Evaluation of salivary nitric oxide levels and C-reactive protein in patients with oral lichen planus and burning mouth syndrome

Abstract

Objectives

The aim of this study was to evaluate oxidative stress factors and C-reactive protein in the saliva of patients with oral lichen planus (OLP) and burning mouth syndrome (BMS).

Methods

This consecutive, cross-sectional study included 20 patients with OLP, 19 with burning mouth syndrome (BMS), and 31 control subjects. The oral cavity of each patient was examined and patients responded to a quality of life questionnaire (OHIP-14) and the Xerostomia Inventory. The following parameters were measured in whole non-stimulated saliva: trolox equivalent antioxidant capacity (TEAC); total antioxidant capacity (TAC); cupric reducing antioxidant capacity (CUPRAC); and ferric reducing ability of plasma (FRAP); C-reactive protein (CRP); nitric oxide; nitrates; and nitrites.

Results

The OLP group presented statistically significant differences in reactive oxygen species (ROS) (26916 cps/g) in comparison with the control group (P<0.05). In the BMS group, ROS was 36028 cps/g with significant difference in comparison with the control group (P<0.05). Significantly higher salivary nitric oxide (254.2 umol/g) and nitrite (182.6 umol/g) levels were found in OLP patients in comparison with BMS and control groups (P<0.05).

Conclusion

Increases in nitric oxide and C-reactive protein were found in the saliva of OLP patients in comparison with BMS and control patients. Further studies are required to confirm these findings.

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