Rescue of T-cell function during persistent pulmonary adenoviral infection by TLR9 activation

Publication date: Available online 19 August 2017
Source:Journal of Allergy and Clinical Immunology
Author(s): Tristan Holland, Dirk Wohlleber, Samira Marx, Thomas Kreutzberg, Salvador Vento-Asturias, Christine Schmitt-Mbamunyo, Meike Welz, Marianne Janas, Karl Komander, Sarah Eickhoff, Anna Brewitz, Mike Hasenberg, Linda Männ, Matthias Gunzer, Christoph Wilhelm, Wolfgang Kastenmüller, Percy Knolle, Zeinab Abdullah, Christian Kurts, Natalio Garbi

Teaser

Pulmonary persistent adenoviral infections induce an immunosuppressive environment in the lung that renders CD8 T-cells dysfunctional. Innate cell activation during persistent infection re-invigorates effector T cell function leading to viral clearance and immune homeostasis.


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