Deconstructive SCNT reveals novel Treg subsets

Publication date: Available online 30 May 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Manching Ku, Eugene Ke, Mohsen Sabouri-Ghomi, Justin Abadejos, Brent Freeman, Amy Nham, Nathaniel Phillips, Kevin Y. Yang, Kathy O. Lui, Oktay Kirak

Teaser

Using single-cell transcriptomic and SCNT, we identify multiple distinct Treg subsets. We show that naturally occurring and agonist-induced Tregs are two of these subsets, which differ amongst in TCR strength, development, differentiation, and Ctla4 expression.


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