Diminished airway macrophage expression of the Axl receptor tyrosine kinase is associated with defective efferocytosis in asthma.

Publication date: Available online 12 April 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Aleksander M. Grabiec, Nicholas Denny, John A. Doherty, Kaisa E. Happonen, Jenny Hankinson, Emma Connolly, Mark E. Fife, Toshifumi Fujimori, Naoya Fujino, Anu Goenka, Susan Holden, Gaël Tavernier, Rajesh Shah, Peter C. Cook, Andrew S. MacDonald, Robert M. Niven, Björn Dahlbäck, Stephen J. Fowler, Angela Simpson, Tracy Hussell

Teaser

The apoptotic cell recognition receptor Axl is highly expressed on human airway/alveolar macrophages, its expression is driven by the lung microenvironment and is significantly reduced in asthma, which may explain defects in apoptotic cell clearance.


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