Maxillomandibular atrophy: Application of buccal fat pad-derived stem cells in combination with autogenous iliac bone graft
Application of buccal fat pad-derived stem cells in combination with autogenous iliac bone graft in the treatment of maxillomandibular atrophy: a preliminary human study: Stem cell therapy for the treatment of bone defects is an alternative or adjunct to autologous bone grafting. This study assessed the efficacy of buccal fat pad-derived stem cells (BFPSCs) with iliac bone block grafting for the treatment of extensive human alveolar ridge defects. Eight patients with extensive jaw atrophy were selected for this study. The jaws were reconstructed with non-vascularized anterior iliac ... περισσότερα »
Bilateral temporomandibular joint (TMJ) hypermobility
Is dextrose prolotherapy superior to placebo for the treatment of temporomandibular joint hypermobility? A randomized clinical trial: A randomized clinical trial involving adult patients with bilateral temporomandibular joint (TMJ) hypermobility referred for treatment was implemented. The sample comprised 30 consecutive patients, who were divided randomly into two groups. *The TMJ hypermobility was treated with either saline (placebo group) or dextrose injections (study group). The solution was injected into five different TMJ areas in three sessions at monthly intervals. The predic... περισσότερα »
Orbital Floor Reconstruction Using a Tensor Fascia Lata Sling After Total Maxillectomy
Orbital Floor Reconstruction Using a Tensor Fascia Lata Sling After Total Maxillectomy: Reconstruction after total maxillectomy with extensive orbital floor defects poses a significant challenge for the reconstruction. The aim of this study is to present the outcomes of orbital floor reconstruction using tensor fascia lata slings after total maxillectomy and to compare these results to orbital floor reconstruction using alloplastic implants.
Flavor Identification and Intensity: Effects of Stimulus Context
Flavor Identification and Intensity: Effects of Stimulus Context: Two experiments presented oral mixtures containing different proportions of the gustatory flavorant sucrose and an olfactory flavorant, either citral (Experiment 1) or lemon (Experiment 2). In 4 different sessions of each experiment, subjects identified each mixture as "mostly sugar" or "mostly citrus/lemon" or rated the perceived intensities of the sweet and citrus components. Different sessions also presented the mixtures in different contexts, with mixtures containing relatively high concentrations of sucrose or c... περισσότερα »
4V (4-Variable screening tool), BQ (Berlin Questionnaire), ESS (Epworth Sleepiness Scale), OSA (Obstructive sleep apnea), PSG (Polysomnography), PSM (Portable sleep monitoring), SOS (Sleep Obstructive apnea score optimized for Stroke), TIA (Transient ischemic attack)
Identifying obstructive sleep apnea after stroke/TIA: evaluating four simple screening tools Highlights • Obstructive sleep apnea (OSA) remains under-appreciated after stroke and TIA • We examined whether paper-based screening tools could rule out OSA after stroke/TIA • We evaluated 69 patients (53 with stroke, 16 with TIA); 32 patients (46.4%) had OSA • The 4V and STOP-BAG were the best tools for ruling out OSA • Future work should refine these tools to enhance their utility after stroke/TIA AbstractObjective Despite its high prevalence and unfavourable clinical consequences, obst... περισσότερα »
Identifying obstructive sleep apnea after stroke/TIA
Identifying obstructive sleep apnea after stroke/TIA: evaluating four simple screening tools Highlights • Obstructive sleep apnea (OSA) remains under-appreciated after stroke and TIA • We examined whether paper-based screening tools could rule out OSA after stroke/TIA • We evaluated 69 patients (53 with stroke, 16 with TIA); 32 patients (46.4%) had OSA • The 4V and STOP-BAG were the best tools for ruling out OSA • Future work should refine these tools to enhance their utility after stroke/TIA AbstractObjective Despite its high prevalence and unfavourable clinical consequences, obs... περισσότερα »
The Just-Meaningful Difference in Speech-to-Noise Ratio
The Just-Meaningful Difference in Speech-to-Noise Ratio: The speech-to-noise ratio (SNR) in an environment plays a vital role in speech communication for both normal-hearing (NH) and hearing-impaired (HI) listeners. While hearing-assistance devices attempt to deliver as favorable an SNR as possible, there may be discrepancies between noticeable and meaningful improvements in SNR. Furthermore, it is not clear how much of an SNR improvement is necessary to induce intervention-seeking behavior. Here, we report on a series of experiments examining the just-meaningful difference (JMD) i...περισσότερα »
Harmonic Frequency Lowering: Effects on the Perception of Music Detail and Sound Quality
Harmonic Frequency Lowering: Effects on the Perception of Music Detail and Sound Quality: A novel algorithm for frequency lowering in music was developed and experimentally tested in hearing-impaired listeners. Harmonic frequency lowering (HFL) combines frequency transposition and frequency compression to preserve the harmonic content of music stimuli. Listeners were asked to make judgments regarding detail and sound quality in music stimuli. Stimuli were presented under different signal processing conditions: original, low-pass filtered, HFL, and nonlinear frequency compressed. Re...περισσότερα »
Comparison of Histopathological Effects of Thymoquinone and Local Nasal Corticosteroids in Allergic Rhinitis in a Rabbit Model
Comparison of Histopathological Effects of Thymoquinone and Local Nasal Corticosteroids in Allergic Rhinitis in a Rabbit Model: *Background/Aims:* In this study, we aimed to evaluate the histopathological effects of thymoquinone treatment of the nasal mucosa in a rabbit model of allergic rhinitis, and we compared its effects with those of nasal mometasone furoate. *Methods:* A total of 24 male New Zealand rabbits were used. The animals were randomly assigned to one of four groups. Group 1 received no treatment, while group 2 underwent ovalbumin (OVA) sensitization only. Group 3 was ... περισσότερα »
Intermittent intraoperative nerve monitoring in thyroid reoperations
Intermittent intraoperative nerve monitoring in thyroid reoperations: Preliminary results of a randomized, single-surgeon study: Abstract Background The purpose of this study was to evaluate whether intermittent intraoperative nerve monitoring (IONM) could reduce the incidence of recurrent laryngeal nerve (RLN) paralysis in thyroid reoperations. Methods Enrolled patients were randomly assigned into the nerve integrity monitor (NIM) group and the control group. Results The incidence of temporary RLN paralysis and permanent RLN paralysis was 12.2% and 4.9% in the NIM group compared wit... περισσότερα »
Scientific Protocol for the Study of Thyroid Cancer and Other Thyroid Disease in Belarus Following the Chernobyl Accident
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Scientific Protocol for the Study of Thyroid Cancer and Other Thyroid Disease in Belarus Following the Chernobyl Accident: *Conditions*: Thyroid Cancer; Non-Cancer Thyroid Disease; Non Thyroid Cancer *Intervention*: *Sponsor*: National Cancer Institute (NCI) Iodine-131(131I) and other radioisotopes of Iodine are contained in fallout from atmospheric nuclear weapons tests and are among the radionuclides most likely to be released in a nuclear reactor accident. In spite of nearly 50 years of experience, the risk of thyroid disease, especially thyroid cancer, attributable... περισσότερα »
Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Malignant Salivary Gland Tumors That Have Been Removed By Surgery
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Radiation Therapy With or Without Chemotherapy in Treating Patients With High-Risk Malignant Salivary Gland Tumors That Have Been Removed By Surgery: *Condition*: Head and Neck Cancer *Interventions*: Drug: cisplatin; Radiation: 3-dimensional conformal radiation therapy; Radiation: intensity-modulated radiation therapy *Sponsors*: Radiation Therapy Oncology Group; National Cancer Institute (NCI); NRG Oncology RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the gro... περισσότερα »
Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 9 δευτερόλεπτα
Individualized Treatment in Treating Patients With Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA: *Conditions*: Epstein-Barr Virus Infection; Stage II Nasopharyngeal Carcinoma; Stage III Nasopharyngeal Carcinoma; Stage IVA Nasopharyngeal Carcinoma; Stage IVB Nasopharyngeal Carcinoma *Interventions*: Drug: Cisplatin; Other: Clinical Observation; Drug: Fluorouracil; Drug: Gemcitabine Hydrochloride; Radiation: Intensity-Modulated Radiation Therapy; Other: Laboratory Biomarker Analysis; Drug: Paclitaxel; Other: Quality-of-Life Assessment *Sponsors*: N... περισσότερα »
Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer: *Sponsors*: NRG Oncology; National Cancer Institute (NCI) This randomized phase II trial studies how well modestly reduced-dose intensity-modulated radiation therapy (IMRT) with or without cisplatin works in treating patients with oropharyngeal cancer that has spread to other places in the body (advanced). Radiation therapy uses high energy x rays to kill tumor cells. Drugs used in chemotherapy, such as cisplatin, work in different ways to st... περισσότερα »
Intraoperative goal-directed hemodynamic management in free tissue transfer for head and neck cancer
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Intraoperative goal-directed hemodynamic management in free tissue transfer for head and neck cancer: Abstract Background The purpose of this study was to determine the effect of algorithmic physiologic management on patients undergoing head and neck free tissue transfer and reconstruction. Methods Ninety-four adult patients were randomized to treatment and control groups. The blood pressure of the control group was managed consistent with contemporary standards. The treatment group was managed using an algorithm based on blood pressure and calculated physiologic values derived from... περισσότερα »
Adherence to guideline-recommended process measures for HNSCC
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 11 δευτερόλεπτα
Adherence to guideline-recommended process measures for squamous cell carcinoma of the head and neck in Ontario: Impact of surgeon and hospital volume: Abstract Background The purpose of this study was to measure adherence rates to guideline-recommended process measures in patients with head and neck cancer. Methods A total of 5720 patients who underwent surgery for head and neck cancer in Ontario between 1993 and 2010 were identified from administrative databases. Adherence to 4 guideline-recommended processes of care was measured and stratified by hospital and physician case volu... περισσότερα »
Regulatory T cells delay disease progression in Alzheimer-like pathology
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
Recent studies highlight the implication of innate and adaptive immunity in the pathophysiology of Alzheimer’s disease, and foster immunotherapy as a promising strategy for its treatment. Vaccines targeting amyloid-β peptide provided encouraging results in mouse models, but severe side effects attributed to T cell responses in the first clinical trial AN1792 underlined the need for […]
Common neurologic emergencies for nonneurologists: When minutes count
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
NEUROLOGIC EMERGENCIES such as acute stroke, status epilepticus, subarachnoid hemorrhage, neuromuscular weakness, and spinal cord injury affect millions of Americans yearly.1,2 These… from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1o174Nd via IFTTT
Bulldog scalp
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
A 54-YEAR-OLD MAN PRESENTED with a 2-year history of unusual skin folds on the scalp with deep furrows in an anteroposterior direction, located in parieto-occipital regions (Figure 1). A… from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1KTcE9g via IFTTT
Oncocytic carcinoma of the major salivary glands
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Oncocytic carcinoma of the major salivary glands: A population-based study of 278 cases: Abstract Background Oncocytic carcinomas of the major salivary glands are extremely rare, with <100 cases reported. Methods A retrospective review of the National Cancer Database was performed from 1998 to 2012. Results We found 278 cases of major salivary oncocytic carcinoma. Most patients were men (61.9%), white (84.8%), with parotid disease (88.5%). Median age was 67 years (range, 16–90 years). Regional and distant metastases were found in 36.4% and 4.7% of cases. Overall survival at 5 and 10...περισσότερα »
Clinical outcomes in patients with T4 laryngeal cancer treated with primary radiotherapy versus primary laryngectomy
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 23 δευτερόλεπτα
Clinical outcomes in patients with T4 laryngeal cancer treated with primary radiotherapy versus primary laryngectomy: ABSTRACT Background The purpose of this study was to determine the clinical outcomes of T4 laryngeal cancers. Methods T4 laryngeal cancers treated with curative intent from January 2003 to December 2010 were analyzed. Outcomes were evaluated in both primary radiotherapy (+/− chemotherapy) (RT/CRT) and primary surgery cohorts. Results Among the 65 primary RT/CRT and 42 primary surgery patients included, median follow-up was 4.4 years. There was a trend for improved loc... περισσότερα »
Improving the quantity, quality and transparency of data used to derive radionuclide transfer parameters for animal products. 1. Goat milk
[image: S0265931X.gif] Publication date: April 2016 *Source:*Journal of Environmental Radioactivity, Volume 154 Author(s): B.J. Howard, C. Wells, C.L. Barnett Under the MODARIA (Modelling and Data for Radiological Impact Assessments Programme of the International Atomic Energy Agency), there has been an initiative to improve the derivation, provenance and transparency of transfer parameter values for radionuclides. The approach taken for animal products is outlined here and the first revised table for goat milk is provided. Data from some references used in TRS 472 were removed and ...περισσότερα »
Regulatory T cells delay disease progression in Alzheimer-like pathology
Recent studies highlight the implication of innate and adaptive immunity in the pathophysiology of Alzheimer's disease, and foster immunotherapy as a promising strategy for its treatment. Vaccines targeting amyloid-β peptide provided encouraging results in mouse models, but severe side effects attributed to T cell responses in the first clinical trial AN1792 underlined the need for better understanding adaptive immunity in Alzheimer's disease. We previously showed that regulatory T cells critically control amyloid-β-specific CD4+ T cell responses in both physiological and patholog... περισσότερα »
Common neurologic emergencies for nonneurologists: When minutes count
NEUROLOGIC EMERGENCIES such as acute stroke, status epilepticus, subarachnoid hemorrhage, neuromuscular weakness, and spinal cord injury affect millions of Americans yearly.1,2 These... from Neurology via xlomafota13 on Inoreader http://ift.tt/1o174Nd via IFTTT
Bulldog scalp
A 54-YEAR-OLD MAN PRESENTED with a 2-year history of unusual skin folds on the scalp with deep furrows in an anteroposterior direction, located in parieto-occipital regions (*Figure 1*). A... from Neurology via xlomafota13 on Inoreader http://ift.tt/1KTcE9g via IFTTT
Cardiac arrest with vagal stimulation during intraoperative nerve monitoring
Cardiac arrest with vagal stimulation during intraoperative nerve monitoring: Abstract Background Intraoperative neuromonitoring (IONM) is widely used during thyroid surgery. During both intermittent and continuous IONM stimulation of the vagus nerve is performed. This has previously been reported to be safe. Methods We present our findings based on the case reports of 2 patients. Results IONM of the recurrent laryngeal nerve (RLN), following the standards of the International Neuromonitoring Study Group, was conducted in 2 patients, one undergoing thyroid surgery and the second para...περισσότερα »
Descending necrotizing mediastinitis
Descending necrotizing mediastinitis: Systematic review on its treatment in the last 6 years, 75 years after its description: ABSTRACT Background Descending necrotizing mediastinitis is a serious infection involving the neck and the chest, in which an odontogenic, pharyngeal, or cervical infection spreads rapidly to the thoracic cavity, with a high death rate by sepsis and organic failure if not treated quickly and properly. Methods A systematic search in the electronic database PubMed was conducted using the keywords “mediastinitis” and “descending necrotizing mediastinitis” result... περισσότερα »
Human olfactory stem cells for injured facial nerve reconstruction
Human olfactory stem cells for injured facial nerve reconstruction in a rat model: Abstract Background The purpose of this study was to show the efficacy of olfactory stem cells for injured facial nerve reconstruction in a rat model. Methods Olfactory stem cells were isolated from the olfactory mucosa of human participants. A 2-mm excision was performed on the right facial nerve of all rats. Reconstruction was performed with a conduit in group 1 (*n* = 9); a conduit and phosphate-buffered saline in group 2 (*n* = 9); and a conduit and labeled olfactory stem cell in group 3 (*n* = 9)... περισσότερα »
Harmonic Frequency Lowering: Effects on the Perception of Music Detail and Sound Quality
A novel algorithm for frequency lowering in music was developed and experimentally tested in hearing-impaired listeners. Harmonic frequency lowering (HFL) combines frequency transposition and frequency compression to preserve the harmonic content of music stimuli. Listeners were asked to make judgments regarding detail and sound quality in music stimuli. Stimuli were presented under different signal processing conditions: original, low-pass filtered, HFL, and nonlinear frequency compressed. Results showed that participants reported perceiving the most detail in the HFL condition. ... περισσότερα »
The Just-Meaningful Difference in Speech-to-Noise Ratio
The speech-to-noise ratio (SNR) in an environment plays a vital role in speech communication for both normal-hearing (NH) and hearing-impaired (HI) listeners. While hearing-assistance devices attempt to deliver as favorable an SNR as possible, there may be discrepancies between noticeable and meaningful improvements in SNR. Furthermore, it is not clear how much of an SNR improvement is necessary to induce intervention-seeking behavior. Here, we report on a series of experiments examining the just-meaningful difference (JMD) in SNR. All experiments used sentences in same-spectrum n...περισσότερα »
Harmonic Frequency Lowering: Effects on the Perception of Music Detail and Sound Quality
A novel algorithm for frequency lowering in music was developed and experimentally tested in hearing-impaired listeners. Harmonic frequency lowering (HFL) combines frequency transposition and frequency compression to preserve the harmonic content of music stimuli. Listeners were asked to make judgments regarding detail and sound quality in music stimuli. Stimuli were presented under different signal processing conditions: original, low-pass filtered, HFL, and nonlinear frequency compressed. Results showed that participants reported perceiving the most detail in the HFL condition. ... περισσότερα »
The Just-Meaningful Difference in Speech-to-Noise Ratio
The speech-to-noise ratio (SNR) in an environment plays a vital role in speech communication for both normal-hearing (NH) and hearing-impaired (HI) listeners. While hearing-assistance devices attempt to deliver as favorable an SNR as possible, there may be discrepancies between noticeable and meaningful improvements in SNR. Furthermore, it is not clear how much of an SNR improvement is necessary to induce intervention-seeking behavior. Here, we report on a series of experiments examining the just-meaningful difference (JMD) in SNR. All experiments used sentences in same-spectrum n...περισσότερα »
Harmonic Frequency Lowering: Effects on the Perception of Music Detail and Sound Quality
A novel algorithm for frequency lowering in music was developed and experimentally tested in hearing-impaired listeners. Harmonic frequency lowering (HFL) combines frequency transposition and frequency compression to preserve the harmonic content of music stimuli. Listeners were asked to make judgments regarding detail and sound quality in music stimuli. Stimuli were presented under different signal processing conditions: original, low-pass filtered, HFL, and nonlinear frequency compressed. Results showed that participants reported perceiving the most detail in the HFL condition. ... περισσότερα »
The Just-Meaningful Difference in Speech-to-Noise Ratio
The speech-to-noise ratio (SNR) in an environment plays a vital role in speech communication for both normal-hearing (NH) and hearing-impaired (HI) listeners. While hearing-assistance devices attempt to deliver as favorable an SNR as possible, there may be discrepancies between noticeable and meaningful improvements in SNR. Furthermore, it is not clear how much of an SNR improvement is necessary to induce intervention-seeking behavior. Here, we report on a series of experiments examining the just-meaningful difference (JMD) in SNR. All experiments used sentences in same-spectrum n...περισσότερα »
Role of Platelet Parameters on Sudden Sensorineural Hearing Loss: A Case-Control Study in Iran
Role of Platelet Parameters on Sudden Sensorineural Hearing Loss: A Case-Control Study in Iran: by Abbas Mirvakili, Mohammad Hossein Dadgarnia, Mohammad Hossein Baradaranfar, Saeid Atighechi, Vahid Zand, Abdollah Ansari Sudden sensorineural hearing loss (SSNHL) is a common otological disorder characterized by a hearing loss greater than 30 dB over three consecutive frequencies, in less than 72 hours. It has been established that platelet parameters, such as mean platelet volume, are associated with ischemic heart events, whose clinical manifestations are similar to those of SSNHL. ...περισσότερα »
Complications of Pediatric Otitis Media
Complications of Pediatric Otitis Media: Objective Otitis media (OM) is a common diagnosis in the pediatric population that is usually managed on an outpatient basis. A small proportion of children are admitted due to a complex disease course. The aim of this study was to investigate the demographics of those patients and the resources utilized during their admissions. Study Design Retrospective review based on the 2009 Kids’ Inpatient Database. Setting Nationwide administrative database. Subjects and Methods A review based on the 2009 Kids’ Inpatient Database was conducted. Inc...περισσότερα »
Clinical Practice Guideline: Otitis Media with Effusion (Update)
Clinical Practice Guideline: Otitis Media with Effusion (Update): Objective This update of a 2004 guideline codeveloped by the American Academy of Otolaryngology—Head and Neck Surgery Foundation, the American Academy of Pediatrics, and the American Academy of Family Physicians, provides evidence-based recommendations to manage otitis media with effusion (OME), defined as the presence of fluid in the middle ear without signs or symptoms of acute ear infection. Changes from the prior guideline include consumer advocates added to the update group, evidence from 4 new clinical practice ...περισσότερα »
Reflections: Using a Second Language to Build a Practice
Reflections: Using a Second Language to Build a Practice: The US Census Bureau reports that 20.7% of Americans speak a language other than English. This is an opportunity of otolaryngologists to build their practice on a second language. This Reflections piece reviews my personal experiences of using my language fluency in Chinese to build a practice in Philadelphia. Through translating office documents, networking with Chinese-speaking physicians, and volunteering at the free clinic in Chinatown, I was able to serve this non-English-speaking community. Although there are translato...περισσότερα »
Head and Neck Cancer Trials
Analysis of 473 US Head and Neck Cancer Trials (1996-2014): Trends, Gaps, and Opportunities: Objective To report on types of investigations being conducted in US clinical trials, the types of therapeutic investigations that predominate, and the publication rates. Study Design Retrospective analysis. Settings US head and neck cancer clinical trials. Subjects and Methods We used the information available on ClinicalTrials.gov to identify trends in head and neck squamous cell carcinoma clinical trials to characterize the types of trials and treatments being investigated. The public... περισσότερα »
Clinical Practice Guideline: Otitis Media with Effusion Executive Summary (Update)
Clinical Practice Guideline: Otitis Media with Effusion Executive Summary (Update): The American Academy of Otolaryngology—Head and Neck Surgery Foundation has published a supplement to this issue of *Otolaryngology—Head and Neck Surgery* featuring the updated "Clinical Practice Guideline: Otitis Media with Effusion." To assist in implementing the guideline recommendations, this article summarizes the rationale, purpose, and key action statements. The 18 recommendations developed emphasize diagnostic accuracy, identification of children who are most susceptible to developmental se... περισσότερα »
Plain Language Summary: Otitis Media with Effusion
Plain Language Summary: Otitis Media with Effusion: Objective This plain language summary serves as an overview in explaining otitis media with effusion (pronounced Oh-TIE-tis ME-dee-uh with Ef-YOO-zhun), abbreviated "OME" and often called "ear fluid." The summary applies to children aged 2 months through 12 years with OME and is based on the 2015 "Clinical Practice Guideline: Otitis Media with Effusion (Update)." The evidence-based guideline includes research to support more effective diagnosis and treatment of OME in children. The guideline was developed as a quality improvement o...περισσότερα »
Outcomes in Advanced Head and Neck Cancer Treated with Up-front Neck Dissection prior to (Chemo)Radiotherapy
Outcomes in Advanced Head and Neck Cancer Treated with Up-front Neck Dissection prior to (Chemo)Radiotherapy: Objective Our aim was to compare outcomes with and without up-front neck dissection prior to (chemo)radiotherapy in head and neck squamous cell carcinoma. Study Design Case series with chart review. Setting Tertiary referral center. Subjects and Methods Outcomes of oropharyngeal, laryngeal, and hypopharyngeal squamous cell carcinoma cases with neck lymph node metastases treated from January 2001 to March 2012 were analyzed. Due to imbalances in baseline characteristics b... περισσότερα »
Systematic Review of Endoscopic Obliteration Techniques for Managing Congenital Piriform Fossa Sinus Tracts in Children
Systematic Review of Endoscopic Obliteration Techniques for Managing Congenital Piriform Fossa Sinus Tracts in Children: Background Piriform fossa sinus tracts (PFSTs) are a recognized cause of recurrent deep neck infections in the pediatric population. Conventional management has historically required open resection, but over recent years minimally invasive endoscopic approaches to obliterate the pharyngeal opening of the sinus have been performed in many centers. However, there is a lack of clear evidence regarding the success rate and safety of these approaches. Objective To det... περισσότερα »
Amblyaudia
Amblyaudia: Review of Pathophysiology, Clinical Presentation, and Treatment of a New Diagnosis: Objective Similar to amblyopia in the visual system, "amblyaudia" is a term used to describe persistent hearing difficulty experienced by individuals with a history of asymmetric hearing loss (AHL) during a critical window of brain development. Few clinical reports have described this phenomenon and its consequent effects on central auditory processing. We aim to (1) define the concept of amblyaudia and (2) review contemporary research on its pathophysiology and emerging clinical relevanc...περισσότερα »
Non-Echo Planar Diffusion-Weighted Magnetic Resonance Imaging for Detection of Primary and Postoperative Cholesteatoma
A Systematic Review of Non-Echo Planar Diffusion-Weighted Magnetic Resonance Imaging for Detection of Primary and Postoperative Cholesteatoma: Objective To investigate the diagnostic value of non–echo planar diffusion-weighted magnetic resonance imaging (DW-MRI) for primary and recurrent/residual (postoperative) cholesteatoma in adults (≥18 years) after canal wall up surgery. Data Sources We conducted a systematic search in PubMed, Embase, and Cochrane up to October 22, 2014. Review methods All studies investigating non–echo planar DW-MRI for primary and postoperative cholesteat...περισσότερα »
Seasonal Difference in Postthyroidectomy Hypocalcemia: A Montreal-Based Study
Seasonal Difference in Postthyroidectomy Hypocalcemia: A Montreal-Based Study: Objective Hypocalcemia following thyroidectomy often prolongs hospital stay and is potentially life-threatening. The objective of this study is to determine whether the season when thyroidectomy is performed is associated with postoperative hypocalcemia. Study Design Retrospective case series of patients undergoing thyroid surgery from 2009 to 2015. Setting Tertiary care academic institution in Montreal, Canada. Subjects and Methods A consecutive sample of 823 patients undergoing thyroidectomy by a si... περισσότερα »
How Does TeamSTEPPS Affect Operating Room Efficiency?
How Does TeamSTEPPS Affect Operating Room Efficiency?: Objective To evaluate the effect of TeamSTEPPS (Team Strategies and Tools to Enhance Performance and Patient Safety) on operating room efficiency for the otolaryngology service at a tertiary care medical center. Study Design Retrospective database review. Setting Otolaryngology department at tertiary care medical center. Subjects and Methods To assess the impact of implementing an evidence-based patient safety initiative, TeamSTEPPS, on operating room efficiency in the otolaryngology department, the operative times, time lost...περισσότερα »
Reoperative Parathyroidectomy: Overly Descended Superior Adenoma
Reoperative Parathyroidectomy: Overly Descended Superior Adenoma: Objectives To identify the importance of the ectopic, overly descended superior parathyroid adenoma variant and its prevalence in primary and reoperative parathyroid surgery and the implications for successful initial parathyroidectomy. Study Design Case series with planned data collection. Setting Tertiary endocrine surgery practice in an academic medical center. Subjects and Methods An analysis was undertaken of 561 consecutive patients undergoing parathyroid surgery in a tertiary endocrine surgery practice from ... περισσότερα »
Subglottic Squamous Cell Carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 37 δευτερόλεπτα
Subglottic Squamous Cell Carcinoma: A Population-Based Study of 889 Cases: Objective Subglottic squamous cell carcinoma (SCCa) is a rare malignancy representing <5% of all laryngeal cancers. Patients often present with late-stage disease, and survival outcomes are reportedly worse than those for SCCa in other regions of the larynx. Study Design Analysis of a population-based tumor registry. Setting Academic medical center. Subjects and Methods The US National Cancer Institute’s Surveillance, Epidemiology, and End Results database was queried for cases of subglottic SCCa from 197... περισσότερα »
Acoustic Reflex Screening of Conductive Hearing Loss for Third Window Disorders
Acoustic Reflex Screening of Conductive Hearing Loss for Third Window Disorders: Objective This study examines the effectiveness of acoustic reflexes in screening for third window disorders (eg, superior semicircular canal dehiscence) prior to middle ear exploration for conductive hearing loss. Study Design Case series with chart review. Setting Outpatient tertiary otology center. Subjects and Methods A review was performed of 212 ears with acoustic reflexes, performed as part of the evaluation of conductive hearing loss in patients without evidence of chronic otitis media. The ... περισσότερα »
New Standard of Care in Metastatic Pancreatic Cancer?New Standard of Care in Metastatic Pancreatic Cancer?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Liposomal irinotecan combined with fluorouracil and leucovorin should be the standard of care for patients with metastatic pancreatic cancer that has progressed on gemcitabine, say researchers. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1o15bQI via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Brachytherapy vs. external beam radiotherapy for choroidal melanoma: Survival and patterns-of-care analyses
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
This study compares the patterns of care and efficacy of EBRT vs. BT based on data in the Surveillance, Epidemiology, and End Results database. (Source: Brachytherapy) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1o15bzX via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
In response to the letter to the editor from Sylvia van Dyk regarding our editorial “High-tech image-guided therapy vs. low-tech, simple, cheap gynecologic brachytherapy”
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Without doubt, our goal is to make the most effective brachytherapy treatment modality available for cervical cancer patients worldwide. Our clear vision is the use of three-dimensional (3D) imaging for treatment planning, which has already become state of the art for most external beam radiotherapy treatment approaches. The 3D planning in brachytherapy should, however, not […]
Calendula officinalis L. (Asteraceae): souci
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1JUI6ZS via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
The Protective Role of Religious Involvement in African American and Caribbean Black Adolescents Experiences of Racial Discrimination
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
For many Black adolescents, racial discrimination increases the risk of developing adverse psychological outcomes. The purpose of this study is to investigate the interrelationships among religious involvement, racial discrimination, and psychological outcomes among a nationally representative sample of African American adolescents and Caribbean Black adolescents from the National Survey of American Life. Multiple regression models […]
Home Environment and Parental Involvement in Homework During Adolescence in Catalonia (Spain)
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
It is well documented that parental behavior is a strong determinant of a child’s educational achievement and general well-being. Thus, it seems relevant to analyze the determinants of parental involvement in the education of their children. While most studies analyze the effect of family characteristics (such as parents’ education, ethnicity, or family structure) on parental […]
Understanding Adolescent Narratives About «Bullying» Through an Intersectional Lens: Implications for Youth Mental Health Interventions
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
This article is based on findings from a qualitative study with 27 adolescents in northern British Columbia, Canada. Our aim was to explore youths’ perspectives on the sources of emotional distress in their lives and how these are connected to peer-based aggression and victimization within their community. Our analysis of narrative findings suggests that youths’ […]
A novel duplex real-time PCR permits simultaneous detection and differentiation of Borrelia miyamotoi and Borrelia burgdorferi sensu lato
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Abstract Purpose For simultaneous detection of Borrelia miyamotoi (relapsing fever spirochete) and Borrelia burgdorferi sensu lato, we have developed a duplex real-time PCR targeting the flagellin gene (flaB; p41), a locus frequently used in routine diagnostic PCR for B. burgdorferi s.l. detection. Methods Primers and probes were designed using multiple alignments of flaB sequences of […]
Ultra-high gain diffusion-driven organic transistor
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Article Organic field-effect transistors offer limited gain due to the large contact resistance and the channel length modulation. Here, Torricelli et al. show a new transistor architecture where the charge injection and extraction are driven by the charge diffusion and a gain larger than 700 is achieved. Nature Communications doi: 10.1038/ncomms10550 Authors: Fabrizio Torricelli, Luigi […]
Engineering of frustration in colloidal artificial ices realized on microfeatured grooved lattices
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 39 δευτερόλεπτα
Article Visualizing the dynamics of electron spins in frustrated systems is a challenging task, which may require an alternative way at the microscale. Here, the authors realize an artificial system composed of interacting colloidal particles to mimick frustrated spins, which is potentially helpful in information storage. Nature Communications doi: 10.1038/ncomms10575 Authors: Antonio Ortiz-Ambriz, Pietro Tierno […]
Improving the quantity, quality and transparency of data used to derive radionuclide transfer parameters for animal products. 1. Goat milk
Publication date: April 2016 Source:Journal of Environmental Radioactivity, Volume 154 Author(s): B.J. Howard, C. Wells, C.L. Barnett Under the MODARIA (Modelling and Data for Radiological Impact Assessments Programme of the International Atomic Energy Agency), there has been an initiative to improve the derivation, provenance and transparency of transfer parameter values for radionuclides. The approach taken… Continue reading Improving the quantity, quality and transparency of data used to derive radionuclide transfer parameters for animal products. 1. Goat milk
There Is Nothing Free About the Health Care Free Market
By NORTIN M HADLER, MD “Universal Health Care”, “Single Payer”, “National Health Insurance”, “Socialized Medicine” are all semiotics symbolizing the subjugation of physician and of patient autonomy to government control for the sake of the common good. This is not sophistry. Max Weber was a Prussian political philosopher who laid the foundation for modern sociology… Continue reading There Is Nothing Free About the Health Care Free Market
New Vaccines in 2016 Pediatric Immunization Schedule New Vaccines in 2016 Pediatric Immunization Schedule
Recommendations for the recently licensed meningococcal B and 9-valent human papillomavirus vaccine are now in the official 2016 childhood immunization schedule Medscape Medical News (Source: Medscape Allergy Headlines) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents too. from #Head and Neck by Sfakianakis via simeraentaxei on… Continue reading New Vaccines in 2016 Pediatric Immunization Schedule New Vaccines in 2016 Pediatric Immunization Schedule
2016 Adult Immunization Schedule Includes New Vaccines2016 Adult Immunization Schedule Includes New Vaccines
New vaccines against meningococcal serogroup B and human papillomavirus and a revision to the pneumococcal vaccine recommendation are among the 2016 changes. Medscape Medical News (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1RX52tR via IFTTT
CDC Alert: Severe Influenza Illness ReportedCDC Alert: Severe Influenza Illness Reported
Clinicians should initiate antiviral treatment to very ill and high-risk patients suspected of having influenza without waiting for test results. ICU admissions and deaths have been reported. Medscape Medical News (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PcnIAd via IFTTT
Asthma-COPD Overlap — A New Clinical EntityAsthma-COPD Overlap — A New Clinical Entity
You know them individually, but what about together? A new review keeps clinicians up-to-date on identification and management of the asthma-COPD overlap syndrome. Medscape Pulmonary Medicine (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1RX54lC via IFTTT
What Are Risk Factors for Latex Allergy?
Discussion Latex comes from the Hevea brasiliensis plants. There are multiple potentially allergenic polypeptides within the plant’s fluid called Heb b 1-13. True sensitizers are Heb b 1, 5 and 6. Heb b 8 and 12 are cross-reacting proteins. The type of the latex product and how it is prepared makes a difference in exposure… Continue reading What Are Risk Factors for Latex Allergy?
Mutations Affect Multiple Stages of CBL Activation Cycle
In this study, we computationally modeled the effects of missense cancer mutations on structures representing four stages of the CBL activation cycle to identify driver mutations that affect CBL stability, binding, and activity. We found that recurrent, homozygous, and leukemia-specific mutations had greater destabilizing effects on CBL states than random noncancer mutations. We further tested… Continue reading Mutations Affect Multiple Stages of CBL Activation Cycle
Harmonic Frequency Lowering: Effects on the Perception of Music Detail and Sound Quality
A novel algorithm for frequency lowering in music was developed and experimentally tested in hearing-impaired listeners. Harmonic frequency lowering (HFL) combines frequency transposition and frequency compression to preserve the harmonic content of music stimuli. Listeners were asked to make judgments regarding detail and sound quality in music stimuli. Stimuli were presented under different signal processing… Continue reading Harmonic Frequency Lowering: Effects on the Perception of Music Detail and Sound Quality
The Just-Meaningful Difference in Speech-to-Noise Ratio
The speech-to-noise ratio (SNR) in an environment plays a vital role in speech communication for both normal-hearing (NH) and hearing-impaired (HI) listeners. While hearing-assistance devices attempt to deliver as favorable an SNR as possible, there may be discrepancies between noticeable and meaningful improvements in SNR. Furthermore, it is not clear how much of an SNR… Continue reading The Just-Meaningful Difference in Speech-to-Noise Ratio
The Usefulness of Preoperative Thyroid-Stimulating Hormone for Predicting Differentiated Thyroid Microcarcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 54 δευτερόλεπτα
The Usefulness of Preoperative Thyroid-Stimulating Hormone for Predicting Differentiated Thyroid Microcarcinoma: Objective Thyroid-stimulating hormone (TSH) is a known thyroid growth factor, but the pathogenic role of TSH in thyroid tumorigenesis is controversial. The aim of this study is to examine the relationship between preoperative TSH and differentiated thyroid microcarcinoma (DTMC). Data Sources We searched PubMed, EMBASE, Ovid, Web of Science, and the Cochrane Library from their inception to March 2015 and performed a systematic literature review of original studies. Revie... περισσότερα »
Potential Benefits of Combination Therapy as Primary Treatment for Sudden Sensorineural Hearing Loss
Potential Benefits of Combination Therapy as Primary Treatment for Sudden Sensorineural Hearing Loss: Objective We analyzed the effectiveness of combination therapy (CT) for idiopathic sudden sensorineural hearing loss (ISSNHL) and the utility of intratympanic dexamethasone injection (ITDI) reapplication as salvage treatment for ISSNHL refractory to CT. Study Design Case series with chart review. Setting Academic university hospital. Subjects and Methods We reviewed 229 patients with ISSNHL and divided these patients into 2 groups according to treatment: systemic steroid therapy...περισσότερα »
Impact of Diabetes Mellitus on Head and Neck Cancer Patients Undergoing Surgery
Impact of Diabetes Mellitus on Head and Neck Cancer Patients Undergoing Surgery: Objective The impact of diabetes mellitus (DM) on surgical outcomes and cost of care for patients undergoing surgery for head and neck cancer (HNCA) is not well established. We used the Nationwide Inpatient Sample to analyze the postoperative impact of DM on HNCA patients. Study Design Population-based inpatient registry analysis. Setting Academic medical center. Subjects and Methods Discharge data from the Nationwide Inpatient Sample were analyzed for patients undergoing HNCA surgery from 2002 to 2... περισσότερα »
Otolaryngology
Grant-Writing Pearls and Pitfalls: Maximizing Funding Opportunities by Liu, J. C., Pynnonen, M. A., St John, M., Rosenthal, E. L., Couch, M. E., Schmalbach, C. E. via Otolaryngology -- Head and Neck Surgery recent issues This invited article reviews the grant process to include the following objectives: (1) to provide an understanding of otolaryngology funding mechanisms in the context of career progression; (2) to outline key components of a well-written grant; (3) to highlight vital members of a successful research team, with emphasis on the mentor-mentee relationship; and (4) to c... περισσότερα »
Transoral Diverticulotomy for Zenkers Diverticulum
Short-term Quality-of-Life Outcomes following Transoral Diverticulotomy for Zenkers Diverticulum: A Prospective Single-Group Study: Objective To prospectively analyze quality-of-life outcomes following transoral diverticulotomy with cricopharyngeal myotomy (DCPM) for Zenker’s diverticulum (ZD). Study Design Prospective single-group study. Settings Tertiary academic institution. Subjects and Methods A prospective multicenter study performed from January 1, 2012, to July 1, 2014, included 18 patients presenting with ZD undergoing DCPM. Standardized questionnaires—including the 10-...περισσότερα »
Gelatin Facial Skin Simulator for Cutaneous Reconstruction
Gelatin Facial Skin Simulator for Cutaneous Reconstruction: Reconstruction of facial defects can be an intimidating endeavor, especially to resident physicians. When local flap reconstruction is preferred, design of the optimal flap can be a difficult choice. Poor selection can lead to unsightly scarring as well as increased morbidity. A low-cost, easy-to-fabricate gelatin prosthetic facial skin simulator is presented to offer training experience in wound closure, local tissue rearrangement, and facial defect reconstruction for resident instruction. In conjunction with a didactic l... περισσότερα »
Nervus Intermedius Guides Auditory Brainstem Implant Surgery in Children with Cochlear Nerve Deficiency
Nervus Intermedius Guides Auditory Brainstem Implant Surgery in Children with Cochlear Nerve Deficiency: Objective To investigate the anatomic features of the nervus intermedius and cranial nerve VII in children with cochlear nerve deficiency and to verify whether the nervus intermedius can provide an additional landmark to help guide placement of the auditory brainstem implant electrode. Study Design Case series with chart review. Setting Tertiary referral center. Subjects and Methods High-definition video was captured during retrosigmoid surgery in 64 children (mean age, 3.91 ... περισσότερα »
Increased Surgical Site Infection Rates following Clindamycin Use in Head and Neck Free Tissue Transfer
Increased Surgical Site Infection Rates following Clindamycin Use in Head and Neck Free Tissue Transfer: Objective The development of surgical site infections (SSIs) can put the viability of free tissue transfer reconstructions at risk, often resulting in considerable postoperative morbidity and prolonged hospitalization. Current antibiotic prophylactic guidelines suggest a first- or second-generation cephalosporin with metronidazole for clean-contaminated cases and recommend clindamycin as an alternative choice in penicillin-allergic patients. This study was designed to examine the... περισσότερα »
Causes for 30-Day Readmission following Transsphenoidal Surgery
Causes for 30-Day Readmission following Transsphenoidal Surgery: Objective The Affordable Care Act Readmissions Reduction Program introduced reimbursement policy changes resulting in penalties for hospitals with higher-than-average readmission rates among several categories, including elective surgical cases. We examined the rate of complications resulting in 30-day readmission following endoscopic transsphenoidal surgery. Study Design Case series with chart review. Setting Academic tertiary care center. Methods A database of 466 consecutive patients who underwent endoscopic tra...περισσότερα »
Eustachian Tube as a Landmark to the Internal Carotid Artery in Endoscopic Skull Base Surgery
Eustachian Tube as a Landmark to the Internal Carotid Artery in Endoscopic Skull Base Surgery: Objective The purpose of this study was to probe the relationship between the eustachian tube and the internal carotid artery in skull base surgery by an intranasal endoscopic approach. Study Design Cadaver study and illustrative cases. Setting Minimally invasive surgery laboratory and operating room. Subjects and Methods A series of 5 cadaveric heads were dissected to elaborate on the relevant surgical anatomy about the eustachian tube and the internal carotid artery. Three cases were... περισσότερα »
Complications of Pediatric Otitis Media
Complications of Pediatric Otitis Media: Objective Otitis media (OM) is a common diagnosis in the pediatric population that is usually managed on an outpatient basis. A small proportion of children are admitted due to a complex disease course. The aim of this study was to investigate the demographics of those patients and the resources utilized during their admissions. Study Design Retrospective review based on the 2009 Kids’ Inpatient Database. Setting Nationwide administrative database. Subjects and Methods A review based on the 2009 Kids’ Inpatient Database was conducted. Inc...περισσότερα »
Correspondence El Niño and climate change—contributing factors in the dispersal of Zika virus in the Americas?
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In their letter, Isaac I Bogoch and colleagues (Jan 23, p 335)1 anticipated the international spread of Zika virus from Brazil through air traffic. Permissive climatic conditions for Aedes mosquitoes might have contributed to the explosive spread of Zika virus in Brazil. In fact, the 2015 El Niño caused exceptional climatic conditions in northeastern South […]
Peripheral Primitive Neuroectodermal Tumor and Neurofibromatosis Type 1 in an Adolescent Male
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
(Source: Pediatric Blood and Cancer) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/20luFcD via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Intratumorally Establishing Type 2 Innate Lymphoid Cells Blocks Tumor Growth TUMOR IMMUNOLOGY
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
A long-standing question in the field of tumor immunotherapy is how Th2 cytokines block tumor growth. Their antitumor effects are particularly prominent when they are secreted continuously in tumors, suggesting that Th2 cytokines may create a tumor microenvironment unfavorable for tumor growth independently of adaptive immunity. In this study, we show that local production of […]
Calcitonin Gene-Related Peptide-Exposed Endothelial Cells Bias Antigen Presentation to CD4+ T Cells toward a Th17 Response IMMUNE REGULATION
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Calcitonin gene–related peptide (CGRP) is a neuropeptide with well-established immunomodulatory functions. CGRP-containing nerves innervate dermal blood vessels and lymph nodes. We examined whether CGRP regulates the outcome of Ag presentation by Langerhans cells (LCs) to T cells through actions on microvascular endothelial cells (ECs). Exposure of primary murine dermal microvascular ECs (pDMECs) to CGRP followed […]
Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing {beta}-1,3 Glucan INFECTIOUS DISEASE AND HOST RESPONSE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Dectin-1 and TLR9 play distinct roles in the recognition and induction of innate immune responses to Aspergillus fumigatus and Candida albicans. Dectin-1 is a receptor for the major fungal cell wall carbohydrate β-1,3 glucan that induces inflammatory cytokines and controls phagosomal maturation through spleen tyrosine kinase activation. TLR9 is an endosomal TLR that also modulates […]
Anti-C1q Autoantibodies from Systemic Lupus Erythematosus Patients Induce a Proinflammatory Phenotype in Macrophages CLINICAL AND HUMAN IMMUNOLOGY
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Anti-C1q autoantibodies (anti-C1q) are frequently found in patients with systemic lupus erythematosus (SLE) and correlate with the occurrence of proliferative lupus nephritis. A previous study of anti-C1q in experimental lupus nephritis demonstrated an important role for FcRs in the pathogenesis of lupus nephritis, suggesting a direct effect on phagocytes. Therefore, we developed an in vitro […]
PcpA Promotes Higher Levels of Infection and Modulates Recruitment of Myeloid-Derived Suppressor Cells during Pneumococcal Pneumonia INFECTIOUS DISEASE AND HOST RESPONSE
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
We used two different infection models to investigate the kinetics of the PcpA-dependent pneumococcal disease in mice. In a bacteremic pneumonia model, we observed a PcpA-dependent increase in bacterial burden in the lungs, blood, liver, bronchoalveolar lavage, and spleens of mice at 24 h postinfection. This PcpA-dependent effect on bacterial burden appeared earlier (within 12 […]
LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation CLINICAL AND HUMAN IMMUNOLOGY
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Germinal centers (GCs) are microanatomical structures critical for the development of high-affinity Abs and B cell memory. They are organized into two zones, light and dark, with coordinated roles, controlled by local signaling. The innate lectin-like transcript 1 (LLT1) is known to be expressed on B cells, but its functional role in the GC reaction […]
ADding negative pRESSure to improve healING (the DRESSING trial): a RCT protocol
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Introduction Obese women are more likely to develop a surgical site infection (SSI) following caesarean section (CS) than non-obese women. Negative pressure wound therapy (NPWT) is increasingly being used to reduce SSI with limited evidence for its effectiveness. Objectives To determine the clinical and cost-effectiveness of using NPWT in obese women having elective and semiurgent […]
Does abortion increase women’s risk for post-traumatic stress? Findings from a prospective longitudinal cohort study
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Objective To prospectively assess women’s risk for post-traumatic stress disorder (PTSD) and of experiencing post-traumatic stress symptoms (PTSS) over 4 years after seeking an abortion, and to assess whether symptoms are attributed to the pregnancy, abortion or birth, or other events in women’s lives. Design Prospective longitudinal cohort study which followed women from approximately 1 […]
Pediatric Facial Trauma from Bicycling
The Vicious Cycle: Pediatric Facial Trauma from Bicycling: Objectives Although prevention of head injuries through helmet use is widespread, there has been a paucity of inquiry and publicity regarding the potential for facial injury stemming from cycling. Our objectives included estimating the incidence of emergency department (ED) visits for bicycle-related facial trauma among the pediatric population and detailing injury patterns. Study Design and Setting Analysis of a nationwide database. Methods The National Electronic Injury Surveillance System, offered by the Consumer Produc... περισσότερα »
Obstructive Sleep Apnea and Gastroesophageal Reflux
Obstructive Sleep Apnea and Gastroesophageal Reflux: A Multivariate Population-Level Analysis: Objectives Previous studies investigating the relationship between gastroesophageal reflux (GER) and obstructive sleep apnea (OSA) demonstrate mixed results and have had limited capacity to control for concurrent confounders. Our objectives were to (1) determine if GER is significantly associated with OSA when simultaneously adjusting for the presence of other potentially confounding conditions and (2) quantify the magnitude of any such association that exists. Study Design Cross-section...περισσότερα »
Olfactory Neuroblastoma: Fate of the Neck
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Olfactory Neuroblastoma: Fate of the Neck--A Long-term Multicenter Retrospective Study: Objective Olfactory neuroblastoma and the management of neck disease has posed considerable challenges to the treating physician. The aims of the study were to determine the incidence and factors influencing neck disease and to identify at-risk patients with cervical node–negative disease at presentation. Study Design Multicenter case series with retrospective chart review. Setting and Subjects In sum, 113 patients with a histopathologic diagnosis of olfactory neuroblastoma across 6 tertiary h...περισσότερα »
Myocutaneous sternocleidomastoid flap for reconstruction after the resection of a parapharyngeal heterotopic glioma
in a child with cleft palate, and systematic review of parapharyngeal glial heterotopia - Héctor M. Prado-Calleros , José R. Arrieta-Gómez , Beatriz Castillo-Ventura , Sara Parraguirre Martínez , Carlos Jiménez-Gutiérrez , Irma Jiménez-Escobar[image: correspondence][image: email] *International Journal of Pediatric Otorhinolaryngology*, Volume 81 DOI: http://dx.doi.org/10.1016/j.ijporl.2015.12.003 | Abstract We describe the surgery and reconstruction employed with a sternocleidomastoid myocutaneous flap for the treatment of a heterotopic ... περισσότερα »
Language development and affecting factors in children aged 5 to 27 months
A study of language development and affecting factors in children aged 5 to 27 months: Nuray Bayar Muluk, MD; Birgül Bayo&gbreve;lu, MSci; Banu Anlar, MD AbstractWe conducted a study to assess the factors that affect language development in infants and toddlers using data obtained during developmental screening. Our study group consisted of 505 children-244 (48.3%) boys and 261 (51.7%) girls, aged 5 to 27 months. The children were divided into four age groups: group 1, which we designated as the “6 months” group (age range: 5 to 7 mo); group 2, designated as the “12 months” group (...περισσότερα »
Lipoma arising in the eustachian tube
A case of lipoma arising in the eustachian tube: Jonathan Dabiri, MD; Georges Choufani, MD; Isabelle Delpierre, MD; Sergio Hassid, PhD AbstractWe report a case of a lipoma inside the eustachian tube, an extremely rare location for this lesion. To the best of our knowledge, this is only the second such case that has been described in the literature. The patient was a 47-year-old man, a fighter pilot, who was referred to our hospital with a 3-year history of (1) fullness in the right ear secondary to recurrent serous otitis media and (2) right ear pain, which was especially acute dur... περισσότερα »
Management of a cocaine-induced palatal perforation with a nasal septal button
Management of a cocaine-induced palatal perforation with a nasal septal button: Matteo Trimarchi, MD; Vittoria Sykopetrites, MD; Mario Bussi, MD AbstractA cocaine-induced midline destructive lesion (CIMDL) is a rare consequence of cocaine insufflation that involves the nose, sinuses, and occasionally the palate. Palatal perforations compromise swallowing, mastication, and speech. An obturator prosthesis can be used to overcome these complications. In selected cases, a nasal septal button is a good alternative for the sealing of a palatal perforation, especially when surgery is not ...περισσότερα »
Laryngitis obscuring an anterior glottic mass
Laryngitis obscuring an anterior glottic mass: James D. Thompson, MD; Jaime Eaglin Moore, MD; Robert T. Sataloff, MD, DMA, FACS *Anterior masses, such as the one seen in this case, can cause glottic insufficiency and vocal strain.* *ENT Journal provides full text articles to our registered members. Please log in or sign up for a FREE membership to view the full content:* - REGISTER AS A MEMBER - If you are already registered, SIGN IN *You may also like to:* - Sign Up For The Free eNews Letter
Urbach-Wiethe disease (lipoid proteinosis) is an autosomal recessive disorder that is characterized by a general thickening of the skin and mucous membranes
Urbach-Wiethe disease in a young woman: A case report: Stefanie Jansen, MD; Gero Quante, MD; Jan-Christoffer Luers, MD; Dirk Beutner, MD AbstractUrbach-Wiethe disease (lipoid proteinosis) is an autosomal recessive disorder that is characterized by a general thickening of the skin and mucous membranes. We report the case of a 22-year-old woman with lipoid proteinosis who presented with hoarseness, poor dentition, and skin lesions, and we discuss the management of this rare disease. *ENT Journal provides full text articles to our registered members. Please log in or sign up for a FR...περισσότερα »
Clival lesion: Atypical osteomyelitis vs. a neoplastic process
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Clival lesion: Atypical osteomyelitis vs. a neoplastic process: Mike C. Butterfield, MD; Juan S. Gomez, MD; Ngoc Ly, MD; Enrique Palacios, MD, FACR *The differential diagnosis of a clival lesion includes malignancy, infection, meningioma, and chordoma. In this patient, a recurrent neoplasm was suspected because of his medical history and the imaging findings* *ENT Journal provides full text articles to our registered members. Please log in or sign up for a FREE membership to view the full content:* - REGISTER AS A MEMBER - If you are already registered, SIGN IN *You may als... περισσότερα »
Intratonsillar metastasis of EBV-positive nasopharyngeal carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Intratonsillar metastasis of EBV-positive nasopharyngeal carcinoma: Matthew R. Naunheim, MD, MBA; Linda N. Lee, MD; Harrison W. Lin, MD; Peter M. Sadow, MD, PhD; Daniel G. Deschler, MD AbstractWe present the case of a 47-year-old man with a history of Epstein-Barr-virus-positive nasopharyngeal carcinoma who developed a metastasis to the palatine tonsil. To the best of our knowledge, this is the first reported case of an intratonsillar metastasis of a nasopharyngeal carcinoma. The aim of this report is to emphasize the importance of vigilant surveillance in patients with nasopharynge...περισσότερα »
Granular cell (Abrikossoff) tumor in the head and neck
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Granular cell (Abrikossoff) tumor in the head and neck: A series of 5 cases: Petros Koltsidopoulos, MD, PhD; Konstantinos Chaidas, MD; Paschalis Chlopsidis, MD; Charalambos Skoulakis, MD, PhD AbstractWe evaluated a series of 5 patients-3 men and 2 women, aged 39 to 70 years (mean: 54.4)-with a granular cell tumor (GCT) of the head and neck in an effort to better define the clinical presentation, imaging characteristics, and surgical management of this type of tumor. In all cases, the diagnosis was established by pathologic analysis. There were 2 cases of laryngeal GCT and 1 case ea... περισσότερα »
Vestibular Neuritis in Children and Adolescents
Vestibular Neuritis in Children and Adolescents: Clinical Features and Recovery: Describe the clinical presentation and recovery of vestibular neuritis in children and adolescents. AbstractObjective Describe the clinical presentation and recovery of vestibular neuritis in children and adolescents. Study Design Retrospective case series Setting Pediatric tertiary care center Subjects and Methods Eleven patients diagnosed with vestibular neuritis were identified from a database of 301 patients evaluated at our pediatric vestibular clinic from January 2012 through January 2015. Medica... περισσότερα »
Spontaneous resolution of laryngomalacia and its symptoms
A systematic review of the evidence on spontaneous resolution of laryngomalacia and its symptoms: Introduction and Objectives: Laryngomalacia (LM) is the most common cause of congenital stridor. Tradition holds that the majority of patients resolve spontaneously by 12-18 months of age. The objective of this study was to systematically review the literature on the spontaneous resolution of LM and/or its presenting symptoms, in otherwise healthy infants. Abstract Introduction and Objectives: Laryngomalacia (LM) is the most common cause of congenital stridor. Tradition holds that th...περισσότερα »
Sleep-disordered breathing in children with Down syndrome: usefulness of home polysomnography
Sleep-disordered breathing in children with Down syndrome: usefulness of home polysomnography: To investigate the technical feasibility of unattended home polysomnography (HPSG) in children with Down syndrome. AbstractObjective To investigate the technical feasibility of unattended home polysomnography (HPSG) in children with Down syndrome. Methods Data from children with Down syndrome under 10 years of age referred to a diagnostic sleep study was analyzed. A full sleep-lab based polysomnography (PSG) or a HPSG with a portable device was performed. Uninterpretable HPSGs were defin... περισσότερα »
Rhinitis, Ocular, Throat and Dermal Symptoms, Headache and Tiredness among Students in Schools: Associations with Fungal DNA and Mycotoxins in Classroom Dust
Rhinitis, Ocular, Throat and Dermal Symptoms, Headache and Tiredness among Students in Schools from Johor Bahru, Malaysia: Associations with Fungal DNA and Mycotoxins in Classroom Dust: by Dan Norbäck, Jamal Hisham Hashim, Gui-Hong Cai, Zailina Hashim, Faridah Ali, Erica Bloom, Lennart Larsson There are few studies on rhinitis and sick building syndrome (SBS) among students in tropical countries. We studied associations between levels of five fungal DNA sequences, two mycotoxins (sterigmatocystin and verrucarol) and cat allergen (Fel d 1) levels in schools and rhinitis and other we... περισσότερα »
Bulldog scalp
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 1 ώρα
A 54-YEAR-OLD MAN PRESENTED with a 2-year history of unusual skin folds on the scalp with deep furrows in an anteroposterior direction, located in parieto-occipital regions (Figure 1). A… from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1KTcE9g via IFTTT
The PBX3/MEIS1 Axis in Leukemia
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Overexpression of HOXA/MEIS1/PBX3 homeobox genes is the hallmark of mixed lineage leukemia (MLL)-rearranged acute myeloid leukemia (AML). HOXA9 and MEIS1 are considered to be the most critical targets of MLL fusions and their coexpression rapidly induces AML. MEIS1 and PBX3 are not individually able to transform cells and were therefore hypothesized to function as cofactors […]
MLK4 Mutations in Colon Cancer Enhance Tumor Growth
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In this study, we assessed the functional consequences of MLK4 mutations in colon tumorigenesis. Biochemical data indicated that a majority of MLK4 mutations are loss-of-function (LOF) mutations that can exert dominant-negative effects. In seeking to understand the abrogated activity of these mutants, we elucidated a new MLK4 catalytic domain structure. To determine whether MLK4 is […]
HEATR1 Negatively Regulates Akt
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In this study, we assessed this hypothesized link in PDAC, where HEATR1 expression is downregulated significantly. HEATR1 silencing in PDAC cells increased resistance to gemcitabine and other chemotherapeutics, where this effect was associated with increased AKT kinase phosphorylation at the Thr308 regulatory site. Mechanistically, HEATR1 enhanced cell responsiveness to gemcitabine by acting as a scaffold […]
RSPO Signaling in Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Deregulation of the β-catenin signaling has long been associated with cancer. Intracellular components of this pathway, including axin, APC, and β-catenin, are frequently mutated in a range of human tumors, but the contribution of specific extracellular ligands that promote cancer development through this signaling axis remains unclear. We conducted a reporter-based screen in a panel […]
Benefit from Bevacizumab and CCNU in Recurrent GBM Patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In this study, we performed gene expression profiling (DASL and RNA-seq) of formalin-fixed, paraffin-embedded tumor material from participants of the BELOB trial to identify patients with recurrent GBM who benefitted most from beva+CCNU treatment. We demonstrate that tumors assigned to the IGS-18 or “classical” subtype and treated with beva+CCNU showed a significant benefit in progression-free […]
DR5 Targeting Triggers Gastrointestinal Toxicity
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In conclusion, the combination of DR5-targeting agonistic mAbs with DNA damaging chemotherapy may pose a risk of developing toxicity-induced conditions, and the effects of mAb-based strategies on the dose-limiting toxicity of chemotherapy must be considered when establishing new combination therapies. Cancer Res; 76(3); 700–12. ©2015 AACR. (Source: Cancer Research) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader […]
Fat, Calories, and Cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
(Source: Cancer Research) from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1PcjOHr via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
A Novel C-Terminal Hsp90 Inhibitor SH-1242
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In this study, we report progress on deguelin analogues that address this limitation, focusing on the novel analogue SH-1242 as a candidate to broadly target human lung cancer cells, including those that are chemoresistant or harboring KRAS mutations. In a KRAS-driven mouse model of lung cancer, SH-1242 administration reduced tumor multiplicity, volume, and load. Similarly, […]
Sig1R Stimulates Cancer Cell Invasiveness
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
In this study, we found that Sig1R dynamically controls the membrane expression of the human voltage-dependent K+ channel human ether-à-go-go-related gene (hERG) in myeloid leukemia and colorectal cancer cell lines. Sig1R promoted the formation of hERG/β1-integrin signaling complexes upon extracellular matrix stimulation, triggering the activation of the PI3K/AKT pathway. Consequently, the presence of Sig1R in […]
Eventual role of EGFR-tyrosine kinase inhibitors in early-stage non-small-cell lung cancer
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 1 ώρα
Future Oncology Ahead of Print. from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/1SAgiLB via IFTTT Medicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174
Unsedated transnasal esophagogastroduodenoscopy
Regular screening of esophageal cancer for 248 newly diagnosed hypopharyngeal squamous cell carcinoma by unsedated transnasal esophagogastroduodenoscopy via ScienceDirect Search: ESOPHAGEAL CANCER Publication date: Available online 1 February 2016 *Source:*Oral Oncology Author(s): Yen-Chieh Huang, Yi-Chia Lee, Ping-Huei Tseng, Tseng-Cheng Chen, Tsung-Lin Yang, Pei-Jen Lou, Jenq-Yuh Ko, Li-Jen Liao, Wan-Lun Hsu, Yih-Leong Chang, Cheng-Ping Wang ObjectivesEsophageal squamous cell carcinoma (ESCC) is common in hypopharyngeal squamous cell carcinoma (HSCC) patients. This prospective study... περισσότερα »
Regular screening of esophageal cancer for newly diagnosed hypopharyngeal squamous cell carcinoma
Alexandros G. SfakianakisστοHead,Neck,Brain,Cervical Spine and Esophageal Cancers by Alexandros G. SfakianakisΠριν από 1 ώρα
Regular screening of esophageal cancer for 248 newly diagnosed hypopharyngeal squamous cell carcinoma by unsedated transnasal esophagogastroduodenoscopy via ScienceDirect Search: ESOPHAGEAL CANCER Publication date: Available online 1 February 2016 *Source:*Oral Oncology Author(s): Yen-Chieh Huang, Yi-Chia Lee, Ping-Huei Tseng, Tseng-Cheng Chen, Tsung-Lin Yang, Pei-Jen Lou, Jenq-Yuh Ko, Li-Jen Liao, Wan-Lun Hsu, Yih-Leong Chang, Cheng-Ping Wang ObjectivesEsophageal squamous cell carcinoma (ESCC) is common in hypopharyngeal squamous cell carcinoma (HSCC) patients. This prospective study... περισσότερα »
Plasma Anti-Glial Fibrillary Acidic Protein Autoantibody Levels during the Acute and Chronic Phases of Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot Study
Journal of Neurotrauma , Vol. 0, No. 0. from Neurology via xlomafota13 on Inoreader http://ift.tt/1PO1KCZ via IFTTT
Suitability of the Quality of Life after Brain Injury Instrument for Older People with Traumatic Brain Injury
Journal of Neurotrauma , Vol. 0, No. 0. from Neurology via xlomafota13 on Inoreader http://ift.tt/1PO1KCP via IFTTT
Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury
Journal of Neurotrauma , Vol. 0, No. 0. from Neurology via xlomafota13 on Inoreader http://ift.tt/1KmOYPB via IFTTT
IMA asks its local and state branches to raise awareness about cancer – Merinews
Merinews IMA asks its local and state branches to raise awareness about cancer Merinews Reducing the rates of tobacco use will significantly decrease the global burden of 13 different types of cancers, including lung, oral cavity etc. Alcohol use has also been linked to cancers of the mouth, pharynx, larynx, esophagus, bowel, liver and …… Continue reading IMA asks its local and state branches to raise awareness about cancer – Merinews
Wig shop moves out of B.C. Cancer Agency in Victoria – Times Colonist
Wig shop moves out of B.C. Cancer Agency in Victoria Times Colonist Leanna Eastgate, owner and operator of Salon Revive, will move from the site near Royal Jubilee Hospital this morning, obeying the eviction notice the shop received from the B.C. Cancer Agency. Eastgate said she will have cupcakes to say thank you to …… Continue reading Wig shop moves out of B.C. Cancer Agency in Victoria – Times Colonist
Increasing Coverage of Appropriate Vaccinations
Publication date: Available online 1 February 2016 Source:American Journal of Preventive Medicine Author(s): Verughese Jacob, Sajal K. Chattopadhyay, David P. Hopkins, Jennifer Murphy Morgan, Adesola A. Pitan, John M. Clymer ContextPopulation-level coverage for immunization against many vaccine-preventable diseases remains below optimal rates in the U.S. The Community Preventive Services Task Force recently recommended several interventions… Continue reading Increasing Coverage of Appropriate Vaccinations
New Vaccines in 2016 Pediatric Immunization Schedule New Vaccines in 2016 Pediatric Immunization Schedule
Recommendations for the recently licensed meningococcal B and 9-valent human papillomavirus vaccine are now in the official 2016 childhood immunization schedule Medscape Medical News (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PRt3Ct via IFTTT
2016 Adult Immunization Schedule Includes New Vaccines2016 Adult Immunization Schedule Includes New Vaccines
New vaccines against meningococcal serogroup B and human papillomavirus and a revision to the pneumococcal vaccine recommendation are among the 2016 changes. Medscape Medical News (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1WZ3oaB via IFTTT
CDC Alert: Severe Influenza Illness ReportedCDC Alert: Severe Influenza Illness Reported
Clinicians should initiate antiviral treatment to very ill and high-risk patients suspected of having influenza without waiting for test results. ICU admissions and deaths have been reported. Medscape Medical News (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1WZ3qPN via IFTTT
Asthma-COPD Overlap — A New Clinical EntityAsthma-COPD Overlap — A New Clinical Entity
You know them individually, but what about together? A new review keeps clinicians up-to-date on identification and management of the asthma-COPD overlap syndrome. Medscape Pulmonary Medicine (Source: Medscape Allergy Headlines) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PRt2P5 via IFTTT
Impaired barrier function in patients with house dust mite–induced allergic rhinitis is accompanied by decrea sed occludin and zonula occludens-1 expression
Tight junction (TJ) defects have recently been associated with asthma and chronic rhinosinusitis. The expression, function, and regulation of nasal epithelial TJs remain unknown in patients with allergic rhinitis (AR). (Source: Journal of Allergy and Clinical Immunology) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://ift.tt/1PRt2OV via IFTTT
A further wheat allergen for baker’s asthma: Tri a 40
Baker’s asthma and baker’s rhinitis are still among the most frequent occupational respiratory disorders.1 Sensitization to inhaled wheat flour comprising an increasing number of identified allergen components plays a key role in the development and diagnosis of baker’s disease.2 Recently, 19 recombinant wheat flour allergen components were evaluated in a group of 101 bakers from… Continue reading A further wheat allergen for baker’s asthma: Tri a 40
Mechanisms Underlying Peanut Allergic Reactions in TRACE Peanut Study Participants: Extension Study
Conditions: Food Hypersensitivity; Peanut HypersensitivityInterventions: Other: DBPCFC to peanut cookie; Other: Single-dose DBPCFCSponsors: Imperial College London; University of Manchester; Food Standards Agency, United Kingdom; Cambridge University Hospitals NHS Foundation TrustNot yet recruiting – verified January 2016 (Source: ClinicalTrials.gov) MedWorm Sponsor Message: Directory of the best January Sales in the UK. Find the best Christmas presents… Continue reading Mechanisms Underlying Peanut Allergic Reactions in TRACE Peanut Study Participants: Extension Study
Orphan immunotherapies for allergic diseases
Publication date: Available online 1 February 2016 *Source:*Annals of Allergy, Asthma & Immunology Author(s): Erminia Ridolo, Marcello Montagni, Cristoforo Incorvaia, Gianenrico Senna, Giovanni Passalacqua ObjectiveAs confirmed by systematic reviews and meta-analyses, allergen immunotherapy is clinically effective in the treatment of allergic diseases. In particular, subcutaneous immunotherapy is a pivotal treatment in patients with severe reactions to Hymenoptera venom, whereas subcutaneous immunotherapy and sublingual immunotherapy are indicated in the treatment of allergic rhinit...περισσότερα »
Interpreting the electrophysiological power spectrum
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Recent experimental findings suggest that there may be rich physiological information embedded within the power spectrum of neurophysiological recordings, which, in addition to power in specific oscillatory frequencies, can be extracted with the appropriate model. This article reviews previous empirical and modeling results, as well as the canonical power law model that is often used […]
The importance of decision onset
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
The neural mechanisms of decision making are thought to require the integration of evidence over time until a response threshold is reached. Much work suggests that response threshold can be adjusted via top-down control as a function of speed or accuracy requirements. In contrast, the time of integration onset has received less attention and is […]
Right fronto-insular white matter tracts link cognitive reserve and pain in migraine patients
medicinesfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026182 & 00306932607174Πριν από 2 ώρες
Background: Structural white matter abnormalities in pain-modulating, regions are present in migraine. Whether they are associated with pain chronification and with cognitive reserve is unclear. Methods: Prospective, cohort, six-month study of adult patients with episodic or chronic migraine, and controls. Cognitive reserve, quality of life, impact of pain on daily living, depression and anxiety were […]
Plasma Anti-Glial Fibrillary Acidic Protein Autoantibody Levels during the Acute and Chronic Phases of Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot Study
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1PO1KCZ via IFTTT
Suitability of the Quality of Life after Brain Injury Instrument for Older People with Traumatic Brain Injury
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1PO1KCP via IFTTT
Multidimensional Analysis of Magnetic Resonance Imaging Predicts Early Impairment in Thoracic and Thoracolumbar Spinal Cord Injury
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 2 ώρες
Journal of Neurotrauma , Vol. 0, No. 0. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/1KmOYPB via IFTTT
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