Effect of nebulized budesonide on decreasing the recurrence of allergic fungal rhinosinusitis

Publication date: Available online 1 February 2017
Source:American Journal of Otolaryngology
Author(s): Qi Dai, Chen Duan, Quan Liu, Hongmeng Yu
ObjectiveTo evaluate the clinical efficacy and the effects on decreasing the recurrence of AFRS (allergic fungal rhinosinusitis) of a budesonide inhalation suspension delivered via transnasal nebulization to patients following endoscopic sinus surgery.Subjects and methodsThirty patients were recruited into this study. Final diagnoses were reached using Bent and Kuhn's criteria. The patients were randomly divided into two groups: the budesonide transnasal nebulization group (group A) and the topical nasal steroids group (group B). Nasal symptoms, Lund-Mackay scores, and Kupferberg grades were evaluated before surgery, after surgery and during the follow-up to assess the effects of these two approaches.ResultsFour of the 15 patients in group B (26.67%) developed recurrent disease, whereas no patients in group A developed recurrent disease. This difference was statistically significant (p=0.032).ConclusionNebulized budesonide is an effective and safe treatment for patients with AFRS following endoscopic sinus surgery, as evidenced by the reduced recurrence rate observed in the budesonide transnasal nebulization group relative to the topical nasal steroids group.



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