αS1-casein Elucidate Major T Cell Responses in Cow’s Milk Allergy

Publication date: Available online 23 March 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): L. Diego Archila, Fatima S. Khan, Nupur Bhatnagar, David Robinson, Mary L. Farrington, William W. Kwok
Cow's milk allergy (CMA) is increasing in prevalence, affecting approximately 4% of children. Cow's milk (CM) is a common cause of fatal/ near fatal anaphylactic reactions. Understanding of CM-specific CD4+ T-cells responses to milk allergens should help elucidate the pathological mechanisms of persistent CMA. Milk allergen epitopes specific T-cells were examined in CMA subjects. Frequencies and phenotypes of these T-cells were found to be different between older and younger subjects.



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