Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions

Publication date: Available online 18 July 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Alexandra Epp, Juliane Hobusch, Yannic C. Bartsch, Janina Petry, Gina-Maria Lilienthal, Carolien A.M. Koeleman, Simon Eschweiler, Christian Möbs, Ashley Hall, Suzanne C. Morris, Dominique Braumann, Christine Engellenner, Josephine Bitterling, Johann Rahmöller, Alexei Leliavski, Robina Thurmann, Mattias Collin, Kelley W. Moremen, Richard T. Strait, Véronique Blanchard, Arnd Petersen, Timo Gemoll, Jens K. Habermann, Frank Petersen, Andreas Nandy, Helga Kahlert, Michael Hertl, Manfred Wuhrer, Wolfgang Pfützner, Uta Jappe, Fred D. Finkelman, Marc Ehlers

Teaser

In presence of high allergen dosis besides IgE also IgG antibodies can induce allergic reactions, whose severity is dependent on the induced type of IgG Fc glycosylation, what should be considered for new AIT protocols containing new adjuvants.


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