Mechanisms of anaphylaxis beyond classically mediated antigen- and IgE-induced events

We have long known that events clinically indistinguishable from IgE- and mast cell–mediated anaphylaxis can occur through other mechanisms, and the term anaphylactoid was used to refer to these events as early as the 1940s,1 but our knowledge of the underlying mechanisms of anaphylactoid events has been limited until recently. However, in the past 2 decades, there have been significant advances in our understanding of the mechanisms underlying non–IgE- and mast cell–mediated anaphylactic episodes.

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