus excision techniques: Objectives/Hypothesis Preauricular sinuses are benign congenital malformations of preauricular soft tissues. Complete excision using either sinectomy or supra-auricular approach is advised to prevent recurrence. Reported recurrence varies between 0 and 42%. We evaluated which surgical technique resulted in lowest complication and recurrence rates. Study Design PubMed, Embase, Scopus, Web of Science. Methods Two authors appraised studies on directness of evidence and risk of bias. Original data wer...περισσότερα »
Case-control study evaluating competing risk factors for angioedema in a high-risk population
Case-control study evaluating competing risk factors for angioedema in a high-risk population: Objectives/Hypothesis Black race is a risk factor for angioedema. The primary aim was to examine the relationship between race–ethnicity and risk factors for angioedema. Study Design Using a retrospective case-control study design, data was extracted with the Clinical Looking Glass utility, a data collection and management tool that captures data from electronic medical record systems within the Montefiore Healthcare System. Cases were emergency department (ED) visits with primary or secon...περισσότερα »
Imaging follow-up study of acute rhinosinusitis
Imaging follow-up study of acute rhinosinusitis: Objectives/Hypothesis To evaluate with imaging the course of acute rhinosinusitis (ARS) and the associations between paranasal imaging results, symptoms, bony anatomic variations, and culture-proven bacterial ARS. Study Design Inception cohort study with 50 conscripts with ARS. Methods During a single ARS episode, we collected symptoms daily and took sequential cone-beam computed tomography (CBCT) scans of the paranasal sinuses of the same patients 2 to 3, 5 to 6 and 9 to 10 days after the onset of symptoms. Culture-proven bacterial AR... περισσότερα »
Identification of biofilms in post-tympanostomy tube otorrhea
Identification of biofilms in post-tympanostomy tube otorrhea: Objectives/Hypothesis Otitis media is a common problem in the pediatric population. Despite antibiotic therapy, post-tympanostomy otorrhea can be difficult to treat. Biofilms have been shown to play a role in chronic and recurrent otitis media and are implicated in otorrhea. This study investigated both the microbial composition and the presence of biofilm fragments rich in extracellular DNA (eDNA) and the bacterial DNA-binding protein, integration host factor (IHF), in post-tympanostomy tube otorrhea. Study Design Clini... περισσότερα »
Nurses’ leader warns government not to pick fight with profession over seven day working
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
If ministers target nurses’ payments for unsocial hours they are more likely to face a flight from the NHS than strike action, according to the new leader of the Royal College of Nursing.Four months… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1mzN8jB via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
John Anthony Chappel
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
bmj;352/jan04_3/h6858/FIG1F1fig1John Anthony Chappel was born in Yorkshire, the grandson of a miner. His father worked in banks and moved the family to London just after the war. John gained his… from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Rlq7fH via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Antioxidant and anti-aging activities of the polysaccharide TLH-3 from Tricholoma lobayense
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Publication date: April 2016 Source:International Journal of Biological Macromolecules, Volume 85 Author(s): Qiuying Ding, Dan Yang, Wenna Zhang, Yongming Lu, Mingzhu Zhang, Liming Wang, Xuehui Li, Liyuan Zhou, Qingxi Wu, Wenjuan Pan, Yan Chen Polysaccharides from edible fungi usually exhibit many bioactivities. Our previous studies found that polysaccharide TLH-3 extracted from Tricholoma lobayense possessed noticeable […]
tRNA conjugation with chitosan nanoparticles: An AFM imaging study
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Publication date: April 2016 Source:International Journal of Biological Macromolecules, Volume 85 Author(s): D. Agudelo, L. Kreplak, H.A. Tajmir-Riahi The conjugation of tRNA with chitosan nanoparticles of different sizes 15,100 and 200kDa was investigated in aqueous solution using multiple spectroscopic methods and atomic force microscopy (AFM). Structural analysis showed that chitosan binds tRNA via G-C and […]
Modified chitosan encapsulated core-shell Ag Nps for superior antimicrobial and anticancer activity
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Publication date: April 2016 Source:International Journal of Biological Macromolecules, Volume 85 Author(s): Sovan Lal Banerjee, Moumita Khamrai, Kishor Sarkar, Nikhil K. Singha, P.P. Kundu This investigation reports a one pot synthesis of silver nanoparticles (Ag Nps) using aqueous solution of chitosan-graft-poly(acrylamide) (Cts-g-PAAm) as a reducing agent and polyethylene glycol (PEG) as a stabilizing agent. The […]
Identification of biofilms in post-tympanostomy tube otorrhea
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Objectives/Hypothesis Otitis media is a common problem in the pediatric population. Despite antibiotic therapy, post-tympanostomy otorrhea can be difficult to treat. Biofilms have been shown to play a role in chronic and recurrent otitis media and are implicated in otorrhea. This study investigated both the microbial composition and the presence of biofilm fragments rich in […]
Imaging follow-up study of acute rhinosinusitis
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Objectives/Hypothesis To evaluate with imaging the course of acute rhinosinusitis (ARS) and the associations between paranasal imaging results, symptoms, bony anatomic variations, and culture-proven bacterial ARS. Study Design Inception cohort study with 50 conscripts with ARS. Methods During a single ARS episode, we collected symptoms daily and took sequential cone-beam computed tomography (CBCT) scans of […]
Case-control study evaluating competing risk factors for angioedema in a high-risk population
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Objectives/Hypothesis Black race is a risk factor for angioedema. The primary aim was to examine the relationship between race–ethnicity and risk factors for angioedema. Study Design Using a retrospective case-control study design, data was extracted with the Clinical Looking Glass utility, a data collection and management tool that captures data from electronic medical record systems […]
A systematic review on the surgical outcome of preauricular sinus excision techniques
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Objectives/Hypothesis Preauricular sinuses are benign congenital malformations of preauricular soft tissues. Complete excision using either sinectomy or supra-auricular approach is advised to prevent recurrence. Reported recurrence varies between 0 and 42%. We evaluated which surgical technique resulted in lowest complication and recurrence rates. Study Design PubMed, Embase, Scopus, Web of Science. Methods Two authors appraised […]
Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 30 δευτερόλεπτα
Objectives/Hypothesis To investigate the clinical significance of arterial stiffness in the development and prognosis of idiopathic sudden sensorineural hearing loss (SSNHL). Study Design A prospective case-control study. Methods Fifty-four adult patients with idiopathic SSNHL and 54 age- and sex-matched controls were evaluated between January 2014 and May 2015. Arterial stiffness was assessed from brachial-ankle pulse […]
NMDA receptor antagonism disrupts acquisition and retention of the context preexposure facilitation effect in adolescent rats
[image: S01664328.gif] Publication date: 15 March 2016 *Source:*Behavioural Brain Research, Volume 301 Author(s): Nicholas A. Heroux, Patrese A. Robinson-Drummer, Jeffrey B. Rosen, Mark E. Stanton The context preexposure facilitation effect (CPFE) is a contextual fear conditioning paradigm in which learning about the context, acquiring the context-shock association, and retrieving/expressing contextual fear are temporally dissociated. The current study investigated the involvement of NMDA receptors in contextual fear acquisition, retention, and expression across all phases of the CP...περισσότερα »
Regional vulnerability of the hippocampus to repeated motor activity deprivation
[image: alertIcon.gif] Publication date: 15 March 2016 *Source:*Behavioural Brain Research, Volume 301 Author(s): Jamshid Faraji, Nabiollah Soltanpour, Reza Moeeini, Seyed Abedin Hosseini, Shiva Pakdel, Alireza Moharrerie, Kaveh Arjang, Nasrin Soltanpour, Gerlinde A.S. Metz Spontaneous vertical and horizontal exploratory movements are integral components of rodent behavior. Little is known, however, about the structural and functional consequences of restricted spontaneous exploration. Here, we report two experiments to probe whether restriction in vertical activity (rearing) in rat... περισσότερα »
Multivariate time series analysis of neuroscience data: some challenges and opportunities
[image: S09594388.gif] Publication date: April 2016 *Source:*Current Opinion in Neurobiology, Volume 37 Author(s): Mohsen Pourahmadi, Siamak Noorbaloochi Neuroimaging data may be viewed as high-dimensional multivariate time series, and analyzed using techniques from regression analysis, time series analysis and spatiotemporal analysis. We discuss issues related to data quality, model specification, estimation, interpretation, dimensionality and causality. Some recent research areas addressing aspects of some recurring challenges are introduced. from Neurology via xlomafota13 on In...περισσότερα »
The efficacy and safety of the Shaoyao Shujin tablet for knee osteoarthritis: study protocol for a randomized controlled trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Abstract Background Knee osteoarthritis (KOA) is a major public health issue causing chronic disability as well as a burden on healthcare resources. In China, a herbal drug tablet has been used as an effective and conventional therapy to alleviate clinical symptoms caused by KOA. However, evidence gathered from systematic reviews or randomized controlled trials that […]
Systemic therapy for vulval Erosive Lichen Planus (the ‘hELP’ trial): study protocol for a randomised controlled trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Abstract Background Erosive lichen planus affecting the vulva (ELPV) is a relatively rare, chronic condition causing painful raw areas in the vulvovaginal region. Symptoms are pain and burning, which impact upon daily living. There is paucity of evidence regarding therapy. A 2012 Cochrane systematic review found no randomised controlled trials (RCTs) in this field. Topically […]
Guided, internet-based, rumination-focused cognitive behavioural therapy (i-RFCBT) versus a no-intervention control to prevent depression in high-ruminating young adults, along with an adjunct assessment of the feasibility of unguided i-RFCBT, in the REducing Stress and Preventing Depression trial (RESPOND): study protocol for a phase III randomised controlled trial
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Abstract Background Depression is a global health challenge. Prevention is highlighted as a priority to reduce its prevalence. Although effective preventive interventions exist, the efficacy and coverage can be improved. One proposed means to increase efficacy is by using interventions to target specific risk factors, such as rumination. Rumination-focused CBT (RFCBT) was developed to specifically […]
Toxins, Vol. 8, Pages 15: Identification and Quantification of a Toxigenic and Non-Toxigenic Aspergillus flavus Strain in Contaminated Maize Using Quantitative Real-Time PCR
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Aflatoxins, which are produced by Aspergillus flavus, are toxic to humans, livestock, and pets. The value of maize (Zea mays) grain is markedly reduced when contaminated with aflatoxin. Plant resistance and biological control using non-toxin producing strains are considered effective strategies for reducing aflatoxin accumulation in maize grain. Distinguishing between the toxin and non-toxin producing […]
Toxins, Vol. 8, Pages 13: Rapid Microfluidic Assay for the Detection of Botulinum Neurotoxin in Animal Sera
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Potent Botulinum neurotoxins (BoNTs) represent a threat to public health and safety. Botulism is a disease caused by BoNT intoxication that results in muscle paralysis that can be fatal. Sensitive assays capable of detecting BoNTs from different substrates and settings are essential to limit foodborne contamination and morbidity. In this report, we describe a rapid […]
Identification of biofilms in post-tympanostomy tube otorrhea
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Objectives/Hypothesis Otitis media is a common problem in the pediatric population. Despite antibiotic therapy, post-tympanostomy otorrhea can be difficult to treat. Biofilms have been shown to play a role in chronic and recurrent otitis media and are implicated in otorrhea. This study investigated both the microbial composition and the presence of biofilm fragments rich in […]
Imaging follow-up study of acute rhinosinusitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Objectives/Hypothesis To evaluate with imaging the course of acute rhinosinusitis (ARS) and the associations between paranasal imaging results, symptoms, bony anatomic variations, and culture-proven bacterial ARS. Study Design Inception cohort study with 50 conscripts with ARS. Methods During a single ARS episode, we collected symptoms daily and took sequential cone-beam computed tomography (CBCT) scans of […]
Case-control study evaluating competing risk factors for angioedema in a high-risk population
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Objectives/Hypothesis Black race is a risk factor for angioedema. The primary aim was to examine the relationship between race–ethnicity and risk factors for angioedema. Study Design Using a retrospective case-control study design, data was extracted with the Clinical Looking Glass utility, a data collection and management tool that captures data from electronic medical record systems […]
A systematic review on the surgical outcome of preauricular sinus excision techniques
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Objectives/Hypothesis Preauricular sinuses are benign congenital malformations of preauricular soft tissues. Complete excision using either sinectomy or supra-auricular approach is advised to prevent recurrence. Reported recurrence varies between 0 and 42%. We evaluated which surgical technique resulted in lowest complication and recurrence rates. Study Design PubMed, Embase, Scopus, Web of Science. Methods Two authors appraised […]
Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 35 δευτερόλεπτα
Objectives/Hypothesis To investigate the clinical significance of arterial stiffness in the development and prognosis of idiopathic sudden sensorineural hearing loss (SSNHL). Study Design A prospective case-control study. Methods Fifty-four adult patients with idiopathic SSNHL and 54 age- and sex-matched controls were evaluated between January 2014 and May 2015. Arterial stiffness was assessed from brachial-ankle pulse […]
Toxins, Vol. 8, Pages 13: Rapid Microfluidic Assay for the Detection of Botulinum Neurotoxin in Animal Sera
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Potent Botulinum neurotoxins (BoNTs) represent a threat to public health and safety. Botulism is a disease caused by BoNT intoxication that results in muscle paralysis that can be fatal. Sensitive assays capable of detecting BoNTs from different substrates and settings are essential to limit foodborne contamination and morbidity. In this report, we describe a rapid […]
Identification of biofilms in post-tympanostomy tube otorrhea
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Objectives/Hypothesis Otitis media is a common problem in the pediatric population. Despite antibiotic therapy, post-tympanostomy otorrhea can be difficult to treat. Biofilms have been shown to play a role in chronic and recurrent otitis media and are implicated in otorrhea. This study investigated both the microbial composition and the presence of biofilm fragments rich in […]
Imaging follow-up study of acute rhinosinusitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Objectives/Hypothesis To evaluate with imaging the course of acute rhinosinusitis (ARS) and the associations between paranasal imaging results, symptoms, bony anatomic variations, and culture-proven bacterial ARS. Study Design Inception cohort study with 50 conscripts with ARS. Methods During a single ARS episode, we collected symptoms daily and took sequential cone-beam computed tomography (CBCT) scans of […]
Case-control study evaluating competing risk factors for angioedema in a high-risk population
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Objectives/Hypothesis Black race is a risk factor for angioedema. The primary aim was to examine the relationship between race–ethnicity and risk factors for angioedema. Study Design Using a retrospective case-control study design, data was extracted with the Clinical Looking Glass utility, a data collection and management tool that captures data from electronic medical record systems […]
A systematic review on the surgical outcome of preauricular sinus excision techniques
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Objectives/Hypothesis Preauricular sinuses are benign congenital malformations of preauricular soft tissues. Complete excision using either sinectomy or supra-auricular approach is advised to prevent recurrence. Reported recurrence varies between 0 and 42%. We evaluated which surgical technique resulted in lowest complication and recurrence rates. Study Design PubMed, Embase, Scopus, Web of Science. Methods Two authors appraised […]
Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Objectives/Hypothesis To investigate the clinical significance of arterial stiffness in the development and prognosis of idiopathic sudden sensorineural hearing loss (SSNHL). Study Design A prospective case-control study. Methods Fifty-four adult patients with idiopathic SSNHL and 54 age- and sex-matched controls were evaluated between January 2014 and May 2015. Arterial stiffness was assessed from brachial-ankle pulse […]
Expecting the unexpected: A mixed methods study of violence to EMS responders in an urban fire department
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Background Struck by injuries experienced by females were observed to be higher compared to males in an urban fire department. The disparity was investigated while gaining a grounded understanding of EMS responder experiences from patient-initiated violence. Methods A convergent parallel mixed methods design was employed. Using a linked injury dataset, patient-initiated violence estimates were calculated […]
Lung transplantation is increasingly common among patients with coal workers’ pneumoconiosis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Background The prevalence of coal workers’ pneumoconiosis (CWP) in U.S. coal miners has increased, and severe presentations are increasingly common. Methods We describe trends in lung transplantation during 1996–2014 for recipients with a primary diagnosis of CWP or pneumoconiosis unspecified, and we summarize recipient characteristics and estimate survival. Results A total of 47 transplants were […]
Short fiber tremolite free chrysotile mesothelioma cohort revealed
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
In 1995, Dell and Teta published a cohort mortality study of asbestos molding compound workers at a Union Carbide Corporation (UCC) plastics manufacturing plant in Bound Brook, New Jersey. They reported that the factory workers were exposed to “asbestos (mostly chrysotile),” implying that the asbestos used at the Bound Brook plant occasionally contained amphiboles. However, […]
Cancer in World Trade Center responders: Findings from multiple cohorts and options for future study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 44 δευτερόλεπτα
Background Three longitudinal studies of cancer incidence in varied populations of World Trade Center responders have been conducted. Methods We compared the design and results of the three studies. Results Separate analyses of these cohorts revealed excess cancer incidence in responders for all cancers combined and for cancers of the thyroid and prostate. Methodological dissimilarities […]
Economic consequences of workplace injuries in the United States: Findings from the National Longitudinal Survey of Youth (NLSY79)
Background This study explored economic consequences of work-related injuries using a longitudinal data source. Methods Data were from the National Longitudinal Survey of Youth, 1979 cohort (n = 12,686). Short-term consequences were measured when the injury was reported. "Difference-in-differences" approach was applied to estimate income and wealth disparities between injured and non-injured workers before and after injury. Fixed effects models were used to identify variations over time. Results The annual earnings growth was $3,715 (in 2000 dollars) less for workers with DAFW ...περισσότερα »
Serious injury and fatality investigations involving pneumatic nail guns, 1985–2012
Background This article examines serious and fatal pneumatic nail gun (PNG) injury investigations for workplace, tool design, and human factors relevant to causation and resulting OS&H authorities' responses in terms of citations and penalties. Methods The U.S. Occupational Safety and Health Administration (OSHA) database of Fatality and Catastrophe Investigation Summaries (F&CIS) were reviewed (1985–2012) to identify n = 258 PNG accidents. Results 79.8% of investigations, and 100% of fatalities, occurred in the construction industry. Between 53–71% of injuries appear to have be... περισσότερα »
Sleep disturbances and neurotoxicity in workers exposed to hydrocarbons. An observational study from Algeria
Background Occupational exposure to solvents may lead to neurotoxicity and sleep disturbances. We aimed to investigate the association of occupational exposure to petroleum-derived hydrocarbons with neurotoxicity and sleep disturbance symptoms. Methods We included male workers handling/distributing petroleum products (exposed, n = 250) and electricians (non-exposed, n = 250) from two companies in Tlemcen (Algeria). Neurotoxicity was evaluated with the Q-16 questionnaire, and sleep disturbances with the Epworth and the Berlin questionnaires. Multivariable Poisson regression models... περισσότερα »
Case-control study evaluating competing risk factors for angioedema in a high-risk population
Objectives/Hypothesis Black race is a risk factor for angioedema. The primary aim was to examine the relationship between race–ethnicity and risk factors for angioedema. Study Design Using a retrospective case-control study design, data was extracted with the Clinical Looking Glass utility, a data collection and management tool that captures data from electronic medical record systems within the Montefiore Healthcare System. Cases were emergency department (ED) visits with primary or secondary International Classification of Diseases, Ninth Revision, code diagnoses of angioedema ...περισσότερα »
Identification of biofilms in post-tympanostomy tube otorrhea
Objectives/Hypothesis Otitis media is a common problem in the pediatric population. Despite antibiotic therapy, post-tympanostomy otorrhea can be difficult to treat. Biofilms have been shown to play a role in chronic and recurrent otitis media and are implicated in otorrhea. This study investigated both the microbial composition and the presence of biofilm fragments rich in extracellular DNA (eDNA) and the bacterial DNA-binding protein, integration host factor (IHF), in post-tympanostomy tube otorrhea. Study Design Clinical samples. Methods Institutional review board approval w... περισσότερα »
Imaging follow-up study of acute rhinosinusitis
Objectives/Hypothesis To evaluate with imaging the course of acute rhinosinusitis (ARS) and the associations between paranasal imaging results, symptoms, bony anatomic variations, and culture-proven bacterial ARS. Study Design Inception cohort study with 50 conscripts with ARS. Methods During a single ARS episode, we collected symptoms daily and took sequential cone-beam computed tomography (CBCT) scans of the paranasal sinuses of the same patients 2 to 3, 5 to 6 and 9 to 10 days after the onset of symptoms. Culture-proven bacterial ARS was verified with maxillary sinus aspirat...περισσότερα »
A systematic review on the surgical outcome of preauricular sinus excision techniques
Objectives/Hypothesis Preauricular sinuses are benign congenital malformations of preauricular soft tissues. Complete excision using either sinectomy or supra-auricular approach is advised to prevent recurrence. Reported recurrence varies between 0 and 42%. We evaluated which surgical technique resulted in lowest complication and recurrence rates. Study Design PubMed, Embase, Scopus, Web of Science. Methods Two authors appraised studies on directness of evidence and risk of bias. Original data were extracted and pooled when I2 was smaller than 50%. Results are reported accordin...περισσότερα »
Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss
Objectives/Hypothesis To investigate the clinical significance of arterial stiffness in the development and prognosis of idiopathic sudden sensorineural hearing loss (SSNHL). Study Design A prospective case-control study. Methods Fifty-four adult patients with idiopathic SSNHL and 54 age- and sex-matched controls were evaluated between January 2014 and May 2015. Arterial stiffness was assessed from brachial-ankle pulse wave velocity (baPWV), and other cardiovascular markers including blood pressure, body mass index, and lipid profiles were determined. The SSNHL patients were di... περισσότερα »
Detailed Imatinib Metabolite Study in Chronic Myeloid Leukemia
[image: shutterstock_96947582.jpg] Therapeutic monitoring of drugs is highly useful in individualizing treatment. Imatinib is a chemotherapeutic used in the treatment of chronic myeloid leukemia (CML). Therapeutic monitoring of imatinib and its metabolites results in better clinical outcomes for the patient. However, imatinib metabolization has been poorly studied. With this in mind, Friedecky et al. (2015) used high-resolution mass spectrometry Read the rest of this article The post Detailed Imatinib Metabolite Study in Chronic Myeloid Leukemia appeared first on Accelerating Sci... περισσότερα »
Structural and Conformational Study of the O-Antigenic Portion of the Lipopolysaccharide Isolated from Burkholderia gladioli pv. cocovenenans
Abstract Lipopolysaccharides (LPSs) are virulence factors that are expressed on the cell surface of Gram-negative bacteria. They represent one of the main traits of bacterial virulence. In this paper, we report the primary structure and the conformational features of the O-chain from the lipopolysaccharide (LPS) produced by *Burkholderia gladioli* pv. *cocovenenans*, a bacterium often associated with the mucoralean fungus *Rhizopus microsporus* var. *oligosporus*, which is traditionally used in food fermentations. With the aim of understanding the organization of bacterial cell-su...περισσότερα »
Differences in the endoscopic detection rates of Barrett’s esophagus using the Japanese and Western criteria: a pilot study
Abstract Background and aim Identification of the esophageal gastric junction (EGJ) is of crucial importance for the consistent detection of Barrett's esophagus (BE). In Japan, the distal end of the lower esophageal palisade vessels is used to define the EGJ. However, in Western countries, the EGJ is defined as the proximal margin of the gastric folds. In this prospective study, we compared the variation in endoscopic diagnosis of BE using the Japanese criteria (J-criteria) and the Prague C & M criteria (P-criteria) as a landmark of the EGJ. Methods A total of 82 patients were en... περισσότερα »
Characteristics and diagnosis of esophageal basaloid squamous cell carcinoma
Abstract Background Basaloid squamous cell carcinoma (BSCC) is a relatively rare, malignant disease of the esophagus. The prognosis of patients with BSCC is thought to be poorer than that of typical squamous cell carcinoma (SCC), but the treatment strategy for BSCC is generally the same as that for typical SCC. This study examined the diagnosis, the clinical and pathological characteristics, and the results of therapy in patients with BSCC. Methods The medical records for 13 patients with pathologically confirmed esophageal BSCC were extracted. The pretreatment endoscopic diagnosi...περισσότερα »
Combination of continuous paravertebral block and epidural anesthesia in postoperative pain control after esophagectomy
Abstract Background We conducted paravertebral block (PVB) for thoracotomy, with epidural anesthesia carried out as usual for laparotomy. To date, there has been no report of combining continuous PVB for thoracotomy and epidural anesthesia for laparotomy after esophagectomy. The aim of this historical study was to evaluate the efficacy of the combination. Methods This is a retrospective analysis of 105 patients who underwent transthoracic esophagectomy at our institution from April 2012 to July 2014. Fifty-three patients underwent two epidural catheter placements for thoracotomy ...περισσότερα »
Welcome to 2016 and a few words from the New Editor
from ! ORL via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mzg8Ia via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Z0JN9x via IFTTT
Aspirin prevents atrophy of esophageal nitrergic myenteric neurons in a mouse model of chronic Chagas disease
Summary The consequences of using aspirin (ASA) for the pathogenesis of Chagas disease are unclear. This study evaluated the effects of treatment of Chagas disease with ASA on the esophageal nitrergic myenteric neuron population and esophageal wall in mice. We observed that treatment of chagasic infection with ASA protects the esophageal myenteric neurons from the atrophy caused by the *Trypanosoma cruzi* infection. The mice were infected with 1300 trypomastigotes of Y strain *T. cruzi* intraperitoneally. Part of infected mice was treated with ASA from fifth to twelfth day after i...περισσότερα »
Simple preoperative risk scale accurately predicts perioperative mortality following esophagectomy for malignancy
Summary Surgery remains one of the major treatment options available to patients with esophageal cancer, with high mortality in certain cohorts. The aim of this study was to develop a simple preoperative risk scale based on patient factors, hospital factors, and tumor pathology to predict the risk of perioperative mortality following esophagectomy for malignancy. The Nationwide Inpatient Sample database was used to create the risk scale. Patients who underwent open or laparoscopic transhiatal and transthoracic esophageal resection were identified using International Classification ... περισσότερα »
Phase I/II study of divided-dose docetaxel, cisplatin and fluorouracil for patients with recurrent or metastatic squamous cell carcinoma of the esophagus
Summary Squamous cell carcinoma of the esophagus (SCCE) has a poor prognosis compared with other gastrointestinal cancers. Many patients present with locoregional unresectable or metastatic disease at the time of diagnosis. For these patients with metastatic esophageal cancer, chemotherapy is generally indicated. The aim of this phase I/II study was to evaluate the efficacy and safety of the combined use of docetaxel, cisplatin (CDDP) and 5-fluorouracil (5-FU)(DCF) in patients with recurrent/metastatic SCCE. This study adopted divided doses of docetaxel and CDDP in order to reduce ...περισσότερα »
Wild-type phosphatase and tensin homolog deleted on chromosome 10 improved the sensitivity of cells to rapamycin through regulating phosphorylation of Akt in esophageal squamous cell carcinoma
Summary Esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in China, but the etiology and mode of carcinogenesis of this disease remain poorly understood. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN), as a negative regulator of Akt/mTOR pathway, frequently mutates or is inactive in many cancers. Although mTOR has been thought a promising cancer therapeutic target, the sensitivity of tumor cells to rapamycin was still to be revaluated. In this study, we measured the effects of rapamycin on cell proliferation and phosphorylatio... περισσότερα »
External validation of a risk score in the prediction of the mortality after esophagectomy for cancer
Summary This study was designed as an external evaluation of the Steyerberg score in the prediction of different categories of postoperative mortality after esophagectomy on a large nationwide database of thoracic surgeons. Data collection was obtained from the Epithor national database encompassing the majority of thoracic procedures performed in France. We retrospectively compared the predicted to the observed postoperative 30-day (30DM), 90-day (90DM) and in-hospital mortality (IHM) rate in each decile of equal patient. Patients included in the study were operated for an esophag...περισσότερα »
Global Head and Neck Cancer Pipeline Review H1 2015 – RD News Mag
*Global Head and Neck Cancer Pipeline Review H1 2015* *RD News Mag* AcuteMarketReports.com has announced the addition of "Global *Head and Neck Cancer* Pipeline Review H1 2015 "Market Research Report to their Database. The '*Head and Neck Cancer* – Pipeline Review, H1 2015′, provides an overview of the Head and … *and more »* from ORL-Medicine by Sfakianakis via alwin on Inoreader http://ift.tt/1OFkJyX via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1mzIG4h via IFTTT
Diaphragmatic herniation after thoracolaparoscopic esophagectomy for carcinoma of the esophagus: a report of six cases
Abstract Diaphragmatic herniation after esophagectomy for carcinoma of the esophagus is a rare postoperative complication. Several recent reports reveal that minimally invasive esophagectomy (MIE) with mediastinal reconstruction is associated with a higher incidence of herniation compared with open esophagectomy. Thoracolaparoscopic esophagectomy (TLE), also called "total MIE", results in fewer peritoneal adhesions around the hiatal region of both the thoracic and abdominal cavities. This may cause abdominal contents to be taken up to the thoracic cavity. We report six cases of dia...περισσότερα »
Brain Health as a Key Concept in the Development of Strategies for Delaying Age- Related Cognitive Decline and Alzheimer’s Disease
The post Brain Health as a Key Concept in the Development of Strategies for Delaying Age- Related Cognitive Decline and Alzheimer's Disease appeared first on Welcome to Avens. from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1TzvxD5 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1R720CR via IFTTT
Role of fibroblast growth factor receptors in esophageal squamous cell carcinoma
Abstract Background We previously reported that the expression of fibroblast growth factor receptor-like 1 (FGFRL1) was associated with the progression of esophageal squamous cell carcinoma (ESCC). However, the clinical roles of FGFR1, FGFR2, FGFR3, and FGFR4 in ESCC have not yet been examined in detail. Furthermore, it currently remains unclear why FGFRL1 is a prognostic factor for ESCC. Materials and methods A squamous cell carcinoma tissue microarray established in Toyama University was used to evaluate the expression of the 4 FGFRs. Sixty-nine ESCC specimens were obtained fro...περισσότερα »
Sustainability, Vol. 8, Pages 40: Research on Steady States of Fuzzy Cognitive Map and its Application in Three-Rivers Ecosystem
Fuzzy Cognitive Map (FCM) offers many advantages such intuitive knowledge representation and fast numerical reasoning ability, etc. It suits modeling and decision-making of dynamic systems. With the aims to effectively help to analyze and control system sustainable evolution, the paper defines the steady states of fixed point and limited cycle of a FCM modeling system. Accordingly, the rules of steady states of the FCM model and the factors influencing the steady states are presented and proved. The Three-Rivers represents a system including population, ecological environment, soci...περισσότερα »
IJMS, Vol. 17, Pages 32: In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol
Recent studies have revealed the high cytotoxicity of p-menthane derivatives against human tumor cells. In this study, the substance perillaldehyde 8,9-epoxide, a p-menthane class derivative obtained from (S)-(−)-perillyl alcohol, was selected in order to assess antitumor activity against experimental sarcoma 180 tumors. Toxicological effects related to the liver, spleen, kidneys and hematology were evaluated in mice submitted to treatment. The tumor growth inhibition rate was 38.4%, 58.7%, 35.3%, 45.4% and 68.1% at doses of 100 and 200 mg/kg/day for perillaldehyde 8,9-epoxide, pe...περισσότερα »
Sustainability, Vol. 8, Pages 40: Research on Steady States of Fuzzy Cognitive Map and its Application in Three-Rivers Ecosystem
Fuzzy Cognitive Map (FCM) offers many advantages such intuitive knowledge representation and fast numerical reasoning ability, etc. It suits modeling and decision-making of dynamic systems. With the aims to effectively help to analyze and control system sustainable evolution, the paper defines the steady states of fixed point and limited cycle of a FCM modeling system. Accordingly, the rules of steady states of the FCM model and the factors influencing the steady states are presented and proved. The Three-Rivers represents a system including population, ecological environment, soci...περισσότερα »
IJMS, Vol. 17, Pages 32: In Vivo Anti-Tumor Activity and Toxicological Evaluations of Perillaldehyde 8,9-Epoxide, a Derivative of Perillyl Alcohol
Recent studies have revealed the high cytotoxicity of p-menthane derivatives against human tumor cells. In this study, the substance perillaldehyde 8,9-epoxide, a p-menthane class derivative obtained from (S)-(−)-perillyl alcohol, was selected in order to assess antitumor activity against experimental sarcoma 180 tumors. Toxicological effects related to the liver, spleen, kidneys and hematology were evaluated in mice submitted to treatment. The tumor growth inhibition rate was 38.4%, 58.7%, 35.3%, 45.4% and 68.1% at doses of 100 and 200 mg/kg/day for perillaldehyde 8,9-epoxide, pe...περισσότερα »
Sustainability, Vol. 8, Pages 42: The Impact of Restaurants’ Green Supply Chain Practices on Firm Performance
This study investigated crucial green supply chain management (GSCM) practice dimensions and firm performance based on restaurants firms in Taiwan. On the basis of a factor analysis, four green supply chain management dimensions were identified: corporate environment policy, green packing, green product, and economic transport. This study investigated crucial GSCM practice dimensions (including corporate environment policy, packaging waste, economic transport, and product recycling), green capability and organizational performance. The results shown: first, green practices in rest...περισσότερα »
Energies, Vol. 9, Pages 25: A Fuzzy-Logic Power Management Strategy Based on Markov Random Prediction for Hybrid Energy Storage Systems
Over the last few years; issues regarding the use of hybrid energy storage systems (HESSs) in hybrid electric vehicles have been highlighted by the industry and in academic fields. This paper proposes a fuzzy-logic power management strategy based on Markov random prediction for an active parallel battery-UC HESS. The proposed power management strategy; the inputs for which are the vehicle speed; the current electric power demand and the predicted electric power demand; is used to distribute the electrical power between the battery bank and the UC bank. In this way; the battery ban... περισσότερα »
Sustainability, Vol. 8, Pages 37: VIKOR Technique: A Systematic Review of the State of the Art Literature on Methodologies and Applications
The main objective of this paper is to present a systematic review of the VlseKriterijuska Optimizacija I Komoromisno Resenje (VIKOR) method in several application areas such as sustainability and renewable energy. This study reviewed a total of 176 papers, published in 2004 to 2015, from 83 high-ranking journals; most of which were related to Operational Research, Management Sciences, decision making, sustainability and renewable energy and were extracted from the "Web of Science and Scopus" databases. Papers were classified into 15 main application areas. Furthermore, papers were...περισσότερα »
JCM, Vol. 5, Pages 5: An Overview of Insulin Pumps and Glucose Sensors for the Generalist
Continuous subcutaneous insulin, or the insulin pump, has gained popularity and sophistication as a near-physiologic programmable method of insulin delivery that is flexible and lifestyle-friendly. The introduction of continuous monitoring with glucose sensors provides unprecedented access to, and prediction of, a patient's blood glucose levels. Efforts are underway to integrate the two technologies, from "sensor-augmented" and "sensor-driven" pumps to a fully-automated and independent sensing-and-delivery system. Implantable pumps and an early-phase "bionic pancreas" are also in ...περισσότερα »
IJMS, Vol. 17, Pages 59: Binding of Sulpiride to Seric Albumins
The aim of this work was to study the interaction of sulpiride with human serum albumin (HSA) and bovine serum albumin (BSA) through the fluorescence quenching technique. As sulpiride molecules emit fluorescence, we have developed a simple mathematical model to discriminate the quencher fluorescence from the albumin fluorescence in the solution where they interact. Sulpiride is an antipsychotic used in the treatment of several psychiatric disorders. We selectively excited the fluorescence of tryptophan residues with 290 nm wavelength and observed the quenching by titrating HSA and...περισσότερα »
Ion Mobility Mass Spectrometry of Peptide, Protein, and Protein Complex Ions using a Radio-Frequency Confining Drift Cell
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02107C, Paper Samuel J. Allen, Kevin Giles, Tony Gilbert, Matthew F. Bush Ion mobility mass spectrometry experiments enable the characterization of mass, assembly, and shape of biological molecules and assemblies. Here, a new radio-frequency confining drift cell is characterized and used to... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1OFGe2M Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :... περισσότερα »
Sustainability, Vol. 8, Pages 42: The Impact of Restaurants’ Green Supply Chain Practices on Firm Performance
This study investigated crucial green supply chain management (GSCM) practice dimensions and firm performance based on restaurants firms in Taiwan. On the basis of a factor analysis, four green supply chain management dimensions were identified: corporate environment policy, green packing, green product, and economic transport. This study investigated crucial GSCM practice dimensions (including corporate environment policy, packaging waste, economic transport, and product recycling), green capability and organizational performance. The results shown: first, green practices in rest...περισσότερα »
Energies, Vol. 9, Pages 25: A Fuzzy-Logic Power Management Strategy Based on Markov Random Prediction for Hybrid Energy Storage Systems
Over the last few years; issues regarding the use of hybrid energy storage systems (HESSs) in hybrid electric vehicles have been highlighted by the industry and in academic fields. This paper proposes a fuzzy-logic power management strategy based on Markov random prediction for an active parallel battery-UC HESS. The proposed power management strategy; the inputs for which are the vehicle speed; the current electric power demand and the predicted electric power demand; is used to distribute the electrical power between the battery bank and the UC bank. In this way; the battery ban... περισσότερα »
Sustainability, Vol. 8, Pages 37: VIKOR Technique: A Systematic Review of the State of the Art Literature on Methodologies and Applications
The main objective of this paper is to present a systematic review of the VlseKriterijuska Optimizacija I Komoromisno Resenje (VIKOR) method in several application areas such as sustainability and renewable energy. This study reviewed a total of 176 papers, published in 2004 to 2015, from 83 high-ranking journals; most of which were related to Operational Research, Management Sciences, decision making, sustainability and renewable energy and were extracted from the "Web of Science and Scopus" databases. Papers were classified into 15 main application areas. Furthermore, papers were...περισσότερα »
JCM, Vol. 5, Pages 5: An Overview of Insulin Pumps and Glucose Sensors for the Generalist
Continuous subcutaneous insulin, or the insulin pump, has gained popularity and sophistication as a near-physiologic programmable method of insulin delivery that is flexible and lifestyle-friendly. The introduction of continuous monitoring with glucose sensors provides unprecedented access to, and prediction of, a patient's blood glucose levels. Efforts are underway to integrate the two technologies, from "sensor-augmented" and "sensor-driven" pumps to a fully-automated and independent sensing-and-delivery system. Implantable pumps and an early-phase "bionic pancreas" are also in ...περισσότερα »
IJMS, Vol. 17, Pages 59: Binding of Sulpiride to Seric Albumins
The aim of this work was to study the interaction of sulpiride with human serum albumin (HSA) and bovine serum albumin (BSA) through the fluorescence quenching technique. As sulpiride molecules emit fluorescence, we have developed a simple mathematical model to discriminate the quencher fluorescence from the albumin fluorescence in the solution where they interact. Sulpiride is an antipsychotic used in the treatment of several psychiatric disorders. We selectively excited the fluorescence of tryptophan residues with 290 nm wavelength and observed the quenching by titrating HSA and...περισσότερα »
Extra-nodal natural killer/T cell lymphoma in elderly patients: the impact of aging on clinical outcomes and treatment tolerability
Abstract Extra-nodal natural killer/T cell lymphoma (ENKTL) is rare in elderly patients, and its clinical course is unclear. The efficacy and tolerability of non-anthracycline-based treatments as a standard regimen in elderly patients have not been fully investigated. This study assessed the impact of aging on clinical outcomes and treatment tolerability. We retrospectively analyzed 51 patients aged ≥60 years who were diagnosed with ENKTL from January 1998 to December 2012. We defined new treatments as non-anthracycline regimens (etoposide, ifosfamide, mesna, cisplatin, and dexame... περισσότερα »
Authors’ response to letter to editor
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Erratum to: Efficacy of Transcatheter Arterial Chemoembolization Followed by Sorafenib for Intermediate/Advanced Hepatocellular Carcinoma in Patients in Japan: A Retrospective Analysis
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Fatal traumatic brain injuries in the construction industry, 2003−2010
Background Research on fatal work-related traumatic brain injuries (TBIs) is limited. This study describes fatal TBIs in the US construction industry. Methods Fatal TBIs were extracted from the Bureau of Labor Statistics Census of Fatal Occupational Injuries. Results From 2003 to 2010, 2,210 fatal TBIs occurred in construction at a rate of 2.6 per 100,000 full-time equivalent (FTE) workers. Workers aged 65 years and older had the highest fatal TBI rates among all workers (7.9 per 100,000 FTE workers). Falls were the most frequent injury event (n = 1,269, 57%). Structural iron an... περισσότερα »
A case of MYH9 disorders caused by a novel mutation (p.K74E)
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Cold antibody autoimmune haemolytic anaemia in a child with diffuse large B cell lymphoma
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Enigmatic meningitis in a patient with T cell lymphoma
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Mortality among World Trade Center rescue and recovery workers, 2002–2011
Background Rescue and recovery workers responding to the 2001 collapse of the World Trade Center (WTC) sustained exposures to toxic chemicals and have elevated rates of multiple morbidities. Methods Using data from the World Trade Center Health Program and the National Death Index for 2002–2011, we examined standardized mortality ratios (SMR) and proportional cancer mortality ratios (PCMR) with indirect standardization for age, sex, race, and calendar year to the U.S. general population, as well as associations between WTC-related environmental exposures and all-cause mortality. ...περισσότερα »
Serious injury and fatality investigations involving pneumatic nail guns, 1985–2012
Background This article examines serious and fatal pneumatic nail gun (PNG) injury investigations for workplace, tool design, and human factors relevant to causation and resulting OS&H authorities' responses in terms of citations and penalties. Methods The U.S. Occupational Safety and Health Administration (OSHA) database of Fatality and Catastrophe Investigation Summaries (F&CIS) were reviewed (1985–2012) to identify n = 258 PNG accidents. Results 79.8% of investigations, and 100% of fatalities, occurred in the construction industry. Between 53–71% of injuries appear to have be... περισσότερα »
Economic consequences of workplace injuries in the United States: Findings from the National Longitudinal Survey of Youth (NLSY79)
Background This study explored economic consequences of work-related injuries using a longitudinal data source. Methods Data were from the National Longitudinal Survey of Youth, 1979 cohort (n = 12,686). Short-term consequences were measured when the injury was reported. "Difference-in-differences" approach was applied to estimate income and wealth disparities between injured and non-injured workers before and after injury. Fixed effects models were used to identify variations over time. Results The annual earnings growth was $3,715 (in 2000 dollars) less for workers with DAFW ...περισσότερα »
Microorganisms, Vol. 4, Pages 2: Influence of pH Regulation Mode in Glucose Fermentation on Product Selection and Process Stability
Mixed culture anaerobic fermentation generates a wide range of products from simple sugars, and is potentially an effective process for producing renewable commodity chemicals. However it is difficult to predict product spectrum, and to control the process. One of the key control handles is pH, but the response is commonly dependent on culture history. In this work, we assess the impact of pH regulation mode on the product spectrum. Two regulation modes were applied: in the first, pH was adjusted from 4.5 to 8.5 in progressive steps of 0.5 and in the second, covered the same pH ra... περισσότερα »
Acute promyelocytic leukemia following solid organ transplantation
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CD34+ highly enriched allogeneic stem cell transplantation in a patient with mixed phenotype acute leukemia and Fusarium solani sepsis
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Sleep disturbances and neurotoxicity in workers exposed to hydrocarbons. An observational study from Algeria
Background Occupational exposure to solvents may lead to neurotoxicity and sleep disturbances. We aimed to investigate the association of occupational exposure to petroleum-derived hydrocarbons with neurotoxicity and sleep disturbance symptoms. Methods We included male workers handling/distributing petroleum products (exposed, n = 250) and electricians (non-exposed, n = 250) from two companies in Tlemcen (Algeria). Neurotoxicity was evaluated with the Q-16 questionnaire, and sleep disturbances with the Epworth and the Berlin questionnaires. Multivariable Poisson regression models... περισσότερα »
Microorganisms, Vol. 4, Pages 1: Microbial Biofilm Community Variation in Flowing Habitats: Potential Utility as Bioindicators of Postmortem Submersion Intervals
Biofilms are a ubiquitous formation of microbial communities found on surfaces in aqueous environments. These structures have been investigated as biomonitoring indicators for stream heath, and here were used for the potential use in forensic sciences. Biofilm successional development has been proposed as a method to determine the postmortem submersion interval (PMSI) of remains because there are no standard methods for estimating the PMSI and biofilms are ubiquitous in aquatic habitats. We sought to compare the development of epinecrotic (biofilms on Sus scrofa domesticus carcass...περισσότερα »
Prognostic value of the inverse platelet to lymphocyte ratio (iPLR) in patients with multiple myeloma who were treated up front with a novel agent-containing regimen
Abstract Recently, reactive thrombosis or platelet to lymphocyte ratio has been reported as a strong predictor of poor prognosis in various types of cancer. However, a study investigating the relationship between platelet counts and thrombopoietic cytokines suggested that low platelet could be important in multiple myeloma (MM), which means platelet count decreased in advanced International Staging System (ISS) stage. Therefore, we developed inverse platelet to lymphocyte ratio (iPLR) and assessed the prognostic value of iPLR in patients with MM. We retrospectively analyzed 283 pat... περισσότερα »
Energies, Vol. 9, Pages 24: Research on Heat Recovery Technology for Reducing the Energy Consumption of Dedicated Ventilation Systems: An Application to the Operating Model of a Laboratory
In this research, the application of heat pipes in the air handler dedicated to decoupling dehumidification from cooling to reduce energy consumption was simulated and investigated by simulations and experimental studies. The cooling load profiles and heat pipes with effectiveness of 0.45 and 0.6, respectively, were evaluated in achieving the desired space conditions and calculated hour by hour. The results demonstrated that for all examined cases, a heat pipe heat exchanger (HPHX) can be used to save over 80% of the energy during the hours of operation of air conditioning. The ov... περισσότερα »
Energies, Vol. 9, Pages 23: Decomposing Industrial Energy-Related CO2 Emissions in Yunnan Province, China: Switching to Low-Carbon Economic Growth
As a less-developed province that has been chosen to be part of a low-carbon pilot project, Yunnan faces the challenge of maintaining rapid economic growth while reducing CO2 emissions. Understanding the drivers behind CO2 emission changes can help decouple economic growth from CO2 emissions. However, previous studies on the drivers of CO2 emissions in less-developed regions that focus on both production and final demand have been seldom conducted. In this study, a structural decomposition analysis-logarithmic mean Divisia index (SDA-LMDI) model was developed to find the drivers b...περισσότερα »
Metals, Vol. 6, Pages 10: In Situ Characterization Techniques Based on Synchrotron Radiation and Neutrons Applied for the Development of an Engineering Intermetallic Titanium Aluminide Alloy
Challenging issues concerning energy efficiency and environmental politics require novel approaches to materials design. A recent example with regard to structural materials is the emergence of lightweight intermetallic TiAl alloys. Their excellent high-temperature mechanical properties, low density and high stiffness constitute a profile perfectly suitable for their application as advanced aero-engine turbine blades or as turbocharger turbine wheels in next-generation automotive engines. As the properties of TiAl alloys during processing as well as during service are dependent on ... περισσότερα »
Universal strategy for visual chiral recognition of [small alpha]-amino acids with L-tartaric acidcapped gold nanoparticles as colorimetric probes
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02434J, Paper Baoxin Li, Guoxin Song, fulin zhou, Chunli Xu Abstract: The ability to recognize and quantify the chirality of alpha-amino acids constitutes the basis of many critical areas for specific targeting in drug development and metabolite probing. It is... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1PHHbNa Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Sustainability, Vol. 8, Pages 37: VIKOR Technique: A Systematic Review of the State of the Art Literature on Methodologies and Applications
The main objective of this paper is to present a systematic review of the VlseKriterijuska Optimizacija I Komoromisno Resenje (VIKOR) method in several application areas such as sustainability and renewable energy. This study reviewed a total of 176 papers, published in 2004 to 2015, from 83 high-ranking journals; most of which were related to Operational Research, Management Sciences, decision making, sustainability and renewable energy and were extracted from the "Web of Science and Scopus" databases. Papers were classified into 15 main application areas. Furthermore, papers were...περισσότερα »
JCM, Vol. 5, Pages 5: An Overview of Insulin Pumps and Glucose Sensors for the Generalist
Continuous subcutaneous insulin, or the insulin pump, has gained popularity and sophistication as a near-physiologic programmable method of insulin delivery that is flexible and lifestyle-friendly. The introduction of continuous monitoring with glucose sensors provides unprecedented access to, and prediction of, a patient's blood glucose levels. Efforts are underway to integrate the two technologies, from "sensor-augmented" and "sensor-driven" pumps to a fully-automated and independent sensing-and-delivery system. Implantable pumps and an early-phase "bionic pancreas" are also in ...περισσότερα »
IJMS, Vol. 17, Pages 59: Binding of Sulpiride to Seric Albumins
The aim of this work was to study the interaction of sulpiride with human serum albumin (HSA) and bovine serum albumin (BSA) through the fluorescence quenching technique. As sulpiride molecules emit fluorescence, we have developed a simple mathematical model to discriminate the quencher fluorescence from the albumin fluorescence in the solution where they interact. Sulpiride is an antipsychotic used in the treatment of several psychiatric disorders. We selectively excited the fluorescence of tryptophan residues with 290 nm wavelength and observed the quenching by titrating HSA and...περισσότερα »
Ion Mobility Mass Spectrometry of Peptide, Protein, and Protein Complex Ions using a Radio-Frequency Confining Drift Cell
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02107C, Paper Samuel J. Allen, Kevin Giles, Tony Gilbert, Matthew F. Bush Ion mobility mass spectrometry experiments enable the characterization of mass, assembly, and shape of biological molecules and assemblies. Here, a new radio-frequency confining drift cell is characterized and used to... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1OFGe2M via IFTTT
Energies, Vol. 9, Pages 24: Research on Heat Recovery Technology for Reducing the Energy Consumption of Dedicated Ventilation Systems: An Application to the Operating Model of a Laboratory
In this research, the application of heat pipes in the air handler dedicated to decoupling dehumidification from cooling to reduce energy consumption was simulated and investigated by simulations and experimental studies. The cooling load profiles and heat pipes with effectiveness of 0.45 and 0.6, respectively, were evaluated in achieving the desired space conditions and calculated hour by hour. The results demonstrated that for all examined cases, a heat pipe heat exchanger (HPHX) can be used to save over 80% of the energy during the hours of operation of air conditioning. The ov... περισσότερα »
Energies, Vol. 9, Pages 23: Decomposing Industrial Energy-Related CO2 Emissions in Yunnan Province, China: Switching to Low-Carbon Economic Growth
As a less-developed province that has been chosen to be part of a low-carbon pilot project, Yunnan faces the challenge of maintaining rapid economic growth while reducing CO2 emissions. Understanding the drivers behind CO2 emission changes can help decouple economic growth from CO2 emissions. However, previous studies on the drivers of CO2 emissions in less-developed regions that focus on both production and final demand have been seldom conducted. In this study, a structural decomposition analysis-logarithmic mean Divisia index (SDA-LMDI) model was developed to find the drivers b...περισσότερα »
Metals, Vol. 6, Pages 10: In Situ Characterization Techniques Based on Synchrotron Radiation and Neutrons Applied for the Development of an Engineering Intermetallic Titanium Aluminide Alloy
Challenging issues concerning energy efficiency and environmental politics require novel approaches to materials design. A recent example with regard to structural materials is the emergence of lightweight intermetallic TiAl alloys. Their excellent high-temperature mechanical properties, low density and high stiffness constitute a profile perfectly suitable for their application as advanced aero-engine turbine blades or as turbocharger turbine wheels in next-generation automotive engines. As the properties of TiAl alloys during processing as well as during service are dependent on ... περισσότερα »
Microorganisms, Vol. 4, Pages 1: Microbial Biofilm Community Variation in Flowing Habitats: Potential Utility as Bioindicators of Postmortem Submersion Intervals
Biofilms are a ubiquitous formation of microbial communities found on surfaces in aqueous environments. These structures have been investigated as biomonitoring indicators for stream heath, and here were used for the potential use in forensic sciences. Biofilm successional development has been proposed as a method to determine the postmortem submersion interval (PMSI) of remains because there are no standard methods for estimating the PMSI and biofilms are ubiquitous in aquatic habitats. We sought to compare the development of epinecrotic (biofilms on Sus scrofa domesticus carcass...περισσότερα »
Microorganisms, Vol. 4, Pages 2: Influence of pH Regulation Mode in Glucose Fermentation on Product Selection and Process Stability
Mixed culture anaerobic fermentation generates a wide range of products from simple sugars, and is potentially an effective process for producing renewable commodity chemicals. However it is difficult to predict product spectrum, and to control the process. One of the key control handles is pH, but the response is commonly dependent on culture history. In this work, we assess the impact of pH regulation mode on the product spectrum. Two regulation modes were applied: in the first, pH was adjusted from 4.5 to 8.5 in progressive steps of 0.5 and in the second, covered the same pH ra... περισσότερα »
Microorganisms, Vol. 4, Pages 3: In Silico Analysis of a Novel Plasmid from the Coral Pathogen Vibrio coralliilyticus Reveals Two Potential “Ecological Islands”
As virulence often correlates with the presence of plasmid replicons in several Vibrio spp., this study investigated whether non-chromosomal DNA could be found in the coral pathogen, Vibrio coralliilyticus BAA-450. A circular plasmid, 26,631 bp in size, was identified. DNA sequence analysis indicated that the plasmid contained 30 open reading frames, six tRNA genes, 12 inverted repeats, three direct repeats and presented no continuous sequence identity to other replicons within the database. Consequently, these findings indicate that this is a novel, previously unidentified, plasm... περισσότερα »
Metals, Vol. 6, Pages 9: In situ Investigation of Titanium Powder Microwave Sintering by Synchrotron Radiation Computed Tomography
In this study, synchrotron radiation computed tomography was applied to investigate the mechanisms of titanium powder microwave sintering in situ. On the basis of reconstructed images, we observed that the sintering described in this study differs from conventional sintering in terms of particle smoothing, rounding, and short-term growth. Contacted particles were also isolated. The kinetic curves of sintering neck growth and particle surface area were obtained and compared with those of other microwave-sintered metals to examine the interaction mechanisms between mass and microwav... περισσότερα »
Metals, Vol. 6, Pages 11: Influence of Loading Rate on the Hydrogen-Assisted Micro-Damage in Bluntly Notched Samples of Pearlitic Steel
The influence of loading rate (crosshead speed) on the fracture process of bluntly notched samples of pearlitic steel under hydrogen environment is analyzed in this paper. Results indicate that the location of the zone where fracture initiates (fracture process zone) in pearlitic steel samples with a blunt notch directly depends on the loading rate or crosshead speed. For slow testing rates, such a zone is placed in the specimen center due to hydrogen diffusion towards the prospective fracture places located in the central area of the section. On the other hand, in the case of high... περισσότερα »
Reproducibility of SNV-calling in multiple sequencing runs from single tumors
We examined 55 technical sequencing replicates of Glioblastoma multiforme (GBM) tumors from The Cancer Genome Atlas (TCGA) to ascertain the degree of repeatability in calling single-nucleotide variants (SNVs). We used the same mutation-calling pipeline on all pairs of samples, and we measured the extent of the overlap between two replicates; that is, how many specific point mutations were found in both replicates. We further tested whether additional filtering increased or decreased the size of the overlap. We found that about half of the putative mutations identified in one seque... περισσότερα »
Disruption of de novo purine biosynthesis in Pseudomonas fluorescens Pf0-1 leads to reduced biofilm formation and a reduction in cell size of surface-attached but not planktonic cells
Pseudomonas fluorescens Pf0-1 is one of the model organisms for biofilm research. Our previous transposon mutagenesis study suggested a requirement for the de novo purine nucleotide biosynthesis pathway for biofilm formation by this organism. This study was performed to verify that observation and investigate the basis for the defects in biofilm formation shown by purine biosynthesis mutants. Constructing deletion mutations in 8 genes in this pathway, we found that they all showed reductions in biofilm formation that could be partly or completely restored by nucleotide supplementa...περισσότερα »
Does suicidal desire moderate the association between frontal delta power and psychological pain?
Psychological pain frequently underlies thoughts of suicide. We investigated if recent suicidal desire moderated the association between potential neurophysiological markers and psychological pain assessed on the Psychache Scale (PS) and the Orbach & Mikulincer Mental Pain Questionnaire (OMMP). The OMMP specifically assesses current psychological pain that may more readily capture emotions present during recent suicidal desire. In contrast, the PS leaves the timeframe undefined. A secondary analysis was conducted of resting-state EEG data and heart rate obtained in adults with a h... περισσότερα »
Real-life experience with personally familiar faces enhances discrimination based on global information
Despite the agreement that experience with faces leads to more efficient processing, the underlying mechanisms remain largely unknown. Building on empirical evidence from unfamiliar face processing in healthy populations and neuropsychological patients, the present experiment tested the hypothesis that personal familiarity is associated with superior discrimination when identity information is derived based on global, as opposed to local facial information. Diagnosticity and availability of local and global information was manipulated through varied physical similarity and spatial...περισσότερα »
The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo
Telomerase core enzyme minimally consists of the telomerase reverse transcriptase domain-containing protein (Est2 in budding yeast S. cerevisiae) and telomerase RNA, which contains the template specifying the telomeric repeat sequence synthesized. Here we report that in vivo, a fraction of S. cerevisiae telomerase RNA (TLC1) molecules form complexes containing at least two molecules of TLC1, via two separable modes: one requiring a sequence in the 3′ region of the immature TLC1 precursor and the other requiring Ku and Sir4. Such physical TLC1-TLC1 association peaked in G1 phase an... περισσότερα »
First steps of bipedality in hominids: evidence from the atelid and proconsulid pelvis
Upright walking absent a bent-hip-bent-knee gait requires lumbar lordosis, a ubiquitous feature in all hominids for which it can be observed. Its first appearance is therefore a central problem in human evolution. Atelids, which use the tail during suspension, exhibit demonstrable lordosis and can achieve full extension of their hind limbs during terrestrial upright stance. Although obviously homoplastic with hominids, the pelvic mechanisms facilitating lordosis appear largely similar in both taxa with respect to abbreviation of upper iliac height coupled with broad sacral alae. B... περισσότερα »
Goodness of fit to a mathematical model for Drosophila sleep behavior is reduced in hyposomnolent mutants
The conserved nature of sleep in Drosophila has allowed the fruit fly to emerge in the last decade as a powerful model organism in which to study sleep. Recent sleep studies in Drosophila have focused on the discovery and characterization of hyposomnolent mutants. One common feature of these animals is a change in sleep architecture: sleep bout count tends to be greater, and sleep bout length lower, in hyposomnolent mutants. I propose a mathematical model, produced by least-squares nonlinear regression to fit the form Y = aX∧b, which can explain sleep behavior in the healthy animal...περισσότερα »
Lemmas induce dormancy but help the seed of Leymus chinensis to resist drought and salinity conditions in Northeast China
Leymus chinensis is a dominant grass in the Songnen grassland of Northern China. The lower germination caused by the presence of lemmas has proved to be an obstacle for the use of the seeds of this plant by humans. However, it is still unknown if the lemmas have other ecological roles such as resisting drought and saline conditions. Three experiments were designed to investigate the ecological roles of the lemmas in Leymus chinensis seeds. The results showed that lemmas significantly improved the amount of water uptake and slowed down the dehydration rate of the seeds under dry co...περισσότερα »
Odd versus even: a scientific study of the ‘rules’ of plating
We report on the results of a series of large-scale computer-based preference tests (conducted at The Science Museum in London and online) that evaluated the widely-held belief that food should be plated in odd rather than even numbers of elements in order to maximize the visual appeal of a dish. Participants were presented with pairs of plates of food showing odd versus even number of seared scallops (3 vs. 4; 1–6 in Experiment 7), arranged in a line, as a polygon or randomly, on either a round or square white plate. No consistent evidence for a preference for odd or even numbers... περισσότερα »
Nutrients, Vol. 8, Pages 6: DHA Effects in Brain Development and Function
Docosahexaenoic acid (DHA) is a structural constituent of membranes specifically in the central nervous system. Its accumulation in the fetal brain takes place mainly during the last trimester of pregnancy and continues at very high rates up to the end of the second year of life. Since the endogenous formation of DHA seems to be relatively low, DHA intake may contribute to optimal conditions for brain development. We performed a narrative review on research on the associations between DHA levels and brain development and function throughout the lifespan. Data from cell and animal ... περισσότερα »
Nutrients, Vol. 8, Pages 7: Maternal Nutrition and Glycaemic Index during Pregnancy Impacts on Offspring Adiposity at 6 Months of Age—Analysis from the ROLO Randomised Controlled Trial
Childhood obesity is associated with increased risk of adult obesity and metabolic disease. Diet and lifestyle in pregnancy influence fetal programming; however the influence of specific dietary components, including low glycaemic index (GI), remains complex. We examined the effect of a maternal low GI dietary intervention on offspring adiposity at 6 months and explored the association between diet and lifestyle factors in pregnancy and infant body composition at 6 months. 280 6-month old infant and mother pairs from the control (n = 142) and intervention group (n = 138), who rece... περισσότερα »
Nutrients, Vol. 8, Pages 25: High Fat Diet Administration during Specific Periods of Pregnancy Alters Maternal Fatty Acid Profiles in the Near-Term Rat
Excessive fat intake is a global health concern as women of childbearing age increasingly ingest high fat diets (HFDs). We therefore determined the maternal fatty acid (FA) profiles in metabolic organs after HFD administration during specific periods of gestation. Rats were fed a HFD for the first (HF1), second (HF2), or third (HF3) week, or for all three weeks (HFG) of gestation. Total maternal plasma non-esterified fatty acid (NEFA) concentrations were monitored throughout pregnancy. At day 20 of gestation, maternal plasma, liver, adipose tissue, and placenta FA profiles were de... περισσότερα »
Nutrients, Vol. 8, Pages 10: Altered Preconception Fatty Acid Intake Is Associated with Improved Pregnancy Rates in Overweight and Obese Women Undertaking in Vitro Fertilisation
Maternal preconception diet is proposed to affect fertility. Prior research assessing the effect of altering the fatty acid profile on female fertility is conflicting. The aim of this study was to assess the effect of preconception maternal diet, specifically fatty acid profile, on pregnancies and live births following in vitro fertilisation (IVF). Forty-six overweight and obese women undergoing IVF were randomised to a diet and physical activity intervention (intervention) or standard care (control). Outcome measures included pregnancy, live birth and pre-study dietary intake fro... περισσότερα »
Nutrients, Vol. 8, Pages 37: Effect of Glycemic Index of Breakfast on Energy Intake at Subsequent Meal among Healthy People: A Meta-Analysis
Meals with low glycemic index (GI) may suppress short-term appetite and reduce subsequent food intake compared with high-GI meals. However, no meta-analysis has been conducted to synthesize the evidence. This meta-analytic study was conducted to assess the effect of high- and low-GI breakfast on subsequent short-term food intake. Trials were identified through MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled trials, and manual searches of bibliographies until May 2015. Randomized controlled and cross-over trials comparing the effect of low- with high-GI...περισσότερα »
Nutrients, Vol. 8, Pages 14: Rise in DPA Following SDA-Rich Dietary Echium Oil Less Effective in Affording Anti-Arrhythmic Actions Compared to High DHA Levels Achieved with Fish Oil in Sprague-Dawley Rats
Stearidonic acid (SDA; C18:4n-3) has been suggested as an alternative to fish oil (FO) for delivering health benefits of C ≥ 20 long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFA). Echium oil (EO) represents a non-genetically-modified source of SDA available commercially. This study compared EO and FO in relation to alterations in plasma and tissue fatty acids, and for their ability to afford protection against ischemia-induced cardiac arrhythmia and ventricular fibrillation (VF). Rats were fed (12 weeks) diets supplemented with either EO or FO at three dose levels (1, 3 and ... περισσότερα »
Nutrients, Vol. 8, Pages 24: Significant Beneficial Association of High Dietary Selenium Intake with Reduced Body Fat in the CODING Study
Selenium (Se) is a trace element which plays an important role in adipocyte hypertrophy and adipogenesis. Some studies suggest that variations in serum Se may be associated with obesity. However, there are few studies examining the relationship between dietary Se and obesity, and findings are inconsistent. We aimed to investigate the association between dietary Se intake and a panel of obesity measurements with systematic control of major confounding factors. A total of 3214 subjects participated in the study. Dietary Se intake was determined from the Willett food frequency questi... περισσότερα »
Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome
Abstract Myelodysplastic syndromes (MDSs) are heterogeneous hematopoietic disease characterized by ineffective haematopoiesis that frequently transforms into acute leukaemia. Alterations in many individual biologic pathways have been reported in MDS pathophysiology. Disease progression along the MDS, acute myeloid leukemia (AML) continuum is believed to be a consequence of stepwise accumulation of DNA mutations which infers a defect in DNA repair. The present study investigated the association between DNA repair genes (XRCC1, XRCC3, OGG1, XPD and RAD51) and the risk of developing M... περισσότερα »
Can iron overload in patients with lower-risk myelodysplastic syndromes be reduced using erythropoiesis-stimulating agents?
Abstract Iron overload (IOL) portends inferior outcome in myelodysplastic syndromes (MDS). Erythropoiesis-stimulating agents (ESA) may reduce red blood cell transfusion requirements. MDS patients receiving ESA were reviewed for characteristics, response to ESA by International Working Group 2006 criteria and ferritin levels. Forty-nine patients received an ESA, had ferritin levels available, and were not receiving iron chelation therapy. Baseline characteristics were not significantly different between ESA responders (ER) and non-responders (ENR; *P* = NS). The median ESA treatmen...περισσότερα »
PulmCrit- Ultrasound-assisted thrombolysis of PE works. The question is, why?
[image: inception.gif?resize=750%2C204] Ultrasound-assisted catheter-directed thrombolysis is increasingly popular for submassive PE. Unfortunately, the actual mechanism of action of this therapy remains unclear. EMCrit by Josh Farkas. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1RZmvll via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Z0GxuH via IFTTT
Screening for viral hepatitis prior to rituximab chemotherapy
Abstract In 2008, the CDC published guidelines recommending screening of all persons undergoing treatment with rituximab to identify persons at risk of hepatitis B virus (HBV) reactivation. We evaluated implementation of this recommendation in veterans, who are at increased risk of HBV, and determined characteristics of those screened. We also evaluated a control setting, rates of hepatitis C virus (HCV) screening among the same rituximab-treated patients. There are no guidelines that recommend HCV screening prior to initiation of rituximab. Medical records of patients receiving r... περισσότερα »
Universal strategy for visual chiral recognition of [small alpha]-amino acids with L-tartaric acidcapped gold nanoparticles as colorimetric probes
[image: CrossMark.jpg] *Analyst*, 2016, Accepted Manuscript *DOI*: 10.1039/C5AN02434J, Paper Baoxin Li, Guoxin Song, fulin zhou, Chunli Xu Abstract: The ability to recognize and quantify the chirality of alpha-amino acids constitutes the basis of many critical areas for specific targeting in drug development and metabolite probing. It is... The content of this RSS Feed (c) The Royal Society of Chemistry from #Medicine via ola Kala on Inoreader http://ift.tt/1PHHbNa via IFTTT
Microorganisms, Vol. 4, Pages 1: Microbial Biofilm Community Variation in Flowing Habitats: Potential Utility as Bioindicators of Postmortem Submersion Intervals
Biofilms are a ubiquitous formation of microbial communities found on surfaces in aqueous environments. These structures have been investigated as biomonitoring indicators for stream heath, and here were used for the potential use in forensic sciences. Biofilm successional development has been proposed as a method to determine the postmortem submersion interval (PMSI) of remains because there are no standard methods for estimating the PMSI and biofilms are ubiquitous in aquatic habitats. We sought to compare the development of epinecrotic (biofilms on Sus scrofa domesticus carcass...περισσότερα »
Erratum to: Efficacy of Transcatheter Arterial Chemoembolization Followed by Sorafenib for Intermediate/Advanced Hepatocellular Carcinoma in Patients in Japan: A Retrospective Analysis
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1OGc1qv via IFTTT
Fatal traumatic brain injuries in the construction industry, 2003−2010
Background Research on fatal work-related traumatic brain injuries (TBIs) is limited. This study describes fatal TBIs in the US construction industry. Methods Fatal TBIs were extracted from the Bureau of Labor Statistics Census of Fatal Occupational Injuries. Results From 2003 to 2010, 2,210 fatal TBIs occurred in construction at a rate of 2.6 per 100,000… Continue reading Fatal traumatic brain injuries in the construction industry, 2003−2010
Extra-nodal natural killer/T cell lymphoma in elderly patients: the impact of aging on clinical outcomes and treatment tolerability
Abstract Extra-nodal natural killer/T cell lymphoma (ENKTL) is rare in elderly patients, and its clinical course is unclear. The efficacy and tolerability of non-anthracycline-based treatments as a standard regimen in elderly patients have not been fully investigated. This study assessed the impact of aging on clinical outcomes and treatment tolerability. We retrospectively analyzed 51 patients… Continue reading Extra-nodal natural killer/T cell lymphoma in elderly patients: the impact of aging on clinical outcomes and treatment tolerability
A case of MYH9 disorders caused by a novel mutation (p.K74E)
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1O02J5e via IFTTT
Authors’ response to letter to editor
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1kEMQq6 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1VBb5Dj via IFTTT
Mortality among World Trade Center rescue and recovery workers, 2002–2011
Background Rescue and recovery workers responding to the 2001 collapse of the World Trade Center (WTC) sustained exposures to toxic chemicals and have elevated rates of multiple morbidities. Methods Using data from the World Trade Center Health Program and the National Death Index for 2002–2011, we examined standardized mortality ratios (SMR) and proportional cancer mortality… Continue reading Mortality among World Trade Center rescue and recovery workers, 2002–2011
Cold antibody autoimmune haemolytic anaemia in a child with diffuse large B cell lymphoma
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Rlff1p via IFTTT
Serious injury and fatality investigations involving pneumatic nail guns, 1985–2012
Background This article examines serious and fatal pneumatic nail gun (PNG) injury investigations for workplace, tool design, and human factors relevant to causation and resulting OS&H authorities’ responses in terms of citations and penalties. Methods The U.S. Occupational Safety and Health Administration (OSHA) database of Fatality and Catastrophe Investigation Summaries (F&CIS) were reviewed (1985–2012) to… Continue reading Serious injury and fatality investigations involving pneumatic nail guns, 1985–2012
Enigmatic meningitis in a patient with T cell lymphoma
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Rlfh9w via IFTTT
Economic consequences of workplace injuries in the United States: Findings from the National Longitudinal Survey of Youth (NLSY79)
Background This study explored economic consequences of work-related injuries using a longitudinal data source. Methods Data were from the National Longitudinal Survey of Youth, 1979 cohort (n = 12,686). Short-term consequences were measured when the injury was reported. “Difference-in-differences” approach was applied to estimate income and wealth disparities between injured and non-injured workers before and after injury.… Continue reading Economic consequences of workplace injuries in the United States: Findings from the National Longitudinal Survey of Youth (NLSY79)
Acute promyelocytic leukemia following solid organ transplantation
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
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Association of XPD (Lys751Gln) and XRCC1 (Arg280His) gene polymorphisms in myelodysplastic syndrome
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Myelodysplastic syndromes (MDSs) are heterogeneous hematopoietic disease characterized by ineffective haematopoiesis that frequently transforms into acute leukaemia. Alterations in many individual biologic pathways have been reported in MDS pathophysiology. Disease progression along the MDS, acute myeloid leukemia (AML) continuum is believed to be a consequence of stepwise accumulation of DNA mutations which infers a […]
Prognostic value of the inverse platelet to lymphocyte ratio (iPLR) in patients with multiple myeloma who were treated up front with a novel agent-containing regimen
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Recently, reactive thrombosis or platelet to lymphocyte ratio has been reported as a strong predictor of poor prognosis in various types of cancer. However, a study investigating the relationship between platelet counts and thrombopoietic cytokines suggested that low platelet could be important in multiple myeloma (MM), which means platelet count decreased in advanced International […]
Global Head and Neck Cancer Pipeline Review H1 2015 – RD News Mag
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Global Head and Neck Cancer Pipeline Review H1 2015 RD News Mag AcuteMarketReports.com has announced the addition of “Global Head and Neck Cancer Pipeline Review H1 2015 “Market Research Report to their Database. The ‘Head and Neck Cancer – Pipeline Review, H1 2015′, provides an overview of the Head and … and more » from […]
Kjempecellearteritt
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
En mann i 60-årene oppsøkte legevakt grunnet forbigående synstap på venstre øye. from #AlexandrosSfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OFkXWR via IFTTT
Redox-Responsive Nanophotosensitizer Composed of Chlorin e6-Conjugated Dextran for Photodynamic Treatment of Colon Cancer Cells
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
We synthesized dextran-chlorin e6 conjugates having disulfide linkage for specific targeting of colonic region and cancer cells. Reductive end group of dextran was treated with sodium borocyanohydride and conjugated with cystamine. Cystamine end group was conjugated with carboxylic acid of chlorin e6 (DEX6ss). DEX6ss conjugates were formed as spherical nanoparticles with small sizes less than […]
Rare Case of Methemoglobinemia Complicating Pregnancy
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A patient at 38 weeks of gestation when taken for emergency cesarean section had her oxygen saturation of 66 to 70% (by saturation probe on monitor) in operation theatre. She was otherwise asymptomatic but her oxygen saturation was persistently low on the monitors. Her arterial blood gas analysis showed all parameters to be normal. Her […]
Effects of Polyphenol, Measured by a Biomarker of Total Polyphenols in Urine, on Cardiovascular Risk Factors After a Long-Term Follow-Up in the PREDIMED Study
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Several epidemiological studies have shown an inverse association between the consumption of polyphenol-rich foods and risk of cardiovascular diseases. However, accuracy and reliability of these studies may be increased using urinary total polyphenol excretion (TPE) as a biomarker for total polyphenol intake. Our aim was to assess if antioxidant activity, measured by a Folin-Ciocalteu assay […]
Unbalanced Threshold Based Distributed Data Collection Scheme in Multisink Wireless Sensor Networks
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In multisink wireless sensor networks, synchronized data collection among multiple sinks is a significant and challenging task. In this paper, we propose an unbalanced threshold based distributed data collection scheme to reconstruct the synchronized sensed data of the whole sensor network in all sinks. The proposed scheme includes the unbalanced threshold based distributed top- query […]
A 27-Year-Old Severely Immunosuppressed Female with Misleading Clinical Features of Disseminated Cutaneous Sporotrichosis
sfakianakisdiseasesστοHuman Diseases Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Sporotrichosis is a subacute or chronic granulomatous mycosis caused by fungus of the Sporothrix schenckii complex. It is considered to be a rare condition in most parts of the world. It mostly causes cutaneous infection but can also cause multisystemic disease. Unlike most deep cutaneous mycoses which have a primary pulmonary focus, it is usually […]
Microorganisms, Vol. 4, Pages 2: Influence of pH Regulation Mode in Glucose Fermentation on Product Selection and Process Stability
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Mixed culture anaerobic fermentation generates a wide range of products from simple sugars, and is potentially an effective process for producing renewable commodity chemicals. However it is difficult to predict product spectrum, and to control the process. One of the key control handles is pH, but the response is commonly dependent on culture history. In […]
Microorganisms, Vol. 4, Pages 1: Microbial Biofilm Community Variation in Flowing Habitats: Potential Utility as Bioindicators of Postmortem Submersion Intervals
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Biofilms are a ubiquitous formation of microbial communities found on surfaces in aqueous environments. These structures have been investigated as biomonitoring indicators for stream heath, and here were used for the potential use in forensic sciences. Biofilm successional development has been proposed as a method to determine the postmortem submersion interval (PMSI) of remains because […]
Microorganisms, Vol. 4, Pages 3: In Silico Analysis of a Novel Plasmid from the Coral Pathogen Vibrio coralliilyticus Reveals Two Potential “Ecological Islands”
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
As virulence often correlates with the presence of plasmid replicons in several Vibrio spp., this study investigated whether non-chromosomal DNA could be found in the coral pathogen, Vibrio coralliilyticus BAA-450. A circular plasmid, 26,631 bp in size, was identified. DNA sequence analysis indicated that the plasmid contained 30 open reading frames, six tRNA genes, 12 […]
Activation of complement following total hip replacement
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract The aim of this study was to investigate if complement activation, via the classical and alternative pathways, occurs following a cemented total hip replacement surgery (THR) due to osteoarthritis. Blood samples were collected systematically from 12 patients; six male/six female; 75 years of age (range 59-90 years), preoperatively, six hours postoperatively and on the […]
Nutrients, Vol. 8, Pages 15: Greater Total Antioxidant Capacity from Diet and Supplements Is Associated with a Less Atherogenic Blood Profile in U.S. Adults
Evidence from epidemiologic studies has shown that total antioxidant capacity (TAC) in the diet might be inversely associated with stroke, heart failure, and inflammatory biomarkers. However, studies on the association of TAC from both diet and supplements with cardiovascular disease (CVD) risk factors in the U.S. population are lacking. This cross-sectional population-based study aimed to investigate the association of TAC with both diet and supplements with CVD risk factors among 4039 U.S. adults in National Health and Nutrition Examination Survey (NHANES) 2007–2012. TAC from bo...περισσότερα »
Nutrients, Vol. 8, Pages 2: Individuals with Metabolically Healthy Overweight/Obesity Have Higher Fat Utilization than Metabolically Unhealthy Individuals
The mechanisms underlying the change in phenotype from metabolically healthy to metabolically unhealthy obesity are still unclear. The aim of this study is to investigate whether a difference in fasting fat utilization exists between overweight/obese individuals with a favorable cardiovascular risk profile and those with Metabolic Syndrome and Type 2 diabetes. Furthermore, we sought to explore whether there is an association between fasting fat utilization and insulin resistance. In this cross-sectional study, 172 overweight/obese individuals underwent a nutritional assessment. Th... περισσότερα »
Nutrients, Vol. 8, Pages 4: Plasma Free Amino Acid Responses to Intraduodenal Whey Protein, and Relationships with Insulin, Glucagon-Like Peptide-1 and Energy Intake in Lean Healthy Men
This study determined the effects of increasing loads of intraduodenal (ID) dairy protein on plasma amino acid (AA) concentrations, and their relationships with serum insulin, plasma glucagon-like peptide-1 (GLP-1) and energy intake. Sixteen healthy men had concentrations of AAs, GLP-1 and insulin measured in response to 60-min ID infusions of hydrolysed whey protein administered, in double-blinded and randomised order, at 2.1 (P2.1), 6.3 (P6.3) or 12.5 (P12.5) kJ/min (encompassing the range of nutrient emptying from the stomach), or saline control (C). Energy intake was quantifie...περισσότερα »
Nutrients, Vol. 8, Pages 23: Fatty Acid Desaturases, Polyunsaturated Fatty Acid Regulation, and Biotechnological Advances
Polyunsaturated fatty acids (PUFAs) are considered to be critical nutrients to regulate human health and development, and numerous fatty acid desaturases play key roles in synthesizing PUFAs. Given the lack of delta-12 and -15 desaturases and the low levels of conversion to PUFAs, humans must consume some omega-3 and omega-6 fatty acids in their diet. Many studies on fatty acid desaturases as well as PUFAs have shown that fatty acid desaturase genes are closely related to different human physiological conditions. Since the first front-end desaturases from cyanobacteria were cloned...περισσότερα »
Sika Deer Antler Collagen Type I-Accelerated Osteogenesis in Bone Marrow Mesenchymal Stem Cells via the Smad Pathway
Deer antler preparations have been used to strengthen bones for centuries. It is particularly rich in collagen type I. This study aimed to unravel part of the purported bioremedial effect of Sika deer antler collagen type I (SDA-Col I) on bone marrow mesenchymal stem cells. The results suggest that SDA-Col I might be used to promote and regulate osteoblast proliferation and differentiation. SDA-Col I might potentially provide the basis for novel therapeutic strategies in the treatment of bone injury and/or in scaffolds for bone replacement strategies. Finally, isolation of SDA-Col... περισσότερα »
Establishment of a Rat Adjuvant Arthritis-Interstitial Lung Disease Model
Introduction. Development of an animal model of rheumatoid arthritis-interstitial lung disease (RA-ILD) and improved knowledge of the pathogenesis of RA-ILD may facilitate earlier diagnosis and the development of more effective targeted therapies. Methods. Adult male Wistar rats were studied in an adjuvant arthritis (AA) model induced by the injection of Freund's complete adjuvant (FCA). Rats were sacrificed on days 7, 14, 21, and 28 after FCA injection. Lung tissue was obtained for histopathological examination and evaluation of Caveolin-1 (Cav-1) and transforming growth factor-β...περισσότερα »
Reproducibility of SNV-calling in multiple sequencing runs from single tumors
We examined 55 technical sequencing replicates of Glioblastoma multiforme (GBM) tumors from The Cancer Genome Atlas (TCGA) to ascertain the degree of repeatability in calling single-nucleotide variants (SNVs). We used the same mutation-calling pipeline on all pairs of samples, and we measured the extent of the overlap between two replicates; that is, how many specific point mutations were found in both replicates. We further tested whether additional filtering increased or decreased the size of the overlap. We found that about half of the putative mutations identified in one seque... περισσότερα »
Disruption of de novo purine biosynthesis in Pseudomonas fluorescens Pf0-1 leads to reduced biofilm formation and a reduction in cell size of surface-attached but not planktonic cells
Pseudomonas fluorescens Pf0-1 is one of the model organisms for biofilm research. Our previous transposon mutagenesis study suggested a requirement for the de novo purine nucleotide biosynthesis pathway for biofilm formation by this organism. This study was performed to verify that observation and investigate the basis for the defects in biofilm formation shown by purine biosynthesis mutants. Constructing deletion mutations in 8 genes in this pathway, we found that they all showed reductions in biofilm formation that could be partly or completely restored by nucleotide supplementa...περισσότερα »
Does suicidal desire moderate the association between frontal delta power and psychological pain?
Psychological pain frequently underlies thoughts of suicide. We investigated if recent suicidal desire moderated the association between potential neurophysiological markers and psychological pain assessed on the Psychache Scale (PS) and the Orbach & Mikulincer Mental Pain Questionnaire (OMMP). The OMMP specifically assesses current psychological pain that may more readily capture emotions present during recent suicidal desire. In contrast, the PS leaves the timeframe undefined. A secondary analysis was conducted of resting-state EEG data and heart rate obtained in adults with a h... περισσότερα »
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