A comparison of four techniques to measure anterior and posterior vertebral body heights and sagittal plane wedge angles in adolescent idiopathic scoliosis
Abstract Adolescent idiopathic scoliosis (AIS) is a three-dimensional (3D) spinal deformity of unknown aetiology. Increased growth of the anterior part of the vertebrae known as anterior overgrowth has been proposed as a potential driver for AIS initiation and progression. To date, there has been no objective evaluation of the 3D measurement techniques used to identify this phenomenon and the majority of previous studies use 2D planar assessments which contain inherent projection errors due to the vertebral rotation which is part of the AIS deformity. In this study, vertebral body ... περισσότερα »
Multi-stacked hyperporous silicon flake for highly active solar hydrogen production
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC04775K, Communication Youn Jeong Jang, Jaegeon Ryu, Dongki Hong, Soojin Park, Jae Sung Lee 3D multi-stacked hyperporous silicon flake (MHSF) are prepared via selective chemical reduction of natural clay minerals bearing MgO negative catalyst layers. The resultant MHSFs are used as a photocatalyst for... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/294wNgE via IFTTT
Intraventricular Hemorrhage: the Role of Blood Components in Secondary Injury and Hydrocephalus
from NeuroSurgery via xlomafota13 on Inoreader http://ift.tt/294Ux8n via IFTTT
Patient-Reported Outcome Instruments for Surgical and Traumatic Scars: A Systematic Review of their Development, Content, and Psychometric Validation
Abstract Background Patient-reported outcomes (PROs) are of growing importance in research and clinical care and may be used as primary outcomes or as compliments to traditional surgical outcomes. In assessing the impact of surgical and traumatic scars, PROs are often the most meaningful. To assess outcomes from the patient perspective, rigorously developed and validated PRO instruments are essential. Methods The authors conducted a systematic literature review to identify PRO instruments developed and/or validated for patients with surgical and/or non-burn traumatic scars. Ident... περισσότερα »
Analysis of Lower Breast Pole Length and Nipple–Areola Complex Position Following Superior Pedicle, Short Horizontal Scar Breast Reduction
Abstract Background Postoperative changes following superior pedicle breast reduction are closely related to the pattern of skin resection. We have observed that the superior pedicle, short horizontal scar breast reduction technique provides a stable breast shape in the long term. We test the validity of our clinical observations through objective analysis of postoperative dimensional changes following superior pedicle, short horizontal scar breast reduction. Methods Of 42 patients who underwent superior pedicle, short horizontal scar breast reductions between January 2011 and Ju... περισσότερα »
Dental abnormalities associated with conditions of or affecting the human integumentary system
AbnormalityCondition(s) Pegged teeth Hypohidrotic ectodermal dysplasia Incontinentia pigmenti Congenital syphilis Pitted teeth Herlitz variant of junctional epidermolysis bullosa Tuberous sclerosis Gorlin syndrome Tricho–dento–osseous syndrome Retention of primary teeth Hyper-IgE syndrome Non-erupted teeth Gardner syndrome Supernumerary teeth Gardner syndrome Hypodontia Hypomelanosis of Ito Schöpf–Schulz–Passarge syndrome Hypohidrotic ectodermal dysplasia EEC syndrome AEC syndrome Erythrodontia Congenital erythropoietic porphyria Hepatoerythropoietic porphyria Eroded tooth enamel Bulimia L... περισσότερα »
Dwarfism of irregular echinoids (Echinocorys) from Poland during the Campanian-Maastrichtian Boundary Event
Publication date: 1 September 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 457 Author(s): Mariusz A. Salamon, Tomasz Brachaniec, Krzysztof R. Brom, Rafał Lach, Dawid Trzęsiok The echinoid genus Echinocorys is one of the dominant irregular echinoid in the Cretaceous of Poland. Our analysis of the body size trends of these echinoids shows that they underwent dwarfism in… Continue reading Dwarfism of irregular echinoids (Echinocorys) from Poland during the Campanian-Maastrichtian Boundary Event
Deep water circulation within the eastern Mediterranean Sea over the last 95kyr: New insights from stable isotopes and benthic foraminiferal assemblages
Publication date: 1 October 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 459 Author(s): Marine Cornuault, Laurence Vidal, Kazuyo Tachikawa, Laetitia Licari, Guillaume Rouaud, Corinne Sonzogni, Marie Revel The response of eastern Mediterranean Sea (EMS) circulation to climate forcings over the last 95kyr BP was studied using core MD04-2722, collected at 1780m water depth within the Levantine Sea.… Continue reading Deep water circulation within the eastern Mediterranean Sea over the last 95kyr: New insights from stable isotopes and benthic foraminiferal assembl... περισσότερα »
End-Wenlock terminal Mulde carbon isotope excursion in Gotland, Sweden: Integration of stratigraphy and taphonomy for correlations across restricted facies and specialized faunas
Publication date: 1 September 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 457 Author(s): Emilia Jarochowska, Oskar Bremer, Daniel Heidlas, Stephanie Pröpster, Thijs R.A. Vandenbroucke, Axel Munnecke The decline of the upper peak of the Homerian Mulde carbon isotope excursion (CIE) is used in low- to mid-paleolatitudes as a marker for the Wenlock/Ludlow boundary, which is otherwise difficult… Continue reading End-Wenlock terminal Mulde carbon isotope excursion in Gotland, Sweden: Integration of stratigraphy and taphonomy for correlations across restricted fa... περισσότερα »
Aeolian activity in the south margin of the Tengger Desert in northern China since the Late Glacial Period revealed by luminescence chronology
Publication date: 1 September 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 457 Author(s): Jun Peng, Zhibao Dong, Fengqing Han, Lei Gao Aeolian sediments from deserts in northern China have been widely used in the study of aeolian sedimentology and its dynamic association with past climate conditions. The Tengger Desert, the fourth-largest desert in China, is sensitive to… Continue reading Aeolian activity in the south margin of the Tengger Desert in northern China since the Late Glacial Period revealed by luminescence chronology
Demise of the last two spire-bearing brachiopod orders (Spiriferinida and Athyridida) at the Toarcian (Early Jurassic) extinction event
Publication date: 1 September 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 457 Author(s): Attila Vörös, Ádám T. Kocsis, József Pálfy Brachiopods were severely hit by several mass extinctions which fundamentally shaped their long evolutionary history. After the devastating end-Permian extinction, the fate of the four surviving orders differed significantly during the Triassic and Jurassic. Two orders, the… Continue reading Demise of the last two spire-bearing brachiopod orders (Spiriferinida and Athyridida) at the Toarcian (Early Jurassic) extinction event
Agglutinated benthic foraminifera in Ordovician and Silurian black mudrock facies of the Holy Cross Mountains (Poland) and their significance in recognition of oxygen content
Publication date: 1 September 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 457 Author(s): Wieslaw Trela The Upper Ordovician and Silurian dark to black shales and claystones in the northern Holy Cross Mountains (Poland) are transgressive facies developed in the early Sandbian, early Katian and early Sheinwoodian times, respectively. They were deposited under dysoxic to anoxic bottom waters… Continue reading Agglutinated benthic foraminifera in Ordovician and Silurian black mudrock facies of the Holy Cross Mountains (Poland) and their significance in recognit... περισσότερα »
Orbital-scale changes in redox condition and biogenic silica/detrital fluxes of the Middle Jurassic Radiolarite in Tethys (Sogno, Lombardy, N-Italy): Possible link with glaciation?
Publication date: 1 September 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 457 Author(s): Masayuki Ikeda, Maximilien Bôle, Peter O. Baumgartner Orbital forcing has been shown to be a fundamental driver of climate change through both icehouse and greenhouse periods. To reveal the impact of orbital-forcing on the oceanic environment through a greenhouse-icehouse transition, we established ~4Myr-long cyclostratigraphy… Continue reading Orbital-scale changes in redox condition and biogenic silica/detrital fluxes of the Middle Jurassic Radiolarite in Tethys (Sogn... περισσότερα »
Long-term weakening of the East Asian summer and winter monsoons during the mid- to late Holocene recorded by aeolian deposits at the eastern edge of the Mu Us Desert
Publication date: 1 September 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 457 Author(s): Shuang Zhao, Dunsheng Xia, Heling Jin, Jia Jia, Guanhua Li, Fuyuan Gao, Youjun Wang The East Asian summer monsoon (EASM) and East Asian winter monsoon (EAWM) are major drivers of environmental conditions in East Asia. However, due to the lack of high-resolution EAWM records,… Continue reading Long-term weakening of the East Asian summer and winter monsoons during the mid- to late Holocene recorded by aeolian deposits at the eastern edge of the Mu Us Desert
Early recovery of sponge framework reefs after Cambrian archaeocyath extinction: Zhangxia Formation (early Cambrian Series 3), Shandong, North China
Publication date: 1 September 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 457 Author(s): Jeong-Hyun Lee, Jongsun Hong, Suk-Joo Choh, Dong-Jin Lee, Jusun Woo, Robert Riding Reefs dominated by the anthaspidellid sponge Rankenella zhangxianensis, the calcimicrobe Epiphyton and the stem-group cnidarian Cambroctoconus orientalis, together with encrusting microstromatolites occur early in the middle Cambrian (Series 3, late Stage 5)… Continue reading Early recovery of sponge framework reefs after Cambrian archaeocyath extinction: Zhangxia Formation (early Cambria... περισσότερα »
Chemostratigraphic age model for the Tornillo Group: A possible link between fluvial stratigraphy and climate
Publication date: 1 September 2016 Source:Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 457 Author(s): Clément P. Bataille, Dylana Watford, Stephen Ruegg, Alexander Lowe, Gabriel J. Bowen The expression of global climate trends (106 to 107years) and events (105years) in terrestrial sedimentary sections can only be assessed from long, continuous continental records. Such records are rare due to the… Continue reading Chemostratigraphic age model for the Tornillo Group: A possible link between fluvial stratigraphy and climate
Facile construction of pyrrolo[1,2-b]isoquinolin-10(5H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC03071H, Communication Shanchao Wu, Na Liu, Guoqiang Dong, Lin Ma, Shengzheng Wang, Wencai Shi, Kun Fang, Shuqiang Chen, Jian Li, WN Zhang, Chunquan Sheng, Wei Wang An efficient redox-amination-aromatization-Friedel-Crafts acylation cascade process from trans-4-hydroxyproline and 2-formylbenzoic acids has been developed for the synthesis of pyrrolo[1,2-b]isoquinolin-10(5H)-ones. Compound 3h was identified as a new potent dual topoisomerase I/II... The content of this RSS Feed (c) The Royal Society of C... περισσότερα »
Poly-carboxylic acids functionalized chitosan nanocarriers for controlled and targeted anti-cancer drug delivery
Publication date: October 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 83 Author(s): Mariappan Rajan, Maruthamuthu Murugan, Deepalekshmi Ponnamma, Kishor Kumar Sadasivuni, Murugan A. Munusamy The present study evaluates the in-vitro cisplatin (CDDP) release from four different poly oxalates cross-linked chitosan (CS) nanocomposites. The poly oxalates were synthesized from the reaction of four different dicarboxylic acids with ethylene glycol (EG). The encapsulation of CDDP on CS cross-linked with Oxalic acid-EG, Succinic acid-EG, Citric acid-EG and tartaric acid-EG carriers w... περισσότερα »
Simvastatin inhibits glucose uptake activity and GLUT4 translocation through suppression of the IR/IRS-1/Akt signaling in C2C12 myotubes
Publication date: October 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 83 Author(s): Weihua Li, Xiaojing Liang, Zhipeng Zeng, Kaizhen Yu, Shaopeng Zhan, Qiang Su, Yinzhi Yan, Huseen Mansai, Weitong Qiao, Qi Yang, Zhongquan Qi, Zhengrong Huang Simvastatin,a 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor, is clinically used in the prevention and treatment of cardiovascular diseases. Numerous studies demonstrate that statins increase the risk of new-onset diabetes in long-term therapy, but mechanisms underpinning this effect are still unclear. Here, we investigated... περισσότερα »
Shear Piezoelectricity in Poly(vinylidenefluoride-co-trifluoroethylene): Full Piezotensor Coefficients by Molecular Modeling, Biaxial Transverse Response, and Use in Suspended Energy-Harvesting Nanostructures
[image: Thumbnail image of graphical abstract] *The intrinsic flexible character of polymeric materials* causes remarkable strain deformations along directions perpendicular to the applied stress. Here the biaxial response in the shear piezoelectricity of polyvinylidenefluoride copolymers is analyzed and their full piezoelectric tensors are provided. The microscopic shear is exploited in single suspended nanowires bent by localized loading to couple flexural deformation and transverse piezoelectric response. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/2... περισσότερα »
An Overview and Future Perspectives of Aluminum Batteries
A critical overview of the latest developments in the aluminum battery technologies is reported. The substitution of lithium with alternative metal anodes characterized by lower cost and higher abundance is nowadays one of the most widely explored paths to reduce the cost of electrochemical storage systems and enable long-term sustainability. Aluminum based secondary batteries could be a viable alternative to the present Li-ion technology because of their high volumetric capacity (8040 mAh cm−3 for Al vs 2046 mAh cm−3 for Li). Additionally, the low cost aluminum makes these batte... περισσότερα »
Cutaneous sarcoidosis in a melanoma patient under Ipilimumab therapy
from Melanoma via xlomafota13 on Inoreader http://ift.tt/296utHJ
Parasympathetic innervation of vertebro-basilar arteries: is this a potential clinical target?
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Abstract This review aims to summarise the contemporary evidence for the presence and function of the parasympathetic innervation of the cerebral circulation with emphasis on the vertebral and basilar arteries (the posterior cerebral circulation). We consider whether the parasympathetic innervation of blood vessels could be used as a means to increase cerebral blood flow. This […]
Xanthine Oxidoreductase mediates membrane docking of milk-fat droplets but is not essential for apocrine lipid secretion
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Abstract Apocrine secretion is utilized by epithelial cells of exocrine glands. These cells bud off membrane-bound particles into the lumen of the gland, losing a portion of cytoplasm in the secretion product. The lactating mammary gland secretes milk lipid by this mechanism, and Xanthine Oxidoreductase (XOR) has long been thought to be functionally important. We […]
Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Abstract The aim of this study was to clarify the effect of water-immersion restraint stress (WIRS) on tryptophan (Trp) catabolism through the kynurenine (Kyn) pathway in rat tissues. The tissues of rats subjected to 6 h of WIRS (+WIRS) had increased tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) activities and increased TDO and IDO1 (one […]
Contact allergens
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Allergen Source Cross reacts with Clinical presentation Dimethylaminopropylamine (DMAPA) Found within cocamidopropyl betaine in liquid soaps and shampoos Eyelid dermatitis Latex[nb 1] Avocado Banana Chestnut Kiwi Passion fruit Peach Mango Pineapple Fig Cantaloupe Apple Papaya Ethylene-ripened fruits Paraphenylenediamine (PPD) Black hair dye Color developer Scuba gear Henna[nb 2] Para-aminobenzoic acid (PABA) Azo dyes Sulfonamides Sulfonylureas […]
Allergy § Other environmental factors
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Allergy § Other environmental factors Name Possible reaction(s) Remarks Balsam of Peru Redness, swelling, itching, allergic contact dermatitisreactions, stomatitis (inflammation and soreness of the mouth or tongue), cheilitis (inflammation, rash, or painful erosion of the lips, oropharyngeal mucosa, or angles of their mouth), pruritis, hand eczema, generalized or resistant plantar dermatitis, rhinitis,conjunctivitis, and blisters. A […]
Drug allergy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Drug allergy Name Possible reaction(s) Remarks Balsam of Peru Redness, swelling, itching, allergic contact dermatitisreactions, stomatitis (inflammation and soreness of the mouth or tongue), cheilitis (inflammation, rash, or painful erosion of the lips, oropharyngeal mucosa, or angles of their mouth), pruritis, hand eczema, generalized or resistant plantar dermatitis, rhinitis,conjunctivitis, and blisters. Present in many drugs, […]
Training Primary Health Professionals in Breast Cancer Prevention: Evidence and Experience from Mexico
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Abstract To analyze the key successful factors of a national educational strategy for early breast cancer detection developed in Mexico for primary health care personnel from 2008 to 2014, an educational strategy to train physicians, nurses, health promoters, and medical students from local ministries of health with a competency-based approach was developed and implemented using […]
Reflections: Spirituality and Cancer Researchers
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Abstract Spirituality is increasingly acknowledged as an essential element to consider within care for cancer and other chronic health conditions. As our colleagues in frontline healthcare roles integrate these concepts into their professional practice, it seems timely for the cancer research community to reflect on the place of spirituality within our work. This reflections article […]
Food allergy
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Food allergy Name Potential reaction(s) Remarks Balsam of Peru Redness, swelling, itching, allergic contact dermatitisreactions, stomatitis (inflammation and soreness of the mouth or tongue), cheilitis (inflammation, rash, or painful erosion of the lips, oropharyngeal mucosa, or angles of their mouth), pruritis, hand eczema, generalized or resistant plantar dermatitis, rhinitis,conjunctivitis, and blisters. Present in many foods, […]
Bilateral intracranial sickle-shaped calcifications of the temporal lobes Lipoid proteinosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 18 δευτερόλεπτα
Urbach–Wiethe disease From Wikipedia, the free encyclopedia Urbach-Wiethe disease Classification and external resources Specialty endocrinology ICD–10 E78.8 ICD–9-CM 272.8 OMIM 247100 DiseasesDB 30808 eMedicine derm/241 MeSH D008065 Urbach–Wiethe disease (also known as lipoid proteinosis and hyalinosis cutis et mucosae) is a rare recessive genetic disorder, with approximately 400 reported cases since its discovery.[1][2][3] It was […]
Biofilm-Forming Methicillin-Resistant Staphylococcus aureus Survive in Kupffer Cells and Exhibit High Virulence
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
Toxins, Vol. 8, Pages 198: in Mice: Although Staphylococcus aureus is part of the normal body flora, heavy usage of antibiotics has resulted in the emergence of methicillin-resistant strains (MRSA). MRSA can form biofilms and cause indwelling foreign body infections, bacteremia, soft tissue infections, endocarditis, and osteomyelitis. Using an in vitro assay, we screened 173 […]
Controlled and targeted anti-cancer drug delivery
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
Poly-carboxylic acids functionalized chitosan nanocarriers for controlled and targeted anti-cancer drug delivery via Biomedicine & Pharmacotherapy Publication date: October 2016Source:Biomedicine & Pharmacotherapy, Volume 83Author(s): Mariappan Rajan, Maruthamuthu Murugan, Deepalekshmi Ponnamma, Kishor Kumar Sadasivuni, Murugan A. MunusamyThe present study evaluates the in-vitro cisplatin (CDDP) release from four different poly oxalates cross-linked chitosan (CS) nanocomposites. The poly oxalates […]
Cocaine Versus Epinephrine Solutions
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
Topical Vasoconstrictors in Cosmetic Rhinoplasty: Comparative Evaluation of Cocaine Versus Epinephrine Solutions: Abstract Background The use of topical vasoconstrictors is a common practice in nasal surgery. These agents reduce bleeding and enable a good surgical field. Topical cocaine and epinephrine, which are frequently used in cosmetic rhinoplasty, are considered safe and effective, but secondary effects […]
Topical Vasoconstrictors in Cosmetic Rhinoplasty
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
Comparative Evaluation of Cocaine Versus Epinephrine Solutions: Abstract Background The use of topical vasoconstrictors is a common practice in nasal surgery. These agents reduce bleeding and enable a good surgical field. Topical cocaine and epinephrine, which are frequently used in cosmetic rhinoplasty, are considered safe and effective, but secondary effects have been described. The aim […]
PD-L1 Immunohistochemical Detection in Tumor Cells and Tumor Microenvironment
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
IJMS, Vol. 17, Pages 1046: PD-L1 Immunohistochemical Detection in Tumor Cells and Tumor Microenvironment: Main Considerations on the Use of Tissue Micro Arrays: PD-1/PD-L1 (programmed death 1/programmed death ligand 1) pathway plays a critical role in immune escape of tumor cells. Recent studies have described that PD-L1 is heterogeneously expressed in various types of cancer, […]
1-year history of oral pain and loose teeth
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
IMAGES IN CLINICAL MEDICINE Loose Teeth and Excessive Thirst Roman H. Khonsari, M.D., Ph.D., and Blandine Ruhin, M.D., Ph.D. N Engl J Med 2016; 374:e25DOI: 10.1056/NEJMicm1512541 A 36-year-old man presented with a 1-year history of oral pain and loose teeth; four teeth had been lost spontaneously within the 6 months before presentation. Increased thirst and […]
Cutaneous Actinomycosis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
IMAGES IN CLINICAL MEDICINE Juan C. Cataño, M.D., and Sara Isabel Gómez Villegas, B.S. N Engl J Med 2016; 374:1773DOI: 10.1056/NEJMicm1511213 A 33-year-old man was referred to our institution in 2015 with lesions on his left knee that had worsened over the course of several years. In 2010, at which time he had an unremarkable […]
Oral Amalgam Tattoo Mimicking Melanoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
IMAGES IN CLINICAL MEDICINE Cristián Vera-Kellet, M.D., and Pablo Del Barrio-Díaz, M.D. N Engl J Med 2016; 374:e21DOI: 10.1056/NEJMicm1510216 A 49-year-old woman without a personal or family history of melanoma presented to the dermatology clinic with an asymptomatic pigmented lesion on the ventral surface of her tongue. The lesion, which had been present for 4 […]
Intrafacial Synkinesis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
IMAGES IN CLINICAL MEDICINE André M. Mansoor, M.D., and Peter D. Sullivan, M.D. N Engl J Med 2016; 374:e27June 2016DOI: 10.1056/NEJMicm1507967 Video Marin-Amat Syndrome. A 52-year-old man was admitted to the hospital with weakness that had progressed over a period of several weeks. Cranial-nerve examination revealed involuntary unilateral ptosis that coincided with voluntary contraction of […]
TSSC
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 21 δευτερόλεπτα
IMAGES IN CLINICAL MEDICINE Squamous-Cell Carcinoma of the Tongue Rui P.P. Albuquerque, D.D.S., Ph.D., and Andrea Richards, B.D.S., F.D.S. (Oral Med.) N Engl J Med 2016; 374:e32June 23, 2016DOI: 10.1056/NEJMicm1513456 A 73-year-old woman presented with a 1-year history of a persistent ulcer and white patch on the right margin of the tongue and soreness while […]
Parasympathetic innervation of vertebro-basilar arteries: is this a potential clinical target?
Abstract This review aims to summarise the contemporary evidence for the presence and function of the parasympathetic innervation of the cerebral circulation with emphasis on the vertebral and basilar arteries (the posterior cerebral circulation). We consider whether the parasympathetic innervation of blood vessels could be used as a means to increase cerebral blood flow. This may have clinical implications for pathologies associated with cerebral hypoperfusion such as for stroke, dementia and hypertension. Relative to the anterior cerebral circulation little is known of the origins... περισσότερα »
Xanthine Oxidoreductase mediates membrane docking of milk-fat droplets but is not essential for apocrine lipid secretion
Abstract Apocrine secretion is utilized by epithelial cells of exocrine glands. These cells bud off membrane-bound particles into the lumen of the gland, losing a portion of cytoplasm in the secretion product. The lactating mammary gland secretes milk lipid by this mechanism, and Xanthine Oxidoreductase (XOR) has long been thought to be functionally important. We generated mammary specific XOR knockout (MGKO) mice, expecting lactation to fail. Histology of the knockout glands showed very large lipid droplets enclosed in the mammary alveolar cells, but milk analysis showed that these... περισσότερα »
Effect of water-immersion restraint stress on tryptophan catabolism through the kynurenine pathway in rat tissues
Abstract The aim of this study was to clarify the effect of water-immersion restraint stress (WIRS) on tryptophan (Trp) catabolism through the kynurenine (Kyn) pathway in rat tissues. The tissues of rats subjected to 6 h of WIRS (+WIRS) had increased tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) activities and increased TDO and IDO1 (one of two IDO isozymes in mammals) mRNA expression levels, with decreased Trp and increased Kyn contents in the liver. +WIRS rats had unchanged TDO and IDO activities in the kidney, decreased TDO activity and unchanged IDO act... περισσότερα »
Photodynamic therapy in lupus miliaris disseminatus faciei's scars
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 23 δευτερόλεπτα
Abstract Lupus miliaris disseminatus faciei is an uncommon granulomatous inflammatory disease, characterized by multiple, monomorphic, reddish translucent papules and nodules, mainly located on the face. Several therapeutic options have been employed with variable results, leaving residual disfiguring scars. On this topic, we report a case of significant improvement of red-atrophic scars in a 54-year-old male after three sessions of photodynamic therapy with 10% aminolevulinic acid. Owing to the high safety profile and the excellent cosmetic result, photodynamic therapy may be con... περισσότερα »
Robotics, Vol. 5, Pages 13: Trajectory Generation and Stability Analysis for Reconfigurable Klann Mechanism Based Walking Robot
Reconfigurable legged robots based on one degree of freedom are highly desired because they are effective on rough and irregular terrains and they provide mobility in such terrain with simple control schemes. It is necessary that reconfigurable legged robots should maintain stability during rest and motion, with a minimum number of legs while maintaining their full range of walking patterns resulting from different gait configuration. In this paper we present a method to generate input trajectory for reconfigurable quadruped robots based on Klann mechanism to properly synchronize ... περισσότερα »
Micromachines, Vol. 7, Pages 112: Design and Experiment of a Solder Paste Jetting System Driven by a Piezoelectric Stack
To compensate for the insufficiency and instability of solder paste dispensing and printing that are used in the SMT (Surface Mount Technology) production process, a noncontact solder paste jetting system driven by a piezoelectric stack based on the principle of the nozzle-needle-system is introduced in this paper, in which a miniscule gap exists between the nozzle and needle during the jetting process. Here, the critical jet ejection velocity is discussed through theoretical analysis. The relations between ejection velocity and needle structure, needle velocity, and nozzle diamet... περισσότερα »
Minerals, Vol. 6, Pages 65: Alternative Process Flow for Underground Mining Operations: Analysis of Conceptual Transport Methods Using Discrete Event Simulation
As the near surface deposits are being mined out, underground mines will increasingly operate at greater depths. This will increase the challenges related to transporting materials from deeper levels to the surface. For many years, the ore and waste transportation from most deep underground mines has depended on some or all of the following: truck haulage, conveyor belts, shafts, rails, and ore pass systems. In sub-level caving, and where ore passes are used, trains operating on the main lower level transport the ore from ore passes to a crusher, for subsequent hoisting to the surf... περισσότερα »
IJERPH, Vol. 13, Pages 665: Sounding the Alarm: Health in the Anthropocene
There is growing scientific and public recognition that human actions, directly and indirectly, have profoundly changed the Earth system, in a still accelerating process, increasingly called the "Anthropocene". Planetary transformation, including of the atmosphere, climate, ecosystems and biodiversity, has enormous implications for human health, many of which are deeply disturbing, especially in low-income settings. A few health consequences of the Anthropocene have been partially recognized, including within environmental epidemiology, but their long-term consequences remain poor... περισσότερα »
Minerals, Vol. 6, Pages 63: Optimization of Acid Leaching of Rare-Earth Elements from Mongolian Apatite-Based Ore
Optimization of the acid leaching process for Mongolian apatite-based ore containing rare-earth elements (REEs) was studied. The ore contained approximately 10% of REEs as total rare earth oxides, and the major impurities were Ca (33% as CaO) and Fe (23% as Fe2O3). Fe bearing minerals could be removed by passing the sample through a wet high-intensity magnetic separator before leaching. After magnetic separation, basic leaching tests were conducted to investigate the influence of the acid type and concentration, temperature, and the pH on the REE leaching level and kinetics. Hydro... περισσότερα »
Flexible and Porous Nanocellulose Aerogels with High Loadings of Metal–Organic-Framework Particles for Separations Applications
[image: Thumbnail image of graphical abstract] *Flexible and porous aerogels* are obtained by combining functional metal–organic frameworks (MOFs) and structural cellulose nanocrystals via a straightforward water-based sol–gel process, followed by freeze-drying. The aerogels have a hierarchical porous structure with controllable MOF loading up to 50 wt%. These hybrid materials can be used as absorbents for water purification. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/29stOQo via IFTTT
Simvastatin inhibits glucose uptake activity and GLUT4 translocation through suppression of the IR/IRS-1/Akt signaling in C2C12 myotubes
Publication date: October 2016 *Source:*Biomedicine & Pharmacotherapy, Volume 83 Author(s): Weihua Li, Xiaojing Liang, Zhipeng Zeng, Kaizhen Yu, Shaopeng Zhan, Qiang Su, Yinzhi Yan, Huseen Mansai, Weitong Qiao, Qi Yang, Zhongquan Qi, Zhengrong Huang Simvastatin,a 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor, is clinically used in the prevention and treatment of cardiovascular diseases. Numerous studies demonstrate that statins increase the risk of new-onset diabetes in long-term therapy, but mechanisms underpinning this effect are still unclear. Here, we investigated... περισσότερα »
An Experimental and Computational Study on the Effect of Caval Valved Stent Oversizing
Abstract Heterotopic implantation of transcatheter tricuspid valve is a new treatment option for tricuspid regurgitation. Transcatheter tricuspid valves are implanted onto the cavoatrial junction in order to avoid the challenging task of anchoring the valve onto the complex tricuspid valve annulus. However, little is known about optimum extent of oversizing of the valved stent in a vena cava. In this study, we implanted valves of the same diameter onto the larger sized inferior vena cava (IVC) and a smaller sized superior vena cava (SVC). The valve in the IVC was oversized by 10.7%... περισσότερα »
Modeling Current Density Maps Using Aliev–Panfilov Electrophysiological Heart Model
Abstract Most existing studies of cardiac arrhythmia rely on surface measurements through optical or electrical mapping techniques. Current density imaging (CDI) is a method which enables us to study current pathways inside the tissue. However, this method entails implementation complexities for beating *ex vivo* hearts. Hence, this work presents an approach to simulate and study the current distributions in different cardiac electrophysiological states. The results are corroborated by experimental data, and they indicate that different states were distinguishable. The CDI simulat... περισσότερα »
Effective influences of 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide (EMIMTFSI) ionic liquid on the ion transport properties of micro-porous zinc-ion conducting poly (vinyl chloride) /poly (ethyl methacrylate) blend-based polymer electrolytes
Abstract A series of new gel polymer electrolytes (GPEs) based on different concentrations of a hydrophobic ionic liquid (IL) 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide (EMIMTFSI) entrapped in an optimized typical composition of polymer blend-salt matrix [poly(vinyl chloride) (PVC) (30 wt%) / poly(ethyl methacrylate) (PEMA) (70 wt%) : 30 wt% zinc triflate Zn(CF3SO3)2] has been prepared using facile solution casting technique. The AC impedance analysis has revealed the occurrence of the maximum ionic conductivity of 1.10 × 10−4 Scm−1 at room temperature (301 K) ... περισσότερα »
Expeditious Synthesis of Early Transition Metal Carbide Nanoparticles on Graphitic Carbons
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC04157D, Communication Debora Ressnig, Simona Moldovan, Ovidiu Ersen, Patricia Beaunier, David Portehault, Clement Sanchez, Sophie Carenco An expeditious synthesis of metal carbide nanoparticles onto various carbon supports is demonstrated. The procedure is versatile and readily yields TiC, VC, Mo2C and W2C nanoparticles on different types of... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/294tvKs via IFTTT
Rhodium(III)-Catalyzed Alkylation of Primary C(sp3)-H Bonds with [small alpha]‑Diazocarbonyl Compounds
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC03846H, Communication Wei Hou, Ya-Xi Yang, Yunxiang Wu, Huijing Feng, Yuan-Chao Li, Bing Zhou A Rh(III)-catalyzed intermolecular chelation-assisted insertion of carbenes derived from [small alpha]-diazocarbonyl compounds into non-acidic primary sp3 C-H bonds, for the first time, is reported under mild reaction conditions, thus affording a... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/297DnXn via IFTTT
A direct and sustainable synthesis of tertiary butyl esters enabled by flow microreactors
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC04588J, Communication Leonardo Degennaro, Daniela Maggiulli, Claudia Carlucci, Flavio Fanelli, Giuseppe Romanazzi, RENZO LUISI Tertiary butyl esters find large applications in syntetic organic chemistry. A straightforward method for the direct introduction of the tert-butoxycarbonyl group into a variety of organic compounds has been developed... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/294tMgu via IFTTT
Unusual Hydridicity of a Cobalt Bound Si-H Moiety
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC03983A, Communication Jin Kim, Yujeong Kim, Indranil Sinha, Koeun Park, Sun Hee Kim, Yunho Lee A paramagnetic cobalt-SiH intermediate possessing a Co-([small eta]1-H-Si) moiety was studied using various spectroscopic techniques. Frozen solution ENDOR experiments show a Co-H distance of ~1.53 A and Si-Co-H angle of ~15[degree],... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/297DClj via IFTTT
Planar Triangular Dy3+Dy3 Single-Molecule Magnet with a Toroidal Magnetic Moment
[image: CrossMark.jpg] *Chem. Commun.*, 2016, Accepted Manuscript *DOI*: 10.1039/C6CC05326B, Communication Xiao-Lei Li, Jianfeng Wu, Jinkui Tang, Boris Le Guennic, Wei Shi, Peng Cheng A unique Dy6 complex with planar Dy3+Dy3 structure was assembled by delicately modifying the axial ligands. Single-molecule magnet behavior, and meanwhile the toroidal magnetic moment in the ground state have... The content of this RSS Feed (c) The Royal Society of Chemistry from BioChemistry via xlomafota13 on Inoreader http://ift.tt/294tDtg via IFTTT
Polymer Capsules for Plaque-Targeted In Vivo Delivery
[image: Thumbnail image of graphical abstract] *Targeted polymer capsules* can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small-molecule drug retention. The synthetic polymer is composed of pH-sensitive blocks (PDPA), low-binding blocks (PEG), and click-groups for postfunctionalization with targeting peptides specific to plaques. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/29bTe8e via IFTTT
A Lamellar Hybrid Assembled from Metal Disulfide Nanowall Arrays Anchored on a Carbon Layer: In Situ Hybridization and Improved Sodium Storage
[image: Thumbnail image of graphical abstract] *A lamellar hybrid assembled from metal disulfide (MoS2, WS2) nanowall arrays anchored on nitrogen-doped carbon layers* is developed via an in situ hybridization strategy through a synergistic pyrolysis reaction of thiourea and oxometalates. Such a hybrid provides adequate electrical and chemical coupling between the active materials and the carbon substrate, thus realizing a high-efficiency electron-conduction/ion-transportation system and exhibiting excellent sodium-storage properties. from Biomedical Engineering via xlomafota13 on ... περισσότερα »
Vertically Conductive MoS2 Spiral Pyramid
[image: Thumbnail image of graphical abstract] *MoS2 spirals grown by the chemical vapor deposition method, driven by a threading dislocation*, has a peculiar rhombohedral-like structure. This threading dislocation can carry helical current in the vertical direction and greatly enhances the vertical conductance in the MoS2 multilayer samples. from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/29bTggq via IFTTT
Topical Vasoconstrictors in Cosmetic Rhinoplasty: Comparative Evaluation of Cocaine Versus Epinephrine Solutions
Abstract Background The use of topical vasoconstrictors is a common practice in nasal surgery. These agents reduce bleeding and enable a good surgical field. Topical cocaine and epinephrine, which are frequently used in cosmetic rhinoplasty, are considered safe and effective, but secondary effects have been described. The aim of the present study was to evaluate and compare the benefits and risks of epinephrine and cocaine employed as topical vasoconstrictive agents in cosmetic rhinoplasty. Methods This prospective non-randomised study included 65 consecutive female patients unde... περισσότερα »
Thumb Tip Defect Reconstruction Using Neurovascular Island Pedicle Flap Obtained From Long Finger
Abstract Introduction Thumb tip reconstruction has been a very challenging issue for hand surgeons. Varieties of reconstructive options have been described or modified to obtain satisfactory sensory recovery. However, none has yielded entirely satisfactory results. This study reports a retrospective review of clinical data records of patients treated with a neurovascular island pedicle flap obtained from the medial aspect of the long finger. Methods We enrolled 15 patients (9 men and 6 women), who received neurovascular island pedicle flaps for thumb tip amputations between Decemb... περισσότερα »
Toxins, Vol. 8, Pages 198: Biofilm-Forming Methicillin-Resistant Staphylococcus aureus Survive in Kupffer Cells and Exhibit High Virulence in Mice
Although Staphylococcus aureus is part of the normal body flora, heavy usage of antibiotics has resulted in the emergence of methicillin-resistant strains (MRSA). MRSA can form biofilms and cause indwelling foreign body infections, bacteremia, soft tissue infections, endocarditis, and osteomyelitis. Using an in vitro assay, we screened 173 clinical blood isolates of MRSA and selected… Continue reading Toxins, Vol. 8, Pages 198: Biofilm-Forming Methicillin-Resistant Staphylococcus aureus Survive in Kupffer Cells and Exhibit High Virulence in Mice
Toxins, Vol. 8, Pages 199: Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells
Understanding how to target cancer stem cells (CSCs) may provide helpful insights for the development of therapeutic or preventive strategies against cancers. Dietary phytochemicals with anticancer properties are promising candidates and have selective impact on CSCs. This review summarizes the influence of phytochemicals on heterogeneous cancer cell populations as well as on specific targeting of… Continue reading Toxins, Vol. 8, Pages 199: Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells
A β -Immunotherapeutic strategies: a wide range of approaches for Alzheimer’s disease treatment
Review Articles Laia Montoliu-Gaya, Sandra Villegas, Expert Reviews in Molecular Medicine, Volume 18, pp e13 Abstract from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29f6wRC via IFTTT
Interaction between Bms1 and Rcl1, two ribosome biogenesis factors, is evolutionally conserved in zebrafish and human
Publication date: Available online 29 June 2016 Source:Journal of Genetics and Genomics Author(s): Yong Wang, Qinfang Zhu, Ling Huang, Yanqing Zhu, Jun Chen, Jinrong Peng, Li Jan Lo from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/29htOnt via IFTTT
A Repetitive DNA-Directed Program of Chromosome Packaging during Mitosis
Publication date: Available online 29 June 2016 Source:Journal of Genetics and Genomics Author(s): Shao-Jun Tang from #Medicine-SfakianakisAlexandros via o.lakala70 on Inoreader http://ift.tt/297e8pV via IFTTT
Interaction between Bms1 and Rcl1, two ribosome biogenesis factors, is evolutionally conserved in zebrafish and human
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 53 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 29 June 2016 *Source:*Journal of Genetics and Genomics Author(s): Yong Wang, Qinfang Zhu, Ling Huang, Yanqing Zhu, Jun Chen, Jinrong Peng, Li Jan Lo from Genetics via xlomafota13 on Inoreader http://ift.tt/29htOnt via IFTTT
A Repetitive DNA-Directed Program of Chromosome Packaging during Mitosis
AlexAndros SfakianakisστοMedicine by Alexandros G.Sfakianakis,Anapafseos 5 Agios Nikolaos,Crete 72100,Greece,tel :00302841026Πριν από 53 δευτερόλεπτα
[image: alertIcon.gif] Publication date: Available online 29 June 2016 *Source:*Journal of Genetics and Genomics Author(s): Shao-Jun Tang from Genetics via xlomafota13 on Inoreader http://ift.tt/297e8pV via IFTTT
Parasympathetic innervation of vertebro-basilar arteries
: is this a potential clinical target?: Abstract This review aims to summarise the contemporary evidence for the presence and function of the parasympathetic innervation of the cerebral circulation with emphasis on the vertebral and basilar arteries (the posterior cerebral circulation). We consider whether the parasympathetic innervation of blood vessels could be used as a means to increase cerebral blood flow. This may have clinical implications for pathologies associated with cerebral hypoperfusion such as for stroke, dementia and hypertension. Relative to the anterior cerebral c... περισσότερα »
Persistence and Elimination of Human Norovirus in Food and on Food Contact Surfaces
A Critical Review: Abstract:This critical review addresses the persistence of human norovirus (NoV) in water, shellfish, and processed meats; on berries, herbs, vegetables, fruits, and salads; and on food contact surfaces. The review focuses on studies using NoV; information from studies involving only surrogates is not included. It also addresses NoV elimination or inactivation by various chemical, physical, or processing treatments. In most studies, persistence or elimination was determined by detection and quantification of the viral genome, although improved methods for d... περισσότερα »
Antimicrobial Resistance of Escherichia coli, Enterococci, Pseudomonas aeruginosa, and Staphylococcus aureus from Raw Fish and Seafood
Imported into Switzerland: This article is currently available as a free download on Ingenta Connect Abstract:A total of 44 samples of salmon, pangasius (shark catfish), shrimps, and oysters were tested for the presence of*Escherichia coli,* enterococci, *Pseudomonas aeruginosa,* and *Staphylococcus aureus,* which are indicator organisms commonly used in programs to monitor antibiotic resistance. The isolated bacterial strains, confirmed by matrix-assisted laser desorption ionization time-of-flight mass spectroscopy, were tested against a panel of 29 antimicrobial agents to ob... περισσότερα »
Congenital hypothyroidism and thyroid dyshormonogenesis
a case report of siblings with a newly identified mutation in thyroperoxidase: Authors: Sparling, David P. / Fabian, Kendra / Harik, Lara / Jobanputra, Vaidehi / Anyane-Yeboa, Kwame / Oberfield, Sharon E. / Fennoy, Ilene Abstract *Background:* Thyroid dyshormonogenesis continues to be a significant cause of congenital hypothyroidism. Over time, forms of thyroid dyshormonogenesis can result in goiter, which can lead to difficult management decisions as the pathologic changes can both mimic or lead to thyroid cancer. *Methods:* Herein we describe the cases of two brothers diagnose... περισσότερα »
Curative treatment of head and neck squamous cell carcinoma
Curative treatment of head and neck squamous cell carcinoma: Abstract IntroductionFor the treatment of head and neck squamous cell carcinoma (HNSCC), there are currently no official standard of care guidelines in German-speaking countries, with the exception of oral cavity cancer. In order to learn about the applied treatment modalities in the clinical routine, we conducted a web-based survey to evaluate the local standards of palliative and curative treatment of HNSCC. This article focuses on the curative treatment options and organ preservation strategies. Materials and method... περισσότερα »
Recurrent urticarial rash and a monoclonal immunoglobulin M gammopathy
Schnitzler Syndrome Without a Monoclonal Gammopathy: A Case Report: Background: Schnitzler syndrome (SS) is a rare autoinflammatory disorder characterized by a recurrent urticarial rash and a monoclonal immunoglobulin M gammopathy, as well as 2 of the following minor criteria: recurrent fever (>38°C), objective signs of abnormal bone remodeling, elevated C-reactive protein level or leukocytosis, and a neutrophilic infiltrate on skin biopsy. Alternatively, a monoclonal immunoglobulin G gammopathy may be present along with 3 minor criteria for diagnosis. Objective: To report a rare ... περισσότερα »
Primary Cutaneous B-Cell Lymphoma
in Young Monozygotic Twins: A Case Report: Although familial aggregation of lymphoproliferative disorders has been described, heredity has not been implicated in the etiology of primary cutaneous B-cell lymphomas (PCBCL). We report herein the first case of 2 young monozygotic twins with PCBCL. The first twin was an 18-year-old woman when she presented with multiple skin nodules on the thorax and head. Histology showed an atypical small B-cell proliferation, consistent with primary cutaneous marginal zone lymphoma (PCMZL). Molecular genetics studies demonstrated B-cell clonality. S... περισσότερα »
Cutaneous B-Cell Lymphoma in Longstanding Systemic Lupus Erythematosus
A Case of Cutaneous B-Cell Lymphoma in Longstanding Systemic Lupus Erythematosus: Background: The association between lymphoproliferative malignancies and autoimmune rheumatological diseases, such as systemic lupus erythematosus (SLE), remains of great interest. It is known that individuals with immune dysregulation also have an increased risk of lymphoma. Objective: To report a case of primary cutaneous diffuse large B-cell lymphoma of the leg type associated with longstanding SLE, as well as to review the literature for similar cases. Methods: A PubMed search was done using the... περισσότερα »
A Pediatric Sedation Protocol for Mechanically Ventilated Patients Requires Sustenance Beyond Implementation.
A Pediatric Sedation Protocol for Mechanically Ventilated Patients Requires Sustenance Beyond Implementation.: Objectives: To reevaluate the effect of a nursing-driven sedation protocol for mechanically ventilated patients on analgesic and sedative medication dosing durations. We hypothesized that lack of continued quality improvement efforts results in increased sedation exposure, as well as mechanical ventilation days, and ICU length of stay. Design: Quasi-experimental, uncontrolled before-after study. Setting: Forty-five-bed tertiary care, medical-surgical-cardiac PICU in a metro... περισσότερα »
Admission Plasma Troponin I in Pediatric Intensive Care.
Admission Plasma Troponin I Is Associated With Mortality in Pediatric Intensive Care.: Objectives: Assessment of whether admission plasma troponin I level is associated with mortality or requirement for vasoactive drugs in pediatric intensive care. Design: Retrospective cohort study. Setting: Single centre, tertiary referral general PICU, without a cardiac surgical program. Patients: Three hundred and nineteen patients 0-18 years old in two cohorts. Cohort 1 was admitted between January 2009 and September 2012 and the cohort 2 between April 2014 and April 2015. Interventions: None... περισσότερα »
Wnt/β-catenin signaling in melanoma
preclinical rationale and novel therapeutic insights: [image: S03057372.gif] Publication date: Available online 29 June 2016 *Source:*Cancer Treatment Reviews Author(s): Xue Gongda, Emanuela Romano, Daniela Massi, Mario Mandalà WNT signaling regulates the embryonic development and tissue homeostasis in adult stage. Evolutionarily, activation of the WNT pathway is triggered by a large family of cytokines and activates a broad spectrum of downstream targets through two independent branches mediated by β-catenin (defined as canonical pathway) or PLC and small GTPase (defined as n... περισσότερα »
Midostaurin in Advanced Systemic Mastocytosis
Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis: Systemic mastocytosis is a myeloid neoplasm that is caused by the accumulation of abnormal mast cells in the bone marrow, liver, spleen, and skin. The KIT D816V mutation, which is detected in approximately 90% of patients, encodes a constitutively activated receptor tyrosine kinase that drives…
Photodynamic therapy in lupus miliaris disseminatus faciei's scars
Photodynamic therapy in lupus miliaris disseminatus faciei's scars: Abstract Lupus miliaris disseminatus faciei is an uncommon granulomatous inflammatory disease, characterized by multiple, monomorphic, reddish translucent papules and nodules, mainly located on the face. Several therapeutic options have been employed with variable results, leaving residual disfiguring scars. On this topic, we report a case of significant improvement of red-atrophic scars in a 54-year-old male after three sessions of photodynamic therapy with 10% aminolevulinic acid. Owing to the high safety profile... περισσότερα »
Wnt/β-catenin signaling in melanoma
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
preclinical rationale and novel therapeutic insights: Publication date: Available online 29 June 2016 Source:Cancer Treatment Reviews Author(s): Xue Gongda, Emanuela Romano, Daniela Massi, Mario Mandalà WNT signaling regulates the embryonic development and tissue homeostasis in adult stage. Evolutionarily, activation of the WNT pathway is triggered by a large family of cytokines and activates a broad […]
Midostaurin in Advanced Systemic Mastocytosis
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis: Systemic mastocytosis is a myeloid neoplasm that is caused by the accumulation of abnormal mast cells in the bone marrow, liver, spleen, and skin. The KIT D816V mutation, which is detected in approximately 90% of patients, encodes a constitutively activated receptor tyrosine kinase that drives… http://ift.tt/295zhfh
Photodynamic therapy in lupus miliaris disseminatus faciei’s scars
otolaryngologistsfakianakisστοOtoRhinoLaryngology by Sfakianakis G.Alexandros,,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,tel : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Photodynamic therapy in lupus miliaris disseminatus faciei’s scars: Abstract Lupus miliaris disseminatus faciei is an uncommon granulomatous inflammatory disease, characterized by multiple, monomorphic, reddish translucent papules and nodules, mainly located on the face. Several therapeutic options have been employed with variable results, leaving residual disfiguring scars. On this topic, we report a case of significant […]
Interaction between Bms1 and Rcl1, two ribosome biogenesis factors, is evolutionally conserved in zebrafish and human
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Publication date: Available online 29 June 2016 Source:Journal of Genetics and Genomics Author(s): Yong Wang, Qinfang Zhu, Ling Huang, Yanqing Zhu, Jun Chen, Jinrong Peng, Li Jan Lo from Genes via ola Kala on Inoreader http://ift.tt/29htOnt via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/294PcxT via IFTTT
A Repetitive DNA-Directed Program of Chromosome Packaging during Mitosis
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Publication date: Available online 29 June 2016 Source:Journal of Genetics and Genomics Author(s): Shao-Jun Tang from Genes via ola Kala on Inoreader http://ift.tt/297e8pV via IFTTT from #Med Blogs by Alexandros G.Sfakianakis via Alexandros G.Sfakianakis on Inoreader http://ift.tt/295zWx2 via IFTTT
Photodynamic therapy in lupus miliaris disseminatus faciei’s scars
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Abstract Lupus miliaris disseminatus faciei is an uncommon granulomatous inflammatory disease, characterized by multiple, monomorphic, reddish translucent papules and nodules, mainly located on the face. Several therapeutic options have been employed with variable results, leaving residual disfiguring scars. On this topic, we report a case of significant improvement of red-atrophic scars in a 54-year-old male […]
Acitretin in erosive penile lichen planus
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Abstract Lichen planus (LP) is an incompletely understood T-cell mediated auto-immune dermatosis. When LP involves the genitalia it may present as painful, pruritic erosions that can be exquisitely tender, causing distress and genitourinary and sexual dysfunction. Management of erosive genital LP is often suboptimal. Despite higher order evidence demonstrating the efficacy of oral acitretin in […]
Robotics, Vol. 5, Pages 13: Trajectory Generation and Stability Analysis for Reconfigurable Klann Mechanism Based Walking Robot
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Reconfigurable legged robots based on one degree of freedom are highly desired because they are effective on rough and irregular terrains and they provide mobility in such terrain with simple control schemes. It is necessary that reconfigurable legged robots should maintain stability during rest and motion, with a minimum number of legs while maintaining their […]
Micromachines, Vol. 7, Pages 112: Design and Experiment of a Solder Paste Jetting System Driven by a Piezoelectric Stack
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
To compensate for the insufficiency and instability of solder paste dispensing and printing that are used in the SMT (Surface Mount Technology) production process, a noncontact solder paste jetting system driven by a piezoelectric stack based on the principle of the nozzle-needle-system is introduced in this paper, in which a miniscule gap exists between the […]
Minerals, Vol. 6, Pages 65: Alternative Process Flow for Underground Mining Operations: Analysis of Conceptual Transport Methods Using Discrete Event Simulation
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
As the near surface deposits are being mined out, underground mines will increasingly operate at greater depths. This will increase the challenges related to transporting materials from deeper levels to the surface. For many years, the ore and waste transportation from most deep underground mines has depended on some or all of the following: truck […]
Primary Cutaneous B-Cell Lymphoma
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
in Young Monozygotic Twins: A Case Report: Although familial aggregation of lymphoproliferative disorders has been described, heredity has not been implicated in the etiology of primary cutaneous B-cell lymphomas (PCBCL). We report herein the first case of 2 young monozygotic twins with PCBCL. The first twin was an 18-year-old woman when she presented with multiple […]
A model to predict the risk of lethal nasopharyngeal necrosis after re-irradiation with intensity-modulated radiotherapy in nasopharyngeal carcinoma patients
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
A model to predict the risk of lethal nasopharyngeal necrosis after re-irradiation with intensity-modulated radiotherapy in nasopharyngeal carcinoma patients: Abstract Background For patients with nasopharyngeal carcinoma (NPC) who undergo re-irradiation with intensity-modulated radiotherapy (IMRT), lethal nasopharyngeal necrosis (LNN) is a severe late adverse event. The purpose of this study was to identify risk factors for […]
Protein stability regulators screening assay (Pro-SRSA): protein degradation meets the CRISPR–Cas9 library
fasoladaellinikiστοOTOLARYNGOLOGY LIFELONG LEARNING : OTOLARYNGOLOGY BY ALEXANDROS SFAKIANAKIS,GREECE CRETE,ANAPAFSEOS 5 AGIOS NIKOLAOS 72100,TEL : 00302841026182,00306932607174Πριν από 57 δευτερόλεπτα
Protein stability regulators screening assay (Pro-SRSA): protein degradation meets the CRISPR–Cas9 library: Abstract The regulation of protein stability is a fundamental issue for biophysical processes, but there has not previously been a convenient and unbiased method of identifying regulators of protein stability. However, as reported in the article entitled «A genome-scale CRISPR–Cas9 screening method for […]
Interaction between Bms1 and Rcl1, two ribosome biogenesis factors, is evolutionally conserved in zebrafish and human
[image: alertIcon.gif] Publication date: Available online 29 June 2016 *Source:*Journal of Genetics and Genomics Author(s): Yong Wang, Qinfang Zhu, Ling Huang, Yanqing Zhu, Jun Chen, Jinrong Peng, Li Jan Lo from Genes via ola Kala on Inoreader http://ift.tt/29htOnt via IFTTT
A Repetitive DNA-Directed Program of Chromosome Packaging during Mitosis
[image: alertIcon.gif] Publication date: Available online 29 June 2016 *Source:*Journal of Genetics and Genomics Author(s): Shao-Jun Tang from Genes via ola Kala on Inoreader http://ift.tt/297e8pV via IFTTT
Toxins, Vol. 8, Pages 199: Therapeutic Effectiveness of Anticancer Phytochemicals on Cancer Stem Cells
Understanding how to target cancer stem cells (CSCs) may provide helpful insights for the development of therapeutic or preventive strategies against cancers. Dietary phytochemicals with anticancer properties are promising candidates and have selective impact on CSCs. This review summarizes the influence of phytochemicals on heterogeneous cancer cell populations as well as on specific targeting of CSCs. from #Medicine via ola Kala on Inoreader http://ift.tt/297BJVV via IFTTT
Materials, Vol. 9, Pages 536: Modeling the Effects of Cu Content and Deformation Variables on the High-Temperature Flow Behavior of Dilute Al-Fe-Si Alloys Using an Artificial Neural Network
The hot deformation behavior of Al-0.12Fe-0.1Si alloys with varied amounts of Cu (0.002–0.31 wt %) was investigated by uniaxial compression tests conducted at different temperatures (400 °C–550 °C) and strain rates (0.01–10 s−1). The results demonstrated that flow stress decreased with increasing deformation temperature and decreasing strain rate, while flow stress increased with increasing Cu content for all deformation conditions studied due to the solute drag effect. Based on the experimental data, an artificial neural network (ANN) model was developed to study the relationship... περισσότερα »
Polymers, Vol. 8, Pages 247: An Osteoconductive Antibiotic Bone Eluting Putty with a Custom Polymer Matrix
With the rising tide of antibiotic resistant bacteria, extending the longevity of the current antibiotic arsenal is becoming a necessity. Developing local, controlled release antibiotic strategies, particularly for difficult to penetrate tissues such as bone, may prove to be a better alternative. Previous efforts to develop an osteoconductive local antibiotic release device for bone were created as solid molded composites; however, intimate contact with host bone was found to be critical to support host bone regrowth; thus, an osteocondconductive antibiotic releasing bone void fil... περισσότερα »
Batteries, Vol. 2, Pages 22: Clean Grain Boundary Found in C14/Body-Center-Cubic Multi-Phase Metal Hydride Alloys
The grain boundaries of three Laves phase-related body-center-cubic (bcc) solid-solution, metal hydride (MH) alloys with different phase abundances were closely examined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and more importantly, electron backscatter diffraction (EBSD) techniques. By using EBSD, we were able to identify the alignment of the crystallographic orientations of the three major phases in the alloys (C14, bcc, and B2 structures). This finding confirms the presence of crystallographically sharp interfaces between neighboring phases... περισσότερα »
Catalysts, Vol. 6, Pages 96: Preparation of PdCu Alloy Nanocatalysts for Nitrate Hydrogenation and Carbon Monoxide Oxidation
Alloying Pd with Cu is important for catalytic reactions such as denitrification reaction and CO oxidation reaction, but understanding of the catalyst preparation and its correlation with the catalyst's activity and selectivity remains elusive. Herein, we report the results of investigations of the preparation of PdCu alloy nanocatalysts using different methods and the catalytic properties of the catalysts in catalytic denitrification reaction and CO oxidation reaction. PdCu alloy nanocatalysts were prepared by conventional dry impregnation method and ligand-capping based wet chem... περισσότερα »
Impact of Weight Extremes on Clinical Outcomes in Pediatric Acute Respiratory Distress Syndrome.
[image: wk-health-logo.gif] Objectives: To determine whether weight extremes impact clinical outcomes in pediatric acute respiratory distress syndrome. Design: Post hoc analysis of a cohort created by combining five multicenter pediatric acute respiratory distress syndrome studies. Setting: Forty-three academic PICUs worldwide. Patients: A total of 711 subjects prospectively diagnosed with pediatric acute respiratory distress syndrome. Intervention: Subjects more than 2 years were included and categorized by Center for Disease Control and Prevention body mass index z score criteria... περισσότερα »
Randomized Trial of Video Laryngoscopy for Endotracheal Intubation of Critically Ill Adults.
[image: wk-health-logo.gif] Objective: To evaluate the effect of video laryngoscopy on the rate of endotracheal intubation on first laryngoscopy attempt among critically ill adults. Design: A randomized, parallel-group, pragmatic trial of video compared with direct laryngoscopy for 150 adults undergoing endotracheal intubation by Pulmonary and Critical Care Medicine fellows. Setting: Medical ICU in a tertiary, academic medical center. Patients: Critically ill patients 18 years old or older. Interventions: Patients were randomized 1:1 to video or direct laryngoscopy for the first at... περισσότερα »
Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis.
[image: wk-health-logo.gif] Objectives: To examine the performance of the urinary biomarker panel tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission. To investigate the effect of nonrenal organ dysfunction on tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in this population. Method: In this ancillary analysis, we included patients with sepsis who were enrolled in either of two trials including 39 ICUs across Europe and North America. The primary endpoint was mode... περισσότερα »
Wnt/β-catenin signaling in melanoma: preclinical rationale and novel therapeutic insights
[image: S03057372.gif] Publication date: Available online 29 June 2016 *Source:*Cancer Treatment Reviews Author(s): Xue Gongda, Emanuela Romano, Daniela Massi, Mario Mandalà WNT signaling regulates the embryonic development and tissue homeostasis in adult stage. Evolutionarily, activation of the WNT pathway is triggered by a large family of cytokines and activates a broad spectrum of downstream targets through two independent branches mediated by β-catenin (defined as canonical pathway) or PLC and small GTPase (defined as non-canonical pathway), respectively. Recent studies have reve... περισσότερα »
Wnt/β-catenin signaling in melanoma: preclinical rationale and novel therapeutic insights
[image: S03057372.gif] Publication date: Available online 29 June 2016 *Source:*Cancer Treatment Reviews Author(s): Xue Gongda, Emanuela Romano, Daniela Massi, Mario Mandalà WNT signaling regulates the embryonic development and tissue homeostasis in adult stage. Evolutionarily, activation of the WNT pathway is triggered by a large family of cytokines and activates a broad spectrum of downstream targets through two independent branches mediated by β-catenin (defined as canonical pathway) or PLC and small GTPase (defined as non-canonical pathway), respectively. Recent studies have reve... περισσότερα »
Minoxidil topical treatment may be more efficient if applied on damp scalp in comparison with dry scalp
ABSTRACT There is yet no consensus among prescribers whether minoxidil (MXD) formulations should be applied on wet/damp or dry scalp and no clear FDA guidelines on the matter. We hypothesized that the use of MXD on damp scalp may lead to higher drug penetration. First, because the drug diffusion and consequent deposition into the hair follicle may be favored when follicle cast is humid. Second, because humidity may also prevent drug crystallization and, therefore, maintain a higher thermodynamic activity for longer periods, which leads to increased penetration. Following in vitro ... περισσότερα »
Successful treatment of hypertrophic lichen planus with betamethasone under occlusion and TCA-peelings
ABSTRACT Hypertrophic lichen planus (HLP) is a variant of lichen planus characterized by marked epidermal hyperplasia and severe pruritus. We present a case of a female patient with HLP and concomitant primary biliary cirrhosis, which responded to topical therapy with betamethasone under occlusion and TCA-peelings. from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/295nGwP via IFTTT
Cutaneous sarcoidosis in a melanoma patient under Ipilimumab therapy
from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/296utHJ via IFTTT
Combined therapy for resistant vitiligo lesions: NB-UVB, microneedling, and topical latanoprost, showed no enhanced efficacy compared to topical latanoprost and NB-UVB
Abstract Vitiligo is depigmenting disorder of the skin and mucous membranes but despite various therapeutic options, complete and satisfactory treatment of vitiligo still remains a challenge. Therapeutic success also varies depending on the localization of lesions; hands and bony prominents are considered to be resistant to treatment. We investigated feasibility of treating resistant bilateral symmetrical vitiligo vulgaris and acrofacialis lesions with combination of narrowband UVB and topical prostaglandins (0.005% latanoprost solution) with or without Dermaroller 0.5 mm needle l... περισσότερα »
Editorial
from Biomedical Engineering via xlomafota13 on Inoreader http://ift.tt/296HkJS via IFTTT
Admission Plasma Troponin I Is Associated With Mortality in Pediatric Intensive Care.
Objectives: Assessment of whether admission plasma troponin I level is associated with mortality or requirement for vasoactive drugs in pediatric intensive care. Design: Retrospective cohort study. Setting: Single centre, tertiary referral general PICU, without a cardiac surgical program. Patients: Three hundred and nineteen patients 0-18 years old in two cohorts. Cohort 1 was admitted between January 2009 and September 2012 and the cohort 2 between April 2014 and April 2015. Interventions: None. Measurements and Main Results: Plasma troponin I was measured in patients in cohort 1 o... περισσότερα »
Comparison of Intraoperative Aminophylline Versus Furosemide in Treatment of Oliguria During Pediatric Cardiac Surgery.
Objectives: To determine if intraoperative aminophylline was superior to furosemide to prevent or attenuate postoperative cardiac surgery-associated acute kidney injury. Design: Single-center, historical control, retrospective cohort study. Setting: PICU, university-affiliated children's hospital. Patients: Children with congenital heart disease in PICU who received furosemide or aminophylline to treat intraoperative oliguria. Interventions: Intraoperative oliguria was treated either with furosemide (September 2007 to February 2012) or with aminophylline (February 2012 to June 2013)... περισσότερα »
Factors Associated With Mortality in Neonates Requiring Extracorporeal Membrane Oxygenation for Cardiac Indications: Analysis of the Extracorporeal Life Support Organization Registry Data.
Objectives: Survival among neonates supported with extracorporeal membrane oxygenation for cardiac indications is 39%. Previous single-center studies have identified factors associated with mortality, but a comprehensive multivariate analysis is not available for this population. Understanding factors associated with mortality may help design treatment strategies, determine optimal timing for cannulation, and inform patient selection. This study identifies factors associated with mortality in neonates supported with extracorporeal membrane oxygenation for cardiac indications. Design... περισσότερα »
A Pediatric Sedation Protocol for Mechanically Ventilated Patients Requires Sustenance Beyond Implementation.
Objectives: To reevaluate the effect of a nursing-driven sedation protocol for mechanically ventilated patients on analgesic and sedative medication dosing durations. We hypothesized that lack of continued quality improvement efforts results in increased sedation exposure, as well as mechanical ventilation days, and ICU length of stay. Design: Quasi-experimental, uncontrolled before-after study. Setting: Forty-five-bed tertiary care, medical-surgical-cardiac PICU in a metropolitan university-affiliated children's hospital. Patients: Children requiring mechanical ventilation longer t... περισσότερα »
THE IMPACT OF PATIENT PROTECTION AND AFFORDABLE CARE ACT ON TRAUMA CARE: A STEP IN THE RIGHT DIRECTION.
Introduction: The Patient Protection and Affordable Care Act (ACA) was implemented to guarantee financial coverage for health care for all Americans. The implementation of ACA is likely to influence the insurance status of Americans and reimbursement rates of trauma centers. The aim of this study was to assess the impact of ACA on the patient insurance status, hospital reimbursements and clinical outcomes at a Level I trauma center. We hypothesized that there would be a significant decrease in the proportion of uninsured trauma patients visiting our level I trauma center following t... περισσότερα »
Impact of Weight Extremes on Clinical Outcomes in Pediatric Acute Respiratory Distress Syndrome.
[image: wk-health-logo.gif] Objectives: To determine whether weight extremes impact clinical outcomes in pediatric acute respiratory distress syndrome. Design: Post hoc analysis of a cohort created by combining five multicenter pediatric acute respiratory distress syndrome studies. Setting: Forty-three academic PICUs worldwide. Patients: A total of 711 subjects prospectively diagnosed with pediatric acute respiratory distress syndrome. Intervention: Subjects more than 2 years were included and categorized by Center for Disease Control and Prevention body mass index z score criteria... περισσότερα »
Randomized Trial of Video Laryngoscopy for Endotracheal Intubation of Critically Ill Adults.
[image: wk-health-logo.gif] Objective: To evaluate the effect of video laryngoscopy on the rate of endotracheal intubation on first laryngoscopy attempt among critically ill adults. Design: A randomized, parallel-group, pragmatic trial of video compared with direct laryngoscopy for 150 adults undergoing endotracheal intubation by Pulmonary and Critical Care Medicine fellows. Setting: Medical ICU in a tertiary, academic medical center. Patients: Critically ill patients 18 years old or older. Interventions: Patients were randomized 1:1 to video or direct laryngoscopy for the first at... περισσότερα »
Urinary Tissue Inhibitor of Metalloproteinase-2 and Insulin-Like Growth Factor-Binding Protein 7 for Risk Stratification of Acute Kidney Injury in Patients With Sepsis.
[image: wk-health-logo.gif] Objectives: To examine the performance of the urinary biomarker panel tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in patients with sepsis at ICU admission. To investigate the effect of nonrenal organ dysfunction on tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 in this population. Method: In this ancillary analysis, we included patients with sepsis who were enrolled in either of two trials including 39 ICUs across Europe and North America. The primary endpoint was mode... περισσότερα »
Bone Failure in Critical Illness.
[image: wk-health-logo.gif] Objectives: The origin of systemic inflammatory response syndrome and multiple organ dysfunction syndrome is poorly understood but remains a fundamental concern in the ICU. This paper provides a critical appraisal on whether bone failure may represent an unrecognized component of systemic inflammatory response syndrome/multiple organ dysfunction syndrome. Data Sources, Data Selection, and Data Extraction: Search of the PubMed database and manual review of selected articles investigating bone pathophysiology in critical illness. Data Synthesis: Bone hyper... περισσότερα »
Sex-related differences in emergency department renal colic management: Females have fewer CT scans but similar outcomes
Abstract Background Sex-related differences occur in many areas of medicine. ED studies have suggested differences in access to care, diagnostic imaging use, pain management, and intervention. We investigated sex-based differences in the care and outcomes for ED patients with acute renal colic. Methods This was a multi-center population-based retrospective observational cohort study using administrative data and supplemented by structured chart review. All patients seen in Calgary Health Region (CHR) emergency departments between January 1, 2014 and December 31, 2014 with an ED dia... περισσότερα »
A Case of Cutaneous B-Cell Lymphoma in Longstanding Systemic Lupus Erythematosus
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Background: The association between lymphoproliferative malignancies and autoimmune rheumatological diseases, such as systemic lupus erythematosus (SLE), remains of great interest. It is known that individuals with immune dysregulation also have an increased risk of lymphoma. Objective: To report a case of primary cutaneous diffuse large B-cell lymphoma of the leg type associated with longstanding SLE, as well as to review the literature for similar cases. Methods: A PubMed search was done using the following search terms: *lupus* and *B-cell lymphoma*. Results: Although several s... περισσότερα »
Schnitzler Syndrome Without a Monoclonal Gammopathy: A Case Report
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Background: Schnitzler syndrome (SS) is a rare autoinflammatory disorder characterized by a recurrent urticarial rash and a monoclonal immunoglobulin M gammopathy, as well as 2 of the following minor criteria: recurrent fever (>38°C), objective signs of abnormal bone remodeling, elevated C-reactive protein level or leukocytosis, and a neutrophilic infiltrate on skin biopsy. Alternatively, a monoclonal immunoglobulin G gammopathy may be present along with 3 minor criteria for diagnosis. Objective: To report a rare case of SS without monoclonal gammopathy and inform physicians of thi... περισσότερα »
Primary Cutaneous B-Cell Lymphoma in Young Monozygotic Twins: A Case Report
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Although familial aggregation of lymphoproliferative disorders has been described, heredity has not been implicated in the etiology of primary cutaneous B-cell lymphomas (PCBCL). We report herein the first case of 2 young monozygotic twins with PCBCL. The first twin was an 18-year-old woman when she presented with multiple skin nodules on the thorax and head. Histology showed an atypical small B-cell proliferation, consistent with primary cutaneous marginal zone lymphoma (PCMZL). Molecular genetics studies demonstrated B-cell clonality. Seven years later, the second twin developed... περισσότερα »
Curative treatment of head and neck squamous cell carcinoma
στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 1 ώρα
Abstract Introduction For the treatment of head and neck squamous cell carcinoma (HNSCC), there are currently no official standard of care guidelines in German-speaking countries, with the exception of oral cavity cancer. In order to learn about the applied treatment modalities in the clinical routine, we conducted a web-based survey to evaluate the local standards of palliative and curative treatment of HNSCC. This article focuses on the curative treatment options and organ preservation strategies. Materials and methods The survey consisted of a web-based questionnaire that was p... περισσότερα »
p27 KIP1 and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice
p27 KIP1 and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice: Abstract PTEN acts as a phosphatase for PIP3 and negatively regulates the PI3K/AKT pathway, and p27KIP1 is a cyclin-dependent kinase inhibitor that regulates the G1 to S-phase transition by binding to and regulating the activity of cyclin-dependent kinases. Genetic alterations of PTEN or CDKN1B (p27KIP1) are common in hematological malignancies. To better understand how mutations in these two genes might cooperate in leukemogenesis, we inactivated both genes in the hematological compartment in mi... περισσότερα »
Use of glucosamine and chondroitin supplements in relation to risk of colorectal cancer: Results from the Nurses' Health Study and Health Professionals Follow-up Study
Abstract Recent epidemiologic evidence has emerged to suggest that use of glucosamine and chondroitin supplements may be associated with reduced risk of colorectal cancer (CRC). We therefore evaluated the association between use of these non-vitamin, non-mineral supplements and risk of CRC in two prospective cohorts, the Nurses' Health Study and Health Professionals Follow-up Study. Regular use of glucosamine and chondroitin was first assessed in 2002 and participants were followed until 2010, over which time 672 CRC cases occurred. Cox proportional hazards regression was used to ... περισσότερα »
Comparison of outcomes after umbilical cord blood and unmanipulated haploidentical hematopoietic stem cell transplantation in children with high-risk acute lymphoblastic leukemia
[image: cover.gif?v=1&s=52b7960573a6f44616d24fa7] Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) is an effective therapy for children with high-risk acute lymphoblastic leukemia (ALL). Human leukocyte antigen (HLA)-haploidentical HSCT (haplo-HSCT) or umbilical cord blood transplantation (UCBT) are both important alternative sources of stem cells for those without an HLA-identical sibling donor or unrelated matched donor. We aimed to compare the therapeutic effects of single UCBT and unmanipulated haplo-HSCT in high-risk ALL children (n = 129). Hematopoietic re... περισσότερα »
A model to predict the risk of lethal nasopharyngeal necrosis after re-irradiation with intensity-modulated radiotherapy in nasopharyngeal carcinoma patients
Abstract Background For patients with nasopharyngeal carcinoma (NPC) who undergo re-irradiation with intensity-modulated radiotherapy (IMRT), lethal nasopharyngeal necrosis (LNN) is a severe late adverse event. The purpose of this study was to identify risk factors for LNN and develop a model to predict LNN after radical re-irradiation with IMRT in patients with recurrent NPC. Methods Patients who underwent radical re-irradiation with IMRT for locally recurrent NPC between March 2001 and December 2011 and who had no evidence of distant metastasis were included in this study. Clini... περισσότερα »
Protein stability regulators screening assay (Pro-SRSA): protein degradation meets the CRISPR–Cas9 library
Abstract The regulation of protein stability is a fundamental issue for biophysical processes, but there has not previously been a convenient and unbiased method of identifying regulators of protein stability. However, as reported in the article entitled "A genome-scale CRISPR–Cas9 screening method for protein stability reveals novel regulators of Cdc25A," recently published in *Cell Discovery*, our team developed a protein stability regulators screening assay (Pro-SRSA) by combining the whole-genome clustered regularly interspaced short palindromic repeats Cas9 (CRISPR–Cas9) libra... περισσότερα »
Low expression of centrosomal protein 78 (CEP78) is associated with poor prognosis of colorectal cancer patients
Abstract Background Centrosomal protein 78 (CEP78) has been characterized as a component of the centrosome required for the regulation of centrosome-related events during the cell cycle, but its role in human cancers remains unclear. This study aimed to investigate the role and the clinical value of CEP78 in colorectal cancer (CRC). Methods Quantitative real-time polymerase chain reaction (qRT-PCR) and immunohistochemistry were performed to examine CEP78 expression in CRC tissues and adjacent noncancerous tissues. The association between CEP78 expression and clinical outcomes of ... περισσότερα »
Palliative primary tumor resection provides survival benefits for the patients with metastatic colorectal cancer and low circulating levels of dehydrogenase and carcinoembryonic antigen
Abstract Background It remains controversial whether palliative primary tumor resection (PPTR) can provide survival benefits to the patients with metastatic colorectal cancer (mCRC) who have unresectable metastases. The aim of this study was to evaluate whether PPTR could improve the survival of patients with mCRC. Methods We conducted a retrospective study on consecutive mCRC patients with unresectable metastases who were diagnosed at Sun Yat-sen University Cancer Center in Guangzhou, Guangdong, China, between January 2005 and December 2012. Overall survival (OS) and progression-... περισσότερα »
Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics
Abstract Validated preclinical studies have provided evidence that anti-vascular endothelial growth factor (VEGF) compounds enhance the activity of subsequent antitumor therapy, but the mechanism of this potentiation is far from clear. The most widespread explanation is enhanced delivery of therapeutics due to vascular remodeling, lower interstitial pressure, and increased blood flow. While the antiangiogenic effects on vascular morphology have been fairly consistent in both preclinical and clinical settings, the improvement of tumor vessel function is debated. This review focuses... περισσότερα »
First-line therapy in HER2 positive metastatic breast cancer: is the mosaic fully completed or are we missing additional pieces?
First-line therapy in HER2 positive metastatic breast cancer: is the mosaic fully completed or are we missing additional pieces?: Abstract The discovery of human epidermal growth factor receptor 2 (HER2) and its role in the biology of breast cancer and the subsequent development of HER2-targeted therapies, have dramatically improved clinical outcomes for women with early-stage and advanced HER2-positive breast cancer (BC). HER-2 targeted therapies represent a major step forward in achieving the goal of delivering individualized targeted therapy for BC, and trastuzumab was the firs... περισσότερα »
Immunomodulatory effect of vitamin D after allo-SCT
Immunomodulatory effect of vitamin D after allo-SCT: Purpose: we describe the results of a prospective multicenter phase I/II trial evaluating the impact of the use of vitamin D (VitD) from day -5 to +100 on the outcome of patients undergoing allogeneic transplantation (EudraCT: 2010-023279-25; ClinicalTrials.gov: NCT02600988). Patients and methods:150 patients were included in three consecutive cohorts of 50 patients each group: control group (CG, not receive VitD); low dose group (LdD, received 1,000 UI VitD daily; and high dose group (HdD, 5,000 UI VitD daily). We measured level... περισσότερα »
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