Risk Factor Analysis of Graft Failure with Concomitant Cyst Enucleation of the Jaw Bone: a Retrospective Multicenter Study

Publication date: Available online 14 February 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Ho-Kyung Lim, Jin-Woo Kim, Ui-Lyong Lee, Ju-Won Kim, Ho Lee
PurposeCysts are common pathological entities in the oral and maxillofacial region. Enucleation is commonly used for treatment and is occasionally followed by bone grafting. However, no studies have evaluated factors affecting the failure of grafts used for cystic defects in the oral and maxillofacial region. Therefore, we conducted the present study to determine the risk factors for postoperative graft failure in patients treated with cyst enucleation and simultaneous bone grafting.MethodsClinical data for 305 patients who had undergone cyst enucleation with simultaneous bone grafting were retrospectively investigated in this multicenter, case–control study. The predictor variables included host, pathological, and treatment factors. The outcome variable was success or failure of the bone graft. Descriptive statistics were computed, and the P-value was set at .05.ResultsBone graft failure was observed in 48 cases. The mean duration from surgery to failure was 38.7 days. Multivariable logistic regression analysis revealed a significant association between graft failure and a lower age [odds ratio (OR), 1.033; P = .016], smoking (OR, 2.598; P = .017), preoperative infection (OR, 4.660; P = .001), large cysts (OR, 1.052; P = .010), impaction of the mandibular third molar in the cystic cavity (OR, 3.021; P = .007), perilesional sclerosis (OR, 4.973; P = .001), and the use of mixed nonautogenous and autogenous bone grafts (OR, 3.891; P = .007).ConclusionsOur study provides a list of important factors that should be considered by clinicians planning enucleation and simultaneous bone grafting for cysts in the oral and maxillofacial region.



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