Health Disparities Research Among Small Tribal Populations: Describing Appropriate Criteria for Aggregating Tribal Health Data
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 4 δευτερόλεπτα
In response to community concerns, we used the Tribal Participatory Research framework in collaboration with 5 American-Indian communities in Washington, Idaho, and Montana to identify the appropriate criteria for aggregating health data on small tribes. Across tribal sites, 10 key informant interviews and 10 focus groups (n = 39) were conducted between July 2012 and […]
Modified Rhytidectomy that Produces a More Natural Look: Experience with 110 Cases
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 4 δευτερόλεπτα
Modified Rhytidectomy that Produces a More Natural Look: Experience with 110 Cases: Abstract Background Recognition of the effects of aging on the ear and the mechanisms leading to ear deformity associated with facelift procedures aid in achieving improved aesthetic results. In 2009, the author developed a novel rhytidectomy technique to provide more natural-looking results than […]
Endocrinology 40 citation
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Ρespiratory tract infections
Burden of respiratory tract infections at post mortem in Zambian children: Background: Autopsy studies are the gold standard for determining cause-of-death and can inform on improved diagnostic strategies and algorithms to improve patient care. We conducted a cross-sectional observational autopsy study to describe the burden of respiratory tract infections in inpatient children who died at the University Teaching Hospital in Lusaka, Zambia. Methods: Gross pathology was recorded and lung tissue was analysed by histopathology and molecular diagnostics. Recruitment bias was estimated ... περισσότερα »
Repeated Intravenous Thrombolysis for Early Recurrent Stroke
Challenging the Exclusion Criterion [Brief Report]: Background and Purpose— Intravenous thrombolysis (IVT) within 4.5 hours from symptom onset improves functional outcome in patients with acute ischemic stroke. Its use in patients with previous stroke within the preceding 3 months is contraindicated because of the assumed higher risk of intracranial hemorrhage. In addition, tissue-type plasminogen activator may itself promote neurotoxicity and blood–brain barrier disruption. However, safety and effectiveness of repeated IVT is essentially unknown in patients with early (<3 months) ... περισσότερα »
Importance of an education programme for patients with chronic widespread pain.
Importance of an education programme for patients with chronic widespread pain.: The structured education programme for patients with chronic widespread pain is the first stage of the interdisciplinary group-based rehabilitation programme for those patients at the University Rehabilitation Institute in Ljubljana, Slovenia. The aim of our pilot study was to investigate the impact of the education programme on the patients' attribution of pain as dangerous. Ninety-three participants with chronic widespread pain volunteered for the study. They were first screened to verify whether they... περισσότερα »
Arterio-Venous Malformations of the Nose
Combined Approach for a Successful Strategy.: Background and Purpose: The purpose of the present study is to evaluate the vascular malformations of the head and neck. They are uncommon lesions, but some areas have a significant potential for fatality, due to their massive bleeding. The vascular anatomy of the nose carries a high recurrence rate, due to the unique characteristic of the nose, especially if deep vascular connection is present. Methods: The present article describes 2 patients of nasal dorsum arteriovenous malformations, both using a combined procedure: preoperative s... περισσότερα »
Fibrosis Within the Tympanic Membrane.
Fibrosis Within the Tympanic Membrane.: A primary mass lesion arising from the tympanic membrane is extremely rare. The authors report a patient of extensive fibrosis within the tympanic membrane in a 65-year-old woman who did not have a history of ear infection. The patient complained of slow progressing hearing loss on the left side without otorrhea or otalgia. Otoscopic examination showed a thick tympanic membrane with whitish mass-like bulge, and pure-tone audiometry revealed conductive hearing loss. The lesion was totally resected, and final findings of a histopathologic examin... περισσότερα »
Collagen Content Limits Optical Coherence Tomography Image Depth in Porcine Vocal Fold Tissue
Collagen Content Limits Optical Coherence Tomography Image Depth in Porcine Vocal Fold Tissue: Objective Vocal fold scarring, a condition defined by increased collagen content, is challenging to treat without a method of noninvasively assessing vocal fold structure in vivo. The goal of this study was to observe the effects of vocal fold collagen content on optical coherence tomography imaging to develop a quantifiable marker of disease. Study Design Excised specimen study. Setting Massachusetts Eye and Ear Infirmary. Subjects and Methods Porcine vocal folds were injected with co... περισσότερα »
Colonisation with methicillin-resistant Staphylococcus aureus and associated factors among nurses with occupational skin diseases
Colonisation with methicillin-resistant Staphylococcus aureus and associated factors among nurses with occupational skin diseases: Objectives To evaluate the prevalence of colonisation with methicillin-resistant *Staphylococcus aureus* (MRSA), associated factors and the effectiveness of decolonisation procedures among nurses with occupational skin diseases (OSD). Methods In a retrospective cohort study, the medical records of 319 nurses from Germany who were screened consecutively for MRSA when participating in a tertiary individual prevention programme (TIP) for severe OSD between ... περισσότερα »
Paracetamol-induced fixed drug eruption in a patient with recurrent fever and rash
Paracetamol-induced fixed drug eruption in a patient with recurrent fever and rash: We describe a 3-year-old boy with recurrent fever and rashes on the same areas of his body and diagnosed multiple fixed drug eruption (FDE) induced by paracetamol. The boy was admitted to a pediatrics clinic with recurrent fever (39°C-40°C) and rash attacks every 2 to 3 months during last year. The skin lesions were painless, without itching above the mouth, around both eyes, above chin and nose, and on the right elbow and right knee. The lesions were red at the beginning and then turned purple in 2 t... περισσότερα »
Multicenter Clinical Trial of Vibroplasty Couplers to Treat Mixed/Conductive Hearing Loss
First Results Audiol Neurootol. 2016 Jun 29;21(4):212-222 Authors: Zahnert T, Löwenheim H, Beutner D, Hagen R, Ernst A, Pau HW, Zehlicke T, Kühne H, Friese N, Tropitzsch A, Lüers JC, Mlynski R, Todt I, Hüttenbrink KB Abstract OBJECTIVE: To evaluate the safety and effectiveness of round window (RW), oval window (OW), CliP and Bell couplers for use with an active middle ear implant. METHODS: This is a multicenter, long-term, prospective trial with consecutive enrollment, involving 6 university hospitals in Germany. Bone conduction, air conduction, implant-aided warble-tone threshol... περισσότερα »
Peripheral and central control of swallowing initiation in healthy humans.
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Aida S, Takeishi R, Magara J, Watanabe M, Ito K, Nakamura Y, Tsujimura T, Hayashi H, Inoue M Abstract We investigated (1) how peripheral inputs might assist central inputs in the control of voluntary evoked swallowing, (2) inter-individual variation in involuntary and voluntary swallowing initiation, and (3) whether natural chewing behavior affects the initiation of involuntary swallowing in healthy humans. Eleven participants completed a repetitive saliva swallowing test (RSST), chewing test (CHEW), and rest period (RES... περισσότερα »
Modified Rhytidectomy that Produces a More Natural Look: Experience with 110 Cases
Modified Rhytidectomy that Produces a More Natural Look: Experience with 110 Cases: Abstract Background Recognition of the effects of aging on the ear and the mechanisms leading to ear deformity associated with facelift procedures aid in achieving improved aesthetic results. In 2009, the author developed a novel rhytidectomy technique to provide more natural-looking results than those achieved through other facelift procedures, which often result in facial and ear distortion/deformity. This technique is designed to optimize aesthetic outcomes by employing incisions hidden within t... περισσότερα »
Recurrent Streptococcus Pneumoniae 23 F meningitis due to cerebrospinal fluid leakage from the ear cannel: a case report.
[image: http:--http://ift.tt/1NMOrDk] [image: http:--http://ift.tt/1Fkw4zC] Authors: Li YC, Chen CY, Wu KH, Kuo HT, Wu HP Abstract BACKGROUND: Bacterial meningitis is a medical emergency, and immediate diagnostic steps must be taken to establish the specific cause. Recurrence of bacterial meningitis in children is not only potentially life-threatening, but also involves or induces psychological trauma to the patients through repeated hospitalization with many invasive investigations. CASE PRESENTATION: A 6-year-old boy was diagnosed with recurrent bacterial meningitis caused by... περισσότερα »
Evaluation in Patients with Vascular Pulsatile Tinnitus Using Transcanal Recording and Spectro-Temporal Analysis.
Pre-Treatment Objective Diagnosis and Post-Treatment Outcome PLoS One. 2016;11(6):e0157722 Authors: Kim SH, An GS, Choi I, Koo JW, Lee K, Song JJ Abstract OBJECTIVE: Although vascular pulsatile tinnitus (VPT) has been classified as "objective", VPT is not easily recognizable or documentable in most cases. In response to this, we have developed transcanal sound recording (TSR) and spectro-temporal analysis (STA) for the objective diagnosis of VPT. By refining our initial method, we were able to apply TSR/STA to post-treatment outcome evaluation, as well as pre-treatment objective ... περισσότερα »
A Novel Approach to Keloid Reconstruction with Bilaminar Dermal Substitute and Epidermal Skin Grafting
A Novel Approach to Keloid Reconstruction with Bilaminar Dermal Substitute and Epidermal Skin Grafting: [image: image]Background: Keloids represent a challenging problem. Surgical excision remains the definitive treatment for immediate lesion debulking, but recurrence rates are reported to be 45 to 100 percent. The authors present a staged reconstructive approach using a dermal regeneration substrate and epidermal grafting to minimize recurrence and donor-site morbidity. Methods: Keloids were completely excised down to normal subcutaneous tissue or perichondrium. A bilaminar dermal ... περισσότερα »
The Essential Anatomical Subunit Approximation Unilateral Cleft Lip Repair
The Essential Anatomical Subunit Approximation Unilateral Cleft Lip Repair: [image: image]Summary: The anatomical subunit approximation cleft lip repair advantageously achieves a balanced lip contour, with the line of repair hidden along seams of aesthetic subunits. Dr. David Fisher's original description of the repair reflects the considerable thought that went into the evolution of his design. As his technique has gained acceptance in the intervening 10 years, the authors note several key principles embodied in it that represent a shift in the cleft lip repair paradigm. The authors... περισσότερα »
Basal Short Nose: How to Identify and Correct It
Basal Short Nose: How to Identify and Correct It: [image: image] [image: PdfPageImage.00006534-201607000-00079.0.] http://ift.tt/29cXd2A OtoRhinoLaryngology by Alexandros G. Sfakianakis
IL6 Polymorphism Predicts Bevacizumab Efficacy
IL6 Polymorphism Predicts Bevacizumab Efficacy: *Purpose:* The IL6/STAT3 axis promotes inflammation, angiogenesis, and cancer. The effect of genetic variants within this pathway on benefit from antiangiogenic cancer therapy is unknown. We tested whether SNPs in genes involved in *IL6*/*STAT3* signaling can predict efficacy of bevacizumab-based chemotherapy in metastatic colorectal cancer (mCRC) patients. *Experimental Design:* Associations between potentially functional *IL6* (rs2069837 and rs1800795) and *STAT3* (rs744166 and rs4796793) SNPs and clinical outcomes [progression-fre... περισσότερα »
Recurrent high-grade invasive mucoepidermoid carcinoma of larynx: a case report and review of the literature
Recurrent high-grade invasive mucoepidermoid carcinoma of larynx: a case report and review of the literature: Recurrent invasive high-grade mucoepidermoid carcinoma of the larynx and hypopharynx is a rare occurrence. These tumors have been commonly associated with salivary gland tumors, most commonly the parotid gland. The patient usually presents with the following symptoms: hoarseness (if larynx is involved), or changes in voice character, sore throat, cough, odynophagia, dysphagia, otalgia, difficulty breathing, weight loss, lymphadenopathy. Here we present a case of a recurrent ... περισσότερα »
Ixabepilone and Sunitinib in Advanced Solid Tumors
Ixabepilone and Sunitinib in Advanced Solid Tumors: *Purpose:* To evaluate the safety, MTD, pharmacokinetics/pharmacodynamics, and early clinical activity of ixabepilone given either weekly or every 3 weeks in combination with daily sunitinib in patients with advanced solid tumors. *Experimental Design:* Eligible patients received either weekly (schedule A) or every 3 weeks (schedule B) ixabepilone at escalating doses (schedule A: 7.5, 15, or 20 mg/m2; schedule B: 20, 30, or 40 mg/m2), and oral sunitinib (37.5 mg daily), starting on day 8 of cycle 1. Dose-limiting toxicities (DLT)... περισσότερα »
Masticator Space Foreign Body in a Child Presenting With Otorrhea and Granulation Tissue of the External Auditory Canal
Masticator Space Foreign Body in a Child Presenting With Otorrhea and Granulation Tissue of the External Auditory Canal: Objective: We report an unusual case of masticator space foreign body in a patient presenting with otorrhea and granulation tissue within the external auditory canal (EAC). Methods: Case report. Results: A 16-month-old male presented with fever, unilateral otorrhea, facial swelling, leukocytosis, and granulation tissue within the EAC that failed to respond to conventional medical treatment. Computed tomography scan showed EAC and middle ear opacification and so... περισσότερα »
CEA TCB antibody targeting solid tumors
CEA TCB antibody targeting solid tumors: *Purpose:* CEA TCB is a novel IgG-based T-cell bispecific (TCB) antibody for the treatment of CEA-expressing solid tumors currently in phase I clinical trials (NCT02324257). Its format incorporates bivalent binding to CEA, a head-to-tail fusion of CEA- and CD3e-binding Fab domains and an engineered Fc region with completely abolished binding to FcRs and C1q. The study provides novel mechanistic insights into the activity and mode of action of CEA TCB. *Experimental Design:* CEA TCB activity was characterized on 110 cell lines *in vitro* and... περισσότερα »
Cortical Auditory Evoked Potentials to Evaluate Cochlear Implant Candidacy in an Ear With Long-standing Hearing Loss: A Case Report
Cortical Auditory Evoked Potentials to Evaluate Cochlear Implant Candidacy in an Ear With Long-standing Hearing Loss: A Case Report: Objectives: We describe a novel use of cortical auditory evoked potentials in the preoperative workup to determine ear candidacy for cochlear implantation. Methods: A 71-year-old male was evaluated who had a long-deafened right ear, had never worn a hearing aid in that ear, and relied heavily on use of a left-sided hearing aid. Electroencephalographic testing was performed using free field auditory stimulation of each ear independently with pure tones ... περισσότερα »
Adjuvant Immunotherapy in Pediatric Sarcomas
Adjuvant Immunotherapy in Pediatric Sarcomas: *Purpose:* Patients with metastatic or relapsed pediatric sarcomas receive cytotoxic regimens that induce high remission rates associated with profound lymphocyte depletion, but ultimately few survive long term. We administered adjuvant immunotherapy to patients with metastatic and recurrent pediatric sarcomas in an effort to improve outcomes. *Experimental Design:* Mononuclear cells were collected via apheresis, and tumor lysate was acquired via percutaneous biopsy at enrollment. Participants received standard antineoplastic therapy, f... περισσότερα »
Vestibular and oculomotor influences on visual dependency
Vestibular and oculomotor influences on visual dependency: The degree to which a person relies on visual stimuli for spatial orientation is termed visual dependency (VD). VD is considered a perceptual trait or cognitive style influenced by psychological factors and mediated by central re-weighting of the sensory inputs involved in spatial orientation. VD is often measured using the rod-and-disk test, wherein participants align a central rod to the subjective visual vertical (SVV) in the presence of a background that is either stationary or rotating around the line of sight - dynamic... περισσότερα »
The Framework for Understanding Effortful Listening (FUEL).
Hearing Impairment and Cognitive Energy Ear Hear. 2016 Jul-Aug;37 Suppl 1:5S-27S Authors: Pichora-Fuller MK, Kramer SE, Eckert MA, Edwards B, Hornsby BW, Humes LE, Lemke U, Lunner T, Matthen M, Mackersie CL, Naylor G, Phillips NA, Richter M, Rudner M, Sommers MS, Tremblay KL, Wingfield A Abstract The Fifth Eriksholm Workshop on "Hearing Impairment and Cognitive Energy" was convened to develop a consensus among interdisciplinary experts about what is known on the topic, gaps in knowledge, the use of terminology, priorities for future research, and implications for practice. The gene... περισσότερα »
The Authors Reply
Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 9 δευτερόλεπτα
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Safety of Computed Tomographic Angiography in the Evaluation of Patients With Acute Stroke: A Single-Center Experience [Original Contribution]
Background and Purpose— Noncontrasted head computed tomography (NCHCT) has long been the standard of care for acute stroke imaging. New guidelines recommending advanced vascular imaging to identify eligible patients for endovascular therapy have renewed safety concerns on the use of contrast in the emergent setting without laboratory confirmation of renal function. Methods— We compared computed tomographic angiography (CTA) versus NCHCT alone during acute stroke evaluation with focus on renal safety and timeliness of therapy delivery. We reviewed data on all emergency department... περισσότερα »
Response to Letter Regarding Article, "Neutrophil-to-Lymphocyte Ratio Predicts the Outcome of Acute Intracerebral Hemorrhage" [Letter to the Editor]
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Preventive aerobic training exerts a cardioprotective effect on rats treated with monocrotaline
Summary Pulmonary arterial hypertension (PAH) is a chronic disease which causes overload to the right ventricle. The effect of preventive training on cardiac remodelling in this condition is still unknown. This study aimed to evaluate the influence of preventive training on hypertrophy, heart function and gene expression of calcium transport proteins in rats with monocrotaline-induced PAH. Thirty-two male Wistar rats were randomly divided into four groups: S, sedentary control; T, trained control; SM, sedentary monocrotaline; and TM, trained monocrotaline. The preventive training ... περισσότερα »
Photodynamic therapy versus surgical excision to basal cell carcinoma: meta-analysis
Summary Background Surgical excision (SE) is a first-line treatment for basal cell carcinoma (BCC). Topical photodynamic therapy (PDT) has also been used and has cosmetic advantages over surgery. The latest European guidelines for topical PDT recommended that it be used to treat nodular basal cell carcinoma (nBCC) but a consensus has not been reached. Our study was to evaluate the efficacy of PDT versus SE for the treatment for nBCC by a meta-analysis. Materials and methods We searched PubMed, EMBASE, the Cochrane Library, CKNI, VIP, and relevant references up to October 2014 in... περισσότερα »
An unknown laboratory microbe exhibiting significant anitifungal property
A nutrient agar upon exposed to laboratory environment and its incubation at room temperature for about 2 days results such microbial colonies. The large dry colony shows notable anti-fungal activity. from #ORL-Sfakianakis via xlomafota13 on Inoreader http://ift.tt/298IhlD via IFTTT
The Clinical Outcome of Posterior Reversible Encephalopathy Syndrome [LETTERS]
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Reply: [LETTERS]
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High-Resolution MRI Findings following Trigeminal Rhizotomy [HEAD & NECK]
BACKGROUND AND PURPOSE: Patients with trigeminal neuralgia often undergo trigeminal rhizotomy via radiofrequency thermocoagulation or glycerol injection for treatment of symptoms. To date, radiologic changes in patients with trigeminal neuralgia post-rhizotomy have not been described, to our knowledge. The aim of this study was to evaluate patients after trigeminal rhizotomy to characterize post-rhizotomy changes on 3D high-resolution MR imaging. MATERIALS AND METHODS: A retrospective review of trigeminal neuralgia protocol studies was performed in 26 patients after rhizotomy co... περισσότερα »
Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome) [ADULT BRAIN]
BACKGROUND AND PURPOSE: DWI infarcts involving the bilateral anterior and posterior circulation suggest an embolic etiology. In the absence of an identifiable embolic source, we analyzed DWI lesions involving these 3 cerebral territories to determine the diagnostic value for ischemic infarction caused by cancer-associated hypercoagulation. MATERIALS AND METHODS: A retrospective analysis of all brain MR imaging studies at our institution from July 2014 to June 2015 was conducted, yielding 4075 studies. Of those, 17% (*n* = 709) contained the terms "restricted-diffusion" plus eith... περισσότερα »
Mechanical Thrombectomy in Patients with Acute Ischemic Stroke and Lower NIHSS Scores: Recanalization Rates, Periprocedural Complications, and Clinical Outcome [INTERVENTIONAL]
BACKGROUND AND PURPOSE: Mechanical thrombectomy, in addition to intravenous thrombolysis, has become standard in acute ischemic stroke treatment in patients with large-vessel occlusion in the anterior circulation. However, previous randomized controlled stroke trials were not focused on patients with mild-to-moderate symptoms. Thus, there are limited data for patient selection, prediction of clinical outcome, and occurrence of complications in this patient population. The purpose of this analysis was to assess clinical and interventional data in patients treated with mechanical ... περισσότερα »
Magnetic Susceptibility from Quantitative Susceptibility Mapping Can Differentiate New Enhancing from Nonenhancing Multiple Sclerosis Lesions without Gadolinium Injection [ADULT BRAIN]
BACKGROUND AND PURPOSE: Magnetic susceptibility values of multiple sclerosis lesions increase as they change from gadolinium-enhancing to nonenhancing. Can susceptibility values measured on quantitative susceptibility mapping without gadolinium injection be used to identify the status of lesion enhancement in surveillance MR imaging used to monitor patients with MS? MATERIALS AND METHODS: In patients who had prior MR imaging and quantitative susceptibility mapping in a current MR imaging, new T2-weighted lesions were evaluated for enhancement on conventional T1-weighted imaging ... περισσότερα »
Orbital Fat Volumetry and Water Fraction Measurements Using T2-Weighted FSE-IDEAL Imaging in Patients with Thyroid-Associated Orbitopathy [HEAD & NECK]
BACKGROUND AND PURPOSE: The quantitative evaluation of orbital fat proliferation and edema and the assessment of extraocular muscles are useful for diagnosing and monitoring thyroid-associated orbitopathy. To evaluate therapy-induced quantitative changes in the orbital fat of patients with thyroid-associated orbitopathy, we performed volumetric and water fraction measurements by using T2-weighted FSE iterative decomposition of water and fat with echo asymmetry and least-squares estimation (FSE-IDEAL) imaging. MATERIALS AND METHODS: Orbital FSE-IDEAL images of 30 volunteers were ... περισσότερα »
Cervical Spinal Cord DTI Is Improved by Reduced FOV with Specific Balance between the Number of Diffusion Gradient Directions and Averages [SPINE]
BACKGROUND AND PURPOSE: Reduced-FOV DTI is promising for exploring the cervical spinal cord, but the optimal set of parameters needs to be clarified. We hypothesized that the number of excitations should be favored over the number of diffusion gradient directions regarding the strong orientation of the cord in a single rostrocaudal axis. MATERIALS AND METHODS: Fifteen healthy individuals underwent cervical spinal cord MR imaging at 3T, including an anatomic 3D-Multi-Echo Recombined Gradient Echo, high-resolution full-FOV DTI with a NEX of 3 and 20 diffusion gradient directions ... περισσότερα »
Disrupted Brain Connectivity Patterns in Patients with Type 2 Diabetes [FUNCTIONAL]
BACKGROUND AND PURPOSE: Type 2 diabetes is associated with an increased risk of dementia. This study investigated the global connectivity patterns in the brains of patients with type 2 diabetes by using a functional MR imaging technique. MATERIALS AND METHODS: Forty patients and 43 age-, sex-, and education-matched healthy controls underwent resting-state functional imaging in a 3T MR imaging unit. Degree centrality, a commonly used measurement of global connectivity, was computed for a full-brain exploration of the regions influenced by type 2 diabetes. We then examined the fun... περισσότερα »
Virtual-versus-Real Implantation of Flow Diverters: Clinical Potential and Influence of Vascular Geometry [INTERVENTIONAL]
BACKGROUND AND PURPOSE: Intracranial stents have become extremely important in the endovascular management of complex intracranial aneurysms. Sizing and landing zone predictions are still very challenging steps in the procedure. Virtual stent deployment may help therapeutic planning, device choice, and hemodynamic simulations. We aimed to assess the predictability of our recently developed virtual deployment model by comparing in vivo and virtual stents implanted in a consecutive series of patients presenting with intracranial aneurysms. MATERIALS AND METHODS: Virtual stents we... περισσότερα »
High-Convexity Tightness Predicts the Shunt Response in Idiopathic Normal Pressure Hydrocephalus [ADULT BRAIN]
BACKGROUND AND PURPOSE: Although neuroimaging plays an important role in the diagnosis of idiopathic normal pressure hydrocephalus, its predictive value for response to shunt surgery has not been established. The purpose of the current study was to identify neuroimaging markers that predict the shunt response of idiopathic normal pressure hydrocephalus. MATERIALS AND METHODS: Sixty patients with idiopathic normal pressure hydrocephalus underwent presurgical brain MR imaging and clinical evaluation before and 1 year after shunt surgery. The assessed MR imaging features included t... περισσότερα »
Antibiotic Resistance Patterns and Related Mobile Genetic Elements of Pneumococci and β-Hemolytic Streptococci in Thai Healthy Children
Abstract Transmission of antibiotic resistance genes among *Streptococcus pneumoniae* and beta-hemolytic streptococcus (BHS) was generally associated with transmissible genetic elements. The objectives of this study were to investigate carriage rate, antibiotic resistance and related mobile genetic elements of pneumococci and BHS from school-children. The pneumococci and BHS were recovered from 220 Thai school-children, and then tested for antibiotic susceptibility pattern by disc diffusion. Antibiotic resistance genes and related genetic elements were detected by PCR with specific... περισσότερα »
Effects of Within-Talker Variability on Speech Intelligibility in Mandarin-Speaking Adult and Pediatric Cochlear Implant Patients
Cochlear implant (CI) speech performance is typically evaluated using well-enunciated speech produced at a normal rate by a single talker. CI users often have greater difficulty with variations in speech production encountered in everyday listening. Within a single talker, speaking rate, amplitude, duration, and voice pitch information may be quite variable, depending on the production context. The coarse spectral resolution afforded by the CI limits perception of voice pitch, which is an important cue for speech prosody and for tonal languages such as Mandarin Chinese. In this st... περισσότερα »
Arterio-Venous Malformations of the Nose
Combined Approach for a Successful Strategy.: Background and Purpose: The purpose of the present study is to evaluate the vascular malformations of the head and neck. They are uncommon lesions, but some areas have a significant potential for fatality, due to their massive bleeding. The vascular anatomy of the nose carries a high recurrence rate, due to the unique characteristic of the nose, especially if deep vascular connection is present. Methods: The present article describes 2 patients of nasal dorsum arteriovenous malformations, both using a combined procedure: preoperative s... περισσότερα »
Fibrosis Within the Tympanic Membrane.
Fibrosis Within the Tympanic Membrane.: A primary mass lesion arising from the tympanic membrane is extremely rare. The authors report a patient of extensive fibrosis within the tympanic membrane in a 65-year-old woman who did not have a history of ear infection. The patient complained of slow progressing hearing loss on the left side without otorrhea or otalgia. Otoscopic examination showed a thick tympanic membrane with whitish mass-like bulge, and pure-tone audiometry revealed conductive hearing loss. The lesion was totally resected, and final findings of a histopathologic examin... περισσότερα »
Collagen Content Limits Optical Coherence Tomography Image Depth in Porcine Vocal Fold Tissue
Collagen Content Limits Optical Coherence Tomography Image Depth in Porcine Vocal Fold Tissue: Objective Vocal fold scarring, a condition defined by increased collagen content, is challenging to treat without a method of noninvasively assessing vocal fold structure in vivo. The goal of this study was to observe the effects of vocal fold collagen content on optical coherence tomography imaging to develop a quantifiable marker of disease. Study Design Excised specimen study. Setting Massachusetts Eye and Ear Infirmary. Subjects and Methods Porcine vocal folds were injected with co... περισσότερα »
Colonisation with methicillin-resistant Staphylococcus aureus and associated factors among nurses with occupational skin diseases
Colonisation with methicillin-resistant Staphylococcus aureus and associated factors among nurses with occupational skin diseases: Objectives To evaluate the prevalence of colonisation with methicillin-resistant *Staphylococcus aureus* (MRSA), associated factors and the effectiveness of decolonisation procedures among nurses with occupational skin diseases (OSD). Methods In a retrospective cohort study, the medical records of 319 nurses from Germany who were screened consecutively for MRSA when participating in a tertiary individual prevention programme (TIP) for severe OSD between ... περισσότερα »
Paracetamol-induced fixed drug eruption in a patient with recurrent fever and rash
Paracetamol-induced fixed drug eruption in a patient with recurrent fever and rash: We describe a 3-year-old boy with recurrent fever and rashes on the same areas of his body and diagnosed multiple fixed drug eruption (FDE) induced by paracetamol. The boy was admitted to a pediatrics clinic with recurrent fever (39°C-40°C) and rash attacks every 2 to 3 months during last year. The skin lesions were painless, without itching above the mouth, around both eyes, above chin and nose, and on the right elbow and right knee. The lesions were red at the beginning and then turned purple in 2 t... περισσότερα »
Multicenter Clinical Trial of Vibroplasty Couplers to Treat Mixed/Conductive Hearing Loss
First Results Audiol Neurootol. 2016 Jun 29;21(4):212-222 Authors: Zahnert T, Löwenheim H, Beutner D, Hagen R, Ernst A, Pau HW, Zehlicke T, Kühne H, Friese N, Tropitzsch A, Lüers JC, Mlynski R, Todt I, Hüttenbrink KB Abstract OBJECTIVE: To evaluate the safety and effectiveness of round window (RW), oval window (OW), CliP and Bell couplers for use with an active middle ear implant. METHODS: This is a multicenter, long-term, prospective trial with consecutive enrollment, involving 6 university hospitals in Germany. Bone conduction, air conduction, implant-aided warble-tone threshol... περισσότερα »
Peripheral and central control of swallowing initiation in healthy humans.
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Aida S, Takeishi R, Magara J, Watanabe M, Ito K, Nakamura Y, Tsujimura T, Hayashi H, Inoue M Abstract We investigated (1) how peripheral inputs might assist central inputs in the control of voluntary evoked swallowing, (2) inter-individual variation in involuntary and voluntary swallowing initiation, and (3) whether natural chewing behavior affects the initiation of involuntary swallowing in healthy humans. Eleven participants completed a repetitive saliva swallowing test (RSST), chewing test (CHEW), and rest period (RES... περισσότερα »
Modified Rhytidectomy that Produces a More Natural Look: Experience with 110 Cases
Modified Rhytidectomy that Produces a More Natural Look: Experience with 110 Cases: Abstract BackgroundRecognition of the effects of aging on the ear and the mechanisms leading to ear deformity associated with facelift procedures aid in achieving improved aesthetic results. In 2009, the author developed a novel rhytidectomy technique to provide more natural-looking results than those achieved through other facelift procedures, which often result in facial and ear distortion/deformity. This technique is designed to optimize aesthetic outcomes by employing incisions hidden within th... περισσότερα »
Recurrent Streptococcus Pneumoniae 23 F meningitis due to cerebrospinal fluid leakage from the ear cannel: a case report.
[image: http:--www.biomedcentral.com-graphics-pu] [image: http:--www.ncbi.nlm.nih.gov-corehtml-pmc] Authors: Li YC, Chen CY, Wu KH, Kuo HT, Wu HP Abstract BACKGROUND: Bacterial meningitis is a medical emergency, and immediate diagnostic steps must be taken to establish the specific cause. Recurrence of bacterial meningitis in children is not only potentially life-threatening, but also involves or induces psychological trauma to the patients through repeated hospitalization with many invasive investigations. CASE PRESENTATION: A 6-year-old boy was diagnosed with recurrent bacter... περισσότερα »
Evaluation in Patients with Vascular Pulsatile Tinnitus Using Transcanal Recording and Spectro-Temporal Analysis.
Pre-Treatment Objective Diagnosis and Post-Treatment Outcome PLoS One. 2016;11(6):e0157722 Authors: Kim SH, An GS, Choi I, Koo JW, Lee K, Song JJ Abstract OBJECTIVE: Although vascular pulsatile tinnitus (VPT) has been classified as "objective", VPT is not easily recognizable or documentable in most cases. In response to this, we have developed transcanal sound recording (TSR) and spectro-temporal analysis (STA) for the objective diagnosis of VPT. By refining our initial method, we were able to apply TSR/STA to post-treatment outcome evaluation, as well as pre-treatment objective ... περισσότερα »
A Novel Approach to Keloid Reconstruction with Bilaminar Dermal Substitute and Epidermal Skin Grafting
A Novel Approach to Keloid Reconstruction with Bilaminar Dermal Substitute and Epidermal Skin Grafting: [image: image]Background: Keloids represent a challenging problem. Surgical excision remains the definitive treatment for immediate lesion debulking, but recurrence rates are reported to be 45 to 100 percent. The authors present a staged reconstructive approach using a dermal regeneration substrate and epidermal grafting to minimize recurrence and donor-site morbidity. Methods: Keloids were completely excised down to normal subcutaneous tissue or perichondrium. A bilaminar dermal ... περισσότερα »
The Essential Anatomical Subunit Approximation Unilateral Cleft Lip Repair
The Essential Anatomical Subunit Approximation Unilateral Cleft Lip Repair: [image: image]Summary: The anatomical subunit approximation cleft lip repair advantageously achieves a balanced lip contour, with the line of repair hidden along seams of aesthetic subunits. Dr. David Fisher's original description of the repair reflects the considerable thought that went into the evolution of his design. As his technique has gained acceptance in the intervening 10 years, the authors note several key principles embodied in it that represent a shift in the cleft lip repair paradigm. The authors... περισσότερα »
Basal Short Nose: How to Identify and Correct It
Basal Short Nose: How to Identify and Correct It: [image: image]
Recurrent high-grade invasive mucoepidermoid carcinoma of larynx: a case report and review of the literature
Recurrent high-grade invasive mucoepidermoid carcinoma of larynx: a case report and review of the literature: Recurrent invasive high-grade mucoepidermoid carcinoma of the larynx and hypopharynx is a rare occurrence. These tumors have been commonly associated with salivary gland tumors, most commonly the parotid gland. The patient usually presents with the following symptoms: hoarseness (if larynx is involved), or changes in voice character, sore throat, cough, odynophagia, dysphagia, otalgia, difficulty breathing, weight loss, lymphadenopathy. Here we present a case of a recurrent ... περισσότερα »
Masticator Space Foreign Body in a Child Presenting With Otorrhea and Granulation Tissue of the External Auditory Canal
Masticator Space Foreign Body in a Child Presenting With Otorrhea and Granulation Tissue of the External Auditory Canal: Objective: We report an unusual case of masticator space foreign body in a patient presenting with otorrhea and granulation tissue within the external auditory canal (EAC). Methods: Case report. Results: A 16-month-old male presented with fever, unilateral otorrhea, facial swelling, leukocytosis, and granulation tissue within the EAC that failed to respond to conventional medical treatment. Computed tomography scan showed EAC and middle ear opacification and so... περισσότερα »
Cortical Auditory Evoked Potentials to Evaluate Cochlear Implant Candidacy in an Ear With Long-standing Hearing Loss: A Case Report
Cortical Auditory Evoked Potentials to Evaluate Cochlear Implant Candidacy in an Ear With Long-standing Hearing Loss: A Case Report: Objectives: We describe a novel use of cortical auditory evoked potentials in the preoperative workup to determine ear candidacy for cochlear implantation. Methods: A 71-year-old male was evaluated who had a long-deafened right ear, had never worn a hearing aid in that ear, and relied heavily on use of a left-sided hearing aid. Electroencephalographic testing was performed using free field auditory stimulation of each ear independently with pure tones ... περισσότερα »
Vestibular and oculomotor influences on visual dependency
Vestibular and oculomotor influences on visual dependency: The degree to which a person relies on visual stimuli for spatial orientation is termed visual dependency (VD). VD is considered a perceptual trait or cognitive style influenced by psychological factors and mediated by central re-weighting of the sensory inputs involved in spatial orientation. VD is often measured using the rod-and-disk test, wherein participants align a central rod to the subjective visual vertical (SVV) in the presence of a background that is either stationary or rotating around the line of sight - dynami... περισσότερα »
The Framework for Understanding Effortful Listening (FUEL).
Hearing Impairment and Cognitive Energy Ear Hear. 2016 Jul-Aug;37 Suppl 1:5S-27S Authors: Pichora-Fuller MK, Kramer SE, Eckert MA, Edwards B, Hornsby BW, Humes LE, Lemke U, Lunner T, Matthen M, Mackersie CL, Naylor G, Phillips NA, Richter M, Rudner M, Sommers MS, Tremblay KL, Wingfield A Abstract The Fifth Eriksholm Workshop on "Hearing Impairment and Cognitive Energy" was convened to develop a consensus among interdisciplinary experts about what is known on the topic, gaps in knowledge, the use of terminology, priorities for future research, and implications for practice. The gene... περισσότερα »
Intranasal administration of CpG oligodeoxynucleotides reduces lower airway inflammation in a murine model of combined allergic rhinitis and asthma syndrome.
[image: http:--linkinghub.elsevier.com-ihub-imag] Authors: Li HT, Zhang TT, Chen ZG, Ye J, Liu H, Zou XL, Wang YH, Yang HL Abstract Given the relationship between allergic rhinitis (AR) and asthma, it can be hypothesized that reducing upper airway inflammation by targeting oligodeoxynucleotides with CpG motifs (CpG-ODN) specifically to the upper airway via intranasal administration in a small volume (10 μL) might improve lower airway (asthma) outcomes. The goal of this study was to investigate the therapeutic efficacy of 10 μL of intranasal versus intradermal administration of ... περισσότερα »
The Neurobiology of Speech Recognition in Challenging Listening Conditions.
Is Listening in Noise Worth It? Ear Hear. 2016 Jul-Aug;37 Suppl 1:101S-110S Authors: Eckert MA, Teubner-Rhodes S, Vaden KI Abstract This review examines findings from functional neuroimaging studies of speech recognition in noise to provide a neural systems level explanation for the effort and fatigue that can be experienced during speech recognition in challenging listening conditions. Neuroimaging studies of speech recognition consistently demonstrate that challenging listening conditions engage neural systems that are used to monitor and optimize performance across a wide range... περισσότερα »
Cortisol, Chromogranin A, and Pupillary Responses Evoked by Speech Recognition Tasks in Normally Hearing and Hard-of-Hearing Listeners: A Pilot Study.
A Pilot Study.: Ear Hear. 2016 Jul-Aug;37 Suppl 1:126S-135S Authors: Kramer SE, Teunissen CE, Zekveld AA Abstract Pupillometry is one method that has been used to measure processing load expended during speech understanding. Notably, speech perception (in noise) tasks can evoke a pupil response. It is not known if there is concurrent activation of the sympathetic nervous system as indexed by salivary cortisol and chromogranin A (CgA) and whether such activation differs between normally hearing (NH) and hard-of-hearing (HH) adults. Ten NH and 10 adults with mild-to-moderate hearin... περισσότερα »
Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy
Comprehensive Audiometric Analysis of Hearing Impairment and Tinnitus After Cisplatin-Based Chemotherapy in Survivors of Adult-Onset Cancer.: J Clin Oncol. 2016 Jun 27; Authors: Frisina RD, Wheeler HE, Fossa SD, Kerns SL, Fung C, Sesso HD, Monahan PO, Feldman DR, Hamilton R, Vaughn DJ, Beard CJ, Budnick A, Johnson EM, Ardeshir-Rouhani-Fard S, Einhorn LH, Lipshultz SE, Dolan ME, Travis LB Abstract PURPOSE: Cisplatin is widely used but highly ototoxic. Effects of cumulative cisplatin dose on hearing loss have not been comprehensively evaluated in survivors of adult-onset cancer. PAT... περισσότερα »
Eagle Syndrome Causing Vascular Compression with Cervical Rotation
Case Report.: Pol J Radiol. 2016;81:277-80 Authors: Demirtaş H, Kayan M, Koyuncuoğlu HR, Çelik AO, Kara M, Şengeze N Abstract BACKGROUND: Eagle syndrome is a condition caused by an elongated styloid process. Unilateral face, neck and ear pain, stinging pain, foreign body sensation and dysphagia can be observed with this syndrome. Rarely, the elongated styloid process may cause pain by compressing the cervical segment of the internal carotid and the surrounding sympathetic plexus, and that pain spreading along the artery can cause neurological symptoms such as vertigo and syncope. ... περισσότερα »
SU-F-T-116: Predicting IQ and the Risk of Hearing Loss Following Proton Versus Photon Radiotherapy for Pediatric Brain Tumor Patients
SU-F-T-116: Predicting IQ and the Risk of Hearing Loss Following Proton Versus Photon Radiotherapy for Pediatric Brain Tumor Patients: Purpose: The increased sparing of normal tissues in intensity modulated proton therapy (IMPT) compared to photon intensity modulated radiotherapy (IMRT) in brain tumor treatments should translate into improved neurocognitive outcomes. Models were used to estimate the intelligence quotient (IQ) and the risk of hearing loss 5 years post radiotherapy and to compare outcomes of proton against photon in pediatric brain tumors. Methods: Patients ... περισσότερα »
Non-schwannomatosis lesions of the internal acoustic meatus-a diagnostic challenge and management: a series report of nine cases.
[image: http:--production.springer.de-OnlineReso] Authors: Moura da Silva LF, Buffon VA, Coelho Neto M, Ramina R Abstract Vestibular schwannomas (VS) are the most common lesions of cerebellopontine angle (CPA) corresponding to 76-91 % of the cases. Usually, these lesions present typical CT and MRI findings. Non-schwannomatous tumors restricted to the internal auditory meatus (IAM) are rare and their preoperative radiological diagnosis may be difficult. This article describes nine surgically treated intrameatal non-schwannomatous lesions (NSL) and reviews the literature. In the l... περισσότερα »
Nursing & Dentistry
Complementary, Alternative, and Integrative Health: A Multicultural Perspective Τετάρτη, 29 Ιουνίου 2016, 7:00:00 πμ | Helda Pinzon-Perez (Editor), Miguel A. Perez (Editor)[image: Go to full article] *A cross-cultural scientific examination of common complementary, alternative, and integrative health practices**Complementary, Alternative, and Integrative Health: A Multicultural Perspective* provides a critical analysis of non-allopathic healing practices, including their uses, limitations, and scientific basis. The evidence-based discussion explores complementary, alterna... περισσότερα »
Family Dentistry and Cosmetic Surgery Clinic
Yesterday, 30 Ιουνίου 2016, 1:43:46 πμ Composite procedure Yesterday, 30 Ιουνίου 2016, 1:43:46 πμ | admin[image: Go to full article] The post Composite procedure appeared first on Family Dentistry and Cosmetic Surgery Clinic. [image: Go to comments]Comments (0) Making of ceramic fillings with CEREC OMNICAM Τετάρτη, 29 Ιουνίου 2016, 2:39:15 μμ | admin[image: Go to full article] The post Making of ceramic fillings with CEREC OMNICAM appeared first on Family Dentistry and Cosmetic Surgery Clinic. [image: Go to comments]Comments (0) TREATMENTS – TOOTH FILLINGS Τετάρτη... περισσότερα »
Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie
Correlation between condylar position and different sagittal skeletal facial types Τετάρτη, 29 Ιουνίου 2016, 3:00:00 πμ[image: Go to full article] AbstractObjective Condylar position may play a key role in the stability of orthodontic treatment of patients presenting with different skeletal patterns. The aim of the present study was to assess via cone beam computed tomography (CBCT) correlations between condylar position and sagittal skeletal relationship. Patients and methods Condylar positions in CBCT images of 20 patients presenting with a Class I skeletal pattern, 20 with a... περισσότερα »
Journal of Prosthodontics
Risk Factors for Implant Failure and Peri-Implant Pathology in Systemic Compromised Patients Τρίτη, 28 Ιουνίου 2016, 1:35:32 πμ | Joana Neves, Miguel Araújo Nobre, Pedro Oliveira, José Martins dos Santos, Paulo Malo[image: Go to full article] Abstract Purpose To identify the possible risk factors for implant failure and peri-implant pathology in a population of systemically compromised patients. Materials and Methods This retrospective clinical study included a total of 721 systemically compromised patients (422 women, 299 men), with an average age of 51 years (range: 20 to 87... περισσότερα »
Journal of Esthetic and Restorative Dentistry
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Journal of Endodontics
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The Angle Orthodontist
Academic Orthodontic Opportunities Τρίτη, 28 Ιουνίου 2016, 11:35:34 πμ[image: Go to full article] The Angle Orthodontist, Volume 86, Issue 4, Page 694-694, July 2016. Orthodontic bracket bonding without previous adhesive priming: A meta-regression analysis Τετάρτη, 15 Ιουλίου 2015, 10:00:00 πμ | Aline Segatto Pires Altmann[image: Go to full article] The Angle Orthodontist, Volume 86, Issue 3, Page 391-398, May 2016.
Clinical Implant Dentistry and Related Research
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American Journal of Orthodontics and Dentofacial Orthopedics
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Transcanal endoscopic myringoplasty: a case series in a university center
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
Transcanal endoscopic myringoplasty: a case series in a university center: ABSTRACT INTRODUCTION: Transcanal myringoplasty has the advantages of demanding lower operative time and minimal external incisions. It can be performed using the microscopic or endoscopic approach. In the last decade, the use of endoscopes in ear surgery has increased significantly. This technique may allow «around […]
Effectiveness of sound therapy in patients with tinnitus resistant to previous treatments: importance of adjustments
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
Effectiveness of sound therapy in patients with tinnitus resistant to previous treatments: importance of adjustments: ABSTRACT INTRODUCTION: The difficulty in choosing the appropriate therapy for chronic tinnitus relates to the variable impact on the quality of life of affected patients and, thus, requires individualization of treatment. OBJECTIVE: To evaluate the effectiveness of using sound generators […]
Effects of sound amplification in self-perception of tinnitus and hearing loss in the elderly
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 22 δευτερόλεπτα
Effects of sound amplification in self-perception of tinnitus and hearing loss in the elderly: ABSTRACT OBJECTIVE: To determine the effect of the use of hearing aids in self-perception of tinnitus and hearing loss in the elderly. METHODS: A total of 24 elderly patients between 60 and 70 years of age with moderate-grade sensorineural hearing loss […]
Immunosuppressive Effect of Soluble BCMA in MM
Purpose: Reduced uninvolved immunoglobulin (Ig) levels are a hallmark of multiple myeloma. We previously showed that B-cell maturation antigen (BCMA) is solubilized and at high levels in multiple myeloma patient serum. We hypothesize that soluble BCMA binds B-cell–activating factor (BAFF) preventing its function to stimulate late B cells, and would result in lower polyclonal antibody… Continue reading Immunosuppressive Effect of Soluble BCMA in MM
Cancer-Initiating Cell Targeting Immunotherapy
Purpose: Cancer-initiating cells (CICs) are thought to be essential for tumor maintenance, recurrence, and distant metastasis, and they are therefore reasonable targets for cancer therapy. Cancer immunotherapy is a novel approach to target cancer. In this study, we aimed to establish novel CIC-targeting immunotherapy. Experimental Design: Colorectal cancer (CRC) CICs were isolated as side population… Continue reading Cancer-Initiating Cell Targeting Immunotherapy
Individualized Tamoxifen Dose Escalation
Tamoxifen may require metabolic activation to endoxifen for efficacy in treating hormone receptor–positive breast cancer. Dose escalation in patients with low endoxifen concentrations could enhance treatment efficacy. This approach is clinically feasible, and successfully increases endoxifen concentrations; however, it is unknown whether patients benefit from individualized tamoxifen dose escalation. Clin Cancer Res; 22(13); 3121–3. ©2016… Continue reading Individualized Tamoxifen Dose Escalation
Sym004 Overcomes EGFR-Mediated Cetuximab Resistance
Purpose: Approved anti-EGFR antibodies cetuximab and panitumumab provide significant clinical benefit in patients with metastatic colorectal cancer (MCRC). However, patients ultimately develop disease progression, often driven by acquisition of mutations in the extracellular domain (ECD) of EGFR. Sym004 is a novel 1:1 mixture of two nonoverlapping anti-EGFR mAbs that recently showed promising clinical activity in… Continue reading Sym004 Overcomes EGFR-Mediated Cetuximab Resistance
Testosterone in Androgen Receptor Signaling and DNA Repair
Androgen suppression mediates transcriptional downregulation of DNA repair genes. Stimulation with supraphysiologic levels of dihydrotestosterone induces formation of lethal DNA breaks through recruitment of topoisomerase II enzymes to fragile DNA sites. Bipolar castration and stimulation that contributes to increasing DNA damage represents a novel strategy of sensitizing prostate cancer to cytotoxic therapies, including radiotherapy. Clin… Continue reading Testosterone in Androgen Receptor Signaling and DNA Repair
Salivary Biomarkers for Oral Cancer Detection
Purpose: This study evaluated the discriminatory power of salivary transcriptomic and proteomic biomarkers in distinguishing oral squamous cell carcinoma cases from controls and potentially malignant oral disorders (PMOD). Experimental Design: A total of 180 samples (60 OSCC patients, 60 controls, and 60 PMOD patients) were used in the study. Seven transcriptomic markers (IL8, IL1β, SAT1,… Continue reading Salivary Biomarkers for Oral Cancer Detection
Talimogene Laherparepvec in Melanoma
Talimogene laherparepvec (T-VEC) is a first-in-class oncolytic virus that mediates local and systemic antitumor activity by direct cancer cell lysis and an «in situ vaccine» effect. Based on an increased durable response rate compared with granulocyte macrophage–colony stimulating factor in a randomized phase III trial, it was approved by the FDA for the treatment of… Continue reading Talimogene Laherparepvec in Melanoma
Molecular Profile and FDG-PET Metabolic Volume at Staging in DLBCL–Letter
from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29aHoIk via IFTTT
DNA Repair in Metastasis
The maintenance of a pristine genome, free from errors, is necessary to prevent cellular transformation and degeneration. When errors in DNA are detected, DNA damage repair (DDR) genes and their regulators are activated to effect repair. When these DDR pathways are themselves mutated or aberrantly downregulated, cancer and neurodegenerative disorders can ensue. Multiple lines of… Continue reading DNA Repair in Metastasis
EGFR Exon 19 Deletion False Negatives
Purpose: Reliable detection of drug-sensitive activating EGFR mutations is critical in the care of advanced non–small cell lung cancer (NSCLC), but such testing is commonly performed using a wide variety of platforms, many of which lack rigorous analytic validation. Experimental Design: A large pool of NSCLC cases was assayed with well-validated, hybrid capture–based comprehensive genomic… Continue reading EGFR Exon 19 Deletion False Negatives
Ear 34 citation
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* ear via xloma.fota13 on Inoreader *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can... περισσότερα »
The Landscape of Arm-Level Copy-Number Alterations Reveals Survival Loci Genomics
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Analysis of TCGA copy number and clinical data identified candidate drivers within prognostic SCNAs. from Cancer via ola Kala on Inoreader http://ift.tt/296vvRZ via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/294GcEm via IFTTT
SIRT6 Loss Promotes PDAC Progression by Epigenetic Induction of LIN28B Pancreatic Cancer
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
SIRT6 loss cooperates with oncogenic KRAS to accelerate PDAC progression and metastasis. from Cancer via ola Kala on Inoreader http://ift.tt/29fFKad via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29cU1nE via IFTTT
OLIG2 Mediates a Phenotypic Switch between Two Glioma Subtypes Glioma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Levels of the proneural-associated gene OLIG2 determine glioma phenotype and regulate cell growth. from Cancer via ola Kala on Inoreader http://ift.tt/296v2zf via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29kn73P via IFTTT
Oncogenic Splicing Factor U2AF35 Mutations Disrupt ATG7 mRNA Processing Splicing
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
U2AF35(S34F) transforms cells via altered ATG7 pre-mRNA processing, inducing an autophagy defect. from Cancer via ola Kala on Inoreader http://ift.tt/29fFIz9 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/294FIhm via IFTTT
Cancer Cell-Astrocyte Gap Junctions Promote Brain Metastasis Formation Metastasis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Carcinoma–astrocyte gap junctions drive growth and chemoresistance of brain metastases. from Cancer via ola Kala on Inoreader http://ift.tt/296viy8 via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/29cV4E2 via IFTTT
An Analog-Sensitive Approach Reveals Specific Functions of PARP1 Transcriptional Regulation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
PARP1 ADP ribosylates and inhibits NELF, enhancing Pol II pause release and transcription elongation. from Cancer via ola Kala on Inoreader http://ift.tt/29fFHLM via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/297CURH via IFTTT
BGB-283 Deemed Effective in Phase I Study News in Brief
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
In a phase I trial, BGB-283, which targets the RAF family of proteins, was found to be safe and tolerable—and effective—in treating patients with a variety of solid tumors harboring mutations in BRAF, KRAS, and NRAS. from Cancer via ola Kala on Inoreader http://ift.tt/29kndbD via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis […]
Endocrinology 40 citation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed! Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! Endocrinology via xlomafota13 on […]
Nitrate reduction in sulfate-reducing bacteria
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Sulfate-reducing bacteria (SRBs) gain their energy by coupling the oxidation of organic substrate to the reduction of sulfate to sulfide. Several SRBs are able to use alternative terminal electron acceptors to sulfate such as nitrate. Nitrate-reducing SRBs have been isolated from a diverse range of environments. In order to be able to understand the significance […]
A novel isolate and widespread abundance of the candidate alphaproteobacterial order (Ellin 329), in southern Appalachian peatlands
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 36 δευτερόλεπτα
Peatlands of all latitudes play an integral role in global climate change by serving as a carbon sink and a primary source of atmospheric methane; however, the microbial ecology of mid-latitude peatlands is vastly understudied. Herein, next generation Illumina amplicon sequencing of small subunit rRNA genes was utilized to elucidate the microbial communities in three […]
Monthly News Roundup - June 2016
Epclusa: First Approval For All Major Forms of Chronic Hepatitis C Virus The U.S. Food and Drug Administration (FDA) has given the go-ahead to Epclusa (sofosbuvir and velpatasvir), a nucleotide analog polymerase inhibitor and pan-genotypic NS5A... from Therapeutics via xlomafota13 on Inoreader http://ift.tt/294uJnY
Effects of Within-Talker Variability on Speech Intelligibility in Mandarin-Speaking Adult and Pediatric Cochlear Implant Patients
Cochlear implant (CI) speech performance is typically evaluated using well-enunciated speech produced at a normal rate by a single talker. CI users often have greater difficulty with variations in speech production encountered in everyday listening. Within a single talker, speaking rate, amplitude, duration, and voice pitch information may be quite variable, depending on the production context. The coarse spectral resolution afforded by the CI limits perception of voice pitch, which is an important cue for speech prosody and for tonal languages such as Mandarin Chinese. In this st... περισσότερα »
Effects of Within-Talker Variability on Speech Intelligibility in Mandarin-Speaking Adult and Pediatric Cochlear Implant Patients
Cochlear implant (CI) speech performance is typically evaluated using well-enunciated speech produced at a normal rate by a single talker. CI users often have greater difficulty with variations in speech production encountered in everyday listening. Within a single talker, speaking rate, amplitude, duration, and voice pitch information may be quite variable, depending on the production context. The coarse spectral resolution afforded by the CI limits perception of voice pitch, which is an important cue for speech prosody and for tonal languages such as Mandarin Chinese. In this st... περισσότερα »
Effects of Within-Talker Variability on Speech Intelligibility in Mandarin-Speaking Adult and Pediatric Cochlear Implant Patients
Cochlear implant (CI) speech performance is typically evaluated using well-enunciated speech produced at a normal rate by a single talker. CI users often have greater difficulty with variations in speech production encountered in everyday listening. Within a single talker, speaking rate, amplitude, duration, and voice pitch information may be quite variable, depending on the production context. The coarse spectral resolution afforded by the CI limits perception of voice pitch, which is an important cue for speech prosody and for tonal languages such as Mandarin Chinese. In this st... περισσότερα »
Read essential research from Agriculture and Food Security
Alexandros G. SfakianakisστοOnline Journals of Otolaryngology Head and Neck Surgery by Alexandros G.SfakianakisΠριν από 48 δευτερόλεπτα
[image: BioMed Central – The Open Access Publisher] Agriculture & Food Security Editors-in-Chief: Malcolm Elliott, Magdy Madkour Agriculture & Food Security Editors-in-Chief: Malcolm Elliott, Magdy Madkour Submit Manuscript | Editorial Board | Submission Guidelines | Article Alerts Dear Dr Sfakianakis, We are writing to let you know of some recent highly accessed articles published in *Agriculture & Food Security*, an open access journal. ------------------------------ Read Our Top Articles RESEARCH The effect of weakened resilience on food insecurity i... περισσότερα »
Methods Mol Biol
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* [image: Feed image] pubmed: "methods mol biol"[j... Preface. Rueff J, Rodrigues AS[image: Go to full article] Related Articles*Preface.* Methods Mol Biol. 2016;1395:v-vii Authors: Rueff J, Rodrigues AS PMID: 27340700 [PubMed - in process] Exosome-Mediated T... περισσότερα »
Environ Monit Assess
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* [image: Feed image] pubmed: "environ monit asses... Surface water pH variations and trends in China from 2004 to 2014. Qiao Y, Feng J, Liu X, Wang W, Zhang P, Zhu L[image: Go to full article] *Surface water pH variations and trends in China from 2004 to 201... περισσότερα »
World J Microbiol Biotechnol
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates Halophiles: biology, adaptation, and their role in decontamination of hypersaline environments. Today, 1 Ιουλίου 2016, 8:02:32 πμ | Edbeib MF, Wahab RA, Huyop F[image: Go to full article] Related Articles*Halophiles: biology, adaptation, and their role in decontamination of hypersaline environments.* World J Microbiol Biotechnol. 2016 Aug;32(8):135 Authors: Edbeib MF, Wahab RA, Huyop F Abstract The unique cellular enzymatic machinery of halophilic microb... περισσότερα »
Expert Opin Ther Pat
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates Therapeutic effects of EGCG: a patent review. Today, 1 Ιουλίου 2016, 8:03:00 πμ | Chakrawarti L, Agrawal R, Dang S, Gupta S, Gabrani R[image: Go to full article] Related Articles*Therapeutic effects of EGCG: a patent review.* Expert Opin Ther Pat. 2016 Jun 29;:1-10 Authors: Chakrawarti L, Agrawal R, Dang S, Gupta S, Gabrani R Abstract INTRODUCTION: Green tea contains polyphenolic flavanoids such as epigallocatechin-3- gallate (EGCG), epicatechin-3-gallate... περισσότερα »
A substudy evaluating treatment intensification on medication adherence among hypertensive patients receiving home blood pressure telemonitoring and pharmacist management
Summary What is known and objective Hypertension is a leading cause of death and major contributor to heart attacks, strokes, heart and kidney failure. Antihypertensive (HTN medication) non-adherence contributes to uncontrolled hypertension. Effective initiatives to improve uncontrolled hypertension include a team-based approach with home blood pressure (BP) monitoring. Our study objective was to evaluate whether objectively measured medication adherence was influenced by home BP telemonitoring and pharmacist management. Methods We analysed HTN medication adherence in 240 patient... περισσότερα »
Ear 34 citation
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 55 δευτερόλεπτα
Your subscribed feeds are not being updated automatically because this setting is turned off. Turn on automatic feed updates You’ve successfully subscribed to this feed!Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds You’ve successfully subscribed to this feed! ear via xloma.fota13 on Inoreader […]
Is Mathematics a Domain for Philosophers of Explanation?
Abstract In this paper we discuss three interrelated questions. First: is explanation in mathematics a topic that philosophers of mathematics can legitimately investigate? Second: are the specific aims that philosophers of mathematical explanation set themselves legitimate? Finally: are the models of explanation developed by philosophers of science useful tools for philosophers of mathematical explanation? We argue that the answer to all these questions is positive. Our views are completely opposite to the views that Mark Zelcer has put forward recently. Throughout this paper, we s... περισσότερα »
Moderate physical activity in older adults is not associated with reduced cardiovascular events
[image: cardiology?d=yIl2AUoC8zA] [image: cardiology?d=dnMXMwOfBR0] [image: cardiology?i=OjheD99lJbU:BtVLMJ0UNX4:F7z] [image: cardiology?d=7Q72WNTAKBA] [image: cardiology?i=OjheD99lJbU:BtVLMJ0UNX4:V_s] [image: cardiology?d=qj6IDK7rITs] [image: cardiology?d=l6gmwiTKsz0] [image: cardiology?i=OjheD99lJbU:BtVLMJ0UNX4:gIN] from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29apYNl via IFTTT
Secondary glaucoma in CAPN5-associated neovascular inflammatory vitreoretinopathy
from Medicine via xlomafota13 on Inoreader http://ift.tt/297TNiy via IFTTT
An Experimental and Computational Study on the Effect of Caval Valved Stent Oversizing
Abstract Heterotopic implantation of transcatheter tricuspid valve is a new treatment option for tricuspid regurgitation. Transcatheter tricuspid valves are implanted onto the cavoatrial junction in order to avoid the challenging task of anchoring the valve onto the complex tricuspid valve annulus. However, little is known about optimum extent of oversizing of the valved stent in a vena cava. In this study, we implanted valves of the same diameter onto the larger sized inferior vena cava (IVC) and a smaller sized superior vena cava (SVC). The valve in the IVC was oversized by 10.7%... περισσότερα »
Modeling Current Density Maps Using Aliev–Panfilov Electrophysiological Heart Model
Abstract Most existing studies of cardiac arrhythmia rely on surface measurements through optical or electrical mapping techniques. Current density imaging (CDI) is a method which enables us to study current pathways inside the tissue. However, this method entails implementation complexities for beating *ex vivo* hearts. Hence, this work presents an approach to simulate and study the current distributions in different cardiac electrophysiological states. The results are corroborated by experimental data, and they indicate that different states were distinguishable. The CDI simulat... περισσότερα »
IJMS, Vol. 17, Pages 1043: Clinical Application of Human Urinary Extracellular Vesicles in Kidney and Urologic Diseases
[image: scifeed_large.png] Extracellular vesicles (EVs) have been isolated in different body fluids, including urine. The cargo of urinary EVs is composed of nucleic acids and proteins reflecting the physiological and possibly pathophysiological state of cells lining the nephron and the urinary tract. Urinary EVs have been confirmed to contain low amounts of various types of RNA that play a role in intercellular communication by transferring genetic information. This communication through EV RNAs includes both continuation of normal physiological processes and conditioning in disea... περισσότερα »
IJMS, Vol. 17, Pages 1046: PD-L1 Immunohistochemical Detection in Tumor Cells and Tumor Microenvironment: Main Considerations on the Use of Tissue Micro Arrays
[image: scifeed_large.png] PD-1/PD-L1 (programmed death 1/programmed death ligand 1) pathway plays a critical role in immune escape of tumor cells. Recent studies have described that PD-L1 is heterogeneously expressed in various types of cancer, although its prognostic/predictive value is still uncertain. These problems are partly due to a not well defined operating protocol for its detection by immunohistochemistry, but also because most of the studies conducted on large case series were made by Tissue Micro Array (TMA). We are going to discuss this latter point, to highlight that... περισσότερα »
Toxins, Vol. 8, Pages 198: Biofilm-Forming Methicillin-Resistant Staphylococcus aureus Survive in Kupffer Cells and Exhibit High Virulence in Mice
Although Staphylococcus aureus is part of the normal body flora, heavy usage of antibiotics has resulted in the emergence of methicillin-resistant strains (MRSA). MRSA can form biofilms and cause indwelling foreign body infections, bacteremia, soft tissue infections, endocarditis, and osteomyelitis. Using an in vitro assay, we screened 173 clinical blood isolates of MRSA and selected 20 high-biofilm formers (H-BF) and low-biofilm formers (L-BF). These were intravenously administered to mice and the general condition of mice, the distribution of bacteria, and biofilm in the liver, ... περισσότερα »
Toxins, Vol. 8, Pages 199: Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells
Understanding how to target cancer stem cells (CSCs) may provide helpful insights for the development of therapeutic or preventive strategies against cancers. Dietary phytochemicals with anticancer properties are promising candidates and have selective impact on CSCs. This review summarizes the influence of phytochemicals on heterogeneous cancer cell populations as well as on specific targeting of CSCs. from Medicine via xlomafota13 on Inoreader http://ift.tt/297BJVV via IFTTT
Non-healing tissue from diabetic foot ulcers reprogrammed as pluripotent stem cells
Results from 2 studies by researchers at Tufts University produce embryonic-like stem cells from patients with diabetic foot ulcers and identify new target for treatment. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/296uNGq via IFTTT
New way out: Researchers show how stem cells exit bloodstream
Researchers at North Carolina State University have discovered that therapeutic stem cells exit the bloodstream in a different manner than was previously thought. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/292cboH via IFTTT
Lou Gehrig's: Safety of stem cell treatment investigated
Stem cell research may offer a glimmer of hope for the future treatment of Lou Gehrig's disease. A new study examines its safety in humans. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/297mhJ5 via IFTTT
Bile acids & nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives
Abstract Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an important risk factor for both hepatic and cardio-metabolic mortality. The rapidly increasing prevalence of this disease and of its aggressive form non-alcoholic steatohepatitis (NASH) will require novel therapeutic approaches to prevent disease progression to advanced fibrosis or cirrhosis and cancer. In recent years, bile acids have emerged as relevant signaling molecules that act at both hepatic and extrahepatic tissues to regulate lipid and carbohydrate metabolic pathways as well ... περισσότερα »
Zinc finger protein 191 inhibits hepatocellular carcinoma metastasis via discs large 1-mediated yes associated protein inactivation
[image: cover.gif?v=1&s=9d8289a651b4cec902676098] Abstract Interplay between cell polarity module SCRIB-LGL-DLG and Yes associated protein (YAP) appears critical in tumor metastasis. Here we identified Zinc finger protein 191 (ZNF191) as a metastasis suppressor acting through DLG-YAP crosstalk in hepatocellular carcinoma (HCC). Over-expressing ZNF191 in HCC cells impaired cell motility, while ZNF191 depletion promoted cell migration *in vitro* and metastasis *in vivo* through triggering YAP signaling. Chromatin immunoprecipitation-sequencing (ChIP-seq) revealed that ZNF191 specif... περισσότερα »
Zika Virus
New England Journal of Medicine, Ahead of Print. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/2978zru via IFTTT
Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies
New England Journal of Medicine, Volume 374, Issue 26, Page 2601-2602, June 2016. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29hmQyD via IFTTT
Hypopyon and Klebsiella Sepsis
New England Journal of Medicine, Volume 374, Issue 26, June 2016. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/2978hRw via IFTTT
Midostaurin in Advanced Systemic Mastocytosis
New England Journal of Medicine, Volume 374, Issue 26, Page 2605-2606, June 2016. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29hmUhP via IFTTT
Saving the World’s Women from Cervical Cancer
New England Journal of Medicine, Volume 374, Issue 26, Page 2509-2511, June 2016. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/2978zrp via IFTTT
Ankylosing Spondylitis and Axial Spondyloarthritis
[image: 160520_NEJM_Banner_ads_animated_Global-t] New England Journal of Medicine, Volume 374, Issue 26, Page 2563-2574, June 2016. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/292c788 via IFTTT
Belatacept and Long-Term Outcomes in Kidney Transplantation
New England Journal of Medicine, Volume 374, Issue 26, Page 2598-2601, June 2016. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29a1pA9 via IFTTT
Passing the Baton — Harnessing the Full Value of Older Scientists
[image: 160520_NEJM_Banner_ads_animated_Global-t] New England Journal of Medicine, Volume 374, Issue 26, Page 2514-2517, June 2016. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/292c9gz via IFTTT
Calcium Pyrophosphate Deposition Disease
[image: nejmra1511117.fp.png_v03] New England Journal of Medicine, Volume 374, Issue 26, Page 2575-2584, June 2016. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29a0XBY via IFTTT
Case 20-2016
[image: 160520_NEJM_Banner_ads_animated_Global-t] New England Journal of Medicine, Volume 374, Issue 26, Page 2586-2593, June 2016. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/292cnnS via IFTTT
Tragedy, Trade-offs, and the Demise of Morcellation
[image: 160520_NEJM_Banner_ads_animated_Global-t] New England Journal of Medicine, Volume 374, Issue 26, Page 2605-2605, June 2016. from Uncategorized via xlomafota13 on Inoreader http://ift.tt/29a1gwW via IFTTT
Nitrate reduction in sulfate-reducing bacteria
Sulfate-reducing bacteria (SRBs) gain their energy by coupling the oxidation of organic substrate to the reduction of sulfate to sulfide. Several SRBs are able to use alternative terminal electron acceptors to sulfate such as nitrate. Nitrate-reducing SRBs have been isolated from a diverse range of environments. In order to be able to understand the significance of nitrate reduction in SRBs, we need to examine the ecology and physiology of the nitrate-reducing SRB isolates. from Infection via ola Kala on Inoreader http://ift.tt/296wvpP via IFTTT
A novel isolate and widespread abundance of the candidate alphaproteobacterial order (Ellin 329), in southern Appalachian peatlands
Peatlands of all latitudes play an integral role in global climate change by serving as a carbon sink and a primary source of atmospheric methane; however, the microbial ecology of mid-latitude peatlands is vastly understudied. Herein, next generation Illumina amplicon sequencing of small subunit rRNA genes was utilized to elucidate the microbial communities in three southern Appalachian peatlands. In contrast to northern peatlands, *Proteobacteria* dominated over *Acidobacteria* in all three sites. An average of 11 bacterial phyla was detected at relative abundance values & gt;1%, wi... περισσότερα »
Photodynamic therapy versus surgical excision to basal cell carcinoma: meta-analysis
Summary Background Surgical excision (SE) is a first-line treatment for basal cell carcinoma (BCC). Topical photodynamic therapy (PDT) has also been used and has cosmetic advantages over surgery. The latest European guidelines for topical PDT recommended that it be used to treat nodular basal cell carcinoma (nBCC) but a consensus has not been reached. Our study was to evaluate the efficacy of PDT versus SE for the treatment for nBCC by a meta-analysis. Materials and methods We searched PubMed, EMBASE, the Cochrane Library, CKNI, VIP, and relevant references up to October 2014 in... περισσότερα »
Granuloma faciale successfully treated with ingenol mebutate
ABSTRACT Granuloma faciale (GF) is a rare chronic inflammatory dermatosis of unknown etiology, characterized by leukocitoclastic vasculitis usually occurring on the face. We report a case of 60-years-old man with 3 year history of multiple actinic keratoses (AK) and persistent asymptomatic erythematous papules and plaques located over his left temporal region and the cheek: histopathology was consistent with GF. Herein we describe the successful treatment of the lesion with ingenol mebutate 0.015% gel focusing on the clinical, dermoscopic and histopathological findings of GF both b... περισσότερα »
Orbital Fat Volumetry and Water Fraction Measurements Using T2-Weighted FSE-IDEAL Imaging in Patients with Thyroid-Associated Orbitopathy [HEAD & NECK]
BACKGROUND AND PURPOSE: The quantitative evaluation of orbital fat proliferation and edema and the assessment of extraocular muscles are useful for diagnosing and monitoring thyroid-associated orbitopathy. To evaluate therapy-induced quantitative changes in the orbital fat of patients with thyroid-associated orbitopathy, we performed volumetric and water fraction measurements by using T2-weighted FSE iterative decomposition of water and fat with echo asymmetry and least-squares estimation (FSE-IDEAL) imaging. MATERIALS AND METHODS: Orbital FSE-IDEAL images of 30 volunteers were ... περισσότερα »
Possible Checkpoint Inhibitor Response across TCGA Cancers
Immune checkpoint inhibitor treatment represents a promising approach toward treating cancer and has been shown to be effective in a subset of melanoma, non–small cell lung cancer (NSCLC), and kidney cancers. Recent studies have suggested that the number of nonsynonymous mutations (NsM) can be used to select melanoma and NSCLC patients most likely to benefit from checkpoint inhibitor treatment. It is hypothesized that a higher burden of NsM generates novel epitopes and gene products, detected by the immune system as foreign. We conducted an assessment of NsM across 7,757 tumor sampl... περισσότερα »
C271 Instability and Melanoma Tumorigenicity
The stability of markers that identify cancer cells that propagate disease is important to the outcomes of targeted therapy strategies. In human melanoma, conflicting data exist as to whether hierarchical expression of CD271/p75/NGFR (nerve growth factor receptor) marks cells with enriched tumorigenicity, which would compel their specific targeting in therapy. To test whether these discrepancies relate to differences among groups in assay approaches, we undertook side-by-side testing of published methods of patient-derived melanoma xenografting (PDX), including comparisons of tissue... περισσότερα »
Radiation Enhances Immune Response to Antitumor Antibodies
Interest in combining radiotherapy and immune checkpoint therapy is growing rapidly. In this study, we explored a novel combination of this type to augment antitumor immune responses in preclinical murine models of melanoma, neuroblastoma, and head and neck squamous cell carcinoma. Cooperative effects were observed with local radiotherapy and intratumoral injection of tumor-specific antibodies, arising in part from enhanced antibody-dependent cell-mediated cytotoxicity (ADCC). We could improve this response by combining radiation with intratumoral injection of an IL2-linked tumor-sp... περισσότερα »
Nano-Immune Conjugate for Cancer Therapy
Antibody-directed chemotherapy (ADC) offers an advantage over conventional chemotherapy because it provides antibody-directed targeting, with resultant improvement in therapeutic efficacy and reduced toxicity. Despite extensive research, with notable exceptions, broad clinical application of ADC remains elusive; major hurdles include the instability of antibody–chemotherapy linkers and reduced tumor toxicity of the chemotherapy when bound to the antibody. To address these challenges, we have developed a platform technology that utilizes the nab-paclitaxel formulation of paclitaxel, ... περισσότερα »
High-Convexity Tightness Predicts the Shunt Response in Idiopathic Normal Pressure Hydrocephalus ADULT BRAIN
BACKGROUND AND PURPOSE: Although neuroimaging plays an important role in the diagnosis of idiopathic normal pressure hydrocephalus, its predictive value for response to shunt surgery has not been established. The purpose of the current study was to identify neuroimaging markers that predict the shunt response of idiopathic normal pressure hydrocephalus. MATERIALS AND METHODS: Sixty patients… Continue reading High-Convexity Tightness Predicts the Shunt Response in Idiopathic Normal Pressure Hydrocephalus ADULT BRAIN
Physical Inactivity and Epithelial Ovarian Cancer Risk
Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to… Continue reading Physical Inactivity and Epithelial Ovarian Cancer Risk
Common Variants in High-Risk Pancreatic Cancer Patients
Individuals from pancreatic cancer families are at increased risk, not only of pancreatic cancer, but also of melanoma, breast, ovarian, and colon cancers. While some of the increased risk may be due to mutations in high-penetrance genes (i.e., BRCA2, PALB2, ATM, p16/CDKN2A or DNA mismatch repair genes), common genetic variants may also be involved. In… Continue reading Common Variants in High-Risk Pancreatic Cancer Patients
Exercise and Inflammatory Markers in Breast Cancer Survivors
Several sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis… Continue reading Exercise and Inflammatory Markers in Breast Cancer Survivors
Early Life Body Fatness, AMH, and Breast Density
Background: Emerging evidence suggests positive associations between serum anti-Müllerian hormone (AMH), a marker of ovarian function, and breast cancer risk. Body size at young ages may influence AMH levels, but few studies have examined this. Also, no studies have examined the relation of AMH levels with breast density, a strong predictor of breast cancer risk.… Continue reading Early Life Body Fatness, AMH, and Breast Density
Cancer Prevention Guideline Adherence and Cancer Outcomes
Many studies have reported that adherence to health promotion guidelines for diet, physical activity, and maintenance of healthy body weight may decrease cancer incidence and mortality. A systematic review was performed to examine associations between adherence to established cancer prevention guidelines for diet and physical activity and overall cancer incidence and mortality. PubMed, Google Scholar,… Continue reading Cancer Prevention Guideline Adherence and Cancer Outcomes
Colorectal Carcinoma in HIV-Positive Patients
Background: Emerging evidence suggests differences in colorectal cancer in HIV-infected patients (HIV+) compared with HIV– patients. Microsatellite instability (MSI), occurring in a subset of colorectal cancer, is present at a higher rate in certain cancers in HIV+ patients. Colorectal cancer with MSI share some characteristics with those reported for HIV+ colorectal cancer. On this premise,… Continue reading Colorectal Carcinoma in HIV-Positive Patients
Prevalence and Comorbidity Burden in Older Survivors
Background: Cancer survivors are a growing population, due in large part to the aging of the baby boomer generation and the related «silver tsunami» facing the U.S. health care system. Understanding the impact of a graying nation on cancer prevalence and comorbidity burden is critical in informing efforts to design and implement quality cancer care… Continue reading Prevalence and Comorbidity Burden in Older Survivors
Editorial Syria: a health crisis too great to ignore
Last week, the Independent International Commission of Inquiry on the Syrian Arab Republic gave an evidence update to the 32nd session of the UN Human Rights Council in Geneva, Switzerland. It reported that the Syrian Government was conducting daily air strikes in the country amid indiscriminate attacks by militant groups, including ISIS. Paulo Pinheiro, chair… Continue reading Editorial Syria: a health crisis too great to ignore
Correspondence Happiness, health, and mortality – Authors’ reply
Results from our prospective UK Million Women Study1 have shown that happiness itself has no direct effect on mortality (except insofar as unhappiness makes people do unhealthy things, such as smoking). The widespread but mistaken belief that unhappiness and stress directly cause ill health has come partly from studies that confuse cause and effect, as… Continue reading Correspondence Happiness, health, and mortality – Authors’ reply
