Αρχειοθήκη ιστολογίου

Αλέξανδρος Γ. Σφακιανάκης
ΩτοΡινοΛαρυγγολόγος
Αναπαύσεως 5
Άγιος Νικόλαος Κρήτη 72100
2841026182
6032607174

Τετάρτη 29 Ιουνίου 2016

OtoRhinoLaryngology & Medicine,New Articles,June 30th,2016


Hepatoprotective and antioxidant potential of Asphodeline lutea (L.) Rchb. roots extract

in experimental models in vitro/in vivo via Biomedicine & Pharmacotherapy Publication date: October 2016Source:Biomedicine & Pharmacotherapy, Volume 83Author(s): Irina Lazarova, Rumyana Simeonova, Vessela Vitcheva, Magdalena Kondeva-Burdina, Reneta Gevrenova, Dimitrina Zheleva-Dimitrova, Gokhan Zengin, Nikolay D. Danchev The aim of this study was to investigate the effect of Asphodeline lutea (L.) Rchb. dry root extract (ALE) administered […]

The renal tubular injury induced by hyperglycemia

SIRT1 activator ameliorates the renal tubular injury induced by hyperglycemia in vivo and in vitro via inhibiting apoptosis via Biomedicine & amp; Pharmacotherapy Publication date: October 2016Source:Biomedicine & Pharmacotherapy, Volume 83Author(s): Xue-ling Wang, Li-yan Wu, Long Zhao, Li-na Sun, Hai-ying Liu, Gang Liu, Guang-ju GuanWe aimed to explore the role of SIRT1 in apoptosis in human kidney […]

Asiaticoside-loaded coaxial nanofibers provide a novel promising option for treatment of deep partial-thickness burn injury

Preparation of asiaticoside-loaded coaxially electrospinning nanofibers and their effect on deep partial-thickness burn injury via Biomedicine & Pharmacotherapy Publication date: October 2016Source:Biomedicine & Pharmacotherapy, Volume 83Author(s): Lifei Zhu, Xiaoyan Liu, Lina Du, Yiguang JinSodium alginate and chitosan were in favor of wound healing. However, the two polymers were not compatible in one formulation due to the […]

Optimal adaptive IMRT strategy to spare the parotid glands in oropharyngeal cancer

Optimal adaptive IMRT strategy to spare the parotid glands in oropharyngeal cancer: In oropharyngeal cancer adaptive radiation therapy (ART), this study aimed to quantify the dosimetric benefit of numerous replanning strategies, defined by various numbers and timings of replannings, with regard to parotid gland (PG) sparing. Abstract Purpose In oropharyngeal cancer adaptive radiation therapy (ART), […]

Radiation-induced creatinine clearance reduction and renal parenchymal volume atrophy

Long-term observations of radiation-induced creatinine clearance reduction and renal parenchymal volume atrophy: The kidney is a dose-limiting organ for upper abdominal radiotherapy. In this study, radiation-induced kidney injury represented by changes of creatinine clearance (Ccr) and renal parenchymal volume measured by computed tomography (CT) were evaluated by analysing dose–volume histograms (DVHs) in patients with primary […]

Ipilimumab for the treatment of patients with metastatic melanoma

Effectiveness, toxicity, and economic evaluation of ipilimumab for the treatment of patients with metastatic melanoma in the Spanish outpatient setting: To evaluate the effectiveness and toxicity profile of ipilimumab treatment and to examine the cost-effectiveness relation in a real-world sample of patients with metastasic melanoma. This was a multicenter, observational, retrospective cohorts study. To assess […]

Ethyl-2-amino-pyrrole-3-carboxylates are novel potent anticancer agents that affect tubulin polymerization, induce G2/M cell-cycle arrest, and effectively inhibit soft tissue cancer cell growth

h in vitro: Microtubules are known to be one of the most attractive and validated targets in cancer therapy. However, the clinical use of drugs that affect the dynamic state of microtubules has been hindered by chemoresistance and toxicity issues. Accordingly, the development of novel agents that target microtubules is needed. Here, we report the […]

Antitumoural activity of a cytotoxic peptide of Lactobacillus casei peptidoglycan

and its interaction with mitochondrial-bound hexokinase: In a previous study, we reported the cytotoxic activity against various tumour cells of the peptidoglycan of Lactobacillus casei. To isolate the most active components, we performed column-chromatography separation of the peptidoglycan complex and tested the related fractions for their cytotoxic activity. The most active fractions were then lyophilized […]

Cabozantinib capsules (COMETRIQ) are approved for the treatment of patients with progressive metastatic medullary thyroid cancer

Pharmacokinetics of cabozantinib tablet and capsule formulations in healthy adults: Abstract Cabozantinib capsules (COMETRIQ) are approved for the treatment of patients with progressive metastatic medullary thyroid cancer. Cabozantinib tablets are investigational drug products considered to be potentially preferred pharmaceutical dosing forms. Two phase I open-label single-dose studies in healthy individuals were carried out to characterize […]

Docetaxel plus lobaplatin for Chinese patients with pulmonary and hepatic metastasis of nasopharyngeal carcinoma

An open-label, single-arm phase II clinical study of To evaluate the efficacy and safety of the chemotherapy program of docetaxel combined with lobaplatin for Chinese patients with pulmonary and hepatic metastasis of nasopharyngeal carcinoma (NPC). This study included 37 NPC patients with pulmonary and hepatic metastasis. The chemotherapy program included docetaxel (75 mg/m2, day 1) plus […]

HER3 targeting sensitizes HNSCC to cetuximab cell PDX models

Purpose:Our previous work suggested that HER3 inhibition sensitizes HNSCC to EGFR inhibition with cetuximab. This study aimed to define the role of HER3 in cetuximab resistance and the anti-tumor mechanisms of EGFR/HER3 dual targeting in HNSCC. Experimental Design:We treated cetuximab-resistant HNSCC UMSCC1-C and parental UMSCC1-P cell lines with anti-EGFR antibody cetuximab, anti-HER3 antibody MM-121, and […]

Myc modulation by HDACi in cancer

Purpose: Histone deacetylase inhibitors (HDACi) are promising anticancer drugs. Although some HDACi have entered the clinic, the mechanism(s) underlying their tumor selectivity are poorly understood. Experimental Design/Results: Using gene expression analysis, we define a core set of 6 genes commonly regulated in acute myeloid leukemia (AML) blasts and cell lines. c-Myc, the most prominently modulated, […]

DNA methylation biomarkers and prostate cancer prognosis

Purpose: Aside from Gleason sum few factors accurately identify the subset of prostate cancer (PCa) patients at high risk for metastatic progression. We hypothesized that epigenetic alterations could distinguish prostate tumors with life-threatening potential. Experimental Design: Epigenome-wide DNA methylation profiling was performed in surgically resected primary tumor tissues from a population-based (n = 430) and […]

Anti-PD-1, anti-TIM-3, and radiation in glioma model

Introduction: Checkpoint molecules like programmed death-1 (PD-1) and T cell immunoglobulin mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the setting of glioblastoma multiforme (GBM). Combined PD-1 blockade and stereotactic radiosurgery (SRS) have been shown to improve antitumor immunity and produce long-term survivors in a murine glioma model (1) . However, tumor-infiltrating […]

Immunomodulatory effect of vitamin D after allo-SCT

Purpose: we describe the results of a prospective multicenter phase I/II trial evaluating the impact of the use of vitamin D (VitD) from day -5 to +100 on the outcome of patients undergoing allogeneic transplantation (EudraCT: 2010-023279-25; ClinicalTrials.gov: NCT02600988). Patients and methods:150 patients were included in three consecutive cohorts of 50 patients each group: control […]

A novel molecular subtype of stage I lung adenocarcinoma

Purpose: The National Lung Cancer Screening Trial has confirmed that lung cancer mortality can be reduced if tumors are diagnosed early, i.e. at stage I. However, a substantial fraction of stage I lung cancer patients still develop metastatic disease within 5 years from surgery. Prognostic biomarkers are therefore needed to identify patients at risk of […]

HER3 targeting sensitizes HNSCC to cetuximab cell PDX models

Purpose:Our previous work suggested that HER3 inhibition sensitizes HNSCC to EGFR inhibition with cetuximab. This study aimed to define the role of HER3 in cetuximab resistance and the anti-tumor mechanisms of EGFR/HER3 dual targeting in HNSCC. Experimental Design:We treated cetuximab-resistant HNSCC UMSCC1-C and parental UMSCC1-P cell lines with anti-EGFR antibody cetuximab, anti-HER3 antibody MM-121, and […]

XPO1 inhibition synergizes with chemotherapy in AML

Purpose: Selinexor, a selective inhibitor of XPO1, is currently being tested as single agent in clinical trials in acute myeloid leukemia (AML). However, considering the molecular complexity of AML, it is unlikely that AML can be cured with monotherapy. Therefore we asked whether adding already established effective drugs such as Topoisomerase (Topo) II inhibitors to […]

Myc modulation by HDACi in cancer

Purpose: Histone deacetylase inhibitors (HDACi) are promising anticancer drugs. Although some HDACi have entered the clinic, the mechanism(s) underlying their tumor selectivity are poorly understood. Experimental Design/Results: Using gene expression analysis, we define a core set of 6 genes commonly regulated in acute myeloid leukemia (AML) blasts and cell lines. c-Myc, the most prominently modulated, […]

Anti-PD-1, anti-TIM-3, and radiation in glioma model

Introduction: Checkpoint molecules like programmed death-1 (PD-1) and T cell immunoglobulin mucin-3 (TIM-3) are negative immune regulators that may be upregulated in the setting of glioblastoma multiforme (GBM). Combined PD-1 blockade and stereotactic radiosurgery (SRS) have been shown to improve antitumor immunity and produce long-term survivors in a murine glioma model (1) . However, tumor-infiltrating […]

Microdermabrasion: a clinical, histometric, and histopathologic study

στοOtoRhinoLaryngology - Head and Neck SurgeryΠριν από 8 δευτερόλεπτα
Summary Background Microdermabrasion is a nonchemical superficial resurfacing procedure that removes the stratum corneum. Because it is a somewhat subtle procedure, it may be difficult to demonstrate its cosmetic benefit. Objectives To assess the efficacy of microdermabrasion in treatment of melasma, postacne scarring, striae distensae, and photoaging by a series of microdermabrasion sittings through clinical, histometric, and histopathologic analysis. Patients and Methods The study was conducted on 38 patients constituting four groups (melasma, acne scars, striae destinsae, and p... περισσότερα »

Live cell monitoring of glycine betaine by FRET-based genetically encoded nanosensor

Alexandros G. SfakianakisστοΒιοΜηχανικήΠριν από 17 δευτερόλεπτα
[image: alertIcon.gif] Publication date: 15 December 2016 *Source:*Biosensors and Bioelectronics, Volume 86 Author(s): Mohammad Ahmad, Seema Ameen, Tariq Omar Siddiqi, Parvez Khan, Altaf Ahmad Glycine betaine (GB) is one of the key compatible solutes that accumulate in the cell at exceedingly high level under the conditions of high salinity. It plays a crucial role in the maintenance of osmolarity of the cell without affecting the physiological processes. Analysis of stress-induced physiological conditions in living cells, therefore, requires real-time monitoring of cellular GB leve... περισσότερα »

Persistent Speech Sound Disorder

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Prevalence and Predictors of Persistent Speech Sound Disorder at Eight Years Old: Findings From a Population Cohort Study: Purpose The purpose of this study was to determine prevalence and predictors of persistent speech sound disorder (SSD) in children aged 8 years after disregarding children presenting solely with common clinical distortions (i.e., residual errors). Method Data from the Avon Longitudinal Study of Parents and Children (Boyd et al., 2012) were used. Children were classified as having persistent SSD on the basis of percentage of consonants correct measures from conne... περισσότερα »

Chemoradiotherapy is the treatment mostly used as organ preservation (OP) strategy worldwide in advanced laryngo-hypopharyngeal cancer

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Non-surgical organ preservation strategies for locally advanced laryngeal tumors: what is the Italian attitude? Results of a national survey on behalf of AIRO and AIOM: Abstract Chemoradiotherapy is the treatment mostly used as organ preservation (OP) strategy worldwide in advanced laryngo-hypopharyngeal cancer. Due to the not homogeneous results of the literature data regarding the pre-treatment assessment and treatment schedule in this setting of patients, the Italian societies of radiation oncology and medical oncology surveyed (by an online survey) their memberships regarding ... περισσότερα »

Anthracycline- and trastuzumab-induced cardiotoxicity

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
a retrospective study: Abstract Some chemotherapeutic agents cause cardiotoxic effects including reduction in left ventricular ejection fraction (LVEF) and occasionally congestive heart failure. Anthracyclines and HER2 monoclonal antibodies are common offenders, but clinical practice data on LVEF changes, risk factors and acute recovery is lacking. We retrospectively examined the electronic medical record at an academic medical center for receipt of anthracyclines and/or trastuzumab from 2000 to 2013 in cancer patients. Patient characteristics and serial LVEF assessments were col... περισσότερα »

Analysis of p.V37I compound heterozygouThe p.V37I (c.109G>A) mutation in the GJB2 gene is the common frequent cause of congenital deafnesss mutations in the GJB2 gene in Chinese infants and young children.

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Analysis of p.V37I compound heterozygous mutations in the GJB2 gene in Chinese infants and young children.: Biosci Trends. 2016 Jun 27; Authors: Du Y, Huang L, Cheng X, Zhao L, Ruan Y, Ni T Abstract The p.V37I (c.109G>A) mutation in the GJB2 gene is the common frequent cause of congenital deafness; however, its pathogenicity is debated. The present study investigated the prevalence of p.V37I in Chinese infants and young children and associated clinical characteristics. The subjects of the present study were screened for mutations in GJB2 (235delC, 299delAT, 176dell6, 35delG), SL... περισσότερα »

Stop, Drop and Talk

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
The Importance of Talking to Your Child; Contributions by Dr. Sonja Pruitt-Lord: *"In a world where emoji's are beginning to replace words and expressions — conveying a message to someone has taken on a new meaning. Public settings have become a little less chatty and it's not uncommon to find rows of people in the bent-neck, plugged-in posture. Very little human-to-human communication, no eye-contact, minimal speech."* - See the full article on Huffington Post! from OtoRhinoLaryngology - Alexandros G. Sfakianakis http://ift.tt/297lcPk via IFTTT http://ift.tt/291TpxA ... περισσότερα »

The effect of first language (L1) background on morphological awareness (MA) development

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
The Development of Morphological Awareness in Young Bilinguals: Effects of Age and L1 Background: Purpose Current understanding about the effect of first language (L1) background on morphological awareness (MA) development in those who are bilingual is largely limited to school-aged second-language learners. This study examined the development of MA in bilingual Mandarin–English (ManEngBi) and Spanish–English (SpaEngBi) children ages 4 to 7 years, whose L1 is predominated by compounding and derivation, respectively. Method We targeted specific word formation rules that develop wit... περισσότερα »

Persistent Speech Sound Disorder

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Prevalence and Predictors of Persistent Speech Sound Disorder at Eight Years Old: Findings From a Population Cohort Study: Purpose The purpose of this study was to determine prevalence and predictors of persistent speech sound disorder (SSD) in children aged 8 years after disregarding children presenting solely with common clinical distortions (i.e., residual errors). Method Data from the Avon Longitudinal Study of Parents and Children (Boyd et al., 2012) were used. Children were classified as having persistent SSD on the basis of percentage of consonants correct measures from con... περισσότερα »

HPV 16 oncoproteins on oncostatin M upregulation in oral squamous cell carcinoma

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Effect of Med Oncol. 2016 Aug;33(8):83 Authors: Chuerduangphui J, Pientong C, Chaiyarit P, Patarapadungkit N, Chotiyano A, Kongyingyoes B, Promthet S, Swangphon P, Wongjampa W, Ekalaksananan T Abstract Human papillomavirus (HPV) infection modulates several host cytokines contributing to cancer development. Oncostatin M (OSM), an IL-6 family cytokine, acts to promote cell senescence and inhibit growth. Its dysregulation promotes cell survival, cell proliferation and metastasis in various malignancies. The effect of HPV on OSM dysregulation has not been investigated. To elucidat... περισσότερα »

Detecting Porphyromonas gingivalis

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Loop-mediated isothermal amplification combined with PCR and immunohistochemistry for detecting *Porphyromonas gingivalis* in periapical periodontitis Taiichi Kitano, Yoshikazu Mikami, Takashi Iwase, Masatake Asano, Kazuo Komiyama Released: June 25, 2016 p.163-169 - [image: Abstract]Abstract - [image: 1x2PXuI]Full Text PDF[2568K] *Porphyromonas gingivalis* is important in the development of marginal periodontitis. However, the precise role and localization of *P. gingivalis* in chronic periapical periodontitis remain unclear. Thus, methods that can detect *P. gingivalis... περισσότερα »

Evaluation of osteoporosis in jaw bones using cone beam CT and dual-energy X-ray absorptiometry

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Enes Güngör, Derya Yildirim, Remzi Çevik Released: June 25, 2016 p.185-194 - [image: Abstract]Abstract - [image: 1x2PXuI]Full Text PDF[1127K] The aim of this study was to evaluate changes in jaw bones due to osteoporosis using cone beam computed tomography (CBCT) images. Subjects that had undergone CBCT for various oral conditions and demonstrating clinical findings of osteoporosis were invited to participate in the study. Dual X-ray absorptiometry (DXA) was performed on 90 patients aged over 30 years who underwent CBCT. The study groups were based on DXA results, and in... περισσότερα »

Headache attributed to temporomandibular disorders and masticatory myofascial pain

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Kazuhiko Hara, Takahiro Shinozaki, Akiko Okada-Ogawa, Yumiko Matsukawa, Ko Dezawa, Yuka Nakaya, Jui-Yen Chen, Noboru Noma, Shunichi Oka, Koichi Iwata, Yoshiki Imamura Released: June 25, 2016 p.195-204 - [image: Abstract]Abstract - [image: 1x2PXuI]Full Text PDF[1427K] We investigated the temporal association between temporomandibular disorders (TMD)-related symptoms and headache during TMD treatment for patients who fulfilled the diagnostic criteria for headache attributed to TMD (HATMD) specified in the Diagnostic criteria for TMD (DC/TMD) and International classificat... περισσότερα »

Surgical eye spears for saliva collection and recovery of secretory immunoglobulin A (s-IgA)

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Surgical eye spears for saliva collection and secretory immunoglobulin A measurements George N. Konstantinou, Christina M. Cherny, Anna Nowak-Węgrzyn Released: June 25, 2016 p.205-210 - [image: Abstract]Abstract - [image: 1x2PXuI]Full Text PDF[965K] We examined the use of surgical eye spears for saliva collection and recovery of secretory immunoglobulin A (s-IgA). We established a protocol for recovering s-IgA at concentrations equivalent to those present in the control samples (untreated by surgical eye spears). Four different types of eye spears were submerged in the s... περισσότερα »

MyoD is regulated by the miR-29a-Tet1 pathway in C2C12 myoblast cells

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Akiyoshi Chikenji, Hitoshi Ando, Megumi Nariyama, Takeo Suga, Ryohei Iida, Kazuhiro Gomi Released: June 25, 2016 p.219-229 - [image: Abstract]Abstract - [image: 1x2PXuI]Full Text PDF[1314K] Skeletal myogenesis is regulated by a considerable number of microRNAs (miRNAs). miRNA regulatory networks are complicated, and details of how they operate remain unclear. In this study, MTT assays confirmed that miR-29a is the most effective miR-29 paralog. Microarray analysis demonstrated upregulation of ten-eleven translocation enzyme-1 (*Tet1*) mRNA in response to miR-29a inhibi... περισσότερα »

Recurrent aphthous ulcers and oral lichen planus

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Stress as an etiologic co-factor in Priyadarshini Karthikeyan, Nalini Aswath Released: June 25, 2016 p.237-240 - [image: Abstract]Abstract - [image: 1x2PXuI]Full Text PDF[957K] This study aimed to examine the role of stress in the occurrence of recurrent aphthous stomatitis (RAS) and oral lichen planus (OLP), as well as to analyze the efficacy of saliva, urine, and serum cortisol levels as markers of stress. This study included 30 subjects with RAS (Group A), 30 with OLP (Group B), and 30 controls (Group C). The serum, salivary, and urinary cortisol levels were measured ... περισσότερα »

Periodontal status and idiopathic male infertility

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Association between periodontal status and idiopathic male infertility Norbert Pásztor, Krisztina Kárpáti, János Szöllősi, Márk Keresztúri, Zoltan Kozinszky, István Gorzó, Márta Radnai Released: June 25, 2016 p.247-253 - [image: Abstract]Abstract - [image: 1x2PXuI]Full Text PDF[814K] About 30% of male infertility cases are idiopathic. Previous studies reported a positive correlation between deep periodontal pockets and sperm sub-motility, which suggests that periodontitis might have a role in idiopathic semen abnormality pathospermia. We evaluated correlations between pe... περισσότερα »

Expression and influence of Notch signaling in oral squamous cell carcinoma

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
Thanaphum Osathanon, Nunthawan Nowwarote, Prasit Pavasant Released: June 25, 2016 p.283-294 - [image: Abstract]Abstract - [image: 1x2PXuI]Full Text PDF[1451K] Notch signaling dysregulation plays an important role in altering cancer cell behaviors; however, its role in oral squamous cell carcinoma (OSCC) remains controversial. This study aimed to investigate the role of Notch signaling related genes in human OSCC using a meta-analysis of Gene Expression Omnibus database (GEO-publicly available gene expression microarray data) and to examine the role of Notch signaling in... περισσότερα »

Journal of oral science.Nihon Daigaku Shigakubu

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.*Turn on automatic feed updates*You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds*You've successfully subscribed to this feed!*pubmed: "j oral sci"[jour]*You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be viewed ... περισσότερα »

Journal of oral science.Nihon Daigaku Shigakubu

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 17 δευτερόλεπτα
http://ift.tt/29etjxf Review Dental applications for silane coupling agents Tomotaro Nihei Released: June 25, 2016 p.151-155 Abstract Full Text PDF[1101K] Silane coupling agents alter the properties of material surfaces, which are modified by means of an organic functional group of specific silanes. This review describes the use of hydrophobic silane compounds for surface modification of silica-based and other materials. (J Oral Sci 58, 151-155, 2016) Original The effect of amine-free initiator system and the polymerization type on color stability of resin cements Çağrı Ural, İbr... περισσότερα »

Epac1 knockdown inhibits the proliferation of ovarian cancer cells by inactivating AKT/Cyclin D1/CDK4 pathway in vitro and in vivo

Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 17 δευτερόλεπτα
Abstract Ovarian cancer is the leading cause of death among gynecological malignancies, and high grade serous ovarian carcinoma is the most common and most aggressive subtype. Recently, it was demonstrated that cAMP mediates protein kinase A-independent effects through Epac (exchange protein directly activated by cAMP) proteins. Epac proteins, including Epac1 and Epac2, are implicated in several diverse cellular responses, such as insulin secretion, exocytosis, cellular calcium handling and formation of cell–cell junctions. Several reports document that Epac1 could play vital role... περισσότερα »

Tinetti Balance scale (TBS) and Berg Balance scale (BBS) in identifying balance disorders

Tinetti and Berg balance scales correlate with disability in hereditary peripheral neuropathies: a preliminary study.: Eur J Phys Rehabil Med. Authors: Monti Bragadin M, Francini L, Bellone E, Grandis M, Reni L, Canneva S, Gemelli C, Ursino G, Maggi G, Mori L, Schenone A Abstract BACKGROUND: The combination of distal muscle weakness, sensory defects and […]

The combination of distal muscle weakness, sensory defects and feet deformities leads to disequilibrium

Tinetti and Berg balance scales correlate with disability in hereditary peripheral neuropathies: a preliminary study.: Eur J Phys Rehabil Med. Authors: Monti Bragadin M, Francini L, Bellone E, Grandis M, Reni L, Canneva S, Gemelli C, Ursino G, Maggi G, Mori L, Schenone A Abstract BACKGROUND: The combination of distal muscle weakness, sensory defects and […]

Multiple sclerosis (MS) symptoms in childhood are characterized by a higher incidence of sensory, cerebellar and brainstem disorders

[May neuroimaging findings of a child with multiple sclerosis surprise us? Clinical and radiological observation].: Przegl Lek. 2016;73(3):197-200 Authors: Biedroń A, Witek I, Wesołowska E Abstract BACKGROUND: Multiple sclerosis (MS) is a chronic disorder characterized by presence of demyelinating changes in the central nervous system. The disease most often affects young adults with a female […]

Intrauterine infections as a risk factor of the development of sensorineural impairment of hearing

[Intrauterine infections as a risk factor of the development of sensorineural impairment of hearing ].: Vestn Otorinolaringol. 2016;81(2):82-7 Authors: Boboshko MY, Vikhnin SM, Savenko IV Abstract Intrauterine infections are a crucial pathogenic factor exerting an appreciable influence on the development of the fetus. They can provoke intrauterine death, cause multiple lesions in the organs and […]

Pontine capillary telangiectasia and developmental venous anomaly

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing-like attacks in a pediatric patient found to have a pontine capillary telangiectasia and developmental venous anomaly: A case report exploring the root of the problem.: Cephalalgia. 2016 Jun ; Authors: Liapounova NA, VanderPluym JH, Bhargava R, Kolski HH Abstract INTRODUCTION: Short-lasting unilateral neuralgiform headache attacks […]

Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing-like attacks in a pediatric patient

found to have a pontine capillary telangiectasia and developmental venous anomaly: A case report exploring the root of the problem.: Cephalalgia. 2016 Jun ; Authors: Liapounova NA, VanderPluym JH, Bhargava R, Kolski HH Abstract INTRODUCTION: Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT)-like attacks are rarely reported in the pediatric population and […]

Prevalence and Predictors of Persistent Speech Sound Disorder at Eight Years Old: Findings From a Population Cohort Study

Purpose The purpose of this study was to determine prevalence and predictors of persistent speech sound disorder (SSD) in children aged 8 years after disregarding children presenting solely with common clinical distortions (i.e., residual errors). Method Data from the Avon Longitudinal Study of Parents and Children (Boyd et al., 2012) were used. Children were classified […]

The Development of Morphological Awareness in Young Bilinguals: Effects of Age and L1 Background

Purpose Current understanding about the effect of first language (L1) background on morphological awareness (MA) development in those who are bilingual is largely limited to school-aged second-language learners. This study examined the development of MA in bilingual Mandarin–English (ManEngBi) and Spanish–English (SpaEngBi) children ages 4 to 7 years, whose L1 is predominated by compounding and […]

Otology and Audiology

Mediterranean Society of Otology and AudiologyThe journal of international advanced otologyhttp://ift.tt/297mcTD EditorialO. Nuri Özgirgin 1 1 Editor in Chief J Int Adv Otol 2016; 12: – Full Text (PDF)Related ArticlesSend a commentShare Cochlear Implant Evaluation: Prognosis Estimation by Data Mining SystemGloria Guerra-Jiménez 1 , Ángel Ramos De Miguel 1 , Juan Carlos Falcón […]

Emetogenic chemotherapy : Sequential addition of aprepitant in patients receiving carboplatin-based chemotherapy

Sequential addition of aprepitant in patients receiving carboplatin-based chemotherapy: Abstract Chemotherapy-induced nausea and vomiting is a challenging issue. Although aprepitant is sometimes used as a therapeutic option in patients receiving moderately emetogenic chemotherapy, the potential benefit of sequential addition of aprepitant to dexamethasone and a 5-hydroxytryptamine-3 (5-HT3) receptor antagonist during the second cycle of carboplatin-based […]

Prevalence and Predictors of Persistent Speech Sound Disorder at Eight Years Old: Findings From a Population Cohort Study

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Purpose The purpose of this study was to determine prevalence and predictors of persistent speech sound disorder (SSD) in children aged 8 years after disregarding children presenting solely with common clinical distortions (i.e., residual errors). Method Data from the Avon Longitudinal Study of Parents and Children (Boyd et al., 2012) were used. Children were classified as having persistent SSD on the basis of percentage of consonants correct measures from connected speech samples. Multivariable logistic regression analyses were performed to identify predictors. Results The estimat... περισσότερα »

The Development of Morphological Awareness in Young Bilinguals: Effects of Age and L1 Background

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Purpose Current understanding about the effect of first language (L1) background on morphological awareness (MA) development in those who are bilingual is largely limited to school-aged second-language learners. This study examined the development of MA in bilingual Mandarin–English (ManEngBi) and Spanish–English (SpaEngBi) children ages 4 to 7 years, whose L1 is predominated by compounding and derivation, respectively. Method We targeted specific word formation rules that develop within different developmental time frames. Forty-two ManEngBi, 30 SpaEngBi, and 27 English monolingual... περισσότερα »

Prevalence and Predictors of Persistent Speech Sound Disorder at Eight Years Old: Findings From a Population Cohort Study

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Purpose The purpose of this study was to determine prevalence and predictors of persistent speech sound disorder (SSD) in children aged 8 years after disregarding children presenting solely with common clinical distortions (i.e., residual errors). Method Data from the Avon Longitudinal Study of Parents and Children (Boyd et al., 2012) were used. Children were classified as having persistent SSD on the basis of percentage of consonants correct measures from connected speech samples. Multivariable logistic regression analyses were performed to identify predictors. Results The estimat... περισσότερα »

The Development of Morphological Awareness in Young Bilinguals: Effects of Age and L1 Background

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Purpose Current understanding about the effect of first language (L1) background on morphological awareness (MA) development in those who are bilingual is largely limited to school-aged second-language learners. This study examined the development of MA in bilingual Mandarin–English (ManEngBi) and Spanish–English (SpaEngBi) children ages 4 to 7 years, whose L1 is predominated by compounding and derivation, respectively. Method We targeted specific word formation rules that develop within different developmental time frames. Forty-two ManEngBi, 30 SpaEngBi, and 27 English monolingual... περισσότερα »

Prevalence and Predictors of Persistent Speech Sound Disorder at Eight Years Old: Findings From a Population Cohort Study

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Purpose The purpose of this study was to determine prevalence and predictors of persistent speech sound disorder (SSD) in children aged 8 years after disregarding children presenting solely with common clinical distortions (i.e., residual errors). Method Data from the Avon Longitudinal Study of Parents and Children (Boyd et al., 2012) were used. Children were classified as having persistent SSD on the basis of percentage of consonants correct measures from connected speech samples. Multivariable logistic regression analyses were performed to identify predictors. Results The estimat... περισσότερα »

The Development of Morphological Awareness in Young Bilinguals: Effects of Age and L1 Background

Αλέξανδρος ΣφακιανάκηςστοAudiology by Alexandros G. SfakianakisΠριν από 27 δευτερόλεπτα
Purpose Current understanding about the effect of first language (L1) background on morphological awareness (MA) development in those who are bilingual is largely limited to school-aged second-language learners. This study examined the development of MA in bilingual Mandarin–English (ManEngBi) and Spanish–English (SpaEngBi) children ages 4 to 7 years, whose L1 is predominated by compounding and derivation, respectively. Method We targeted specific word formation rules that develop within different developmental time frames. Forty-two ManEngBi, 30 SpaEngBi, and 27 English monolingual... περισσότερα »

Exploring the potential of antimicrobial hand hygiene products in reducing the infectious burden in low-income countries: An integrative review

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 29 δευτερόλεπτα
Publication date: 1 July 2016 *Source:*American Journal of Infection Control, Volume 44, Issue 7 Author(s): Jessie de Witt Huberts, Katie Greenland, Wolf-Peter Schmidt, Val Curtis BackgroundThe purpose of this review was to understand whether adding antimicrobial agents to hand hygiene products could increase the health benefits of handwashing with plain soap (HWWS) in low-income settings.MethodsA review of experimental studies comparing the effects of HWWS with antimicrobial soap and waterless hand sanitizer on health and hand contamination in naturalistic conditions was conducted.... περισσότερα »

Millions of reads, thousands of taxa: microbial community structure and associations analyzed via marker genes

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 29 δευτερόλεπτα
With high-throughput sequencing (HTS), we are able to explore the hidden world of microscopic organisms to an unpre-cedented level. The fast development of molecular technology and statistical methods means that microbial ecologists must keep their toolkits updated. Here, we review and evaluate some of the more widely adopted and emerging techniques for analysis of diversity and community composition, and the inference of species interactions from co-occurrence data generated by HTS of marker genes. We emphasize the importance of observational biases and statistical properties of ... περισσότερα »

Squamous cell carcinoma (SCC) - Cancer - Melanoma

Alexandros G. SfakianakisστοSquamous cell carcinoma (SCC) - Cancer - MelanomaΠριν από 34 δευτερόλεπτα
1h Squamous cell carcinomas by Alexandros G.Sfakianakis Preoperative chemoradiotherapy with cisplatin and docetaxel for stage IIIB non-small cell lung cancer: 10-year follow-up of the SAKK 16/01 trial Preoperative chemoradiotherapy with cisplatin and docetaxel for stage IIIB non-small cell lung cancer: 10-year follow-up of the SAKK 16/01 trial: from Cancer via ola Kala on Inoreader via IFTTT 1h Squamous cell carcinomas by Alexandros G.Sfakianakis Outcome according to KRAS-, NRAS- and BRAF-mutation as well as KRAS mutation variants - pooled analysis of five randomized trials in metas... περισσότερα »

HPV16 infection

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 34 δευτερόλεπτα
n in oral cavity and oropharyngeal cancer patients.: J Oral Sci. 2016;58(2):265-9 Authors: Dang J, Feng Q Abstract Our objective was to compare archived tissue biopsy samples from the oral cavity and oropharynx, in terms of human papillomavirus (HPV) 16 infection. We used Taqman real-time PCR assay to detect HPV16 in 121 archived biopsy samples from the oral cavity and 100 samples from the oropharynx. Among patients with oral cavity cancer (OCC), 9% (6/65) had HPV16 infection which was significantly less than those with oropharyngeal cancer (OPC) where 79% (39/50) were HPV16 pos... περισσότερα »

OtoRhinoLaryngology

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 34 δευτερόλεπτα
3hOtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on InoreaderPolyglycolic acid sheet application for intractable acute hemorrhagic rectal ulcer from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/296oeY8 via IFTTT5hOtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on InoreaderLow-Dose Tricyclics for Esophageal Hypersensitivity: Is it all Placebo Effect? Related Articles Low-Dose Tricyclics for Esophageal Hypersensitivity: Is it all Placebo Effect? Am J Gastroenterol. 2016 Feb;111(2):225-7 Authors: Keefer L, Ka... περισσότερα »

Prevalence and Predictors of Persistent Speech Sound Disorder at Eight Years Old: Findings From a Population Cohort Study

Alexandros G. SfakianakisστοΦωνή κ' ΛόγοςΠριν από 35 δευτερόλεπτα
Purpose The purpose of this study was to determine prevalence and predictors of persistent speech sound disorder (SSD) in children aged 8 years after disregarding children presenting solely with common clinical distortions (i.e., residual errors). Method Data from the Avon Longitudinal Study of Parents and Children (Boyd et al., 2012) were used. Children were classified as having persistent SSD on the basis of percentage of consonants correct measures from connected speech samples. Multivariable logistic regression analyses were performed to identify predictors. Results The estimat... περισσότερα »

Prevalence and clinical profile of fungal rhinosinusitis.

Related Articles Prevalence and clinical profile of fungal rhinosinusitis. Allergy Rhinol (Providence). 2016 Jun 21; Authors: Suresh S, Arumugam D, Zacharias G, Palaninathan S, Vishwanathan R, Venkatraman V Abstract BACKGROUND: There are only a few landmark studies from the Indian subcontinent on fungal rhinosinusitis. The lack of awareness among clinicians regarding the varying clinical presentations […]

Bone stability around implants in elderly patients with reduced bone mineral density – a prospective study on mandibular overdentures

Abstract Objective The purpose of this prospective clinical study was to determine whether reduced bone mineral density (BMD) is correlated with a higher risk for dental implant therapy in an elderly patient population. Material and methods Seventy-nine patients recruited at the Prince Philip Dental Hospital were provided with 2-implant-supported mandibular overdentures. Skeletal BMD was recorded […]

Recurrent aphthous ulcers and oral lichen planus

Stress as an etiologic co-factor in Priyadarshini Karthikeyan, Nalini Aswath Released: June 25, 2016 p.237-240 Abstract Full Text PDF[957K] This study aimed to examine the role of stress in the occurrence of recurrent aphthous stomatitis (RAS) and oral lichen planus (OLP), as well as to analyze the efficacy of saliva, urine, and serum cortisol levels […]

Prevalence and clinical profile of fungal rhinosinusitis.

Related Articles Prevalence and clinical profile of fungal rhinosinusitis. Allergy Rhinol (Providence). 2016 Jun 21; Authors: Suresh S, Arumugam D, Zacharias G, Palaninathan S, Vishwanathan R, Venkatraman V Abstract BACKGROUND: There are only a few landmark studies from the Indian subcontinent on fungal rhinosinusitis. The lack of awareness among clinicians regarding the varying clinical presentations […]

Brief communication: A 61-year-old woman with vesicular eruption after varicella zoster vaccination.

Related Articles Brief communication: A 61-year-old woman with vesicular eruption after varicella zoster vaccination. Allergy Rhinol (Providence). 2016 Jun 21; Authors: Ganacias K, Spriet S, Banks TA Abstract BACKGROUND: Vesicular rashes are associated with a variety of infectious and noninfectious causes. OBJECTIVE: To discuss the differential diagnoses of vesicular rashes. METHODS: We present the clinical […]

Brief communication: A 61-year-old woman with vesicular eruption after varicella zoster vaccination.

Related Articles Brief communication: A 61-year-old woman with vesicular eruption after varicella zoster vaccination. Allergy Rhinol (Providence). 2016 Jun 21; Authors: Ganacias K, Spriet S, Banks TA Abstract BACKGROUND: Vesicular rashes are associated with a variety of infectious and noninfectious causes. OBJECTIVE: To discuss the differential diagnoses of vesicular rashes. METHODS: We present the clinical […]

Odontogenic abscess complicated by descending necrotizing mediastinitis: evidence of medical and dental malpractice.

Related Articles Odontogenic abscess complicated by descending necrotizing mediastinitis: evidence of medical and dental malpractice. Minerva Stomatol. 2016 Jun 28; Authors: Ventura Spagnolo E, Mondello C, Cardia L, Ventura Spagnolo O, Bartoloni G PMID: 27351109 [PubMed – as supplied by publisher] from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/298REm1 via IFTTT from #Med Blogs by […]

The place of otorhinolaryngology in modern medicine.

Related Articles [The place of otorhinolaryngology in modern medicine]. Vestn Otorinolaringol. 2016;81(2):4-6 Authors: Pal’chun VT Abstract This publication is devoted to the peculiar features of the development of otorhinolaryngology as an integral component of modern medical science and practice and the place it now occupies among other disciplines. Much attention is given to the formation […]

The functional conditions of nasal cavity mucosa and paranasal sinuses following radical and minimally invasive surgical interventions.

Related Articles [The functional conditions of nasal cavity mucosa and paranasal sinuses following radical and minimally invasive surgical interventions]. Vestn Otorinolaringol. 2016;81(2):88-92 Authors: Magomedov MM, Zeinalova DF, Magomedova NM, Starostina AE Abstract The data of the literature are presented concerning the state of the mucous membrane of the nasal cavity, nasal turbinates, and maxillary sinus […]

Intrauterine infections as a risk factor of the development of sensorineural impairment of hearing .

Related Articles [Intrauterine infections as a risk factor of the development of sensorineural impairment of hearing ]. Vestn Otorinolaringol. 2016;81(2):82-7 Authors: Boboshko MY, Vikhnin SM, Savenko IV Abstract Intrauterine infections are a crucial pathogenic factor exerting an appreciable influence on the development of the fetus. They can provoke intrauterine death, cause multiple lesions in the […]

HPV 16 oncoproteins on oncostatin M upregulation in oral squamous cell carcinoma

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
Effect of Med Oncol. 2016 Aug;33(8):83 Authors: Chuerduangphui J, Pientong C, Chaiyarit P, Patarapadungkit N, Chotiyano A, Kongyingyoes B, Promthet S, Swangphon P, Wongjampa W, Ekalaksananan T Abstract Human papillomavirus (HPV) infection modulates several host cytokines contributing to cancer development. Oncostatin M (OSM), an IL-6 family cytokine, acts to promote cell senescence and inhibit growth. Its dysregulation promotes cell survival, cell proliferation and metastasis in various malignancies. The effect of HPV on OSM dysregulation has not been investigated. To elucidate ... περισσότερα »

Detecting Porphyromonas gingivalis

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
Loop-mediated isothermal amplification combined with PCR and immunohistochemistry for detecting *Porphyromonas gingivalis* in periapical periodontitis Taiichi Kitano, Yoshikazu Mikami, Takashi Iwase, Masatake Asano, Kazuo Komiyama Released: June 25, 2016 p.163-169 - [image: Abstract]Abstract - [image: icon_tool_pdf_free.png]Full Text PDF[2568K] *Porphyromonas gingivalis* is important in the development of marginal periodontitis. However, the precise role and localization of *P. gingivalis* in chronic periapical periodontitis remain unclear. Thus, methods that can detect... περισσότερα »

Evaluation of osteoporosis in jaw bones using cone beam CT and dual-energy X-ray absorptiometry

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
Enes Güngör, Derya Yildirim, Remzi Çevik Released: June 25, 2016 p.185-194 - [image: Abstract]Abstract - [image: icon_tool_pdf_free.png]Full Text PDF[1127K] The aim of this study was to evaluate changes in jaw bones due to osteoporosis using cone beam computed tomography (CBCT) images. Subjects that had undergone CBCT for various oral conditions and demonstrating clinical findings of osteoporosis were invited to participate in the study. Dual X-ray absorptiometry (DXA) was performed on 90 patients aged over 30 years who underwent CBCT. The study groups were based on DXA r... περισσότερα »

Headache attributed to temporomandibular disorders and masticatory myofascial pain

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
Kazuhiko Hara, Takahiro Shinozaki, Akiko Okada-Ogawa, Yumiko Matsukawa, Ko Dezawa, Yuka Nakaya, Jui-Yen Chen, Noboru Noma, Shunichi Oka, Koichi Iwata, Yoshiki Imamura Released: June 25, 2016 p.195-204 - [image: Abstract]Abstract - [image: icon_tool_pdf_free.png]Full Text PDF[1427K] We investigated the temporal association between temporomandibular disorders (TMD)-related symptoms and headache during TMD treatment for patients who fulfilled the diagnostic criteria for headache attributed to TMD (HATMD) specified in the Diagnostic criteria for TMD (DC/TMD) and Internatio... περισσότερα »

Surgical eye spears for saliva collection and recovery of secretory immunoglobulin A (s-IgA)

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
Surgical eye spears for saliva collection and secretory immunoglobulin A measurements George N. Konstantinou, Christina M. Cherny, Anna Nowak-Węgrzyn Released: June 25, 2016 p.205-210 - [image: Abstract]Abstract - [image: icon_tool_pdf_free.png]Full Text PDF[965K] We examined the use of surgical eye spears for saliva collection and recovery of secretory immunoglobulin A (s-IgA). We established a protocol for recovering s-IgA at concentrations equivalent to those present in the control samples (untreated by surgical eye spears). Four different types of eye spears were sub... περισσότερα »

MyoD is regulated by the miR-29a-Tet1 pathway in C2C12 myoblast cells

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
Akiyoshi Chikenji, Hitoshi Ando, Megumi Nariyama, Takeo Suga, Ryohei Iida, Kazuhiro Gomi Released: June 25, 2016 p.219-229 - [image: Abstract]Abstract - [image: icon_tool_pdf_free.png]Full Text PDF[1314K] Skeletal myogenesis is regulated by a considerable number of microRNAs (miRNAs). miRNA regulatory networks are complicated, and details of how they operate remain unclear. In this study, MTT assays confirmed that miR-29a is the most effective miR-29 paralog. Microarray analysis demonstrated upregulation of ten-eleven translocation enzyme-1 (*Tet1*) mRNA in response to... περισσότερα »

Recurrent aphthous ulcers and oral lichen planus

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
Stress as an etiologic co-factor in Priyadarshini Karthikeyan, Nalini Aswath Released: June 25, 2016 p.237-240 - [image: Abstract]Abstract - [image: icon_tool_pdf_free.png]Full Text PDF[957K] This study aimed to examine the role of stress in the occurrence of recurrent aphthous stomatitis (RAS) and oral lichen planus (OLP), as well as to analyze the efficacy of saliva, urine, and serum cortisol levels as markers of stress. This study included 30 subjects with RAS (Group A), 30 with OLP (Group B), and 30 controls (Group C). The serum, salivary, and urinary cortisol levels... περισσότερα »

Periodontal status and idiopathic male infertility

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
Association between periodontal status and idiopathic male infertility Norbert Pásztor, Krisztina Kárpáti, János Szöllősi, Márk Keresztúri, Zoltan Kozinszky, István Gorzó, Márta Radnai Released: June 25, 2016 p.247-253 - [image: Abstract]Abstract - [image: icon_tool_pdf_free.png]Full Text PDF[814K] About 30% of male infertility cases are idiopathic. Previous studies reported a positive correlation between deep periodontal pockets and sperm sub-motility, which suggests that periodontitis might have a role in idiopathic semen abnormality pathospermia. We evaluated correlati... περισσότερα »

Expression and influence of Notch signaling in oral squamous cell carcinoma

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
Thanaphum Osathanon, Nunthawan Nowwarote, Prasit Pavasant Released: June 25, 2016 p.283-294 - [image: Abstract]Abstract - [image: icon_tool_pdf_free.png]Full Text PDF[1451K] Notch signaling dysregulation plays an important role in altering cancer cell behaviors; however, its role in oral squamous cell carcinoma (OSCC) remains controversial. This study aimed to investigate the role of Notch signaling related genes in human OSCC using a meta-analysis of Gene Expression Omnibus database (GEO-publicly available gene expression microarray data) and to examine the role of Not... περισσότερα »

Journal of oral science.Nihon Daigaku Shigakubu

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
*Your subscribed feeds are not being updated automatically because this setting is turned off.* Turn on automatic feed updates *You've successfully subscribed to this feed!* Updated content can be viewed in Internet Explorer and other programs that use the Common Feed List. View my feeds *You've successfully subscribed to this feed!* pubmed: "j oral sci"[jour] *You are viewing a feed that contains frequently updated content.* When you subscribe to a feed, it is added to the Common Feed List. Updated information from the feed is automatically downloaded to your computer and can be vie... περισσότερα »

The role of IL-37 in cancer

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
The role of IL-37 in cancer: AbstractInterleukin 37 (IL-37) is a new member of the IL-1 family which all have a similar β-barrel structure. Since its discovery, IL-37 has been studied extensively in immunological field. It has been established that IL-37 possesses anti-inflammatory characteristics both in innate immune response as well as in acquired immune responses by downregulating pro-inflammatory molecules. This review will discuss the role of IL-37 in immunological processes and neoplastic pathogenesis.

Journal of oral science.Nihon Daigaku Shigakubu

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
http://ift.tt/29etjxf Review Dental applications for silane coupling agents Tomotaro Nihei Released: June 25, 2016 p.151-155 Abstract Full Text PDF[1101K] Silane coupling agents alter the properties of material surfaces, which are modified by means of an organic functional group of specific silanes. This review describes the use of hydrophobic silane compounds for surface modification of silica-based and other materials. (J Oral Sci 58, 151-155, 2016) Original The effect of amine-free initiator system and the polymerization type on color stability of resin cements Çağrı Ural, İbr... περισσότερα »

Non-surgical organ preservation strategies

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
for locally advanced laryngeal tumors: what is the Italian attitude? Results of a national survey on behalf of AIRO and AIOM: AbstractChemoradiotherapy is the treatment mostly used as organ preservation (OP) strategy worldwide in advanced laryngo-hypopharyngeal cancer. Due to the not homogeneous results of the literature data regarding the pre-treatment assessment and treatment schedule in this setting of patients, the Italian societies of radiation oncology and medical oncology surveyed (by an online survey) their memberships regarding the Italian attitude on larynx preservation ... περισσότερα »

HPV16 infection

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 37 δευτερόλεπτα
n in oral cavity and oropharyngeal cancer patients.: J Oral Sci. 2016;58(2):265-9 Authors: Dang J, Feng Q Abstract Our objective was to compare archived tissue biopsy samples from the oral cavity and oropharynx, in terms of human papillomavirus (HPV) 16 infection. We used Taqman real-time PCR assay to detect HPV16 in 121 archived biopsy samples from the oral cavity and 100 samples from the oropharynx. Among patients with oral cavity cancer (OCC), 9% (6/65) had HPV16 infection which was significantly less than those with oropharyngeal cancer (OPC) where 79% (39/50) were HPV16 posit... περισσότερα »

Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk

Alexandros G. SfakianakisστοΘεραπείαΠριν από 38 δευτερόλεπτα
Publication date: 20 September 2016 *Source:*European Journal of Pharmaceutical Sciences, Volume 92 Author(s): Woan-Ruoh Lee, Shing-Chuan Shen, Ibrahim A. Aljuffali, Yin-Ku Lin, Chang-Wei Huang, Jia-You Fang Use of the ablative laser has been approved to enhance topical drug penetration. Investigation into the usefulness of the non-ablative laser for assisting drug delivery is very limited. In this study, we explored the safety and efficacy of the non-ablative fractional erbium:glass (Er:glass) laser as an enhancement approach to promote drug permeation. Both pig and nude mouse skin... περισσότερα »

Prevalence and Predictors of Persistent Speech Sound Disorder at Eight Years Old: Findings From a Population Cohort Study

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα
Purpose The purpose of this study was to determine prevalence and predictors of persistent speech sound disorder (SSD) in children aged 8 years after disregarding children presenting solely with common clinical distortions (i.e., residual errors). Method Data from the Avon Longitudinal Study of Parents and Children (Boyd et al., 2012) were used. Children were classified as having persistent SSD on the basis of percentage of consonants correct measures from connected speech samples. Multivariable logistic regression analyses were performed to identify predictors. Results The estimat... περισσότερα »

The Development of Morphological Awareness in Young Bilinguals: Effects of Age and L1 Background

Αλέξανδρος ΣφακιανάκηςστοOtoRhinoLaryngology by Alexandros G.SfakianakisΠριν από 45 δευτερόλεπτα
Purpose Current understanding about the effect of first language (L1) background on morphological awareness (MA) development in those who are bilingual is largely limited to school-aged second-language learners. This study examined the development of MA in bilingual Mandarin–English (ManEngBi) and Spanish–English (SpaEngBi) children ages 4 to 7 years, whose L1 is predominated by compounding and derivation, respectively. Method We targeted specific word formation rules that develop within different developmental time frames. Forty-two ManEngBi, 30 SpaEngBi, and 27 English monolingual... περισσότερα »

OtoRhinoLaryngology

Alexandros G. SfakianakisστοHead and Neck DiseasesΠριν από 51 δευτερόλεπτα
3h OtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Polyglycolic acid sheet application for intractable acute hemorrhagic rectal ulcer from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/296oeY8 via IFTTT 5h OtoRhinoLaryngology - Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Low-Dose Tricyclics for Esophageal Hypersensitivity: Is it all Placebo Effect? Related Articles Low-Dose Tricyclics for Esophageal Hypersensitivity: Is it all Placebo Effect? Am J Gastroenterol. 2016 Feb;111(2):225-7 Authors: Kee... περισσότερα »

Effect of human papillomavirus 16 oncoproteins on oncostatin M upregulation in oral squamous cell carcinoma

Alexandros G. SfakianakisστοHead and NeckΠριν από 52 δευτερόλεπτα
Effect of human papillomavirus 16 oncoproteins on oncostatin M upregulation in oral squamous cell carcinoma: AbstractHuman papillomavirus (HPV) infection modulates several host cytokines contributing to cancer development. Oncostatin M (OSM), an IL-6 family cytokine, acts to promote cell senescence and inhibit growth. Its dysregulation promotes cell survival, cell proliferation and metastasis in various malignancies. The effect of HPV on OSM dysregulation has not been investigated. To elucidate this, immunohistochemistry was used on formalin-fixed, paraffin-embedded oral squamous c... περισσότερα »

Incidence and consequences of varicella in children treated for cancer in Guatemala.

Alexandros G. SfakianakisστοHead and NeckΠριν από 52 δευτερόλεπτα
Related Articles *Incidence and consequences of varicella in children treated for cancer in Guatemala.* World J Pediatr. 2016 Aug;12(3):320-326 Authors: Brown AE, Asturias EJ, Melgar M, Antillon-Klussmann FA, Mettler P, Levin MJ Abstract BACKGROUND: Varicella-zoster virus infection is associated with significant morbidity and mortality in immune-compromised children, despite treatment with antiviral agents. Universal varicella vaccine programs have significantly decreased this risk in many highincome countries, but in most low-income and middleincome countries, the burden of var... περισσότερα »

Dosimetry of ionising radiation in modern radiation oncology.

Alexandros G. SfakianakisστοHead and NeckΠριν από 52 δευτερόλεπτα
Related Articles *Dosimetry of ionising radiation in modern radiation oncology.* Phys Med Biol. 2016 Jun 28;61(14):R167-R205 Authors: Kron T, Lehmann J, Greer PB Abstract Dosimetry of ionising radiation is a well-established and mature branch of physical sciences with many applications in medicine and biology. In particular radiotherapy relies on dosimetry for optimisation of cancer treatment and avoidance of severe toxicity for patients. Several novel developments in radiotherapy have introduced new challenges for dosimetry with small and dynamically changing radiation fields be... περισσότερα »

Prospective changes in global DNA methylation and cancer incidence and mortality.

Alexandros G. SfakianakisστοHead and NeckΠριν από 52 δευτερόλεπτα
Related Articles *Prospective changes in global DNA methylation and cancer incidence and mortality.* Br J Cancer. 2016 Jun 28; Authors: Joyce BT, Gao T, Zheng Y, Liu L, Zhang W, Dai Q, Shrubsole MJ, Hibler EA, Cristofanilli M, Zhang H, Yang H, Vokonas P, Cantone L, Schwartz J, Baccarelli A, Hou L Abstract BACKGROUND: Methylation of repetitive elements Alu and LINE-1 in humans is considered a surrogate for global DNA methylation. Previous studies of blood-measured Alu/LINE-1 and cancer risk are inconsistent. METHODS: We studied 1259 prospective methylation measurements from blood ... περισσότερα »

The Impact of Underweight Status on the Prognosis of Ovarian Cancer Patients: A Meta-Analysis.

Alexandros G. SfakianakisστοHead and NeckΠριν από 52 δευτερόλεπτα
Related Articles *The Impact of Underweight Status on the Prognosis of Ovarian Cancer Patients: A Meta-Analysis.* Nutr Cancer. 2016 Jun 28;:1-8 Authors: Pergialiotis V, Doumouchtsis SK, Perrea D, Vlachos GD Abstract Malnutrition and underweight status pose an unfavorable prognosis for cancer patients. Several studies have addressed the impact of a low body mass index (BMI) (<18.5 kg/m(2)) on ovarian cancer progression. However, their results seem to be conflicting. The present meta-analysis investigates whether the underweight status negatively affects the progress of ovarian ca... περισσότερα »

OtoRhinoLaryngology

3h OtoRhinoLaryngology – Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Polyglycolic acid sheet application for intractable acute hemorrhagic rectal ulcer from #Esophageal Cancer via a.lsfakia on Inoreader http://ift.tt/296oeY8 via IFTTT 5h OtoRhinoLaryngology – Alexandros G. Sfakianakis via Alexandros G.Sfakianakis on Inoreader Low-Dose Tricyclics for Esophageal Hypersensitivity: Is it all Placebo Effect? Related […]

Zoledronic Acid Improves Bone Quality in the Streptozotocin-Induced Diabetes Rat through Affecting the Expression of the Osteoblast-Regulating Transcription Factors

Alexandros G. SfakianakisστοΕνδοκρινολογίαΠριν από 1 ώρα
Exp Clin Endocrinol Diabetes DOI: 10.1055/s-0042-105282 Aims: To evaluate the short term effect of zoledronic acid on bone remodeling in the streptozotocin induced diabetes rats. Materials and Methods: Diabetes was induced by an injection of streptozotocin (60 mg/kg). The rats were treated with zoledronic acid (0.1 mg/kg) at the onset of diabetes (Z-I group) and 2 weeks later (Z-II group). Rats were sacrificed at the 1, 2, 3, 4 and 5 weeks after the onset of diabetes. Real–time PCR and western blot were performed to detect the expression of the following osteogenic gene mRNAs and ... περισσότερα »

Cytomegalovirus Infection of Seminal Vesicles

Alexandros G. SfakianakisστοΠαθολοΑνατομίαΠριν από 1 ώρα
from Anatomy Pathology via ola Kala on Inoreader http://ift.tt/293XeD0 via IFTTT

Bone stability around implants in elderly patients with reduced bone mineral density – a prospective study on mandibular overdentures

Alexandros G. SfakianakisστοOroFacial Medicine by Alexandros G.SfakianakisΠριν από 1 ώρα
Abstract Objective The purpose of this prospective clinical study was to determine whether reduced bone mineral density (BMD) is correlated with a higher risk for dental implant therapy in an elderly patient population. Material and methods Seventy-nine patients recruited at the Prince Philip Dental Hospital were provided with 2-implant-supported mandibular overdentures. Skeletal BMD was recorded before the implant therapy. The World Health Organization Osteoporosis Diagnosis Classification (femoral neck score) was utilized to define the osteoporosis status of patients. Periapica... περισσότερα »

Multicentre cohort study ‘Rehabilitation of Occupational Skin Diseases – Optimization and Quality Assurance of Inpatient Management (ROQ)’: results from a 3-year follow-up

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 1 ώρα
Summary Background A tertiary individual prevention programme (TIP) is offered to patients with severe occupational skin disease (OSD) in Germany. Previously, it was shown that the burden of OSDs is considerably reduced in patients up to 1 year after the TIP. Objectives To evaluate the long-term effects of the TIP. Patients and methods In a prospective multicentre cohort study, the clinical and patient-reported outcome data for up to 3 years after the TIP were evaluated. Results Of the 1788 patients initially included in the study, 1410 were available for the 3-year follow-up... περισσότερα »

Editorial Board

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Publication date: 1 July 2016 *Source:*American Journal of Infection Control, Volume 44, Issue 7 from Infection via ola Kala on Inoreader http://ift.tt/29r8xqc via IFTTT

Clostridium difficile infection epidemiology and management: Comparison of results of a prospective study with a retrospective one in a reference teaching and research hospital in Northern Italy

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Publication date: Available online 29 June 2016 *Source:*American Journal of Infection Control Author(s): G. Domeniconi, S. Serafino, M. Migone De Amicis, S. Formica, M. Lanzoni, A. Maraschini, F. Sisto, D. Consonni, M.D. Cappellini, G. Fabio, S. Castaldi BackgroundClostridium difficile–associated disease (CDAD) is the most common infectious antibiotic-associated diarrhea and is a growing health care problem. Prevention of Clostridium difficile infection focuses on clinical and epidemiologic infection control measures.MethodsBetween 2008 and 2009, we conducted a retrospective study ... περισσότερα »

APIC Masthead

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Publication date: 1 July 2016 *Source:*American Journal of Infection Control, Volume 44, Issue 7 from Infection via ola Kala on Inoreader http://ift.tt/29r9jmM via IFTTT

Information for Readers

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Publication date: 1 July 2016 *Source:*American Journal of Infection Control, Volume 44, Issue 7 from Infection via ola Kala on Inoreader http://ift.tt/295AXr3 via IFTTT

Information for Authors

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Publication date: 1 July 2016 *Source:*American Journal of Infection Control, Volume 44, Issue 7 from Infection via ola Kala on Inoreader http://ift.tt/29r8HxP via IFTTT

APIC salutes the 2016 Heroes of Infection Prevention

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Publication date: 1 July 2016 *Source:*American Journal of Infection Control, Volume 44, Issue 7 from Infection via ola Kala on Inoreader http://ift.tt/295AW6t via IFTTT

Table of Contents

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Publication date: 1 July 2016 *Source:*American Journal of Infection Control, Volume 44, Issue 7 from Infection via ola Kala on Inoreader http://ift.tt/29r8Oti via IFTTT

The first point prevalence survey of health care–associated infection and antimicrobial use in a Japanese university hospital: A pilot study

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Publication date: 1 July 2016 *Source:*American Journal of Infection Control, Volume 44, Issue 7 Author(s): Hiroshi Morioka, Aki Hirabayashi, Mitsutaka Iguchi, Yuka Tomita, Daizo Kato, Naokazu Sato, Miyuki Hyodo, Naoko Kawamura, Takuya Sadomoto, Kazuya Ichikawa, Takayuki Inagaki, Yoshiaki Kato, Yuichi Kouyama, Yoshinori Ito, Tetsuya Yagi BackgroundPoint prevalence surveys (PPSs) in Japanese hospitals have not yet been reported. The purpose of this pilot PPS study was to evaluate the epidemiology of health care–associated infections (HAIs) and antimicrobial use in a Japanese tertiary... περισσότερα »

Prevention of transmitted infections in a pet therapy program: An exemplar

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Publication date: 1 July 2016 *Source:*American Journal of Infection Control, Volume 44, Issue 7 Author(s): Pam Hardin, Janice Brown, Mary Ellen Wright The focus of the patient experience in health care delivery has afforded the opportunity to integrate pet therapy as a part of patient care. The purpose of this article is to present the implementation of a pet therapy program that includes guidelines for the prevention of transmitted infections. Consideration of infection prevention strategies has resulted in a 16-year program with no documented incidences of transmitted infections,... περισσότερα »

Tetanus, diphtheria, and acellular pertussis vaccination among women of childbearing age—United States, 2013

Alexandros G. SfakianakisστοΛοίμωξηΠριν από 1 ώρα
Publication date: 1 July 2016 *Source:*American Journal of Infection Control, Volume 44, Issue 7 Author(s): Alissa C. O'Halloran, Peng-jun Lu, Walter W. Williams, Helen Ding, Sarah A. Meyer The incidence of pertussis in the United States has increased since the 1990s. Tetanus, diphtheria, and acellular pertussis (Tdap) vaccination of pregnant women provides passive protection to infants. Tdap vaccination is currently recommended for pregnant women during each pregnancy, but coverage among pregnant women and women of childbearing age has been suboptimal. Data from the 2013 Behavioral... περισσότερα »

Secondary Breast Augmentation

Learning Objectives: After studying this article, the participant should be able to: 1. Assess common clinical problems in the secondary breast augmentation patient. 2. Describe a treatment plan to correct the most common complications of breast augmentation. 3. Provide surgical and nonsurgical options for managing complications of breast augmentation. 4. Decrease the incidence of future […]

Basal Short Nose: How to Identify and Correct It

No abstract available from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/294JBE2 via IFTTT

Analyzing Regional Differences over a 15-Year Trend of One-Stage versus Two-Stage Breast Reconstruction in 941,191 Postmastectomy Patients

Background: Implant-based reconstruction is the predominant form of breast reconstruction, with the two-stage tissue expander/implant approach being the most popular. Recently, the direct-to-implant, one-stage breast reconstruction procedure has gained momentum. In this study, national and regional trends across the United States for the two different types of implant-based reconstructions were evaluated. Methods: The Nationwide Inpatient […]

A Need For Clear Thinking

No abstract available from Aesthetic via Alexandros G.Sfakianakis on Inoreader http://ift.tt/2940rXp via IFTTT

Comparison of Outcomes following Autologous Breast Reconstruction Using the DIEP and Pedicled TRAM Flaps: A 12-Year Clinical Retrospective Study and Literature Review

Background: There are few studies that compare the deep inferior epigastric artery perforator (DIEP) flap to the pedicled transverse rectus abdominis myocutaneous (pTRAM) flap for use in reconstructive breast surgery. The authors examined four factors that aid in decision-making: donor-site morbidity, need for surgery related to abdominal morbidity, operative time, and complications. Methods: This is […]

An Analysis of the Decisions Made for Contralateral Prophylactic Mastectomy and Breast Reconstruction

Background: Little is known about the role breast reconstruction plays in decisions made for contralateral prophylactic mastectomy. This study explores factors critical to patient medical decision-making for contralateral prophylactic mastectomy and reconstruction among women with early stage, unilateral breast cancer. Methods: A mixed methods approach was used to gain an understanding of patients’ choices and […]

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου