Estimation of serum and salivary level of resistin in obese patients with periodontitis

Reema M Rao, Nina Shenoy, Biju Thomas

Indian Journal of Oral Sciences 2016 7(2):87-91

Context: Obesity is considered as one of the risk indicators of periodontal diseases. Resistin could be one such marker that could provide a link among the periodontitis-obesity. Aims: The aim of this study was to corelate the serum and saliva resistin levels and its association in obese individuals with chronic periodontitis. Settings and Design: A cross-sectional study was done to co-relate the serum and saliva resistin levels and its association in obese individuals with chronic periodontitis. Subjects and Methods: Participants were divided into Group I comprising 15 obese individuals with healthy gingiva (control group) and Group II comprising 15 obese individuals with chronic moderate periodontitis (periodontitis group).Gingival index, clinical attachment level and body mass index were determined. Enzyme-linked immunosorbent assay test was used to determine the level of resistin in both serum and saliva. Statistical Analysis Used: To study the difference in the levels of resistin between two groups in terms of saliva and serum, independent sample t-test was used. Results: The highest resistin levels were seen in the serum and saliva of Group II. Correlation of serum resistin concentration with salivary resistin concentration was positive among both the groups. A positive corelation was observed between resistin and clinical parameters and was statistically significant. Conclusion: Thus, resistin can be considered as a potential mediator linking obesity and periodontal disease. Hence, it can be concluded that resistin probably may bear similar features of a proinflammatory cytokine and could play a role in inflammatory diseases like periodontitis.

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