Odontogenic carcinosarcoma: morphological and immunohistochemical description of one case.

Publication date: Available online 30 May 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Jean Nunes dos Santos, João Paulo Silva Servato, Sergio Vitorino Cardoso, Paulo Rogério de Faria, Bruno Cunha Pires, Adriano Mota Loyola
ObjectivesThe goal of this study was to describe an extremely rare case of odontogenic carcinosarcoma (OCS) and compare the findings with a literature review.Study DesignThe clinical and pathological data of an OCS affecting the posterior maxilla of a 42-year-old male patient was described. The lesion was immunostained for cell-cycle, cytokeratin (CK), and mesenchymal markers. A review of literature from 1960 to 2017 was conducted in a search for similar well-documented case reports. Descriptive statistics were calculated to compare clinical and pathological variables.ResultsIn the reported case, the percentage of Ki-67-positive epithelial and mesenchymal cells was estimated as 40% and 25%, respectively. Epithelial cells were focally positive for CKs 7, 8, 14, 18, and diffusely positive for CK19, p53, and p16. Mesenchymal cells were strongly positive for desmin, HHF-35, and vimentin. Our review showed that OCS is diagnosed mostly in advanced stage. All patients with relapsed tumors had died because of the disease.ConclusionsThe very few cases reported in the literature support that most OCSs develop in the posterior mandible in a wide age range, without gender and racial predilections. Only one other OCS case has been reported in the maxilla. Until today, the best treatment remains unknown.



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