Photodynamic therapy in lupus miliaris disseminatus faciei's scars
Today, 30 Ιουνίου 2016, 1 hour ago
Abstract
Lupus miliaris disseminatus faciei is an uncommon granulomatous inflammatory disease, characterized by multiple, monomorphic, reddish translucent papules and nodules, mainly located on the face. Several therapeutic options have been employed with variable results, leaving residual disfiguring scars. On this topic, we report a case of significant improvement of red-atrophic scars in a 54-year-old male after three sessions of photodynamic therapy with 10% aminolevulinic acid. Owing to the high safety profile and the excellent cosmetic result, photodynamic therapy may be considered a useful tool to both prevent and treat undesirable scarring.
http://ift.tt/292hrbX
A Case of Cutaneous B-Cell Lymphoma in Longstanding Systemic Lupus Erythematosus
Today, 30 Ιουνίου 2016, 2 hours ago
Background: The association between lymphoproliferative malignancies and autoimmune rheumatological diseases, such as systemic lupus erythematosus (SLE), remains of great interest. It is known that individuals with immune dysregulation also have an increased risk of lymphoma.
Objective: To report a case of primary cutaneous diffuse large B-cell lymphoma of the leg type associated with longstanding SLE, as well as to review the literature for similar cases.
Methods: A PubMed search was done using the following search terms: lupus and B-cell lymphoma.
Results: Although several studies show that non-Hodgkin lymphoma is significantly increased in SLE, there is currently no literature reporting specifically on the risk of primary cutaneous lymphomas in patients with SLE.
Conclusion: Our report highlights the possibility that patients with autoimmune disease are at increased risk of not only the classic forms of non-Hodgkin lymphoma but also primary cutaneous B-cell lymphomas.
http://ift.tt/297OEVm
Objective: To report a case of primary cutaneous diffuse large B-cell lymphoma of the leg type associated with longstanding SLE, as well as to review the literature for similar cases.
Methods: A PubMed search was done using the following search terms: lupus and B-cell lymphoma.
Results: Although several studies show that non-Hodgkin lymphoma is significantly increased in SLE, there is currently no literature reporting specifically on the risk of primary cutaneous lymphomas in patients with SLE.
Conclusion: Our report highlights the possibility that patients with autoimmune disease are at increased risk of not only the classic forms of non-Hodgkin lymphoma but also primary cutaneous B-cell lymphomas.
http://ift.tt/297OEVm
Schnitzler Syndrome Without a Monoclonal Gammopathy: A Case Report
Today, 30 Ιουνίου 2016, 2 hours ago
Background: Schnitzler syndrome (SS) is a rare autoinflammatory disorder characterized by a recurrent urticarial rash and a monoclonal immunoglobulin M gammopathy, as well as 2 of the following minor criteria: recurrent fever (>38°C), objective signs of abnormal bone remodeling, elevated C-reactive protein level or leukocytosis, and a neutrophilic infiltrate on skin biopsy. Alternatively, a monoclonal immunoglobulin G gammopathy may be present along with 3 minor criteria for diagnosis.
Objective: To report a rare case of SS without monoclonal gammopathy and inform physicians of this possible clinical presentation so that treatment is not delayed.
Methods: We report a case of a 62-year-old white man with a clinical diagnosis of SS without monoclonal gammopathy. He presented with chronic urticaria unresponsive to conventional therapy.
Results and Conclusions: To our knowledge, there have only been 3 case reports of SS in the absence of monoclonal gammopathy documented in the literature. SS should be considered based on clinical presentation, even in the absence of monoclonal gammopathy, to facilitate appropriate management.
http://ift.tt/297OEEB
Objective: To report a rare case of SS without monoclonal gammopathy and inform physicians of this possible clinical presentation so that treatment is not delayed.
Methods: We report a case of a 62-year-old white man with a clinical diagnosis of SS without monoclonal gammopathy. He presented with chronic urticaria unresponsive to conventional therapy.
Results and Conclusions: To our knowledge, there have only been 3 case reports of SS in the absence of monoclonal gammopathy documented in the literature. SS should be considered based on clinical presentation, even in the absence of monoclonal gammopathy, to facilitate appropriate management.
http://ift.tt/297OEEB
Primary Cutaneous B-Cell Lymphoma in Young Monozygotic Twins: A Case Report
Today, 30 Ιουνίου 2016, 2 hours ago
Although familial aggregation of lymphoproliferative disorders has been described, heredity has not been implicated in the etiology of primary cutaneous B-cell lymphomas (PCBCL). We report herein the first case of 2 young monozygotic twins with PCBCL. The first twin was an 18-year-old woman when she presented with multiple skin nodules on the thorax and head. Histology showed an atypical small B-cell proliferation, consistent with primary cutaneous marginal zone lymphoma (PCMZL). Molecular genetics studies demonstrated B-cell clonality. Seven years later, the second twin developed her first lesion that was histologically similar to that of her twin. She subsequently developed other clinically similar lesions. Histology was consistent with PCMZL and showed B-cell clonality. Occurrence of PCBCL in these monozygotic twins raises the possibility of a genetic risk factor. Further study of such rare cases may offer valuable insights into the molecular basis of the etiology and pathogenesis of this unusual disorder.
http://ift.tt/29eWH6v
http://ift.tt/29eWH6v
Curative treatment of head and neck squamous cell carcinoma
Today, 30 Ιουνίου 2016, 2 hours ago
Abstract
Introduction
For the treatment of head and neck squamous cell carcinoma (HNSCC), there are currently no official standard of care guidelines in German-speaking countries, with the exception of oral cavity cancer. In order to learn about the applied treatment modalities in the clinical routine, we conducted a web-based survey to evaluate the local standards of palliative and curative treatment of HNSCC. This article focuses on the curative treatment options and organ preservation strategies.Materials and methods
The survey consisted of a web-based questionnaire that was performed between November 2013 and July 2014. The questionnaire included ten multiple-choice questions and four open questions in the section about curative treatment.Results
Altogether, 62 of the 204 addressed centers participated in the survey. For primary chemoradiation (CRT), most centers used a platinum-based chemotherapy (52/54, 96.3 %). Induction chemotherapy (ICT) was offered in 37 of the 62 centers (60 %). In oral cavity cancer, CRT and ICT were used in 37.5 and 4.3 % of the cases, respectively. In oropharyngeal cancer, CRT and ICT were applied in 44.5 and 10.3 % of cases, respectively. For hypopharyngeal cancer, 44.8 % of the patients received CRT and 11.8 % received ICT, while for laryngeal cancer 35.9 % received CRT and 9.4 % underwent ICT.Conclusion
Our data showed that a variety of treatments are used for HNSCC within German-speaking countries. Many centers offer ICT. The majority of the hospitals uses platinum-based therapy as a conservative first-line option in their organ preservation protocols.http://ift.tt/29a1fJo
Acitretin in erosive penile lichen planus
Today, 30 Ιουνίου 2016, 3 hours ago
Abstract
Lichen planus (LP) is an incompletely understood T-cell mediated auto-immune dermatosis. When LP involves the genitalia it may present as painful, pruritic erosions that can be exquisitely tender, causing distress and genitourinary and sexual dysfunction. Management of erosive genital LP is often suboptimal. Despite higher order evidence demonstrating the efficacy of oral acitretin in the management of cutaneous and oral LP, it still features below other immunosuppressive and immunomodulatory therapies in many clinicians’ therapeutic ladder. We present a case of severe erosive penile LP, successfully treated with oral acitretin after topical and oral corticosteroids failed to induce remission.
http://ift.tt/294EVBL
Transient acantholytic dyskeratosis (Grover's disease) after bone marrow transplantation
Today, 30 Ιουνίου 2016, 3 hours ago
Abstract
Cutaneous eruptions in recipients of allogeneic haematopoietic stem cell transplantation (AHSCT) are frequent, and common aetiologies include graft-versus-host disease (GVHD), drug reactions, viral infections and engraftment syndrome. Transient acantholytic dermatosis or Grover’s disease has been described in oncology patients and it is rarely reported after AHSCT. However, this benign and self-limiting condition should be histologically distinguished from other, more serious entities, mainly stage IV GVHD, in order to avoid inappropriate treatment with corticosteroids and intensive immunosuppression.
http://ift.tt/295p5Dk
Subcortical correlates of auditory perceptual organization in humans
Today, 30 Ιουνίου 2016, 3 hours ago
Publication date: Available online 29 June 2016
Source:Hearing Research
Author(s): Shimpei Yamagishi, Sho Otsuka, Shigeto Furukawa, Makio Kashino
To make sense of complex auditory scenes, the auditory system sequentially organizes auditory components into perceptual objects or streams. In the conventional view of this process, the cortex plays a major role in perceptual organization, and subcortical mechanisms merely provide the cortex with acoustical features. Here, we show that the neural activities of the brainstem are linked to perceptual organization, which alternates spontaneously for human listeners without any stimulus change. The stimulus used in the experiment was an unchanging sequence of repeated triplet tones, which can be interpreted as either one or two streams. Listeners were instructed to report the perceptual states whenever they experienced perceptual switching between one and two streams throughout the stimulus presentation. Simultaneously, we recorded event related potentials with scalp electrodes. We measured the frequency-following response (FFR), which is considered to originate from the brainstem. We also assessed thalamo-cortical activity through the middle-latency response (MLR). The results demonstrate that the FFR and MLR varied with the state of auditory stream perception. In addition, we found that the MLR change precedes the FFR change with perceptual switching from a one-stream to a two-stream percept. This suggests that there are top-down influences on brainstem activity from the thalamo-cortical pathway. These findings are consistent with the idea of a distributed, hierarchical neural network for perceptual organization and suggest that the network extends to the brainstem level.
http://ift.tt/294EYh0
Correlation between word recognition score and intracochlear new bone and fibrous tissue after cochlear implantation in the human
Today, 30 Ιουνίου 2016, 3 hours ago
Publication date: Available online 29 June 2016
Source:Hearing Research
Author(s): Takefumi Kamakura, Joseph B. Nadol
Cochlear implantation is an effective, established procedure for patients with profound deafness. Although implant electrodes have been considered as biocompatible prostheses, surgical insertion of the electrode induces various changes within the cochlea. Immediate changes include insertional trauma to the cochlea. Delayed changes include a tissue response consisting of inflammation, fibrosis and neo-osteogenesis induced by trauma and an immunologic reaction to a foreign body. The goal of this study was to evaluate the effect of these delayed changes on the word recognition scores achieved post-operatively. Seventeen temporal bones from patients who in life had undergone cochlear implantation were prepared for light microscopy. We digitally calculated the volume of fibrous tissue and new bone within the cochlea using Amira® three-dimensional reconstruction software and assessed the correlations of various clinical and histologic factors. The postoperative CNC word score was positively correlated with total spiral ganglion cell count. Fibrous tissue and new bone were found within the cochlea of all seventeen specimens. The postoperative CNC word score was negatively correlated with the % volume of new bone within the scala tympani, scala media/vestibuli and the cochlea, but not with the % volume of fibrous tissue. The % volume of new bone in the scala media/vestibuli was positively correlated with the degree of intracochlear insertional trauma, especially trauma to the basilar membrane.Our results revealed that the % volume of new bone as well as residual total spiral ganglion cell count are important factors influencing post-implant hearing performance. New bone formation may be reduced by limiting insertional trauma and increasing the biocompatibility of the electrodes.
http://ift.tt/294EY0F
Minoxidil topical treatment may be more efficient if applied on damp scalp in comparison with dry scalp
Today, 30 Ιουνίου 2016, 3 hours ago
ABSTRACT
There is yet no consensus among prescribers whether minoxidil (MXD) formulations should be applied on wet/damp or dry scalp and no clear FDA guidelines on the matter. We hypothesized that the use of MXD on damp scalp may lead to higher drug penetration. First, because the drug diffusion and consequent deposition into the hair follicle may be favored when follicle cast is humid. Second, because humidity may also prevent drug crystallization and, therefore, maintain a higher thermodynamic activity for longer periods, which leads to increased penetration. Following in vitro experiments on rat and porcine skin we confirmed the hypothesis, which could markedly improve treatment effectiveness.
http://ift.tt/294Dunb
Successful treatment of hypertrophic lichen planus with betamethasone under occlusion and TCA-peelings
Today, 30 Ιουνίου 2016, 3 hours ago
ABSTRACT
Hypertrophic lichen planus (HLP) is a variant of lichen planus characterized by marked epidermal hyperplasia and severe pruritus. We present a case of a female patient with HLP and concomitant primary biliary cirrhosis, which responded to topical therapy with betamethasone under occlusion and TCA-peelings.
http://ift.tt/295nGwP
Cutaneous sarcoidosis in a melanoma patient under Ipilimumab therapy
Today, 30 Ιουνίου 2016, 3 hours ago
Combined therapy for resistant vitiligo lesions: NB-UVB, microneedling, and topical latanoprost, showed no enhanced efficacy compared to topical latanoprost and NB-UVB
Today, 30 Ιουνίου 2016, 3 hours ago
Abstract
Vitiligo is depigmenting disorder of the skin and mucous membranes but despite various therapeutic options, complete and satisfactory treatment of vitiligo still remains a challenge. Therapeutic success also varies depending on the localization of lesions; hands and bony prominents are considered to be resistant to treatment. We investigated feasibility of treating resistant bilateral symmetrical vitiligo vulgaris and acrofacialis lesions with combination of narrowband UVB and topical prostaglandins (0.005% latanoprost solution) with or without Dermaroller 0.5 mm needle length-assisted microneedling. Frequency of repigmentation onset was generally low (37.8%) and pronounced repigmentation was infrequently seen (26–50% repigmentation in 20.8%, and >50% repigmentation in only 8.8% of repigmenting lesions). Our study, however, showed that latanoprost can be used in combination with NB-UVB phototherapy to induce repigmentation in some vitiligo lesions in resistant-to-treatment location, while addition of skin microneedling seems not to improve the treatment outcome and possibly needs modification.
http://ift.tt/294DEei
The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils
Today, 30 Ιουνίου 2016, 3 hours ago
Maternally administered cyclic-glycine-proline increases insulin-like growth factor-1 bioavailability and novelty recognition in developing offspring
Today, 30 Ιουνίου 2016, 3 hours ago
Emerging Points of the Supraorbital and Supratrochlear Nerves in the Supraorbital Margin With Reference to the Lacrimal Caruncle: Implications for Regional Nerve Block in Upper Eyelid and Dermatologic Surgery.
Today, 30 Ιουνίου 2016, 4 hours ago
BACKGROUND: Blocking the supraorbital nerve (SON) and supratrochlear nerve (STN) by injecting anesthetic distal to the surgical site has the advantage in upper eyelid surgery that avoids obscuring the surgical landmarks and compromising the levator function. OBJECTIVE: To identify the emerging points of the SON and STN in the supraorbital margin with reference to the lacrimal caruncle. METHODS: Forty-nine orbits from 27 embalmed Korean cadavers were dissected. The lacrimal caruncle and facial midline were used as landmarks. The emerging points of the SON and STN in the supraorbital margin were determined. RESULTS: The emerging points of the SON and STN were, respectively, located at 3.0 mm lateral and 3.3 mm medial to the vertical line through the apex of the lacrimal caruncle along the supraorbital margin. The horizontal distances from the facial midline to the emerging points of the SON and STN were 22.8 and 15.2 mm, respectively. CONCLUSION: The optimum sites for achieving SON and STN block are, respectively, located approximately 3 mm lateral and 3 mm medial to the vertical line through the apex of lacrimal caruncle along the supraorbital margin. This knowledge will help the surgeon achieve an easy and accurate approach for regional nerve block. © 2016 by the American Society for Dermatologic Surgery, Inc. Published by Wolters Kluwer Health, Inc. All rights reserved.
http://ift.tt/29cE9Ca
http://ift.tt/29cE9Ca
Use of an Abdominal Binder to Minimize Postprocedural Complications After Cutaneous Surgery on the Trunk.
Today, 30 Ιουνίου 2016, 4 hours ago
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