Chronic pain may be linked to genetic changes in the immune system
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Chronic pain following injury may involve epigenetic changes, implying a potential future role for medications that target specific genes. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PPn417 via IFTTT
Neural networks adapt to the presence of a toxic HIV protein
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
HIV-associated neurocognitive disorders (HAND) afflict approximately half of HIV infected patients.Nearly half of HIV infected patients suffer from impaired neurocognitive function. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PPmUGX via IFTTT
Practice makes perfect, York U brain study confirms
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
In this study, Faculty of Health researchers were looking at fMRI brain scans of professional ballet dancers to measure the long-term effects of learning. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1nYiTnf via IFTTT
UTEP professor shows that hearing aids improve memory, speech
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
A recent study by Jamie Desjardins, Ph.D., an assistant professor in the speech-language pathology program at The University of Texas at El Paso, found that hearing aids improve brain function in… from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1Q6rURH via IFTTT
Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Polycomb repressive complexes PRC1 and PRC2 regulate expression of genes involved in proliferation and development. In mouse early embryos, however, canonical PRC1 localizes to paternal pericentric heterochromatin (pat-PCH), where it represses transcription of major satellite repeats. In contrast, maternal PCH (mat-PCH) is enriched for H3 lysine 9 tri-methylation (H3K9me3) and Hp1β. How PRC1 is targeted […]
Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Polycomb repressive complexes PRC1 and PRC2 regulate expression of genes involved in proliferation and development. In mouse early embryos, however, canonical PRC1 localizes to paternal pericentric heterochromatin (pat-PCH), where it represses transcription of major satellite repeats. In contrast, maternal PCH (mat-PCH) is enriched for H3 lysine 9 tri-methylation (H3K9me3) and Hp1β. How PRC1 is targeted […]
Clinical features and outcomes of delayed facial palsy after head trauma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 δευτερόλεπτα
Publication date: Available online 1 February 2016 Source:Auris Nasus Larynx Author(s): Qiang Li, Yanfei Jia, Qian Feng, Bo Tang, Naili Wei, Yinian Zhang, Yefeng Li, Xuanfen Zhang ObjectiveTo investigate clinical features and outcomes of delayed facial palsy after head trauma.MethodsThe cases who had delayed facial palsy after head trauma treated from March 2008 to March […]
Scuba Diving After Extensive Head and Neck Reconstructive Surgery: Is it Possible?.
Scuba Diving After Extensive Head and Neck Reconstructive Surgery: Is it Possible?
Endoscopic Sinus Surgery in Sinus-Oral Pathology.
Endoscopic Sinus Surgery in Sinus-Oral Pathology
Neonatal hyperbilirubinaemia
Paediatrics and Child Health from #Medicine via ola Kala on Inoreader http://ift.tt/1SwD2Ml Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Daclatasvir, sofosbuvir, and ribavirin for hepatitis C virus genotype 3 and advanced liver disease: A randomized phase III study (ALLY-3+)
Hepatology from #Medicine via ola Kala on Inoreader http://ift.tt/1nz8nm2 Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Significant intratumoral heterogeneity of HER2 status in gastric cancer: A comparative study among IHC, FISH, and DISH
Cancer Science from #Medicine via ola Kala on Inoreader http://ift.tt/1SwD2fn Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Celiac disease in a large cohort of children and adolescents with recurrent headache: A retrospective study
Digestive and Liver Diseases from #Medicine via ola Kala on Inoreader http://ift.tt/1m7WodZ Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal.
Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal Chem Senses. 2016 Jan 28; Authors: Sun X, Veldhuizen MG, Babbs AE, Sinha R, Small DM Abstract Animal studies have shown that olfactory sensitivity is greater when fasted than when fed. However, human research has generated inconsistent results. One possible explanation for these conflicting findings is metabolic health. Many metabolic peptides, including ghrelin, are moderated by adiposity and influence olfaction and olfactory-guided behaviors. We tested wh...περισσότερα »
Chyle Leak Following Neck Dissection: Could Radiotherapy Be Considered a Management Option?.
Chyle Leak Following Neck Dissection: Could Radiotherapy Be Considered a Management Option?.: Chyle leak after neck dissection is a relatively rare complication in head and neck cancer scenario. This review summarizes the basic knowledge of chyle leak underlying the potential benefit induced by low-dose radiation therapy and may serve as basis for future studies, necessary to optimize chyle leak management in head and neck cancer patients. (C) 2016 by Mutaz B. Habal, MD.
Maxillary Reconstruction for Sinus Lift Complications With Oro-Antral Fistula: The Le Fort I Approach.
Maxillary Reconstruction for Sinus Lift Complications With Oro-Antral Fistula: The Le Fort I Approach.: Although sinus lift procedures are reliable, some complications can lead to serious maxillary sequelae, including the development of oro-antral fistula (OAF). Maxillary reconstruction in such patients presents a challenge owing to sinus floor alterations, graft remnants, chronic infection, and morbidity from the original sinus lift approach. The current study describes our technique of maxillary reconstruction using a Le Fort 1 approach following major sinus lift complications wit... περισσότερα »
Zygomatic Symmetry in Normal, Uninjured Faces
A Three-dimensional Analysis of Zygomatic Symmetry in Normal, Uninjured Faces.: Current approaches to facial reconstruction are based on the assumption of facial symmetry, though this has yet to be established in the literature. Through quantitative and qualitative analysis, symmetry of normal, male faces is examined here using the zygomatic complex as a bellwether for the rest of the facial skeleton. Three-dimensional models reconstructed from the computed tomography scans of 30 adult male patients displaying normal facial skeletal anatomy were analyzed. Seven zygomatic landmarks w... περισσότερα »
Social and Support Services Offered by Cleft and Craniofacial Teams: A National Survey and Institutional Experience.
Social and Support Services Offered by Cleft and Craniofacial Teams: A National Survey and Institutional Experience.: Background: A multidisciplinary approach to patients with craniofacial abnormalities is the standard of care by the American Cleft Palate-Craniofacial Association (ACPA). The standards of team care, however, do not require provision of social support services beyond access to a social worker. The purpose of this investigation is to study social support services provided by ACPA teams, funding sources for services, and family interest in services. Methods: A survey was...περισσότερα »
Temporomandibular Joint Osteophytes
Magnetic Resonance Image Evaluation of Temporomandibular Joint Osteophytes: Influence of Clinical Factors and Artrogenics Changes.: This research aims to examine the presence of osteophyte in patients with arthrogenic temporomandibular disorders through magnetic resonance imaging (MRI); to investigate the influence of sex and clinical symptoms in its prevalence; and the position of the osteophytes in the condyle. The study was based on 100 MRI and on reports of patients, which corresponded to the evaluation of 200 joints. Patients of both sexes were aged from 18 to 82 years (average ... περισσότερα »
Combined Intralesional Neodymium-Doped Yttrium Aluminium Garnet Laser and Intratumoral Ligation as Curative Treatment for Craniofacial Arteriovenous Malformations.
Combined Intralesional Neodymium-Doped Yttrium Aluminium Garnet Laser and Intratumoral Ligation as Curative Treatment for Craniofacial Arteriovenous Malformations.: Craniofacial arteriovenous malformation (AVM), although very rare, has been a very difficult problem to treat especially when it is large and involves important structures. Surgical resection often results in unacceptable complications but still not curative. At our institution, treatment by combined intralesional neodymium-doped yttrium aluminium garnet laser and intratumoral ligation has been successful in venous malfo... περισσότερα »
A Reduction in Radiation Exposure During Pediatric Craniofacial Computed Tomography.
A Reduction in Radiation Exposure During Pediatric Craniofacial Computed Tomography.: Background: Radiation exposure during computed tomography (CT) evaluation in children is the subject of growing professional and public concern. The authors previously demonstrated an 18% reduction in effective radiation dose during craniofacial CT imaging using a modified head position ("exaggerated sniff"), without any compromise of image diagnostic quality. The current study reports additional reduction of radiation exposure using a commercially available iterative reconstruction CT technique. M... περισσότερα »
The Extended Subfrontal and Fronto-Orbito-Zygomatic Approach in Skull Base Meningioma Surgery
: Clinical, Radiologic, and Cosmetic Outcome. by Soleman, Jehuda; Leiggener, Christoph; Schlaeppi, Ai-Jeanine; Kienzler, Jenny; Fathi, Ali-Reza; Fandino, Javier viaJournal of Craniofacial Surgery - Published Ahead-of-Print Objective: To review the outcome and cosmetic results of patients undergoing extended subfrontal and fronto-orbito-zygomatic craniotomy for resection of skull base meningiomas. Methods: All surgeries were performed in cooperation with an oral and maxillofacial surgeon between 2006 and 2012. Clinical presentation, surgical techniques and complications, cosmetic, cli... περισσότερα »
Outer Fascia of Orbicularis Oculi Muscle as an Anchoring Target Tissue in Double Eyelid Surgery
Outer Fascia of Orbicularis Oculi Muscle as an Anchoring Target Tissue in Double Eyelid Surgery. by Choi, Yeop; Eo, SuRak via Journal of Craniofacial Surgery - Published Ahead-of-Print Background: Natural adhesion between the levator aponeurosis and the subcutaneous layer in the upper lid is essential for an aesthetically pleasing double eyelid. The study aims to emphasize the outer fascia of orbicularis oculi muscle (OFOOM) as a fixation point on the double eyelid surgery. Methods: The authors examined the detailed anatomy of the anterior lamella microscopically during 28 cases of p...περισσότερα »
Microstructural Change and Cognitive Alteration in Maxillofacial Trauma and Mild Traumatic Brain Injury
: A Diffusion Tensor Imaging Study via Oral and Maxillofacial Surgery Publication date: Available online 30 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Vigneswaran Veeramuthu, Firdaus Hariri, Vairavan Narayanan, Tan Li Kuo, Norlisah Ramli, Dharmendra Ganesan PurposeThe aim of the study was to establish the incidence of maxillofacial (MF) injury accompanying mild head trauma (mTBI) and the associated neurocognitive deficits and white matter changes.Materials and MethodsA prospective review of 41 patients with mTBI patients with maxillofacial injury (with o...περισσότερα »
Juvenile Mandibular Chronic Osteomyelitis
: Role of Surgical Debridement and Antibiotics via Oral and Maxillofacial Surgery Publication date: Available online 29 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Shravan Renapurkar, Mark S. Pasternack, G. Petur Nielsen, Leonard B. Kaban PurposeTo document outcomes of management of juvenile mandibular chronic osteomyelitis (JMCO) using a standardized treatment protocol including open biopsy, decortication, microbial culture and long-term antibiotic therapy.MethodsThis was a retrospective case study of pediatric patients with JMCO treated at Massachusetts... περισσότερα »
Moral Fixations: The Role of Moral Integrity and Social Anxiety in the Selective Avoidance of Social Threat
[image: alertIcon.gif] Publication date: Available online 1 February 2016 *Source:*Biological Psychology Author(s): Lotte F. Van Dillen, Dorien Enter, Leonie P.M. Peters, Wilco W. van Dijk, Mark Rotteveel People derive their sense of belonging from perceptions of being a moral person. Research moreover suggests that social cues of rejection rapidly influence visual scanning, and result in avoidant gaze behavior, especially in socially anxious individuals. With the current eye-tracking experiment, we therefore examined whether moral integrity threats and affirmations influence select... περισσότερα »
Phylogenetic and morphologic evidence confirm the presence of a new montane cloud forest associated bird species in Mexico, the Mountain Elaenia (Elaenia frantzii; Aves: Passeriformes: Tyrannidae)
Here we provide evidence to support an extension of the recognized distributional range of the Mountain Elaenia (Elaenia frantzii) to include southern Mexico. We collected two specimens in breeding condition in northwestern Sierra Norte de Chiapas, Mexico. Morphologic and genetic evidence support their identity as Elaenia frantzii. We compared environmental parameters of records across the entire geographic range of the species to those at the northern Chiapas survey site and found no climatic differences among localities. from #Medicine via ola Kala on Inoreader http://ift.tt/1Sw... περισσότερα »
Unequal contribution of native South African phylogeographic lineages to the invasion of the African clawed frog, Xenopus laevis, in Europe
Due to both deliberate and accidental introductions, invasive African Clawed Frog (Xenopus laevis) populations have become established worldwide. In this study, we investigate the geographic origins of invasive X. laevis populations in France and Portugal using the phylogeographic structure of X. laevis in its native South African range. In total, 80 individuals from the whole area known to be invaded in France and Portugal were analysed for two mitochondrial and three nuclear genes, allowing a comparison with 185 specimens from the native range. Our results show that native phylo... περισσότερα »
Feasibility of self-administered sleep assessment in older women
Feasibility of self-administered sleep assessment in older women in the Women's Health Initiative (WHI): Abstract Purpose Laboratory-based polysomnography (PSG) is the gold standard assessment of sleep disordered breathing (SDB). In large cohort studies and clinical trials, however, these overnight procedures can be expensive and burdensome to participants, especially older adults. In preparation for a large observational study, we determined the feasibility of self-administering two devices mailed to participants' homes that estimate indices of SDB. Methods In two separate st... περισσότερα »
Craniofacial and upper airway morphology in adult obstructive sleep apnea
Craniofacial and upper airway morphology in adult obstructive sleep apnea patients: a systematic review and meta-analysis of cephalometric studies: Obstructive sleep apnea (OSA) is one of the common sleep disordered breathings in adults, characterised by frequent episodes of upper airway collapse during sleep. Craniofacial disharmony is an important risk factor for OSA. Overnight polysomnography (PSG) study is considered to be the most reliable confirmatory investigation for OSA diagnosis, whereas the precise localization of site of obstruction to the airflow cannot be detected. Ide... περισσότερα »
Comprehensive Sleep Bruxism Therapy as related to Sleep Disordered Breathing
Comprehensive Sleep Bruxism Therapy as related to Sleep Disordered Breathing : *Sleep Bruxism is a condition that is receiving a tremendous amount of attention of late in the news. Perhaps as a result of the number of dentists who are providing high level diagnostics using a medical grade sleep bruxism monitor to collect surface EMG data. This kind of objective data has opened the opportunity to improve speed to treat for patient with jaw symptoms. Patients who clench and grind do not all generate pain or present with a jaw pain complaint in fact they may be unaware that they suffe...περισσότερα »
The genomic landscape of cutaneous melanoma
Summary Somatic mutation analysis of melanoma has been done at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last five years next-generation sequencing (NGS) has enabled even more comprehensive mutational screening at the level of multi-gene panels, exomes and genomes. These studies have uncovered many new and unexpected players in melanoma development. The recent landmark study from The Cancer Genome Atlas (TCGA) consortium describing th...περισσότερα »
Mutational characteristics of ANK1 and SPTB genes in hereditary spherocytosis
Abstract The aim of the present study was to describe the mutational characteristics in Korean hereditary spherocytosis(HS) patients. Relevant literatures including genetically confirmed cases with well-documented clinical summaries and relevant information was also reviewed to investigate the mutational gene- or domain-specific laboratory and clinical association. Twenty-five HS patients carried one heterozygous mutation of *ANK1*(n=13) or *SPTB*(n=12) but not in *SPTA1*, *SLC4A1*, or *EPB42*. Deleterious mutations including frameshift, nonsense, and splice site mutations were id...περισσότερα »
Home Sessualità Malattie veneree Sesso orale, virus HPV aumenta il rischio di tumori a testa e… – Ok Salute e Benessere
*Home Sessualità Malattie veneree Sesso orale, virus HPV aumenta il rischio di tumori a testa e…* *Ok Salute e Benessere* Il sesso orale può "darvi alla testa", e non è solo un modo di dire: tutta colpa dell'infezione da Papilloma virus (HPV), che può aumentare il rischio di sviluppare *tumori di testa e collo* fino a 22 volte. Il più pericoloso è il ceppo HPV-16, legato *…* from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PLhNkP via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 003069326... περισσότερα »
HPV e tumori di testa e collo: giovani sempre più colpiti – Ok Salute e Benessere
*HPV e tumori di testa e collo: giovani sempre più colpiti* *Ok Salute e Benessere* «I *tumori di testa e collo* sono malattie piuttosto rare che generalmente compaiono in età avanzata, ma negli ultimi anni stiamo osservando un inaspettato aumento dei casi tra i più giovani, anche sotto i 40 anni», afferma l'esperto di Ok Salute Antonio *…* *and more »* from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1Kl1PBP via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blog... περισσότερα »
Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach
ABSTRACT There is a large amount of functional genetic data available, which can be used to inform fine-mapping association studies (in diseases with well-characterised disease pathways). Single nucleotide polymorphism (SNP) prioritization via Bayes factors is attractive because prior information can inform the effect size or the prior probability of causal association. This approach requires the specification of the effect size. If the information needed to estimate a priori the probability density for the effect sizes for causal SNPs in a genomic region isn't consistent or isn't ... περισσότερα »
Advanced Management of Complex Cases: Children with Multiple Medical Conditions
Cochlear implantation was introduced in the United States as a viable treatment for hearing loss in the 1980s. Originally, the anticipated benefits were awareness of sound and enhancement of speech reading. Therefore, the early candidacy guidelines were very strict. There were concerns that the benefit from a cochlear implant would be limited or potentially be very difficult to measure, so the industry was conservative about who it considered for an implant. Original FDA GuidelinesAt the time of the original Food and Drug Administration (FDA) guidelines for the pediatric clinical ... περισσότερα »
The YY1/MMP2 axis promotes trophoblast invasion at the maternal-foetal interface
Abstract YY1 is a sequence-specific DNA-binding transcription factor that has many important biological roles. However, its function in trophoblasts at the maternal-foetal interface remains to be elucidated. In this study, we used an mRNA microarray and reverse transcription qPCR and compared the *YY1* mRNA expression level in trophoblasts between patients with recurrent miscarriage (RM) and healthy control subjects. Our results revealed that *YY1* mRNA expression was significantly lower in the trophoblasts of the RM group compared with the healthy control group. Furthermore, immu...περισσότερα »
Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney (CCSK) : Not the full story…
[image: cover.gif?v=1&s=a6fb6e56b7c271e97744ac7f] Abstract Internal tandem duplication within the *BCOR* gene sequence that encodes the PUFD domain, important in the formation of the non-canonical or variant polycomb repressor complex 1 (v-PRC1), was very recently described in 100% of 20 clear cell sarcoma of kidney (CCSK). None of those 20 cases bore the *YWHAE-NUTM2* transcript, previously described by us in CCSK, and which constitutes the only other recurrent genetic aberration observed in CCSK, prompting consideration that these mutations might be mutually exclusive in CCSK. ... περισσότερα »
Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles
Abstract Papillary thyroid carcinoma (PTC) is the most common adult thyroid malignancy and often presents with multiple anatomically distinct foci within the thyroid, known as multifocal papillary thyroid carcinoma (MPTC). The widespread application of the next-generation sequencing technologies in cancer genomics research provides novel insights into determining the clonal relationship between multiple tumours within the same thyroid gland. For eight MPTC patients, we performed whole-exome sequencing and targeted region sequencing to identify the non-synonymous point mutations and...περισσότερα »
Mesothelial-to-mesenchymal transition in the pathogenesis of post-surgical peritoneal adhesions
[image: cover.gif?v=1&s=a6fb6e56b7c271e97744ac7f] Abstract Peritoneal adhesions (PAs) are fibrotic bands formed between bowel loops, solid organs and the parietal peritoneum, that may appear following surgery, infection or endometriosis. They represent an important health problem with no effective treatment. Mesothelial cells (MCs) line the peritoneal cavity and undergo a mesothelial-to-mesenchymal transition (MMT) under pathological conditions, transforming into myofibroblasts, which are abundant in peritoneal fibrotic tissue. The aim of this study was to investigate if peritone...περισσότερα »
Tips and Tricks for Implementation of Sleep Dentistry into your Practice
*I have been attending entry level Dental CE courses for snoring and sleep apnea for over 20 years. It has always been fascinating to me that a dentist can take hundreds of hours of course hours but never really manage to get Sleep Apnea Dentistry implemented into his or her practice. This is an all two common occurrence and I thought the article below by Dr Erin Elliott does a great job setting out some really clear, real world. tips for beating "Wednesday Morning Syndrome". The condition that some staff members find themselves in when the Dr gets back from a course with lots of ... περισσότερα »
The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy
Abstract Converging evidence points to glycogen synthase kinase (GSK) 3 as a key player in the pathogenesis of podocytopathy and proteinuria. However, it remains unclear if GSK3 is involved in podocyte autonomous injury in glomerular disease. In normal kidneys, the β isoform of GSK3 was found to be the major GSK3 expressed in glomeruli and intensely stained in podocytes. GSK3β expression in podocytes was markedly elevated in experimental or human proteinuric glomerulopathy. Podocyte specific somatic ablation of GSK3β in adult mice attenuated proteinuria and ameliorated podocyte in... περισσότερα »
TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/β-catenin and MAPK signalling
Abstract Colorectal cancer (CRC) is one of the most common malignancies and is the second leading cause of cancer death in humans. Tumour suppressor candidate 3 (*TUSC3*) plays an important role in embryogenesis and metabolism. Deletion of *TUSC3* often causes non-syndromic mental retardation. Even though *TUSC3* deregulation is frequently observed in epithelial cancers, the function of *TUSC3* in CRC has remained unknown. In this study, we observed greater expression of TUSC3 at the mRNA and protein level in clinical colorectal tumour samples compared with paired normal tissues. ... περισσότερα »
The genomic landscape of cutaneous melanoma
Summary Somatic mutation analysis of melanoma has been done at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last five years next-generation sequencing (NGS) has enabled even more comprehensive mutational screening at the level of multi-gene panels, exomes and genomes. These studies have uncovered many new and unexpected players in melanoma development. The recent landmark study from The Cancer Genome Atlas (TCGA) consortium describing th...περισσότερα »
Major involvement of trunk muscles in myotonic dystrophy type 1
Objectives The motor impairments in Myotonic Dystrophy 1 (DM1) are assumed to progress from distal toward proximal parts of the extremities in the Juvenile and Adult forms of DM1. On occasion and late in progress spine deformity is observed. In this study we have examined whether and to what extent trunk muscles are impaired in DM1, and if this impairment is correlated with the duration of the disorder, walking capacity, mobility, balance, and CTG-repeats. Materials & methods Manual muscle testing (MMT) of skeletal muscle strength in trunk and extremities, reassessment of the mu... περισσότερα »
Anxiety in Multiple Sclerosis: psychometric properties of the State-Trait Anxiety Inventory
Objective The aims of the present study were to examine psychometric properties of the Spielberger State-Trait Anxiety Inventory (STAI-Y-1 and STAI-Y-2, respectively) in a Multiple Sclerosis (MS) population and to identify a cut-off score to detect those MS patients with high level of state and/or trait anxiety who could be more vulnerable to development of depression and/or cognitive defects. Material and methods The STAI-Y-1 and STAI-Y-2 was completed by a group of patients (*n* = 175) affected by MS and a group of healthy subjects (*n* = 150) matched for age, educational leve...περισσότερα »
Prevalence of Diabetic Retinopathy in a Population of Diabetics From the Middle East With Microvascular Ocular Motor Palsies.
Background: Vascular risk factors are increasing rapidly in the Middle East. Growing inactivity and obesity have contributed to an epidemic of Type 2 diabetes mellitus (DM) in the Arab population. Microvascular palsies of the third, fourth, and sixth cranial nerves, which occur in an isolated manner, are relatively common in patients with DM, hypertension, or other vascular risk factors. Methods: In this retrospective analysis, patients with diabetes with microvascular palsies were assessed for the prevalence of diabetic retinopathy (DR). We compared these data with the prevalence of... περισσότερα »
Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach
ABSTRACT There is a large amount of functional genetic data available, which can be used to inform fine-mapping association studies (in diseases with well-characterised disease pathways). Single nucleotide polymorphism (SNP) prioritization via Bayes factors is attractive because prior information can inform the effect size or the prior probability of causal association. This approach requires the specification of the effect size. If the information needed to estimate a priori the probability density for the effect sizes for causal SNPs in a genomic region isn't consistent or isn't ... περισσότερα »
Surgical Site Infections (SSIs)
Prevalence of Surgical Site Infections Following Orthognathic Surgery: A Retrospective Cohort Analysis via Oral and Maxillofacial Surgery Publication date: Available online 30 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Clayton M. Davis, Curtis E. Gregoire, Thomas W. Steeves, Amanda Demsey PurposeThe purpose of this retrospective study was to determine the prevalence of surgical site infection (SSI) following orthognathic surgery at the Department of Oral and Maxillofacial Surgery in Halifax, Nova Scotia, Canada.Patients and MethodsA retrospective chart r...περισσότερα »
Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea
Quality of Life Assessment Following via Oral and Maxillofacial Surgery Publication date: Available online 30 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Kevin J. Butterfield, Patricia L.G. Marks, Laurie McLean, Jack Newton PurposeWhile maxillomandibular advancement (MMA) surgery is highly efficacious for management of obstructive sleep apnea (OSA), little information exists regarding the subjective impact of this treatment modality. The present study was undertaken to investigate the impact of MMA on patient-perceived quality of life (QOL) in OSA.Method... περισσότερα »
Lip cancer
: a clinicopathological study and treatment outcomes in a 25-year experience via Oral and Maxillofacial Surgery Publication date: Available online 30 January 2016 *Source:*Journal of Oral and Maxillofacial Surgery Author(s): Éder Ricardo Biasoli, Vitor Bonetti Valente, Bruna Mantovan, Francisco Urbano Collado, Sebastião Conrado Neto, Maria Lúcia Marçal Mazza Sundefeld, Glauco Issamu Miyahara, Daniel Galera Bernabé PurposeThere are few clinical studies focusing on the lip cancer treatment outcomes. This study aims to investigate the clinicopathological variables profile of a large sample...περισσότερα »
Early changes in condylar position after mandibular advancement
Early changes in condylar position after mandibular advancement: a three-dimensional analysis: The aim of this study was to perform a three-dimensional (3D) assessment of positional changes of the mandibular condyle after bilateral sagittal split osteotomy (BSSO). A prospective evaluation of 22 skeletal class II patients who underwent a BSSO for mandibular advancement was performed. Pre- and postoperative cone beam computed tomography scans were taken. Using the cranial base as a stable reference, the pre- and postoperative 3D skull models were superimposed virtually. Positional cha...περισσότερα »
Application of Deuteporfin in the Metastatic Lymph Node Mapping of Pancreatic Cancer: An in vivo Study
Abstract For most cancer patients, the presence of metastatic lymph nodes usually indicates regional recurrence and poor prognosis. Therefore, lymph node mapping is a requisite for disease staging, prognosis prediction, and decision making in the treatment of cancer. Deuteporfin, a second-generation photosensitizer, has a maximum excitation wavelength that can reach the near infrared (NIR) region (650-700 nm). We aimed to take advantage of these aspects of deuteporfin and use it as a fluorescent probe for metastatic lymph node mapping *in vivo* using NIR fluorescent imaging. In ou... περισσότερα »
Macular pigmentation of uncertain aetiology revisited: two case reports and a proposed algorithm for clinical classification
Abstract Ashy dermatosis, erythema dyschromicum perstans, lichen planus pigmentosus and idiopathic eruptive macular pigmentation are various types of acquired macular hyperpigmentation disorders of the skin described in literature. However, a global consensus on the definitions of these entities is lacking. We report two cases of acquired macular (hyper)pigmentation of uncertain aetiology diagnosed as ashy dermatosis and attempt to clarify the various confusing nosologies based on existing literature. We infer that acquired small and large macular pigmentation of uncertain aetiolog...περισσότερα »
Ιnferior alveolar nerve lateralization and atrophied mandibles
Implant survival and complications in cases of inferior alveolar nerve lateralization and atrophied mandibles with 5-year follow-up: The objectives of this study were to evaluate the survival after 5 years of implants placed using inferior alveolar nerve (IAN) lateralization in cases of mandibular atrophy and to determine the incidence of complications. Twenty-seven patients received 74 implants by means of the IAN lateralization technique. Implant survival after 5 years of loading was 98.6%. Eighteen months after surgery, the recovery of sensitivity was complete in 26 cases. Implan... περισσότερα »
Stylo-mandibular fusion complicating recurrent bilateral temporomandibular joint ankylosis
Stylo-mandibular fusion complicating recurrent bilateral temporomandibular joint ankylosis Abstract Ankylosis of the temporomandibular joint (TMJ) is debilitating, and difficult to manage because it recurs. Recurrent bilateral ankylosis is further complicated by the fusion of the styloid process and the mandible. We report such a case, and to our knowledge no similar case has been reported previously. Keywords:Temporomandibular joint ankylosis, Stylo-mandibular fusion
Tumour seeding after fine-needle aspiration and core biopsy of the head and neck - a systematic review
Tumour seeding after fine-needle aspiration and core biopsy of the head and neck - a systematic review: Although fine-needle aspiration cytology (FNAC) and core needle biopsy are essential diagnostic investigations of lumps in the head and neck, seeding along the needle track has long been a concern, and various factors have been implicated. We therefore searched the Medline database for relevant English language papers published between 1970 and 2014, excluding those on the thyroid and parathyroid, and systematically reviewed them to assess the risk. In the 610 articles reviewed we ...περισσότερα »
Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal
Perceptual and Brain Response to Odors Is Associated with Body Mass Index and Postprandial Total Ghrelin Reactivity to a Meal: Animal studies have shown that olfactory sensitivity is greater when fasted than when fed. However, human research has generated inconsistent results. One possible explanation for these conflicting findings is metabolic health. Many metabolic peptides, including ghrelin, are moderated by adiposity and influence olfaction and olfactory-guided behaviors. We tested whether the effect of a meal on the perceived intensity of suprathreshold chemosensory stimuli i... περισσότερα »
Moral Fixations: The Role of Moral Integrity and Social Anxiety in the Selective Avoidance of Social Threat
[image: alertIcon.gif] Publication date: Available online 1 February 2016 *Source:*Biological Psychology Author(s): Lotte F. Van Dillen, Dorien Enter, Leonie P.M. Peters, Wilco W. van Dijk, Mark Rotteveel People derive their sense of belonging from perceptions of being a moral person. Research moreover suggests that social cues of rejection rapidly influence visual scanning, and result in avoidant gaze behavior, especially in socially anxious individuals. With the current eye-tracking experiment, we therefore examined whether moral integrity threats and affirmations influence select... περισσότερα »
Phylogenetic and morphologic evidence confirm the presence of a new montane cloud forest associated bird species in Mexico, the Mountain Elaenia (Elaenia frantzii; Aves: Passeriformes: Tyrannidae)
Here we provide evidence to support an extension of the recognized distributional range of the Mountain Elaenia (Elaenia frantzii) to include southern Mexico. We collected two specimens in breeding condition in northwestern Sierra Norte de Chiapas, Mexico. Morphologic and genetic evidence support their identity as Elaenia frantzii. We compared environmental parameters of records across the entire geographic range of the species to those at the northern Chiapas survey site and found no climatic differences among localities. from #Medicine via ola Kala on Inoreader http://ift.tt/1Sw... περισσότερα »
Unequal contribution of native South African phylogeographic lineages to the invasion of the African clawed frog, Xenopus laevis, in Europe
Due to both deliberate and accidental introductions, invasive African Clawed Frog (Xenopus laevis) populations have become established worldwide. In this study, we investigate the geographic origins of invasive X. laevis populations in France and Portugal using the phylogeographic structure of X. laevis in its native South African range. In total, 80 individuals from the whole area known to be invaded in France and Portugal were analysed for two mitochondrial and three nuclear genes, allowing a comparison with 185 specimens from the native range. Our results show that native phylo... περισσότερα »
Feasibility of self-administered sleep assessment in older women
Feasibility of self-administered sleep assessment in older women in the Women’s Health Initiative (WHI): Abstract PurposeLaboratory-based polysomnography (PSG) is the gold standard assessment of sleep disordered breathing (SDB). In large cohort studies and clinical trials, however, these overnight procedures can be expensive and burdensome to participants, especially older adults. In preparation for a large observational study, we determined the feasibility of self-administering two devices mailed to participants’ homes that estimate indices of SDB. MethodsIn two separate stud...περισσότερα »
Craniofacial and upper airway morphology in adult obstructive sleep apnea
Craniofacial and upper airway morphology in adult obstructive sleep apnea patients: a systematic review and meta-analysis of cephalometric studies: Obstructive sleep apnea (OSA) is one of the common sleep disordered breathings in adults, characterised by frequent episodes of upper airway collapse during sleep. Craniofacial disharmony is an important risk factor for OSA. Overnight polysomnography (PSG) study is considered to be the most reliable confirmatory investigation for OSA diagnosis, whereas the precise localization of site of obstruction to the airflow cannot be detected. Ide... περισσότερα »
Comprehensive Sleep Bruxism Therapy as related to Sleep Disordered Breathing
Comprehensive Sleep Bruxism Therapy as related to Sleep Disordered Breathing: *Sleep Bruxism is a condition that is receiving a tremendous amount of attention of late in the news. Perhaps as a result of the number of dentists who are providing high level diagnostics using a medical grade sleep bruxism monitor to collect surface EMG data. This kind of objective data has opened the opportunity to improve speed to treat for patient with jaw symptoms. Patients who clench and grind do not all generate pain or present with a jaw pain complaint in fact they may be unaware that they suff... περισσότερα »
Poor Oral Health
Psychological Interventions for Poor Oral Health: A Systematic Review: The aim of this systematic review and meta-analysis was to study the effectiveness of psychological interventions in adults and adolescents with poor oral health. The review follows the PRISMA guidelines for systematic reviews. The PICO format (population, intervention, comparison, and outcome) was used to define eligible studies. The populations were adults or adolescents (≥13 y of age and independent of others) with poor oral health (defined as dental caries, periodontal disease, and/or peri-implantitis). The ... περισσότερα »
Cochlear implantation : Children with Multiple Medical Conditions
Advanced Management of Complex Cases: Children with Multiple Medical Conditions: Cochlear implantation was introduced in the United States as a viable treatment for hearing loss in the 1980s. Originally, the anticipated benefits were awareness of sound and enhancement of speech reading. Therefore, the early candidacy guidelines were very strict. There were concerns that the benefit from a cochlear implant would be limited or potentially be very difficult to measure, so the industry was conservative about who it considered for an implant. Original FDA GuidelinesAt the time of the ori... περισσότερα »
Τopical steroids vs. PPIs for the treatment of the spectrum of eosinophilic oesophagitis
Systematic review with network meta-analysis: comparative effectiveness of topical steroids vs. PPIs for the treatment of the spectrum of eosinophilic oesophagitis: Summary Background Controversy surrounds the clinical and histological response to topical steroids in patients with eosinophilic oesophagitis (EoE). Aim To perform a systematic review and network meta-analysis of randomised controlled trials to assess the efficacy of topical steroids compared with placebo or proton pump inhibitor (PPIs) for the management of eosinophilic oesophagitis. Methods Cochrane Central Register o... περισσότερα »
Head and Neck Reconstruction with Chimeric Anterolateral Thigh Free Flap
Head and Neck Reconstruction with Chimeric Anterolateral Thigh Free Flap: Indications, Outcomes, and Technical Considerations: Objective Chimeric anterolateral thigh free flaps are composed of multiple skin paddles or muscular components that allow for the reconstruction of complex 3-dimensional defects. We present our experience with the technique and applications for various head and neck defects. Study Design Retrospective chart review. Setting Academic tertiary care center. Subjects and Methods Subjects include 24 consecutive patients undergoing reconstruction with a chimeri... περισσότερα »
Predictors of Nodal Metastasis in Parotid Malignancies
Predictors of Nodal Metastasis in Parotid Malignancies: A National Cancer Data Base Study of 22,653 Patients: Objective (1) To identify predictors of nodal disease in parotid malignancies using various clinical and pathologic variables. (2) To examine the effect of nodal disease on overall survival (OS) in parotid cancers Study Design Retrospective database review. Setting National Cancer Data Base (1998-2012). Subjects and Methods We identified all cases of primary parotid malignancies in the United States between 1998 and 2012 in the National Cancer Data Base. Eight histopatho...περισσότερα »
Increased Expression of FGF19 Contributes to Tumor Progression and Cell Motility of Human Thyroid Cancer
Increased Expression of FGF19 Contributes to Tumor Progression and Cell Motility of Human Thyroid Cancer: Objective Numerous reports indicate a role for aberrant expression of fibroblast growth factor 19 (FGF19) in tumor development and progression, and several drugs have been developed to target it. The aim of this study was to investigate the clinical significance of FGF19 and examine whether it plays any roles in progression of thyroid cancer. Study Design Translation research. Setting Navy General Hospital of Chinese PLA, China. Subjects and Methods Expression patterns of FG...περισσότερα »
Prognostic Indicators for Salvage Surgery of Recurrent Sinonasal Malignancy
Prognostic Indicators for Salvage Surgery of Recurrent Sinonasal Malignancy: Objective Identify prognostic factors after salvage surgery for recurrent sinonasal malignancy (SNM). Study Design Case series with chart review. Setting University of Pittsburgh Medical Center. Subjects Forty-two patients who underwent curative surgery for locally recurrent SNM ± adjuvant therapy from June 5, 2000, to December 19, 2012. Patients without follow-up were excluded. Methods Chart review with established prognostic indicators for primary malignancies. Statistical analysis included Kaplan-M... περισσότερα »
Impact of Microcalcifications on Risk of Malignancy in Thyroid Nodules with Indeterminate or Benign Cytology
Impact of Microcalcifications on Risk of Malignancy in Thyroid Nodules with Indeterminate or Benign Cytology: Objective Adverse sonographic features such as microcalcification may predict increased likelihood of malignant cytology by fine-needle aspiration and, accordingly, increased risk of malignant histology. Our objective was to study the predictive value of microcalcifications and other sonographic features for malignancy among thyroid nodules with benign or indeterminate cytology. Study Design Case series with chart review. Setting Academic teaching hospital. Subjects Pat... περισσότερα »
Utility of Allergy Testing in Patients with Chronic Laryngopharyngeal Symptoms: Is It Allergic Laryngitis?
Utility of Allergy Testing in Patients with Chronic Laryngopharyngeal Symptoms: Is It Allergic Laryngitis?: Objective To determine the utility of allergy evaluation in patients with chronic refractory laryngeal symptoms. Study Design Case series with chart review. Setting Tertiary academic medical center. Subjects All patients who underwent in vitro allergy testing at a single institution from 2006 to 2010, for a total of 998 patients. Methods Charts of patients who underwent in vitro allergy testing were identified. The charts were reviewed for the primary indication for aller... περισσότερα »
A Pediatric Grading Scale for Lingual Tonsil Hypertrophy
A Pediatric Grading Scale for Lingual Tonsil Hypertrophy: Lingual tonsil hypertrophy (LTH) is a common finding for children with residual obstructive sleep apnea (OSA) following an adenotonsillectomy. Secondary to the significant morbidity associated with OSA, identification and treatment of residual OSA are paramount. A dedicated LTH grading scale for children does not exist. The current adult LTH scale is impractical for children. Imaging is not routine for children, since it frequently requires sedation. We present a pediatric LTH grading scale with substantial interrater reliab... περισσότερα »
Paranasal Sinus Balloon Catheter Dilation
Paranasal Sinus Balloon Catheter Dilation for Treatment of Chronic Rhinosinusitis: A Systematic Review and Meta-analysis: Objective Paranasal sinus balloon catheter dilation (BCD) represents a commonly used tool in the management of chronic rhinosinusitis (CRS) for which the indications, utilization, and outcomes have not been well established. A systematic review and meta-analysis were undertaken to evaluate change in quality of life and sinus opacification following paranasal sinus BCD in the treatment of CRS. Data Sources MEDLINE and EMBASE databases. Review Methods Preferred ... περισσότερα »
Cbx2 targets PRC1 to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Polycomb repressive complexes PRC1 and PRC2 regulate expression of genes involved in proliferation and development. In mouse early embryos, however, canonical PRC1 localizes to paternal pericentric heterochromatin (pat-PCH), where it represses transcription of major satellite repeats. In contrast, maternal PCH (mat-PCH) is enriched for H3 lysine 9 tri-methylation (H3K9me3) and Hp1β. How PRC1 is targeted […]
Clinical features and outcomes of delayed facial palsy after head trauma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Publication date: Available online 1 February 2016 Source:Auris Nasus Larynx Author(s): Qiang Li, Yanfei Jia, Qian Feng, Bo Tang, Naili Wei, Yinian Zhang, Yefeng Li, Xuanfen Zhang ObjectiveTo investigate clinical features and outcomes of delayed facial palsy after head trauma.MethodsThe cases who had delayed facial palsy after head trauma treated from March 2008 to March […]
Clinical features and outcomes of delayed facial palsy after head trauma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Publication date: Available online 1 February 2016 Source:Auris Nasus Larynx Author(s): Qiang Li, Yanfei Jia, Qian Feng, Bo Tang, Naili Wei, Yinian Zhang, Yefeng Li, Xuanfen Zhang ObjectiveTo investigate clinical features and outcomes of delayed facial palsy after head trauma.MethodsThe cases who had delayed facial palsy after head trauma treated from March 2008 to March […]
Erratum
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Future Oncology Ahead of Print. from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/1P8AwHE via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20hWbI8 via IFTTT
Moral Fixations: The Role of Moral Integrity and Social Anxiety in the Selective Avoidance of Social Threat
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Publication date: Available online 1 February 2016 Source:Biological Psychology Author(s): Lotte F. Van Dillen, Dorien Enter, Leonie P.M. Peters, Wilco W. van Dijk, Mark Rotteveel People derive their sense of belonging from perceptions of being a moral person. Research moreover suggests that social cues of rejection rapidly influence visual scanning, and result in avoidant gaze […]
Phylogenetic and morphologic evidence confirm the presence of a new montane cloud forest associated bird species in Mexico, the Mountain Elaenia (Elaenia frantzii; Aves: Passeriformes: Tyrannidae)
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Here we provide evidence to support an extension of the recognized distributional range of the Mountain Elaenia (Elaenia frantzii) to include southern Mexico. We collected two specimens in breeding condition in northwestern Sierra Norte de Chiapas, Mexico. Morphologic and genetic evidence support their identity as Elaenia frantzii. We compared environmental parameters of records across the […]
Unequal contribution of native South African phylogeographic lineages to the invasion of the African clawed frog, Xenopus laevis, in Europe
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Due to both deliberate and accidental introductions, invasive African Clawed Frog (Xenopus laevis) populations have become established worldwide. In this study, we investigate the geographic origins of invasive X. laevis populations in France and Portugal using the phylogeographic structure of X. laevis in its native South African range. In total, 80 individuals from the whole […]
Nanomaterials, Vol. 6, Pages 26: Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which are biodegradable and biocompatible polymers, have been approved by both the Food & Drug Administration (FDA) and European Medicine Agency (EMA), making […]
Clinical features and outcomes of delayed facial palsy after head trauma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Publication date: Available online 1 February 2016 Source:Auris Nasus Larynx Author(s): Qiang Li, Yanfei Jia, Qian Feng, Bo Tang, Naili Wei, Yinian Zhang, Yefeng Li, Xuanfen Zhang ObjectiveTo investigate clinical features and outcomes of delayed facial palsy after head trauma.MethodsThe cases who had delayed facial palsy after head trauma treated from March 2008 to March […]
IDO in the Tumor Microenvironment: Inflammation, Counter-regulation, and Tolerance
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 24 δευτερόλεπτα
Publication date: Available online 31 January 2016 Source:Trends in Immunology Author(s): David H. Munn, Andrew L. Mellor Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan metabolism. These include counter-regulation (controlling inflammation) and acquired tolerance in T cells. Recent findings reveal that IDO can be triggered by innate responses during tumorigenesis, and also by attempted […]
Moral Fixations: The Role of Moral Integrity and Social Anxiety in the Selective Avoidance of Social Threat
[image: alertIcon.gif] Publication date: Available online 1 February 2016 *Source:*Biological Psychology Author(s): Lotte F. Van Dillen, Dorien Enter, Leonie P.M. Peters, Wilco W. van Dijk, Mark Rotteveel People derive their sense of belonging from perceptions of being a moral person. Research moreover suggests that social cues of rejection rapidly influence visual scanning, and result in avoidant gaze behavior, especially in socially anxious individuals. With the current eye-tracking experiment, we therefore examined whether moral integrity threats and affirmations influence select... περισσότερα »
Phylogenetic and morphologic evidence confirm the presence of a new montane cloud forest associated bird species in Mexico, the Mountain Elaenia (Elaenia frantzii; Aves: Passeriformes: Tyrannidae)
Here we provide evidence to support an extension of the recognized distributional range of the Mountain Elaenia (Elaenia frantzii) to include southern Mexico. We collected two specimens in breeding condition in northwestern Sierra Norte de Chiapas, Mexico. Morphologic and genetic evidence support their identity as Elaenia frantzii. We compared environmental parameters of records across the entire geographic range of the species to those at the northern Chiapas survey site and found no climatic differences among localities. from #Medicine via ola Kala on Inoreader http://ift.tt/1Sw... περισσότερα »
Unequal contribution of native South African phylogeographic lineages to the invasion of the African clawed frog, Xenopus laevis, in Europe
Due to both deliberate and accidental introductions, invasive African Clawed Frog (Xenopus laevis) populations have become established worldwide. In this study, we investigate the geographic origins of invasive X. laevis populations in France and Portugal using the phylogeographic structure of X. laevis in its native South African range. In total, 80 individuals from the whole area known to be invaded in France and Portugal were analysed for two mitochondrial and three nuclear genes, allowing a comparison with 185 specimens from the native range. Our results show that native phylo... περισσότερα »
Nanomaterials, Vol. 6, Pages 26: Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer
The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which are biodegradable and biocompatible polymers, have been approved by both the Food & Drug Administration (FDA) and European Medicine Agency (EMA), making them ideal biomaterials that can be advanced from laboratory development to clinical oral and parental administrations. PLGA and chitosan encapsulated nanoparticles (NPs) have... περισσότερα »
Algorithms, Vol. 9, Pages 14: Two Efficient Derivative-Free Iterative Methods for Solving Nonlinear Systems
In this work, two multi-step derivative-free iterative methods are presented for solving system of nonlinear equations. The new methods have high computational efficiency and low computational cost. The order of convergence of the new methods is proved by a development of an inverse first-order divided difference operator. The computational efficiency is compared with the existing methods. Numerical experiments support the theoretical results. Experimental results show that the new methods remarkably reduce the computing time in the process of high-precision computing. from #Medi... περισσότερα »
Agriculture, Vol. 6, Pages 7: Monitoring Soil Sealing in Guadarrama River Basin, Spain, and Its Potential Impact in Agricultural Areas
This study analyzes soil sealing and its repercussions in the loss of fertile soils, which are more appropriate for agriculture use. Also, soil sealing increases flood risk. The main objective is to estimate soil loss by sealing in the Guadarrama River Basin (Madrid, Spain) between 1961 and 2011. The combination of digital processing (Normalized Difference Vegetation Index (NDVI), principal components and convolution filters) of satellite imagery with the digital terrain model helps to detect risk areas and allows quick updating of sealed soil mapping. The supervised classificatio... περισσότερα »
Clinical features and outcomes of delayed facial palsy after head trauma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Publication date: Available online 1 February 2016 Source:Auris Nasus Larynx Author(s): Qiang Li, Yanfei Jia, Qian Feng, Bo Tang, Naili Wei, Yinian Zhang, Yefeng Li, Xuanfen Zhang ObjectiveTo investigate clinical features and outcomes of delayed facial palsy after head trauma.MethodsThe cases who had delayed facial palsy after head trauma treated from March 2008 to March […]
IDO in the Tumor Microenvironment: Inflammation, Counter-regulation, and Tolerance
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Publication date: Available online 31 January 2016 Source:Trends in Immunology Author(s): David H. Munn, Andrew L. Mellor Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan metabolism. These include counter-regulation (controlling inflammation) and acquired tolerance in T cells. Recent findings reveal that IDO can be triggered by innate responses during tumorigenesis, and also by attempted […]
IDO in the Tumor Microenvironment: Inflammation, Counter-regulation, and Tolerance
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Publication date: Available online 31 January 2016 Source:Trends in Immunology Author(s): David H. Munn, Andrew L. Mellor Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory roles associated with tryptophan metabolism. These include counter-regulation (controlling inflammation) and acquired tolerance in T cells. Recent findings reveal that IDO can be triggered by innate responses during tumorigenesis, and also by attempted […]
Systematic review with network meta-analysis: comparative effectiveness of topical steroids vs. PPIs for the treatment of the spectrum of eosinophilic oesophagitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Summary Background Controversy surrounds the clinical and histological response to topical steroids in patients with eosinophilic oesophagitis (EoE). Aim To perform a systematic review and network meta-analysis of randomised controlled trials to assess the efficacy of topical steroids compared with placebo or proton pump inhibitor (PPIs) for the management of eosinophilic oesophagitis. Methods Cochrane Central […]
Single-staged vs. two-staged implant placement using bone ring technique in vertically deficient alveolar ridges – Part 1: histomorphometric and micro-CT analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Abstract Background Simultaneous implant placement with bone grafting shortens the overall treatment period, but might lead to the peri-implant bone loss or even implant failure. The aim of this study was to compare the single-staged to two-staged implant placement using the bone ring technique. Material and methods Four standardized alveolar bone defects were made in […]
Systematic review with network meta-analysis: comparative effectiveness of topical steroids vs. PPIs for the treatment of the spectrum of eosinophilic oesophagitis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Summary Background Controversy surrounds the clinical and histological response to topical steroids in patients with eosinophilic oesophagitis (EoE). Aim To perform a systematic review and network meta-analysis of randomised controlled trials to assess the efficacy of topical steroids compared with placebo or proton pump inhibitor (PPIs) for the management of eosinophilic oesophagitis. Methods Cochrane Central […]
Single-staged vs. two-staged implant placement using bone ring technique in vertically deficient alveolar ridges – Part 1: histomorphometric and micro-CT analysis
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 37 δευτερόλεπτα
Abstract Background Simultaneous implant placement with bone grafting shortens the overall treatment period, but might lead to the peri-implant bone loss or even implant failure. The aim of this study was to compare the single-staged to two-staged implant placement using the bone ring technique. Material and methods Four standardized alveolar bone defects were made in […]
Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
Malaria accounts for an enormous burden of disease globally, with *Plasmodium falciparum* accounting for the majority of malaria, and *P. vivax* being a second important cause, especially in Asia, the Americas and the Pacific. During infection with *Plasmodium* spp., the merozoite form of the parasite invades red blood cells and replicates inside them. It is during the blood-stage of infection that malaria disease occurs and, therefore, understanding merozoite invasion, host immune responses to merozoite surface antigens, and targeting merozoite surface proteins and invasion ligan... περισσότερα »
Phylogenetic diversity of rhizobial species and symbiovars nodulating Phaseolus vulgaris in Iran
The phylogenetic diversity of twenty nine rhizobial strains nodulating *Phaseolus vulgaris* in Iran was analysed on the basis of their core and symbiotic genes. These strains displayed five 16S rRNA-RFLP patterns and belong to eight ERIC-PCR clusters. The phylogenetic analyses of 16S rRNA, *recA* and *atpD* core genes allowed the identification of several strains as *Rhizobium sophoriradicis, Rhizobium leguminosarum, Rhizobium tropici* and *Pararhizobium giardinii* whereas other strains represented a new phylogenetic lineage related to *Rhizobium vallis*. These strains and those id... περισσότερα »
Single-staged vs. two-staged implant placement using bone ring technique in vertically deficient alveolar ridges – Part 1: histomorphometric and micro-CT analysis
Abstract Background Simultaneous implant placement with bone grafting shortens the overall treatment period, but might lead to the peri-implant bone loss or even implant failure. The aim of this study was to compare the single-staged to two-staged implant placement using the bone ring technique. Material and methods Four standardized alveolar bone defects were made in the mandibles of nine dogs. Dental implants (Straumann BL®, Basel, Switzerland) were inserted simultaneously with bone ring technique in test group and after 6 months of healing period in control group. Animals of b...περισσότερα »
Advanced Management of Complex Cases: Children with Multiple Medical Conditions
Cochlear implantation was introduced in the United States as a viable treatment for hearing loss in the 1980s. Originally, the anticipated benefits were awareness of sound and enhancement of speech reading. Therefore, the early candidacy guidelines were very strict. There were concerns that the benefit from a cochlear implant would be limited or potentially be very difficult to measure, so the industry was conservative about who it considered for an implant. Original FDA GuidelinesAt the time of the original Food and Drug Administration (FDA) guidelines for the pediatric clinical ... περισσότερα »
The YY1/MMP2 axis promotes trophoblast invasion at the maternal-foetal interface
Abstract YY1 is a sequence-specific DNA-binding transcription factor that has many important biological roles. However, its function in trophoblasts at the maternal-foetal interface remains to be elucidated. In this study, we used an mRNA microarray and reverse transcription qPCR and compared the *YY1* mRNA expression level in trophoblasts between patients with recurrent miscarriage (RM) and healthy control subjects. Our results revealed that *YY1* mRNA expression was significantly lower in the trophoblasts of the RM group compared with the healthy control group. Furthermore, immun...περισσότερα »
Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles
Abstract Papillary thyroid carcinoma (PTC) is the most common adult thyroid malignancy and often presents with multiple anatomically distinct foci within the thyroid, known as multifocal papillary thyroid carcinoma (MPTC). The widespread application of the next-generation sequencing technologies in cancer genomics research provides novel insights into determining the clonal relationship between multiple tumours within the same thyroid gland. For eight MPTC patients, we performed whole-exome sequencing and targeted region sequencing to identify the non-synonymous point mutations and ...περισσότερα »
TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/β-catenin and MAPK signalling
Abstract Colorectal cancer (CRC) is one of the most common malignancies and is the second leading cause of cancer death in humans. Tumour suppressor candidate 3 (*TUSC3*) plays an important role in embryogenesis and metabolism. Deletion of *TUSC3* often causes non-syndromic mental retardation. Even though *TUSC3* deregulation is frequently observed in epithelial cancers, the function of *TUSC3* in CRC has remained unknown. In this study, we observed greater expression of TUSC3 at the mRNA and protein level in clinical colorectal tumour samples compared with paired normal tissues. G... περισσότερα »
Mesothelial-to-mesenchymal transition in the pathogenesis of post-surgical peritoneal adhesions
[image: cover.gif?v=1&s=a6fb6e56b7c271e97744ac7f] Abstract Peritoneal adhesions (PAs) are fibrotic bands formed between bowel loops, solid organs and the parietal peritoneum, that may appear following surgery, infection or endometriosis. They represent an important health problem with no effective treatment. Mesothelial cells (MCs) line the peritoneal cavity and undergo a mesothelial-to-mesenchymal transition (MMT) under pathological conditions, transforming into myofibroblasts, which are abundant in peritoneal fibrotic tissue. The aim of this study was to investigate if peritonea...περισσότερα »
Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney (CCSK) : Not the full story…
[image: cover.gif?v=1&s=a6fb6e56b7c271e97744ac7f] Abstract Internal tandem duplication within the *BCOR* gene sequence that encodes the PUFD domain, important in the formation of the non-canonical or variant polycomb repressor complex 1 (v-PRC1), was very recently described in 100% of 20 clear cell sarcoma of kidney (CCSK). None of those 20 cases bore the *YWHAE-NUTM2* transcript, previously described by us in CCSK, and which constitutes the only other recurrent genetic aberration observed in CCSK, prompting consideration that these mutations might be mutually exclusive in CCSK. ... περισσότερα »
The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy
Abstract Converging evidence points to glycogen synthase kinase (GSK) 3 as a key player in the pathogenesis of podocytopathy and proteinuria. However, it remains unclear if GSK3 is involved in podocyte autonomous injury in glomerular disease. In normal kidneys, the β isoform of GSK3 was found to be the major GSK3 expressed in glomeruli and intensely stained in podocytes. GSK3β expression in podocytes was markedly elevated in experimental or human proteinuric glomerulopathy. Podocyte specific somatic ablation of GSK3β in adult mice attenuated proteinuria and ameliorated podocyte inj... περισσότερα »
The genomic landscape of cutaneous melanoma
Summary Somatic mutation analysis of melanoma has been done at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last five years next-generation sequencing (NGS) has enabled even more comprehensive mutational screening at the level of multi-gene panels, exomes and genomes. These studies have uncovered many new and unexpected players in melanoma development. The recent landmark study from The Cancer Genome Atlas (TCGA) consortium describing the...περισσότερα »
Tips and Tricks for Implementation of Sleep Dentistry into your Practice
*I have been attending entry level Dental CE courses for snoring and sleep apnea for over 20 years. It has always been fascinating to me that a dentist can take hundreds of hours of course hours but never really manage to get Sleep Apnea Dentistry implemented into his or her practice. This is an all two common occurrence and I thought the article below by Dr Erin Elliott does a great job setting out some really clear, real world. tips for beating “Wednesday Morning Syndrome”. The condition that some staff members find themselves in when the Dr gets back from a course with lots of ... περισσότερα »
Prevalence of Diabetic Retinopathy in a Population of Diabetics From the Middle East With Microvascular Ocular Motor Palsies.
Background: Vascular risk factors are increasing rapidly in the Middle East. Growing inactivity and obesity have contributed to an epidemic of Type 2 diabetes mellitus (DM) in the Arab population. Microvascular palsies of the third, fourth, and sixth cranial nerves, which occur in an isolated manner, are relatively common in patients with DM, hypertension, or other vascular risk factors. Methods: In this retrospective analysis, patients with diabetes with microvascular palsies were assessed for the prevalence of diabetic retinopathy (DR). We compared these data with the prevalence of... περισσότερα »
Major involvement of trunk muscles in myotonic dystrophy type 1
Objectives The motor impairments in Myotonic Dystrophy 1 (DM1) are assumed to progress from distal toward proximal parts of the extremities in the Juvenile and Adult forms of DM1. On occasion and late in progress spine deformity is observed. In this study we have examined whether and to what extent trunk muscles are impaired in DM1, and if this impairment is correlated with the duration of the disorder, walking capacity, mobility, balance, and CTG-repeats. Materials & methods Manual muscle testing (MMT) of skeletal muscle strength in trunk and extremities, reassessment of the mutat... περισσότερα »
Anxiety in Multiple Sclerosis: psychometric properties of the State-Trait Anxiety Inventory
Objective The aims of the present study were to examine psychometric properties of the Spielberger State-Trait Anxiety Inventory (STAI-Y-1 and STAI-Y-2, respectively) in a Multiple Sclerosis (MS) population and to identify a cut-off score to detect those MS patients with high level of state and/or trait anxiety who could be more vulnerable to development of depression and/or cognitive defects. Material and methods The STAI-Y-1 and STAI-Y-2 was completed by a group of patients (*n* = 175) affected by MS and a group of healthy subjects (*n* = 150) matched for age, educational level, ...περισσότερα »
Prevalence of Diabetic Retinopathy in a Population of Diabetics From the Middle East With Microvascular Ocular Motor Palsies.
Background: Vascular risk factors are increasing rapidly in the Middle East. Growing inactivity and obesity have contributed to an epidemic of Type 2 diabetes mellitus (DM) in the Arab population. Microvascular palsies of the third, fourth, and sixth cranial nerves, which occur in an isolated manner, are relatively common in patients with DM, hypertension, or other vascular risk factors. Methods: In this retrospective analysis, patients with diabetes with microvascular palsies were assessed for the prevalence of diabetic retinopathy (DR). We compared these data with the prevalence of... περισσότερα »
Diffuse traumatic axonal injury in mice induces complex behavioral alterations that are normalized by neutralization of interleukin- 1β
Abstract Widespread traumatic axonal injury (TAI) results in brain network dysfunction which commonly leads to persisting cognitive and behavioral impairments following traumatic brain injury (TBI). TBI induces a complex neuroinflammatory response, frequently located at sites of axonal pathology. The role of the pro-inflammatory cytokine interleukin-1β (IL-1β) has not been established in TAI. An IL-1β-neutralizing or a control antibody was administered intraperitoneally at 30 min following central fluid percussion injury (cFPI), a mouse model of widespread TAI. Animals subjected to... περισσότερα »
Subcellular calcium dynamics during juvenile development in mouse hippocampal astrocytes
Abstract Astrocytes generate calcium signals throughout their fine processes, which are assumed to locally regulate neighboring neurotransmission and blood flow. The intercellular morphological relationships mature during juvenile periods when astrocytes elongate highly ramified processes. In this study, we examined developmental changes in calcium activity patterns of single hippocampal astrocytes using a transgenic mouse line in which astrocytes selectively express a genetically encoded calcium indicator, Yellow Cameleon-Nano50. Compared with postnatal day 7, astrocytes at postnat...περισσότερα »
Oscillations in the embryonic chick olfactory bulb: initial expression and development revealed by optical imaging with a voltage-sensitive dye
Abstract In our previous study, we applied a multiple-site optical recording technique with a voltage-sensitive dye to the embryonic chick olfactory system and showed that functional synaptic transmission in the olfactory bulb was expressed at the embryonic 6-7-day stage. It is known that oscillations, i.e., stereotyped sinusoidal neural activity, appear in the olfactory system of various species. The focus of the present study is to determine whether the oscillation is also generated in the embryonic chick olfactory bulb and, if this is the case, when the oscillation appears and h... περισσότερα »
Striatonigral control of movement velocity in mice
Abstract The basal ganglia have long been implicated in action initiation. Using three-dimensional motion capture, we quantified the effects of optogenetic stimulation of the striatonigral (direct) pathway on movement kinematics. We generated transgenic mice with Channelrhodopsin-2 expression in striatal neurons that express the D1-like dopamine receptor. With optic fibers placed in the sensorimotor striatum, an area known to contain movement velocity-related single units, photo-stimulation reliably produced movements that could be precisely quantified with our motion capture progr... περισσότερα »
Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
Malaria accounts for an enormous burden of disease globally, with *Plasmodium falciparum* accounting for the majority of malaria, and *P. vivax* being a second important cause, especially in Asia, the Americas and the Pacific. During infection with *Plasmodium* spp., the merozoite form of the parasite invades red blood cells and replicates inside them. It is during the blood-stage of infection that malaria disease occurs and, therefore, understanding merozoite invasion, host immune responses to merozoite surface antigens, and targeting merozoite surface proteins and invasion ligan... περισσότερα »
Cisplatin-Induced Ototoxicity and the Effects of Intratympanic Diltiazem
Cisplatin-Induced Ototoxicity and the Effects of Intratympanic Diltiazem in a Mouse Model: Objective To evaluate whether the calcium-channel blocker diltiazem has protective effects against cisplatin-induced ototoxicity in a mouse model. Study Design Original basic science in vivo investigation. Setting Academic setting: Otolaryngology–Head and Neck Surgery laboratory at University of Connecticut Health Center. Subjects Thirty-nine female CBA/J mice. Methods Pure tone– or click-evoked auditory brainstem responses (ABRs) were recorded in CBA/J mice to determine auditory threshol... περισσότερα »
Tinnitus Trials: Reassessment of Tinnitus Guideline
A Systematic Review of Eligibility and Outcomes in Tinnitus Trials: Reassessment of Tinnitus Guideline: Objective To analyze existing tinnitus treatment trials with regard to eligibility criteria, outcome measures, study quality, and external validity and to recognize the effect of patient demographics, symptom duration, severity, and otologic comorbidity on research findings to help practitioners apply them to patient encounters. Data Sources Systematic literature search conducted by an information specialist for development of the American Academy of Otolaryngology—Head and Neck ...περισσότερα »
Head and Neck and Non-Head and Neck Malignant Peripheral Nerve Sheath Tumors
Comparative Analysis of Head and Neck and Non-Head and Neck Malignant Peripheral Nerve Sheath Tumors: Objectives Malignant peripheral nerve sheath tumors (MPNSTs) are a group of tumors that arise from peripheral nerves or from the various elements of the nerve sheath, including Schwann cells and perineural fibroblasts. Head and neck MPNSTs (HN-MPNSTs) are rare, accounting for 8% to 16% of all soft tissue sarcomas. This study analyzes the demographic, clinicopathologic, and survival characteristics of HN-MPNSTs and establishes comparisons with MPNSTs at other body sites (other-MPNSTs... περισσότερα »
Parotid Fine-Needle Aspiration
Sensitivity, Specificity, and Posttest Probability of Parotid Fine-Needle Aspiration: A Systematic Review and Meta-analysis: Objectives (1) To analyze the sensitivity and specificity of fine-needle aspiration (FNA) in distinguishing benign from malignant parotid disease. (2) To determine the anticipated posttest probability of malignancy and probability of nondiagnostic and indeterminate cytology with parotid FNA. Data Sources Independently corroborated computerized searches of PubMed, Embase, and Cochrane Central Register were performed. These were supplemented with manual searche... περισσότερα »
Cranial Nerve Stimulation for Obstructive Sleep Apnea
Three-Year Outcomes of Cranial Nerve Stimulation for Obstructive Sleep Apnea: The STAR Trial: Objective To describe the 36-month clinical and polysomnography (PSG) outcomes in an obstructive sleep apnea (OSA) cohort treated with hypoglossal cranial nerve upper airway stimulation (UAS). Study Design A multicenter prospective cohort study. Setting Industry-supported multicenter academic and clinical setting. Subjects Participants (n = 116) at 36 months from a cohort of 126 implanted participants. Methods Participants were enrolled in a prospective phase III trial evaluating the ... περισσότερα »
Reflection: The Early Career Surgeon-Scientists Pathway to Independence
Reflection: The Early Career Surgeon-Scientists Pathway to Independence: The surgeon-scientist offers a unique perspective as one who can arguably best comprehend clinical needs, identify areas ripe for research, and translate discoveries from bench to bedside. However, the long transition from postdoc to independent investigator can prove to be quite challenging. Surgeons have long been described as having results-oriented personalities, and so the long road to independence can be fraught with frustration at times. It requires humility in seeking scientific direction and mentorship...περισσότερα »
The triticeous cartilage is a small ovoid cartilaginous structure variably present as a component of the laryngeal skeleton. This structure has received scant attention in the literature and has yet to be described adequately on cross-sectional imaging.
Triticeous Cartilage CT Imaging Characteristics, Prevalence, Extent, and Distribution of Ossification: Objective The triticeous cartilage is a small ovoid cartilaginous structure variably present as a component of the laryngeal skeleton. This structure has received scant attention in the literature and has yet to be described adequately on cross-sectional imaging. Study Design and Setting Retrospective study in a tertiary medical center. Subjects and Methods We investigated triticeous cartilage prevalence in a large population utilizing computed tomography images. The cases of all... περισσότερα »
Empirical Derivation of Correction Factors for Human Spiral Ganglion Cell Nucleus and Nucleolus Count Units
Empirical Derivation of Correction Factors for Human Spiral Ganglion Cell Nucleus and Nucleolus Count Units: Objective Profile count method for estimating cell number in sectioned tissue applies a correction factor for double count (resulting from transection during sectioning) of count units selected to represent the cell. For human spiral ganglion cell counts, we attempted to address apparent confusion between published correction factors for nucleus and nucleolus count units that are identical despite the role of count unit diameter in a commonly used correction factor formula. ... περισσότερα »
Completion Lymph Node Dissection Based on Risk of Nonsentinel Metastasis in Cutaneous Melanoma of the Head and Neck
Completion Lymph Node Dissection Based on Risk of Nonsentinel Metastasis in Cutaneous Melanoma of the Head and Neck: Objective Theoretically, completion lymph node dissection (CNLD) should have the lowest benefit in the absence of nonsentinel lymph node (NSLN) metastases. For this reason, substantial research efforts have attempted to define specific criteria that are associated with a low-enough risk of NSLN positivity so that CLND can be deferred. Our objectives were (1) to identify features associated with low risk of NSLN positivity in sentinel lymph node–positive cutaneous mela...περισσότερα »
Use of modified lateral upper arm free flap for reconstruction of soft tissue defect after resection of oral cancer
Use of modified lateral upper arm free flap for reconstruction of soft tissue defect after resection of oral cancer: Abstract BackgroundTo evaluate the suitability of a modified lateral upper arm free flap (LAFF) for reconstruction of soft tissue defects after resection of oral cancer. MethodsEighteen cases of soft tissue defect repair performed between January 2011 and December 2013 using a modified LAFF after resection of oral cancer were reviewed. The design and harvest of the LAFF, the reconstruction procedure, and postoperative morbidity were reviewed and evaluated over a... περισσότερα »
Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior
Expression of cell adhesion molecule CD44 in mucoepidermoid carcinoma and its association with the tumor behavior: Abstract BackgroundThe most common malignant salivary gland tumors that affect both adult and children is mucoepidermoid carcinoma. It usually affects both minor and major salivary glands but parotid gland is considering the most common site in which this tumor arises. CD44, a trans-membrane glycoprotein, is an adhesion molecule of cell surface that play a role in the connections between cell-cell and cell-matrix. Many malignant tumors express high levels of CD44, thu...περισσότερα »
Efficacy of Recombinant Epstein-Barr Virus (EBV) Vaccine in Patients With Nasopharyngeal Cancer Who Had Residual EBV DNA Load After Conventional Therapy
Efficacy of Recombinant Epstein-Barr Virus (EBV) Vaccine in Patients With Nasopharyngeal Cancer Who Had Residual EBV DNA Load After Conventional Therapy: *Conditions*: Nasopharyngeal Cancer; Epstein-Barr Virus Infections *Intervention*: Biological: Recombinant Epstein-Barr Virus (EBV) Vaccine *Sponsor*: Chinese University of Hong Kong The purpose of this study is to evaluate the efficacy (clinical benefit rate) of MVA EBNA1/LMP2 vaccine in patients with persistent, recurrent or metastatic nasopharyngeal carcinoma, and its impact on disease progression. ConditionInterventi...περισσότερα »
Assessing Drug Response for Treatment of Nasopharyngeal Cancer
New Approach of Assessing Drug Response for Treatment of Nasopharyngeal Cancer: *Condition*: Advanced Nasopharyngeal Carcinoma *Intervention*: Drug: Chemotherapy *Sponsor*: Chinese University of Hong Kong The combination of pEBV DNA (half-life) and PET-CT following 1 course of chemotherapy allow earlier and more detection of drug response in advanced NPC than RECIST method, in patients with previously untreated advanced NPC who will receive platinum-based chemotherapy. This study will also determine if this new method can predict survival in these patients. This study may h... περισσότερα »
The role of heart rate in the left ventricular twist response to increased arterial blood pressure: a ‘stiff’ challenge?
from #Medicine via ola Kala on Inoreader http://ift.tt/1Q5XQpp Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PL2gS7 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KkUrq5 via IFTTT
DR5 Targeting Triggers Gastrointestinal Toxicity
The combination of TRAIL death receptor agonists and radiochemotherapy to treat advanced cancers continues to be investigated in clinical trials. We previously showed that normal cells with a functional DNA damage response (DDR) upregulate the expression of death-inducing receptor DR5/TRAILR2/TNFRSF10B in a p53-dependent manner that sensitizes them to treatment with DR5 agonists. However, it is unclear if targeting DR5 selectively sensitizes cancer cells to agonist treatment following exposure to DNA-damaging chemotherapy, and to what extent normal tissues are targeted. Here, we s...περισσότερα »
Sunderland’s shocking health legacy: Five people a week die from smoking – Sunderland Echo
[image: 1UC0xmB] Sunderland Echo*Sunderland’s shocking health legacy: Five people a week die from smoking* *Sunderland Echo* Besides lung *cancer*, smoking also causes *cancers* of the mouth, nasal cavities, pharynx and *larynx*, stomach, kidney, bowel, liver, pancreas, cervix, bladder and ovaries, oesophagus and ureter, as well as myeloid leukaemia. Worryingly, a survey of North … from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1QS2dZS via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 0030... περισσότερα »
Benefit from Bevacizumab and CCNU in Recurrent GBM Patients
The results from the randomized phase II BELOB trial provided evidence for a potential benefit of bevacizumab (beva), a humanized monoclonal antibody against circulating VEGF-A, when added to CCNU chemotherapy in patients with recurrent glioblastoma (GBM). In this study, we performed gene expression profiling (DASL and RNA-seq) of formalin-fixed, paraffin-embedded tumor material from participants of the BELOB trial to identify patients with recurrent GBM who benefitted most from beva+CCNU treatment. We demonstrate that tumors assigned to the IGS-18 or “classical” subtype and treat...περισσότερα »
Engraftment of enteric neural progenitor cells into the injured adult brain – BMC Blogs Network
[image: 1P83Z4H] BMC Blogs Network*Engraftment of enteric neural progenitor cells into the injured adult brain* *BMC Blogs Network* With a current lack of effective therapies for most neurological disorders, such as neurodegenerative diseases, traumatic brain injury, or long-term neurotoxicity from *cancer* therapy, and a steadily growing aging population with increasing prevalence *…* from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1RV5R6v via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & ... περισσότερα »
Observations on Radiation-Induced Lymphoid Tumors of Mice
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1JTtyK3 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tw6Ae4 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OZGxc0 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KkUqTa via IFTTT
Microscale distribution of virioplankton and heterotrophic bacteria in the Bohai Sea
In light of limited research in the relationship between the microscale distribution and dynamic changes of microplankton in the shallow Bohai Sea, here, we used flow cytometry to analyze samples collected from the Bohai Sea channel in winter and summer. Results showed that both the average of viral abundance (VA) and bacterial abundance (BA) were lower in winter (3.61 x 107 cells/mL and 1.84 x 106 cells/mL, respectively) than in summer (7.47 x 107 cells/mL and 5.05 x 106 cells/mL, respectively). At all 16 stations, VA was one order of magnitude greater than BA, with a positive re... περισσότερα »
Highlights from Recent Cancer Literature
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PKSgZ9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20B9ksq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tw8hbs via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KRj0WP via IFTTT
Editorial Board
from #Medicine via ola Kala on Inoreader http://ift.tt/1Q5XNda Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QS2V9v via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1KkUouy via IFTTT
Large Genomic Rearrangement in Pancreatic Ductal Tumors
Many somatic mutations have been detected in pancreatic ductal adenocarcinoma (PDAC), leading to the identification of some key drivers of disease progression, but the involvement of large genomic rearrangements has often been overlooked. In this study, we performed mate pair sequencing (MPseq) on genomic DNA from 24 PDAC tumors, including 15 laser-captured microdissected PDAC and 9 patient-derived xenografts, to identify genome-wide rearrangements. Large genomic rearrangements with intragenic breakpoints altering key regulatory genes involved in PDAC progression were detected in ...περισσότερα »
Microscale distribution of virioplankton and heterotrophic bacteria in the Bohai Sea
In light of limited research in the relationship between the microscale distribution and dynamic changes of microplankton in the shallow Bohai Sea, here, we used flow cytometry to analyze samples collected from the Bohai Sea channel in winter and summer. Results showed that both the average of viral abundance (VA) and bacterial abundance (BA) were lower in winter (3.61 x 107 cells/mL and 1.84 x 106 cells/mL, respectively) than in summer (7.47 x 107 cells/mL and 5.05 x 106 cells/mL, respectively). At all 16 stations, VA was one order of magnitude greater than BA, with a positive re... περισσότερα »
Antiangiogenesis Restores Bone Marrow Vascular Niche
Antiangiogenesis–based cancer therapies, specifically those targeting the VEGF-A/VEGFR2 pathway, have been approved for subsets of solid tumors. However, these therapies result in an increase in hematologic adverse events. We surmised that both the bone marrow vasculature and VEGF receptor–positive hematopoietic cells could be impacted by VEGF pathway–targeted therapies. We used a mouse model of spontaneous breast cancer to decipher the mechanism by which VEGF pathway inhibition alters hematopoiesis. Tumor-bearing animals, while exhibiting increased angiogenesis at the primary tum... περισσότερα »
Fat, Calories, and Cancer
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PKSjEq via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tw6Ae6 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tw8hIr via IFTTT
Oncogenic KRAS Modulates EZH2 Expression in NSCLC
EZH2 overexpression promotes cancer by increasing histone methylation to silence tumor suppressor genes, but how EZH2 levels become elevated in cancer is not understood. In this study, we investigated the mechanisms by which EZH2 expression is regulated in non–small cell lung carcinoma cells by oncogenic KRAS. In cells harboring KRASG12C and KRASG12D mutations, EZH2 expression was modulated by MEK–ERK and PI3K/AKT signaling, respectively. Accordingly, MEK–ERK depletion decreased EZH2 expression in cells harboring the KRASG12C mutation, whereas PI3K/AKT depletion decreased EZH2 exp... περισσότερα »
DR5 Targeting Triggers Gastrointestinal Toxicity
The combination of TRAIL death receptor agonists and radiochemotherapy to treat advanced cancers continues to be investigated in clinical trials. We previously showed that normal cells with a functional DNA damage response (DDR) upregulate the expression of death-inducing receptor DR5/TRAILR2/TNFRSF10B in a p53-dependent manner that sensitizes them to treatment with DR5 agonists. However, it is unclear if targeting DR5 selectively sensitizes cancer cells to agonist treatment following exposure to DNA-damaging chemotherapy, and to what extent normal tissues are targeted. Here, we s...περισσότερα »
Benefit from Bevacizumab and CCNU in Recurrent GBM Patients
The results from the randomized phase II BELOB trial provided evidence for a potential benefit of bevacizumab (beva), a humanized monoclonal antibody against circulating VEGF-A, when added to CCNU chemotherapy in patients with recurrent glioblastoma (GBM). In this study, we performed gene expression profiling (DASL and RNA-seq) of formalin-fixed, paraffin-embedded tumor material from participants of the BELOB trial to identify patients with recurrent GBM who benefitted most from beva+CCNU treatment. We demonstrate that tumors assigned to the IGS-18 or “classical” subtype and treat...περισσότερα »
Observations on Radiation-Induced Lymphoid Tumors of Mice
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1JTtyK3 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tw6Ae4 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1OZGxc0 via IFTTT
Highlights from Recent Cancer Literature
from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1PKSgZ9 via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/20B9ksq via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1Tw8hbs via IFTTT
Large Genomic Rearrangement in Pancreatic Ductal Tumors
Many somatic mutations have been detected in pancreatic ductal adenocarcinoma (PDAC), leading to the identification of some key drivers of disease progression, but the involvement of large genomic rearrangements has often been overlooked. In this study, we performed mate pair sequencing (MPseq) on genomic DNA from 24 PDAC tumors, including 15 laser-captured microdissected PDAC and 9 patient-derived xenografts, to identify genome-wide rearrangements. Large genomic rearrangements with intragenic breakpoints altering key regulatory genes involved in PDAC progression were detected in ...περισσότερα »
Modeling the Impact of Surgery on Metastasis
Rapid improvements in the detection and tracking of early-stage tumor progression aim to guide decisions regarding cancer treatments as well as predict metastatic recurrence in patients following surgery. Mathematical models may have the potential to further assist in estimating metastatic risk, particularly when paired with in vivo tumor data that faithfully represent all stages of disease progression. Herein, we describe mathematical analysis that uses data from mouse models of spontaneous metastasis developing after surgical removal of orthotopically implanted primary tumors. B... περισσότερα »
Engraftment of enteric neural progenitor cells into the injured adult brain – BMC Blogs Network
[image: 1P83Z4H] BMC Blogs Network*Engraftment of enteric neural progenitor cells into the injured adult brain* *BMC Blogs Network* With a current lack of effective therapies for most neurological disorders, such as neurodegenerative diseases, traumatic brain injury, or long-term neurotoxicity from *cancer* therapy, and a steadily growing aging population with increasing prevalence *…* from #ORL-AlexandrosSfakianakis via simeraentaxei on Inoreader http://ift.tt/1RV5R6v via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & ... περισσότερα »
BEZ235 plus Dexamethasone in ALL
*Purpose:* The aim of our study is to evaluate the preclinical therapeutic activity and mechanism of action of BEZ235, a dual PI3K/mTOR inhibitor, in combination with dexamethasone in acute lymphoblastic leukemia (ALL). *Experimental Design:* The cytotoxic effects of BEZ235 and dexamethasone as single agents and in combination were assessed in a panel of ALL cell lines and xenograft models. The underlying mechanism of BEZ235 and dexamethasone was evaluated using immunoblotting, TaqMan RT-PCR, siRNA, immunohistochemistry, and immunoprecipitation. *Results:* Inhibition of the PI3K/A... περισσότερα »
Blast from the past! Phrenic motor memory of antecedent episodic hypercapnia is serotonin dependent: relevance to respiratory rehabilitation and sleep-disordered breathing?
from #Medicine via ola Kala on Inoreader http://ift.tt/23CT2BN Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1UC1Npz via IFTTT
The role of heart rate in the left ventricular twist response to increased arterial blood pressure: a ‘stiff’ challenge?
from #Medicine via ola Kala on Inoreader http://ift.tt/1Q5XQpp Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1PL2gS7 via IFTTT
Editorial Board
from #Medicine via ola Kala on Inoreader http://ift.tt/1Q5XNda Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174 from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/1QS2V9v via IFTTT
Positron Emission Tomography (PET) During Radio-chemotherapy to Treat Otorhinolaryngological Cancer
Positron Emission Tomography (PET) During Radio-chemotherapy to Treat Otorhinolaryngological Cancer: *Conditions*: Malignant Neoplasm of Head and Neck; Locally Advanced Malignant Neoplasm *Interventions*: Device: Positron emission tomography; Radiation: radiochemotherapy *Sponsor*: Center Eugene Marquis ArmsAssigned InterventionsExperimental: Positron emission tomography Two additional PET Scan will be performed at 2 and 4 weeks for the first 30 patients. Then for the other patients only one additional PET-Scan will be performed Device: Positron emission tomography Radia...περισσότερα »
Vertebral Artery and Cerebral Hemodynamics After Various Head Positions & Manipulation in Patients With Neck Pain
Vertebral Artery and Cerebral Hemodynamics After Various Head Positions & Manipulation in Patients With Neck Pain: *Conditions*: Vertebral Artery Dissection; Cerebrovascular Accident; Stroke *Intervention*: Other: Head positions and spinal manipulation *Sponsors*: Canadian Memorial Chiropractic College; Canadian Medical Protective Association; National Chiropractic Mutual Insurance Company (NCMIC) ArmsAssigned InterventionsExperimental: Intervention group Participants included in the experimental arm will be adults aged 18 years and older with chronic/recurrent neck ...περισσότερα »
The Inflatable Thymus Herniation of the Normal Mediastinal Thymus
: A Case Report and Review of the Literature via International Journal of Pediatric Otorhinolaryngology Publication date: Available online 28 January 2016 *Source:*International Journal of Pediatric Otorhinolaryngology Author(s): Marijn Stuut, Gusta van Zwieten, Jos M. Straetmans, Martin Lacko, Constance T.R.M. Stumpel Anterior neck masses in young children can be a diagnostic challenge for otolaryngologists and radiologists. We present a rare case of herniation of normal mediastinal thymus in a four-year-old girl. Additional medical features as an inguinal hernia and trochlear nerve pa...περισσότερα »
Inflammation in gastric cancer: Interplay of the COX-2/PGE2 and TLR/MyD88 pathways
Abstract Cyclooxygenase 2 (COX-2) and its downstream product prostaglandin E2 (PGE2) play a key role in generation of inflammatory microenvironment in tumor tissues. Gastric cancer is closely associated with *Helicobacter pylori* infection, which stimulates innate immune responses through Toll-like receptors (TLRs), inducing COX-2/PGE2 pathway through NF-κB activation. A pathway analysis of human gastric cancer shows that both COX-2 pathway and Wnt/β-catenin signaling are significantly activated in tubular-type gastric cancer, while basal levels of these pathways are also increased... περισσότερα »
Burden of cancer associated with type 2 diabetes mellitus in Japan, 2010-2030
Summary Diabetes mellitus constitutes a major disease burden globally, and the prevalence of diabetes continues to increase worldwide. We aimed to estimate the burden of cancer associated with type 2 diabetes mellitus in Japan between 2010 and 2030. In this study, we estimated the Population Attributable Fraction of cancer risk associated with type 2 diabetes in 2010 and 2030 using the prevalence estimates of type 2 diabetes in Japan from 1990 to 2030, summary hazard ratios of diabetes and cancer risk from a pooled analysis of eight large-scale Japanese cohort studies, observed in...περισσότερα »
Pan-HER Augments Radiation Response
*Purpose:* Aberrant regulation of the EGF receptor family (EGFR, HER2, HER3, HER4) contributes to tumorigenesis and metastasis in epithelial cancers. Pan-HER represents a novel molecular targeted therapeutic composed of a mixture of six monoclonal antibodies against EGFR, HER2, and HER3. *Experimental Design:* In the current study, we examine the capacity of Pan-HER to augment radiation response across a series of human lung and head and neck cancers, including EGFR inhibitor–resistant cell lines and xenografts. *Results:* Pan-HER demonstrates superior antiproliferative and radio...περισσότερα »
MYBL1-NFIB Fusions in Adenoid Cystic Carcinoma
*Purpose:* Adenoid cystic carcinoma (ACC) is an indolent salivary gland malignancy, characterized by t(6;9) translocations and *MYB*–*NFIB* gene fusions in approximately 50% of the tumors. The genetic alterations underlying t(6;9)-negative and t(6;9)-positive/*MYB–NFIB* fusion–negative ACC remain unknown. To uncover the genetic alterations in ACC lacking the canonical translocation and fusion transcript and identify new abnormalities in translocation positive tumors. *Experimental Design:* We performed whole-genome sequencing in 21 salivary ACCs and conducted targeted molecular an... περισσότερα »
Measuring Toxicity in Phase I Clinical Trials
The standard categorical system for assessing attribution of toxicity to study drug(s) in phase I trials is cumbersome and uninformative. Although a binary system ("related" vs. "unrelated") would be sufficient to define maximum tolerated dose (MTD), a probability estimation would better support dose selection for randomized dose-ranging phase II trials. *Clin Cancer Res; 22(3); 527–9. ©2015 AACR*. *See related article by Eaton et al., p. 553* from Cancer via ola Kala on Inoreader http://ift.tt/1P7YN0v via IFTTT
NKTR-214, an Engineered Cytokine for Cancer Immunotherapy
*Purpose:* Aldesleukin, recombinant human IL2, is an effective immunotherapy for metastatic melanoma and renal cancer, with durable responses in approximately 10% of patients; however, severe side effects limit maximal dosing and thus the number of patients able to receive treatment and potential cure. NKTR-214 is a prodrug of conjugated IL2, retaining the same amino acid sequence as aldesleukin. The IL2 core is conjugated to 6 releasable polyethylene glycol (PEG) chains. *In vivo*, the PEG chains slowly release to generate active IL2 conjugates. *Experimental Design:* We evaluate... περισσότερα »
Local Tumor Immunity and Cancer Vaccine
Cancer vaccine boost via the cervicovaginal rather than the intramuscular route of immunization appears to be crucial to induce genital CD8+ T cells and tumor regression. This clinical activity is correlated with the ability of the mucosal boost to elicit resident memory T cells in the genital tract. *Clin Cancer Res; 22(3); 530–2. ©2015 AACR*. *See related article by Sun et al., p. 657* from Cancer via ola Kala on Inoreader http://ift.tt/1RV2igK via IFTTT
Stress-Related Signaling and Lethal Prostate Cancer
*Purpose:* Recent data suggest that neuroendocrine signaling may influence progression in some cancers. We aimed to determine whether genes within the five major stress-related signaling pathways are differentially expressed in tumor tissue when comparing prostate cancer patients with lethal and nonlethal disease. *Experimental Design:* We measured mRNA expression of 51 selected genes involved in predetermined stress-related signaling pathways (adrenergic, glucocorticoid, dopaminergic, serotoninergic, and muscarinic systems) in tumor tissue and normal prostate tissue collected fro...περισσότερα »
How HIPAA Regulation Changes Affect Research
In 2013, the U.S. Department of Health and Human Services modified the Health Insurance Portability and Accountability Act Privacy Rule to "strengthen privacy and security protections" while "improving workability and effectiveness to increase flexibility for and decrease burden on regulated entities." In this article, we attempt to translate these generalized goals into the real-world implications of these changes. Under the new rules, researchers can obtain participants' permission to use their protected health information for more research activities with a single, upfront auth... περισσότερα »
Local HPV Vaccinia Boost Enhances T-cell Responses
*Purpose:* Two viral oncoproteins, E6 and E7, are expressed in all human papillomavirus (HPV)–infected cells, from initial infection in the genital tract to metastatic cervical cancer. Intramuscular vaccination of women with high-grade cervical intraepithelial neoplasia (CIN2/3) twice with a naked DNA vaccine, pNGVL4a-sig/E7(detox)/HSP70, and a single boost with HPVE6/E7 recombinant vaccinia vaccine (TA-HPV) elicited systemic HPV-specific CD8 T-cell responses that could traffic to the lesion and was associated with regression in some patients (NCT00788164). *Experimental Design:* ... περισσότερα »
Mitochondrial Control of Tumor Progression
Small-molecule inhibitors of the phosphoinositide 3-kinase (PI3K), Akt, and mTOR pathway currently in the clinic produce a paradoxical reactivation of the pathway they are intended to suppress. Furthermore, fresh experimental evidence with PI3K antagonists in melanoma, glioblastoma, and prostate cancer shows that mitochondrial metabolism drives an elaborate process of tumor adaptation culminating with drug resistance and metastatic competency. This is centered on reprogramming of mitochondrial functions to promote improved cell survival and to fuel the machinery of cell motility a...περισσότερα »
PD-L1 Expression and TILs in HNSCC
*Purpose:* Programmed death-ligand 1 (PD-L1; also known as CD274 or B7-H1) expression represents a mechanism of immune escape for cancer. Our purpose was to characterize tumor PD-L1 expression and associated T-cell infiltration in primary laryngeal squamous cell carcinomas (SCC). *Experimental Design:* A well-annotated cohort of 260 operable primary laryngeal SCCs [formalin-fixed paraffin-embedded (FFPE) specimens] was morphologically characterized for stromal tumor-infiltrating lymphocytes (TIL), on hematoxylin/eosin-stained whole sections and for PD-L1 mRNA expression by qRT-PCR... περισσότερα »
ALK in Pediatric Cancer
In this era of more rational therapies, substantial efforts are being made to identify optimal targets. The discovery of translocations involving the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase in a subset of non–small cell lung cancers has become a paradigm for precision medicine. Notably, ALK was initially discovered as the fusion gene in anaplastic large cell non-Hodgkin lymphoma, a disease predominantly of childhood. The discovery of activating kinase domain mutations of the full-length ALK receptor as the major cause of hereditary neuroblastoma, and that somatic...περισσότερα »
p53-KLF4-CEBPA Axis in AML
*Purpose:* In acute myeloid leukemia (AML), the transcription factors CEBPA and KLF4 as well as the universal tumor suppressor p53 are frequently deregulated. Here, we investigated the extent of dysregulation, the molecular interactions, and the mechanisms involved. *Experimental Design:* One hundred ten AML patient samples were analyzed for protein levels of CEBPA, KLF4, p53, and p53 modulators. Regulation of *CEBPA* gene expression by KLF4 and p53 or by chemical p53 activators was characterized in AML cell lines. *Results:* We found that *CEBPA* gene transcription can be directl...περισσότερα »
Toxicity Attribution in Phase I Trials
*Purpose:* Phase I studies rely on investigators to accurately attribute adverse events as related or unrelated to study drug. This information is ultimately used to help establish a safe dose. Attribution in the phase I setting has not been widely studied and assessing the accuracy of attribution is complicated by the lack of a gold standard. We examined dose–toxicity relationships as a function of attribution and toxicity category to evaluate for evidence of toxicity misattribution. *Experimental Design:* Individual patient records from 38 phase I studies activated between 2000 ... περισσότερα »
Applied Sciences, Vol. 6, Pages 40: A Microfluidic Device for Hydrodynamic Trapping and Manipulation Platform of a Single Biological Cell
To perform specific analysis for the single cell, individual cells have to be captured and separated from each other before further treatments and analysis can be carried out. This paper presents the design, simulation, fabrication, and testing of a microfluidic device for trapping a single cell/particle based on a hydrodynamic technique. A T-channel trapping chip has been proposed to provide single-cell trapping and consequently could be a platform for cell treatments and manipulations. A finite element T-channel trapping model was developed using Abaqus FEA™ software to observe ... περισσότερα »
Applied Sciences, Vol. 6, Pages 39: Frequency-Dependent Amplitude Panning for the Stereophonic Image Enhancement of Audio Recorded Using Two Closely Spaced Microphones
In this paper, we propose a new frequency-dependent amplitude panning method for stereophonic image enhancement applied to a sound source recorded using two closely spaced omni-directional microphones. The ability to detect the direction of such a sound source is limited due to weak spatial information, such as the inter-channel time difference (ICTD) and inter-channel level difference (ICLD). Moreover, when sound sources are recorded in a convolutive or a real room environment, the detection of sources is affected by reverberation effects. Thus, the proposed method first tries to...περισσότερα »
Applied Sciences, Vol. 6, Pages 38: A Novel Bearing Lubricating Device Based on the Piezoelectric Micro-Jet
A novel bearing lubricating device, which is embedded in gyroscope's bearing system and based on the theory of the piezoelectric micro-jet, was designed for this study. The embedded structure of a bearing lubricating system can make effective use of the limited space of bearing systems without increasing the whole mass of the system. The drop-on-demand (DOD) lubrication can be realized by the piezoelectric micro-jet system to implement the long acting lubrication of the bearing system. A mathematical model of inlet boundary conditions was established to carry on the numerical simu...περισσότερα »
Issue Information
from #Medicine via ola Kala on Inoreader http://ift.tt/1P8azbf Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Pharmacy, Vol. 4, Pages 12: What is a Pharmacist: Opinions of Pharmacy Department Academics and Community Pharmacists on Competences Required for Pharmacy Practice
This paper looks at the opinions of 241 European academics (who provide pharmacy education), and of 258 European community pharmacists (who apply it), on competences for pharmacy practice. A proposal for competences was generated by a panel of experts using Delphi methodology. Once finalized, the proposal was then submitted to a large, European-wide community of academics and practicing pharmacists in an additional Delphi round. Academics and community pharmacy practitioners recognized the importance of the notion of patient care competences, underlining the nature of the pharmaci...περισσότερα »
Robotics, Vol. 5, Pages 4: Sensor Fusion and Autonomy as a Powerful Combination for Biological Assessment in the Marine Environment
The ocean environment and the physical and biological processes that govern dynamics are complex. Sampling the ocean to better understand these processes is difficult given the temporal and spatial domains and sampling tools available. Biological systems are especially difficult as organisms possess behavior, operate at horizontal scales smaller than traditional shipboard sampling allows, and are often disturbed by the sampling platforms themselves. Sensors that measure biological processes have also generally not kept pace with the development of physical counterparts as their re...περισσότερα »
Remote Sensing, Vol. 8, Pages 107: Rank-Based Methods for Selection of Landscape Metrics for Land Cover Pattern Change Detection
Often landscape metrics are not thoroughly evaluated with respect to remote sensing data characteristics, such as their behavior in relation to variation in spatial and temporal resolution, number of land cover classes or dominant land cover categories. In such circumstances, it may be difficult to ascertain whether a change in a metric is due to landscape pattern change or due to the inherent variability in multi-temporal data. This study builds on this important consideration and proposes a rank-based metric selection process through computation of four difference-based indices ... περισσότερα »
Sensors, Vol. 16, Pages 179: Secure and Privacy-Preserving Body Sensor Data Collection and Query Scheme
With the development of body sensor networks and the pervasiveness of smart phones, different types of personal data can be collected in real time by body sensors, and the potential value of massive personal data has attracted considerable interest recently. However, the privacy issues of sensitive personal data are still challenging today. Aiming at these challenges, in this paper, we focus on the threats from telemetry interface and present a secure and privacy-preserving body sensor data collection and query scheme, named SPCQ, for outsourced computing. In the proposed SPCQ sch...περισσότερα »
Geosciences, Vol. 6, Pages 8: Medical Geology: Impacts of the Natural Environment on Public Health
All living organisms are composed of major, minor, and trace elements, given by nature and supplied by geology. from #Medicine via ola Kala on Inoreader http://ift.tt/1nyWdcO Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
IJGI, Vol. 5, Pages 8: Integrated WiFi/PDR/Smartphone Using an Adaptive System Noise Extended Kalman Filter Algorithm for Indoor Localization
Wireless signal strength is susceptible to the phenomena of interference, jumping, and instability, which often appear in the positioning results based on Wi-Fi field strength fingerprint database technology for indoor positioning. Therefore, a Wi-Fi and PDR (pedestrian dead reckoning) real-time fusion scheme is proposed in this paper to perform fusing calculation by adaptively determining the dynamic noise of a filtering system according to pedestrian movement (straight or turning), which can effectively restrain the jumping or accumulation phenomena of wireless positioning and t... περισσότερα »
Molecules, Vol. 21, Pages 178: Unusual Nitrogenous Phenalenone Derivatives from the Marine-Derived Fungus Coniothyrium cereale
The new phenalenone metabolites 1, 2, 4, and 6 were isolated from the marine-derived endophytic fungus Coniothyrium cereale, in addition to the ergostane-type sterol (3) and entatrovenetinone (5). Compounds 1 and 2 represent two unusual nitrogen-containing compounds, which are composed of a sterol portion condensed via two bonds to phenalenone derivatives. Compound 6, which contains unprecedented imine functionality between two carbonyl groups to form a oxepane -imine-dione ring, exhibited a moderate cytotoxicity against K562, U266, and SKM1 cancer cell lines. Moreover, molecular ... περισσότερα »
Agronomy, Vol. 6, Pages 10: Selected Abiotic and Biotic Environmental Stress Factors Affecting Two Economically Important Sugarcane Stalk Boring Pests in the United States
Sugarcane, Saccharum spp., in the United States is attacked by a number of different arthropod pests. The most serious among those pests are two stalk boring moths in the Family Crambidae: the sugarcane borer, Diatraea saccharalis (F.), and the Mexican rice borer, Eoreuma loftini (Dyar). The two species are affected by abiotic and biotic environmental stress factors. Water deficit and excessive soil nitrogen alter physical and physiochemical aspects of the sugarcane plant that make the crop increasingly vulnerable to E. loftini. Weed growth can be competitive with sugarcane but it... περισσότερα »
Minerals, Vol. 6, Pages 8: Ciriottiite, Cu(Cu,Ag)3Pb19(Sb,As)22(As2)S56, the Cu-Analogue of Sterryite from the Tavagnasco Mining District, Piedmont, Italy
The new mineral species ciriottiite, ideally Cu(Cu,Ag)3Pb19(Sb,As)22(As2)S56 has been discovered in the Tavagnasco mining district, Piedmont, Italy, as very rare black metallic tubular crystals, up to 150 μm in length, associated with Bi sulfosalts and arsenopyrite. Its Vickers hardness (VHN10) is 203 kg/mm2 (range 190–219). In reflected light, ciriottiite is light grey in color, distinctly anisotropic with brownish to greenish rotation tints. Internal reflections are absent. Reflectance values for the four COM wavelengths (Rmin, Rmax (%) (λ in nm)) are: 33.2, 37.8 (471.1); 31.8, ... περισσότερα »
Batteries, Vol. 2, Pages 2: A Technical Report of the Robust Affordable Next Generation Energy Storage System-BASF Program
The goal of the Robust Affordable Next Generation Energy Storage System (RANGE)-BASF program is to provide an alternative solution for the energy storage media that powers electric vehicles other than the existing Li-ion battery. With the use of a rare-earth-free metal hydride (MH) as the active negative electrode material, together with a core-shell type alpha-beta nickel hydroxide as the active positive electrode and a sealed pouch design, an energy density of 145 Wh·kg−1 and cost model of $120 kWh−1 are shown to be feasible. Combined with the proven safety record and cycle stab... περισσότερα »
Micromachines, Vol. 7, Pages 23: A New XYZ Compliant Parallel Mechanism for Micro-/Nano-Manipulation: Design and Analysis
Based on the constraint and position identification (CPI) approach for synthesizing XYZ compliant parallel mechanisms (CPMs) and configuration modifications, this paper proposes a new fully-symmetrical XYZ CPM with desired motion characteristics such as reduced cross-axis coupling, minimized lost motion, and relatively small parasitic motion. The good motion characteristics arise from not only its symmetric configuration, but also the rigid linkages between non-adjacent rigid stages. Comprehensive kinematic analysis is carried out based on a series of finite element simulations ov... περισσότερα »
Algorithms, Vol. 9, Pages 13: Algorithms for Managing, Querying and Processing Big Data in Cloud Environments
Big data (e.g., [1–3]) has become one of the most challenging research topics in current years. Big data is everywhere, from social networks to web advertisements, from sensor and stream systems to bio-informatics, from graph management tools to smart cities, and so forth. [...] from #Medicine via ola Kala on Inoreader http://ift.tt/1SmfcET Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
JDB, Vol. 4, Pages 7: Restricted Pax3 Deletion within the Neural Tube Results in Congenital Hydrocephalus
Congenital hydrocephalus is a common birth-defect whose developmental origins are poorly understood. Pax3-null mutants show defects in myogenesis, neural tube closure, neural crest morphogenesis, and heart development that, consequently, results in embryonic lethality. Here we demonstrate that conditional deletion of the mouse Pax3 transcription factor results in fully-penetrant congenital obstructive hydrocephalus. To identify the role of Pax3 during cranial development, we deleted Pax3 within the neuroepithelium (via Pax7−Cre), in the neural crest (via P0-Cre), and in both the n... περισσότερα »
Nanomaterials, Vol. 6, Pages 26: Manufacturing Techniques and Surface Engineering of Polymer Based Nanoparticles for Targeted Drug Delivery to Cancer
The evolution of polymer based nanoparticles as a drug delivery carrier via pharmaceutical nano/microencapsulation has greatly promoted the development of nano- and micro-medicine in the past few decades. Poly(lactide-co-glycolide) (PLGA) and chitosan, which are biodegradable and biocompatible polymers, have been approved by both the Food & Drug Administration (FDA) and European Medicine Agency (EMA), making them ideal biomaterials that can be advanced from laboratory development to clinical oral and parental administrations. PLGA and chitosan encapsulated nanoparticles (NPs) have... περισσότερα »
Algorithms, Vol. 9, Pages 14: Two Efficient Derivative-Free Iterative Methods for Solving Nonlinear Systems
In this work, two multi-step derivative-free iterative methods are presented for solving system of nonlinear equations. The new methods have high computational efficiency and low computational cost. The order of convergence of the new methods is proved by a development of an inverse first-order divided difference operator. The computational efficiency is compared with the existing methods. Numerical experiments support the theoretical results. Experimental results show that the new methods remarkably reduce the computing time in the process of high-precision computing. from #Medi... περισσότερα »
Agriculture, Vol. 6, Pages 7: Monitoring Soil Sealing in Guadarrama River Basin, Spain, and Its Potential Impact in Agricultural Areas
This study analyzes soil sealing and its repercussions in the loss of fertile soils, which are more appropriate for agriculture use. Also, soil sealing increases flood risk. The main objective is to estimate soil loss by sealing in the Guadarrama River Basin (Madrid, Spain) between 1961 and 2011. The combination of digital processing (Normalized Difference Vegetation Index (NDVI), principal components and convolution filters) of satellite imagery with the digital terrain model helps to detect risk areas and allows quick updating of sealed soil mapping. The supervised classificatio... περισσότερα »
Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach
ABSTRACT There is a large amount of functional genetic data available, which can be used to inform fine-mapping association studies (in diseases with well-characterised disease pathways). Single nucleotide polymorphism (SNP) prioritization via Bayes factors is attractive because prior information can inform the effect size or the prior probability of causal association. This approach requires the specification of the effect size. If the information needed to estimate a priori the probability density for the effect sizes for causal SNPs in a genomic region isn't consistent or isn't ... περισσότερα »
The genomic landscape of cutaneous melanoma
Summary Somatic mutation analysis of melanoma has been done at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last five years next-generation sequencing (NGS) has enabled even more comprehensive mutational screening at the level of multi-gene panels, exomes and genomes. These studies have uncovered many new and unexpected players in melanoma development. The recent landmark study from The Cancer Genome Atlas (TCGA) consortium describing th...περισσότερα »
Searching for cognitive enhancement in the Morris watermaze: Better and worse performance in D-amino acid oxidase knockout (Dao-/-) mice
Abstract A common strategy when searching for cognitive enhancing drugs has been to target the NMDA receptor, given its putative role in synaptic plasticity and learning. Evidence in favour of this approach has come primarily from studies with rodents using behavioural assays like the Morris watermaze. D-amino acid oxidase (DAO) degrades neutral D-amino acids such as D-serine, the primary endogenous co-agonist acting at the glycine site of the synaptic NMDA receptor. Inhibiting DAO could therefore provide an effective and viable means of enhancing cognition, particularly in disorde... περισσότερα »
Neurochemical and behavioral indices of exercise reward are independent of exercise controllability
Abstract Brain reward circuits are implicated in stress-related psychiatric disorders. Exercise reduces the incidence of stress-related disorders, but the contribution of exercise reward to stress resistance is unknown. Exercise-induced stress resistance is independent of exercise controllability; both voluntary and forced wheel running protect rats against anxiety- and depression-like behavioral consequences of stress. Voluntary exercise is a natural reward, but whether rats find forced wheel running rewarding is unknown. Moreover, the contribution of dopamine (DA) and striatal r... περισσότερα »
Microglia-Derived Purines Modulate Mossy Fiber Synaptic Transmission and Plasticity through P2X4 and A1 Receptors
Abstract Recent data have provided evidence that microglia, the brain resident macrophage-like cells, modulate neuronal activity in both physiological and pathophysiological conditions and consequently microglia are now recognized as synaptic partners. Among different neuromodulators, purines, which are produced and be released by microglia, have emerged as promising candidates to mediate interactions between microglia and synapses. Cellular effects of purines are mediated through a large family of receptors for adenosine and for ATP (P2 receptors). These receptors are present at b...περισσότερα »
Tips and Tricks for Implementation of Sleep Dentistry into your Practice
*I have been attending entry level Dental CE courses for snoring and sleep apnea for over 20 years. It has always been fascinating to me that a dentist can take hundreds of hours of course hours but never really manage to get Sleep Apnea Dentistry implemented into his or her practice. This is an all two common occurrence and I thought the article below by Dr Erin Elliott does a great job setting out some really clear, real world. tips for beating "Wednesday Morning Syndrome". The condition that some staff members find themselves in when the Dr gets back from a course with lots of ... περισσότερα »
The genomic landscape of cutaneous melanoma
Summary Somatic mutation analysis of melanoma has been done at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last five years next-generation sequencing (NGS) has enabled even more comprehensive mutational screening at the level of multi-gene panels, exomes and genomes. These studies have uncovered many new and unexpected players in melanoma development. The recent landmark study from The Cancer Genome Atlas (TCGA) consortium describing th...περισσότερα »
Mutational characteristics of ANK1 and SPTB genes in hereditary spherocytosis
Abstract The aim of the present study was to describe the mutational characteristics in Korean hereditary spherocytosis(HS) patients. Relevant literatures including genetically confirmed cases with well-documented clinical summaries and relevant information was also reviewed to investigate the mutational gene- or domain-specific laboratory and clinical association. Twenty-five HS patients carried one heterozygous mutation of *ANK1*(n=13) or *SPTB*(n=12) but not in *SPTA1*, *SLC4A1*, or *EPB42*. Deleterious mutations including frameshift, nonsense, and splice site mutations were id...περισσότερα »
Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ABSTRACT There is a large amount of functional genetic data available, which can be used to inform fine-mapping association studies (in diseases with well-characterised disease pathways). Single nucleotide polymorphism (SNP) prioritization via Bayes factors is attractive because prior information can inform the effect size or the prior probability of causal association. This approach requires the […]
Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
ABSTRACT There is a large amount of functional genetic data available, which can be used to inform fine-mapping association studies (in diseases with well-characterised disease pathways). Single nucleotide polymorphism (SNP) prioritization via Bayes factors is attractive because prior information can inform the effect size or the prior probability of causal association. This approach requires the […]
The genomic landscape of cutaneous melanoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Somatic mutation analysis of melanoma has been done at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last five years next-generation sequencing (NGS) has enabled even more comprehensive mutational screening at the level of multi-gene panels, […]
The genomic landscape of cutaneous melanoma
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Somatic mutation analysis of melanoma has been done at the single gene level extensively over the past several decades. This has provided considerable insight into the critical pathways controlling melanoma initiation and progression. During the last five years next-generation sequencing (NGS) has enabled even more comprehensive mutational screening at the level of multi-gene panels, […]
Recombinant human thyrotropin-stimulated thyroglobulin level at the time of radioactiveiodine ablation is an independent prognostic marker of differentiated thyroid carcinoma in the setting of prophylactic central neck dissection
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objective We investigated the value of the stimulated thyroglobulin (Tg) level at the time of recombinant human thyrotropin (rhTSH)-aided remnant ablation for predicting disease status 1 year later in DTC patients who underwent total thyroidectomy with central neck dissection (CND). Design, setting, and participant This was a prospective observational study of 253 consecutive DTC […]
The cell- and tissue-specific transcription mechanism of the TATA-less syntaxin 1A gene Research Communication
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Syntaxin 1A (Stx1a) plays an important role in regulation of neuronal synaptic function. To clarify the mechanism of basic transcriptional regulation and neuron-specific transcription of Stx1a we cloned the Stx1a gene from rat, in which knowledge of the expression profile was accumulated, and elucidated that Stx1a consisting of 10 exons, possesses multiple transcription initiation sites […]
Cell rearrangement in transplanted human islets Research Communication
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The major feature of the human pancreatic islet architecture is the organization of endocrine cells into clusters comprising central β cells and peripheral α cells surrounded by vasculature. To have an insight into the mechanisms that govern this unique islet architecture, islet cells were isolated, and reaggregation of α and β cells into islet-like structures […]
Skeletal muscle-specific eukaryotic translation initiation factor 2{alpha} phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism Research Communication
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The eukaryotic translation initiation factor 2α (eIF2α) phosphorylation-dependent integrated stress response (ISR), a component of the unfolded protein response, has long been known to regulate intermediary metabolism, but the details are poorly worked out. We report that profiling of mRNAs of transgenic mice harboring a ligand-activated skeletal muscle–specific derivative of the eIF2α protein kinase R-like […]
Galectin-4 interacts with the drug transporter human concentrative nucleoside transporter 3 to regulate its function Research Communication
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
The intracellular N-terminal domain of the nucleoside and drug transporter human concentrative nucleoside transporter (hCNT)3 was used as bait in a glutathione S-transferase pull-down approach, to identify hCNT3 protein partners, using human colon homogenates as a prey source. Galectin (Gal)-4 was identified as a potential hCNT3 partner in the colon. The biochemical validation of the […]
Hepatocyte {beta}-Klotho regulates lipid homeostasis but not body weight in mice Research Communication
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
β-Klotho (β-Kl), a transmembrane protein expressed in the liver, pancreas, adipose tissues, and brain, is essential for feedback suppression of hepatic bile acid synthesis. Because bile acid is a key regulator of lipid and energy metabolism, we hypothesized potential and tissue-specific roles of β-Kl in regulating plasma lipid levels and body weight. By crossing β-kl–/– […]
Site-specific recombination in the chicken genome using Flipase recombinase-mediated cassette exchange Research Communication
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Targeted genome recombination has been applied in diverse research fields and has a wide range of possible applications. In particular, the discovery of specific loci in the genome that support robust and ubiquitous expression of integrated genes and the development of genome-editing technology have facilitated rapid advances in various scientific areas. In this study, we […]
A novel method of preparing the monoform structure of catalytic antibody light chain Research Communication
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Along with the development of antibody drugs and catalytic antibodies, the structural diversity (heterogeneity) of antibodies has been given attention. For >20 yr, detailed studies on the subject have not been conducted, because the phenomenon presents many difficult and complex problems. Structural diversity provides some (or many) isoforms of an antibody distinguished by different charges, […]
Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the {alpha}-synuclein-elicited immune response Research Communication
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
We have investigated the potential role of molecular chaperones as modulators of the immune response by using α-synuclein (αSyn) as an aggregation-prone model protein. We first performed an in vitro immunoscreening with 21 preselected candidate chaperones and selected 2 from this set as displaying immunological activity with differential profiles, Grp94/Gp96 and FKBP4/52. We then immunized […]
The YY1/MMP2 axis promotes trophoblast invasion at the maternal-foetal interface
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract YY1 is a sequence-specific DNA-binding transcription factor that has many important biological roles. However, its function in trophoblasts at the maternal-foetal interface remains to be elucidated. In this study, we used an mRNA microarray and reverse transcription qPCR and compared the YY1 mRNA expression level in trophoblasts between patients with recurrent miscarriage (RM) and […]
Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Papillary thyroid carcinoma (PTC) is the most common adult thyroid malignancy and often presents with multiple anatomically distinct foci within the thyroid, known as multifocal papillary thyroid carcinoma (MPTC). The widespread application of the next-generation sequencing technologies in cancer genomics research provides novel insights into determining the clonal relationship between multiple tumours within the […]
TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/β-catenin and MAPK signalling
Abstract Colorectal cancer (CRC) is one of the most common malignancies and is the second leading cause of cancer death in humans. Tumour suppressor candidate 3 (*TUSC3*) plays an important role in embryogenesis and metabolism. Deletion of *TUSC3* often causes non-syndromic mental retardation. Even though *TUSC3* deregulation is frequently observed in epithelial cancers, the function of *TUSC3* in CRC has remained unknown. In this study, we observed greater expression of TUSC3 at the mRNA and protein level in clinical colorectal tumour samples compared with paired normal tissues. ... περισσότερα »
Mesothelial-to-mesenchymal transition in the pathogenesis of post-surgical peritoneal adhesions
[image: cover.gif?v=1&s=a6fb6e56b7c271e97744ac7f] Abstract Peritoneal adhesions (PAs) are fibrotic bands formed between bowel loops, solid organs and the parietal peritoneum, that may appear following surgery, infection or endometriosis. They represent an important health problem with no effective treatment. Mesothelial cells (MCs) line the peritoneal cavity and undergo a mesothelial-to-mesenchymal transition (MMT) under pathological conditions, transforming into myofibroblasts, which are abundant in peritoneal fibrotic tissue. The aim of this study was to investigate if peritone...περισσότερα »
Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney (CCSK) : Not the full story…
[image: cover.gif?v=1&s=a6fb6e56b7c271e97744ac7f] Abstract Internal tandem duplication within the *BCOR* gene sequence that encodes the PUFD domain, important in the formation of the non-canonical or variant polycomb repressor complex 1 (v-PRC1), was very recently described in 100% of 20 clear cell sarcoma of kidney (CCSK). None of those 20 cases bore the *YWHAE-NUTM2* transcript, previously described by us in CCSK, and which constitutes the only other recurrent genetic aberration observed in CCSK, prompting consideration that these mutations might be mutually exclusive in CCSK. ... περισσότερα »
The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy
Abstract Converging evidence points to glycogen synthase kinase (GSK) 3 as a key player in the pathogenesis of podocytopathy and proteinuria. However, it remains unclear if GSK3 is involved in podocyte autonomous injury in glomerular disease. In normal kidneys, the β isoform of GSK3 was found to be the major GSK3 expressed in glomeruli and intensely stained in podocytes. GSK3β expression in podocytes was markedly elevated in experimental or human proteinuric glomerulopathy. Podocyte specific somatic ablation of GSK3β in adult mice attenuated proteinuria and ameliorated podocyte in... περισσότερα »
The YY1/MMP2 axis promotes trophoblast invasion at the maternal-foetal interface
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract YY1 is a sequence-specific DNA-binding transcription factor that has many important biological roles. However, its function in trophoblasts at the maternal-foetal interface remains to be elucidated. In this study, we used an mRNA microarray and reverse transcription qPCR and compared the YY1 mRNA expression level in trophoblasts between patients with recurrent miscarriage (RM) and […]
Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Papillary thyroid carcinoma (PTC) is the most common adult thyroid malignancy and often presents with multiple anatomically distinct foci within the thyroid, known as multifocal papillary thyroid carcinoma (MPTC). The widespread application of the next-generation sequencing technologies in cancer genomics research provides novel insights into determining the clonal relationship between multiple tumours within the […]
TUSC3 promotes colorectal cancer progression and epithelial-mesenchymal transition (EMT) through WNT/β-catenin and MAPK signalling
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Colorectal cancer (CRC) is one of the most common malignancies and is the second leading cause of cancer death in humans. Tumour suppressor candidate 3 (TUSC3) plays an important role in embryogenesis and metabolism. Deletion of TUSC3 often causes non-syndromic mental retardation. Even though TUSC3 deregulation is frequently observed in epithelial cancers, the function […]
Mesothelial-to-mesenchymal transition in the pathogenesis of post-surgical peritoneal adhesions
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Peritoneal adhesions (PAs) are fibrotic bands formed between bowel loops, solid organs and the parietal peritoneum, that may appear following surgery, infection or endometriosis. They represent an important health problem with no effective treatment. Mesothelial cells (MCs) line the peritoneal cavity and undergo a mesothelial-to-mesenchymal transition (MMT) under pathological conditions, transforming into myofibroblasts, which […]
Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney (CCSK) : Not the full story…
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Internal tandem duplication within the BCOR gene sequence that encodes the PUFD domain, important in the formation of the non-canonical or variant polycomb repressor complex 1 (v-PRC1), was very recently described in 100% of 20 clear cell sarcoma of kidney (CCSK). None of those 20 cases bore the YWHAE-NUTM2 transcript, previously described by us […]
The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Converging evidence points to glycogen synthase kinase (GSK) 3 as a key player in the pathogenesis of podocytopathy and proteinuria. However, it remains unclear if GSK3 is involved in podocyte autonomous injury in glomerular disease. In normal kidneys, the β isoform of GSK3 was found to be the major GSK3 expressed in glomeruli and […]
Tips and Tricks for Implementation of Sleep Dentistry into your Practice
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
I have been attending entry level Dental CE courses for snoring and sleep apnea for over 20 years. It has always been fascinating to me that a dentist can take hundreds of hours of course hours but never really manage to get Sleep Apnea Dentistry implemented into his or her practice. This is an all […]
Recombinant human thyrotropin-stimulated thyroglobulin level at the time of radioactiveiodine ablation is an independent prognostic marker of differentiated thyroid carcinoma in the setting of prophylactic central neck dissection
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Abstract Objective We investigated the value of the stimulated thyroglobulin (Tg) level at the time of recombinant human thyrotropin (rhTSH)-aided remnant ablation for predicting disease status 1 year later in DTC patients who underwent total thyroidectomy with central neck dissection (CND). Design, setting, and participant This was a prospective observational study of 253 consecutive DTC […]
Prevalence of Diabetic Retinopathy in a Population of Diabetics From the Middle East With Microvascular Ocular Motor Palsies.
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Background: Vascular risk factors are increasing rapidly in the Middle East. Growing inactivity and obesity have contributed to an epidemic of Type 2 diabetes mellitus (DM) in the Arab population. Microvascular palsies of the third, fourth, and sixth cranial nerves, which occur in an isolated manner, are relatively common in patients with DM, hypertension, or […]
Major involvement of trunk muscles in myotonic dystrophy type 1
alsfakianakisστοOtolaryngology lifelong learning : Otolaryngology by Alexandros Sfakianakis,Greece Crete,Anapafseos 5 Agios Nikolaos 72100,tel : 00302841026182,00306932607174Πριν από 1 ώρα
Objectives The motor impairments in Myotonic Dystrophy 1 (DM1) are assumed to progress from distal toward proximal parts of the extremities in the Juvenile and Adult forms of DM1. On occasion and late in progress spine deformity is observed. In this study we have examined whether and to what extent trunk muscles are impaired in […]
Recombinant human thyrotropin-stimulated thyroglobulin level at the time of radioactiveiodine ablation is an independent prognostic marker of differentiated thyroid carcinoma in the setting of prophylactic central neck dissection
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Objective We investigated the value of the stimulated thyroglobulin (Tg) level at the time of recombinant human thyrotropin (rhTSH)-aided remnant ablation for predicting disease status 1 year later in DTC patients who underwent total thyroidectomy with central neck dissection (CND). Design, setting, and participant This was a prospective observational study of 253 consecutive DTC […]
Inflammation in gastric cancer: Interplay of the COX-2/PGE2 and TLR/MyD88 pathways
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Abstract Cyclooxygenase 2 (COX-2) and its downstream product prostaglandin E2 (PGE2) play a key role in generation of inflammatory microenvironment in tumor tissues. Gastric cancer is closely associated with Helicobacter pylori infection, which stimulates innate immune responses through Toll-like receptors (TLRs), inducing COX-2/PGE2 pathway through NF-κB activation. A pathway analysis of human gastric cancer shows […]
Burden of cancer associated with type 2 diabetes mellitus in Japan, 2010-2030
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Summary Diabetes mellitus constitutes a major disease burden globally, and the prevalence of diabetes continues to increase worldwide. We aimed to estimate the burden of cancer associated with type 2 diabetes mellitus in Japan between 2010 and 2030. In this study, we estimated the Population Attributable Fraction of cancer risk associated with type 2 diabetes […]
Applied Sciences, Vol. 6, Pages 40: A Microfluidic Device for Hydrodynamic Trapping and Manipulation Platform of a Single Biological Cell
To perform specific analysis for the single cell, individual cells have to be captured and separated from each other before further treatments and analysis can be carried out. This paper presents the design, simulation, fabrication, and testing of a microfluidic device for trapping a single cell/particle based on a hydrodynamic technique. A T-channel trapping chip has been proposed to provide single-cell trapping and consequently could be a platform for cell treatments and manipulations. A finite element T-channel trapping model was developed using Abaqus FEA™ software to observe ... περισσότερα »
Prevalence of Diabetic Retinopathy in a Population of Diabetics From the Middle East With Microvascular Ocular Motor Palsies.
Background: Vascular risk factors are increasing rapidly in the Middle East. Growing inactivity and obesity have contributed to an epidemic of Type 2 diabetes mellitus (DM) in the Arab population. Microvascular palsies of the third, fourth, and sixth cranial nerves, which occur in an isolated manner, are relatively common in patients with DM, hypertension, or other vascular risk factors. Methods: In this retrospective analysis, patients with diabetes with microvascular palsies were assessed for the prevalence of diabetic retinopathy (DR). We compared these data with the prevalence of... περισσότερα »
Major involvement of trunk muscles in myotonic dystrophy type 1
Objectives The motor impairments in Myotonic Dystrophy 1 (DM1) are assumed to progress from distal toward proximal parts of the extremities in the Juvenile and Adult forms of DM1. On occasion and late in progress spine deformity is observed. In this study we have examined whether and to what extent trunk muscles are impaired in DM1, and if this impairment is correlated with the duration of the disorder, walking capacity, mobility, balance, and CTG-repeats. Materials & methods Manual muscle testing (MMT) of skeletal muscle strength in trunk and extremities, reassessment of the mu... περισσότερα »
Anxiety in Multiple Sclerosis: psychometric properties of the State-Trait Anxiety Inventory
Objective The aims of the present study were to examine psychometric properties of the Spielberger State-Trait Anxiety Inventory (STAI-Y-1 and STAI-Y-2, respectively) in a Multiple Sclerosis (MS) population and to identify a cut-off score to detect those MS patients with high level of state and/or trait anxiety who could be more vulnerable to development of depression and/or cognitive defects. Material and methods The STAI-Y-1 and STAI-Y-2 was completed by a group of patients (*n* = 175) affected by MS and a group of healthy subjects (*n* = 150) matched for age, educational leve...περισσότερα »
Prevalence of Diabetic Retinopathy in a Population of Diabetics From the Middle East With Microvascular Ocular Motor Palsies.
Background: Vascular risk factors are increasing rapidly in the Middle East. Growing inactivity and obesity have contributed to an epidemic of Type 2 diabetes mellitus (DM) in the Arab population. Microvascular palsies of the third, fourth, and sixth cranial nerves, which occur in an isolated manner, are relatively common in patients with DM, hypertension, or other vascular risk factors. Methods: In this retrospective analysis, patients with diabetes with microvascular palsies were assessed for the prevalence of diabetic retinopathy (DR). We compared these data with the prevalence of... περισσότερα »
Diffuse traumatic axonal injury in mice induces complex behavioral alterations that are normalized by neutralization of interleukin- 1β
Abstract Widespread traumatic axonal injury (TAI) results in brain network dysfunction which commonly leads to persisting cognitive and behavioral impairments following traumatic brain injury (TBI). TBI induces a complex neuroinflammatory response, frequently located at sites of axonal pathology. The role of the pro-inflammatory cytokine interleukin-1β (IL-1β) has not been established in TAI. An IL-1β-neutralizing or a control antibody was administered intraperitoneally at 30 min following central fluid percussion injury (cFPI), a mouse model of widespread TAI. Animals subjected t... περισσότερα »
Subcellular calcium dynamics during juvenile development in mouse hippocampal astrocytes
Abstract Astrocytes generate calcium signals throughout their fine processes, which are assumed to locally regulate neighboring neurotransmission and blood flow. The intercellular morphological relationships mature during juvenile periods when astrocytes elongate highly ramified processes. In this study, we examined developmental changes in calcium activity patterns of single hippocampal astrocytes using a transgenic mouse line in which astrocytes selectively express a genetically encoded calcium indicator, Yellow Cameleon-Nano50. Compared with postnatal day 7, astrocytes at postna...περισσότερα »
Oscillations in the embryonic chick olfactory bulb: initial expression and development revealed by optical imaging with a voltage-sensitive dye
Abstract In our previous study, we applied a multiple-site optical recording technique with a voltage-sensitive dye to the embryonic chick olfactory system and showed that functional synaptic transmission in the olfactory bulb was expressed at the embryonic 6-7-day stage. It is known that oscillations, i.e., stereotyped sinusoidal neural activity, appear in the olfactory system of various species. The focus of the present study is to determine whether the oscillation is also generated in the embryonic chick olfactory bulb and, if this is the case, when the oscillation appears and ... περισσότερα »
Striatonigral control of movement velocity in mice
Abstract The basal ganglia have long been implicated in action initiation. Using three-dimensional motion capture, we quantified the effects of optogenetic stimulation of the striatonigral (direct) pathway on movement kinematics. We generated transgenic mice with Channelrhodopsin-2 expression in striatal neurons that express the D1-like dopamine receptor. With optic fibers placed in the sensorimotor striatum, an area known to contain movement velocity-related single units, photo-stimulation reliably produced movements that could be precisely quantified with our motion capture prog... περισσότερα »
Selected Articles from This Issue
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Prosigna ROR Score Predicts Chemosensitivity
*Purpose:* Most hormone receptor (HR)+/HER2– breast cancer patients respond unfavorably to neoadjuvant chemotherapy (NAC); however, genomic tests may identify those patients who are likely to benefit. Using the Prosigna assay, we first evaluated the technical performance of core needle biopsy (CNB) tissues. We then determined whether Prosigna risk of relapse (ROR) score and intrinsic subtype predicted response to NAC in HR+/HER2– patients using CNB samples. *Experimental Design:* Using the NanoString's nCounter Dx analysis system and a development tissue sample set, we established... περισσότερα »
Therapeutic Wnt Pathway Inhibition in Colorectal Cancer
*Purpose:* Oncogenic mutations in the KRAS/PI3K/AKT pathway are one of the most frequent alterations in cancer. Although PI3K or AKT inhibitors show promising results in clinical trials, drug resistance frequently emerges. We previously revealed Wnt/β-catenin signaling hyperactivation as responsible for such resistance in colorectal cancer. Here we investigate Wnt-mediated resistance in patients treated with PI3K or AKT inhibitors in clinical trials and evaluate the efficacy of a new Wnt/tankyrase inhibitor, NVP-TNKS656, to overcome such resistance. *Experimental Design:* Colorect... περισσότερα »
Prognostic Value of BRAF Mutation Detection in Circulation
*Purpose:* Tumor-derived circulating cell–free DNA (cfDNA) is a potential alternative source from which to derive tumor mutation status. cfDNA data from four clinical studies of the BRAF inhibitor (BRAFi) dabrafenib or the MEK inhibitor (MEKi) trametinib were analyzed to determine the association between *BRAF* mutation status in cfDNA and tumor tissue, and the association of *BRAF* cfDNA mutation status with baseline factors and clinical outcome. *Experimental Design:* Patients with *BRAF* V600 mutation–positive melanoma were enrolled in each study after central confirmation of *... περισσότερα »
Prostate Cancer Stem Cell Therapy
*Purpose:* Clinical evidence suggests increased cancer stem cells (CSCs) in a tumor mass may contribute to the failure of conventional therapies because CSCs seem to be more resistant than differentiated tumor cells. Thus, unveiling the mechanism regulating CSCs and candidate target molecules will provide new strategy to cure the patients. *Experimental design:* The stem-like cell properties were determined by a prostasphere assay and dye exclusion assay. To find critical stem cell marker and reveal regulation mechanism, basic biochemical and molecular biologic methods, such as qu...περισσότερα »
Editorial Board
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
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Large Genomic Rearrangement in Pancreatic Ductal Tumors
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Many somatic mutations have been detected in pancreatic ductal adenocarcinoma (PDAC), leading to the identification of some key drivers of disease progression, but the involvement of large genomic rearrangements has often been overlooked. In this study, we performed mate pair sequencing (MPseq) on genomic DNA from 24 PDAC tumors, including 15 laser-captured microdissected PDAC and […]
Inflammation in gastric cancer: Interplay of the COX-2/PGE2 and TLR/MyD88 pathways
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Abstract Cyclooxygenase 2 (COX-2) and its downstream product prostaglandin E2 (PGE2) play a key role in generation of inflammatory microenvironment in tumor tissues. Gastric cancer is closely associated with Helicobacter pylori infection, which stimulates innate immune responses through Toll-like receptors (TLRs), inducing COX-2/PGE2 pathway through NF-κB activation. A pathway analysis of human gastric cancer shows […]
Burden of cancer associated with type 2 diabetes mellitus in Japan, 2010-2030
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Summary Diabetes mellitus constitutes a major disease burden globally, and the prevalence of diabetes continues to increase worldwide. We aimed to estimate the burden of cancer associated with type 2 diabetes mellitus in Japan between 2010 and 2030. In this study, we estimated the Population Attributable Fraction of cancer risk associated with type 2 diabetes […]
Diabetesrisiko aus dem Bauch heraus bestimmen
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 2 ώρες
Fettverteilung ist wichtig Körpermaße, welche die abdominale Fettverteilung spiegeln, sind bedeutsamer für das Diabetesrisiko als Body-Mass-Index und Körpergewicht. Das hat eine Analyse der Daten von fünf deutschen Studien bestätigt. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1VB6tMT via IFTTT
Inflammation in gastric cancer: Interplay of the COX-2/PGE2 and TLR/MyD88 pathways
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Abstract Cyclooxygenase 2 (COX-2) and its downstream product prostaglandin E2 (PGE2) play a key role in generation of inflammatory microenvironment in tumor tissues. Gastric cancer is closely associated with Helicobacter pylori infection, which stimulates innate immune responses through Toll-like receptors (TLRs), inducing COX-2/PGE2 pathway through NF-κB activation. A pathway analysis of human gastric cancer shows […]
Burden of cancer associated with type 2 diabetes mellitus in Japan, 2010-2030
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Summary Diabetes mellitus constitutes a major disease burden globally, and the prevalence of diabetes continues to increase worldwide. We aimed to estimate the burden of cancer associated with type 2 diabetes mellitus in Japan between 2010 and 2030. In this study, we estimated the Population Attributable Fraction of cancer risk associated with type 2 diabetes […]
Applied Sciences, Vol. 6, Pages 39: Frequency-Dependent Amplitude Panning for the Stereophonic Image Enhancement of Audio Recorded Using Two Closely Spaced Microphones
In this paper, we propose a new frequency-dependent amplitude panning method for stereophonic image enhancement applied to a sound source recorded using two closely spaced omni-directional microphones. The ability to detect the direction of such a sound source is limited due to weak spatial information, such as the inter-channel time difference (ICTD) and inter-channel level difference (ICLD). Moreover, when sound sources are recorded in a convolutive or a real room environment, the detection of sources is affected by reverberation effects. Thus, the proposed method first tries to...περισσότερα »
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