Multiple and recurrent squamous cell carcinoma of the oral cavity after graft-versus-host disease

Publication date: Available online 22 February 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Weng Xiu Hong, Zhen Xing Yu, Bo Cheng
Oral squamous cell carcinoma (OSCC) is one of the most common secondary solid tumors in patients with hematopoietic stem cell transplantation (HSCT). However, according to previous reports, multiple and recurrent OSCC is very rare. The case presented here shows the susceptibility of patients who present with chronic graft-versus-host disease (cGVHD) after HSCT to the development of secondary malignancies, particularly oral cancer. OSCC after HSCT appears to be more invasive and has a tendency to recur, with a poor prognosis. Therefore, regular and thorough evaluations of the oral mucosa are recommended for all patients who undergo bone marrow transplantation (BMT) and are suffering from cGHVD.



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