Oral and maxillofacial metastasis of male breast cancer: report of a rare case and literature review

Publication date: Available online 30 May 2018
Source:Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Nathalia de Almeida Freire, Bruno Augusto Benevenuto de Andrade, Nathalie Henriques da Silva Canedo, Michelle Agostini, Mário José Romañach
Oral and maxillofacial metastatic tumors are uncommon, with the breast, prostate, lung and kidney representing the most common primary sites. Less than 1% of all breast cancers occur in male patients, and to date, only eight cases of metastatic breast adenocarcinoma to the oral and maxillofacial region in a male patient have been reported in the literature. An 88-year-old male with previous history of a successfully treated primary breast adenocarcinoma 12 years earlier was referred for evaluation of an oral swelling lasting 6 months. Intraoral examination revealed a 2 cm reddish, pedunculated nodule with a smooth surface located in the left retromolar region. Imaging revealed maxillary sinus involvement. The patient was submitted to incisional biopsy, and microscopic evaluation revealed invasive tumor islands compounded by malignant epithelial cells, sometimes exhibiting ductal arrangement, which were positive for the estrogen receptor and GCDFP-15. The final diagnosis was metastatic breast adenocarcinoma. Breast metastases are exceedingly rare in the oral and maxillofacial region of male patients; however, clinicians should consider breast metastasis when evaluating reddish oral nodules in older patients, including men, especially those with a history of malignancy.



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