Bacillus Calmette–Guérin vaccine complications in Iranian children at a University Hospital

Publication date: Available online 1 February 2017
Source:Allergologia et Immunopathologia
Author(s): M.R. Bolursaz, F. Lotfian, A.A. Velayati
BackgroundAlthough the BCG vaccine remains the only available vaccine, a number of complications from local to systemic adverse reactions can occur.ObjectiveThe aim of the study was to review the clinical features and treatment of Bacillus Calmette–Guérin (BCG) complications in children.MethodsChildren with clinical and laboratory findings compatible with a diagnosis of local complication and disseminated disease at Masih Daneshvari Medical Center were enrolled from March 2013 to September 2015.ResultsAmong 49 children with BCG complications, 35 (71%) had local complications and 14 (29%) had disseminated disease. The mean age at presentation was nine months (range: 1m–13y). The male to female ratio was 1.7:1. Suppurative lymphadenitis was seen in 25 of 35 (71%) cases. Among cases with disseminated disease, primary immunodeficiency (PID) was identified in nine (64%) cases. All cases with non-suppurative lymphadenitis were managed conservatively. Twenty (80%) cases with suppurative lymphadenitis were managed differently with medical treatment or surgery. In disseminated cases, three (43%) were treated with only medical treatment and eight (57%) with both medical and surgical treatment.ConclusionsMost children with BCG complications had a local disease in our study. A higher rate of disseminated disease was also observed. In addition, PID was identified in most children with disseminated disease. Development of more appropriate BCG vaccines and changing the current vaccination programme in cases with suspected PID are required in our country.



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