The expanding microRNA world in psoriasis

Abstract

Psoriasis skin lesions are characterized by dramatic changes in the transcriptome, reflecting altered activity of multiple signaling pathways in resident and infiltrating cells. MiRNAs are small non-coding RNAs that have a large impact on cellular functions by regulating multiple genes simultaneously, and they have been shown to play key roles in skin homeostasis and inflammation. In this commentary to the review article "MicroRNAs in Psoriasis: Immunological Functions and Potential Biomarkers" by Liu et al., the role of miRNAs in psoriasis, their diagnostic and therapeutic potential is discussed and remaining unanswered questions are highlighted.

This article is protected by copyright. All rights reserved.

http://ift.tt/2h2dhYu